Pharmaceutical composition overcoming postoperative sleep disorder

A technology for sleep disorders and compositions, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as aggravating sleep disorders, failing to improve sleep structure, etc., achieving no side effects, prolonging total sleep time, The effect of improving sleep efficiency

Inactive Publication Date: 2016-02-03
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0032] In order to solve the problem that the sleep medicine aids in the prior art cannot improve the sleep structure, or even aggravate the sleep disturbance, the present invention provides a pharmaceutical composition that can overcome postoperative sleep disturbance. The pharmaceutical composition is injected into the body Injection exists, and it mainly realizes the object of the present invention by injecting a pharmaceutical composition containing dexmedetomidine or a pharmaceutically acceptable salt thereof, and adopting intravenous injection of the pharmaceutical composition provided by the present invention can significantly improve postoperative sleep structure and subjective sleep quality

Method used

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  • Pharmaceutical composition overcoming postoperative sleep disorder
  • Pharmaceutical composition overcoming postoperative sleep disorder
  • Pharmaceutical composition overcoming postoperative sleep disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] 1. Preparation of pharmaceutical composition

[0070] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 4ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 4ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0071] 2. Medication for patients

[0072] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients, who were 76 elderly patients aged 65 or over who were admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.

[0073] Inject the 4ug / ml dexmedetomidine solution obtai...

Embodiment 2

[0076] 1. Preparation of pharmaceutical composition

[0077] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 2ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 2ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0078] 2. Medication for patients

[0079] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients who were 65 years old or older and admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.

[0080] The 4ug / ml dexmedetomidine solution obtained in step 1 was injected ...

Embodiment 3

[0083] 1. Preparation of pharmaceutical composition

[0084] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 6ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 6ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.

[0085] 2. Medication plan

[0086] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients who were 65 years old or older and admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.

[0087] The 4ug / ml dexmedetomidine solution obtained in step 1 was injected into the...

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Abstract

The invention relates to the field of pharmaceutical compositions, and especially relates to a pharmaceutical composition overcoming postoperative sleep disorder. The provided pharmaceutical composition contains a pharmaceutical solvent carrier and dexmedetomidine or pharmaceutically-acceptable salts thereof dissolved in the solvent carrier. The pharmaceutical composition is used to improve postoperative patient sleep structure, thereby improving patient sleep quality. The pharmaceutical composition also is capable of mitigating patient pain, is safe to use and low in cost, and is usable by being matched with one or more of other sedatives, narcotics, hypnotics and opioids.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition for overcoming postoperative sleep disorders. Background technique [0002] Sleep disorders include sleep deprivation, disturbed sleep, and abnormal sleep architecture [1,2]. Elderly patients often suffer from sleep disorders after surgical operations, especially major operations [3]. On polysomnography, circadian rhythm disturbances, prolonged sleep latency, sleep fragmentation, decreased sleep efficiency, and non-fast phase 1 and 2 Eye movement sleep is abnormally increased and slow wave sleep and rapid eye movement sleep are decreased [4,5]. The occurrence of sleep disturbance will bring many adverse effects on the postoperative recovery of patients, including increased risk of cardiovascular events, prolonged mechanical ventilation events, induction of delirium, physical and mental decline, and immune function involvement (may increase ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K45/06A61P25/20
Inventor 王东信苏仙
Owner PEKING UNIV FIRST HOSPITAL
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