Pharmaceutical composition overcoming postoperative sleep disorder

A technology for sleep disorders and compositions, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as aggravating sleep disorders, failing to improve sleep structure, etc., achieving no side effects, prolonging total sleep time, The effect of improving sleep efficiency

CN105287518AInactive Publication Date: 2016-02-03PEKING UNIV FIRST HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2016-02-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of pharmaceutical compositions, and especially relates to a pharmaceutical composition overcoming postoperative sleep disorder. The provided pharmaceutical composition contains a pharmaceutical solvent carrier and dexmedetomidine or pharmaceutically-acceptable salts thereof dissolved in the solvent carrier. The pharmaceutical composition is used to improve postoperative patient sleep structure, thereby improving patient sleep quality. The pharmaceutical composition also is capable of mitigating patient pain, is safe to use and low in cost, and is usable by being matched with one or more of other sedatives, narcotics, hypnotics and opioids.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition for overcoming postoperative sleep disorders. Background technique

[0002] Sleep disorders include sleep deprivation, disturbed sleep, and abnormal sleep architecture [1,2]. Elderly patients often suffer from sleep disorders after surgical operations, especially major operations [3]. On polysomnography, circadian rhythm disturbances, prolonged sleep latency, sleep fragmentation, decreased sleep efficiency, and non-fast phase 1 and 2 Eye movement sleep is abnormally increased and slow wave sleep and rapid eye movement sleep are decreased [4,5]. The occurrence of sleep disturbance will bring many adverse effects on the postoperative recovery of patients, including increased risk of cardiovascular events, prolonged mechanical ventilation events, induction of delirium, physical and mental decline, and immune function involvement (may increase ...

Examples

Embodiment 1

[0069] 1. Preparation of pharmaceutical composition

[0070] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 4ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 4ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0071] 2. Medication for patients

[0072] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients, who were 76 elderly patients aged 65 or over who were admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.

[0073] Inject the 4ug / ml dexmedetomidine solution obtai...

Embodiment 2

[0076] 1. Preparation of pharmaceutical composition

[0077] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 2ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 2ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0078] 2. Medication for patients

[0079] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients who were 65 years old or older and admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.

[0080] The 4ug / ml dexmedetomidine solution obtained in step 1 was injected ...

Embodiment 3

[0083] 1. Preparation of pharmaceutical composition

[0084] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 6ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 6ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0085] 2. Medication plan

[0086] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients who were 65 years old or older and admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.

[0087] The 4ug / ml dexmedetomidine solution obtained in step 1 was injected into the...