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Pharmaceutical composition preventing postoperative delirium

A technology of composition and medicine, which is applied in the field of pharmaceutical composition, can solve the problems of reduced stress ability of the elderly body, inability to correctly judge the surrounding environment, injury to people, destruction of property or self-injury, etc., to improve subjective sleep quality, Overcoming sleep disorders, wide-ranging effects

Inactive Publication Date: 2016-02-03
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Surgery puts the body in a state of stress. During stress, the sympathetic nerves are excited, and the concentrations of catecholamines, epinephrine, norepinephrine, and dopamine in the plasma increase. The stronger the stimulation, the higher the level of increase. Reduced system reliability, increased sensitivity to stressors, strong stress response, and abnormal excitatory conduction lead to postoperative delirium in elderly patients
[0005] At present, benzodiazepines are mostly used in the treatment of delirium, such as diazepam 10mg slow intravenous injection, high-efficiency benzodiazepines such as alprazolam 0.8-1.6mg, rola 2-4mg or clonazepam 2-4mg, etc. However, patients with physical diseases will be more sensitive to the above drugs, which may easily cause a drop in blood pressure or cause acute extrapyramidal reactions
Because patients with delirium have impaired consciousness, cannot correctly judge the surrounding environment, and may be affected by hallucinations or delusions, accidents such as hurting people, destroying objects, or self-injury may occur. The best way should be prevention, but there are no effective preventive measures.

Method used

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  • Pharmaceutical composition preventing postoperative delirium
  • Pharmaceutical composition preventing postoperative delirium
  • Pharmaceutical composition preventing postoperative delirium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation of embodiment 1 pharmaceutical composition

[0044] 1. Preparation of pharmaceutical composition

[0045] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 4ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 4ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0046] 2. Medication for patients

[0047] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients, who were 76 elderly patients aged 65 or over who were admitted to the ICU after non-cardiac surgery and did not require mechanical ve...

Embodiment 2

[0050] The preparation of embodiment 2 pharmaceutical compositions

[0051] 1. Preparation of pharmaceutical composition

[0052] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 2ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 2ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0053] 2. Medication for patients

[0054] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients, who were 76 elderly patients aged 65 or over who were admitted to the ICU after non-cardiac surgery and did not require mechanical v...

Embodiment 3

[0057] The preparation of embodiment 3 pharmaceutical compositions

[0058] 1. Preparation of pharmaceutical composition

[0059] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 6ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 6 ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0060] 2. Medication plan

[0061] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients, who were 76 elderly patients aged 65 or over who were admitted to the ICU after non-cardiac surgery and did not require mechanical ventilat...

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Abstract

The invention relates to the field of pharmaceutical compositions, and especially relates to a pharmaceutical composition preventing postoperative delirium. The provided pharmaceutical composition contains a pharmaceutical solvent carrier and dexmedetomidine or pharmaceutically-acceptable salts dissolving in the solvent carrier. The pharmaceutical composition is applicable to improve postoperative patient sleep structure, thereby improving patient sleep quality. The pharmaceutical composition is capable of preventing postoperative patient delirium, also is capable of mitigating patient pain, is safe to use and low in cost, and is usable by being matched with one or more of other sedatives, narcotics, hypnotics and opioids.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition for preventing postoperative delirium. Background technique [0002] Delirium is an acute confusional state in the elderly, a transient organic brain syndrome accompanied by disturbances in attention, feeling, thinking, memory, psychomotor and sleep cycles, and is a relatively common and important postoperative complication in the elderly. Clinically, it is often misdiagnosed as senile dementia. [0003] The occurrence of postoperative delirium is affected by many factors. Severe postoperative pain is one of the risk factors for postoperative delirium. Pain is the body's response to noxious stimuli. Continuous pain can cause anxiety, tension, fear and other emotions. Reaction, causing physiological dysfunction, significantly affecting sleep time and quality, and the incidence of postoperative delirium is related to sleep dysfunction. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K45/06A61P25/04A61P25/20
Inventor 王东信苏仙
Owner PEKING UNIV FIRST HOSPITAL
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