A kind of terlipressin acetate preparation and preparation method thereof

A technology of terlipressin and acetic acid is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., and can solve the problems of low product yield, poor stability, limited application and the like, To achieve the effect of improving stability and reconstitution, improving stability and shape, and being easy to industrialize production
CN110251469BActive Publication Date: 2021-11-09南京诺卡医药技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
南京诺卡医药技术有限公司
Publication Date
2021-11-09

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Abstract

The invention relates to the technical field of pharmacy, in particular to a terlipressin acetate preparation and a preparation method thereof. The preparation method of the terlipressin acetate preparation comprises the following steps: freezing and drying a drug solution obtained by mixing terlipressin acetate, glycine and a drug solvent to obtain a terlipressin acetate preparation; The weight ratio of terlipressin acetate and glycine is 1:10-20; the pH of the drug solution is 3.5-4.5. The terlipressin acetate preparation obtained by the specific preparation method of the present invention has a complete appearance, which improves the product yield; the water content of the preparation is low, which improves the stability of the preparation during transportation and storage; it can be quickly reconstituted; and Under the conditions of high temperature and light, the impurity content is small, which improves the safety of the preparation in clinical administration.
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Description

Technical field

[0001] The present invention relates to the field of pharmaceutical techniques, and in particular, a specific pressurin preparation thereof and a preparation method thereof thereof. Background technique

[0002] Television is known as N-α-tritlatin-8-lysine-plug, is a white powder. It can be used for bleeding of gastrointestinal and urinary reproductive systems, such as esteem veins, stomach and duodenal ulcers, functionalities and other reasons caused by bleeding caused by bleeding, etc., can be used for surgery The treatment of the post-bleeding, especially bleeding in the abdominal cavity and pelvic area.

[0003] The prior art is poorly stabilized, the product yield is low, the moisture content is large, the impurity content is more, and the solubility is poor, and it limits its in medical applications.

[0004] In view of this, the present invention is proposed. Inventive content

[0005] The present invention relates to a method of preparing acetate-specifi...

Claims

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