4results about How to "Improve reconstitution performance" patented technology

The application relates to a soluble silk fibroin pellet quick-freezing, separating and collecting device. The device comprises a low-temperature treatment tank, an external heat preservation tank, a feeding assembly, a separating assembly and an electric control system. The low-temperature treatment tank is nested in the external heat preservation tank and is adiabatic; the feeding assembly is arranged between a top cover plate and an adiabatic plate and comprises a material feeding pipe, a liquid nitrogen feeding pipe and a recovery pipe; a liquid drop pipe is arranged in the material pipe and is provided with a heating device arranged inside the liquid drop pipe to prevent freezing; liquid drops fall through the adiabatic plate into liquid nitrogen to be quickly frozen into small balls. The parameters of a stirring paddle can be adjusted to control the particle diameter, and a peristaltic pump and the specification of the drop pipe are used to control the size. The quick-frozen mixture flows into a separating tank through a low-temperature electromagnetic valve, small balls are intercepted by a screen, and liquid nitrogen is recycled. The electric control system is used for regulating and controlling stirring, the electromagnetic valve and heating power. The device can ensure resolubility through low shear quick freezing, the quick-frozen mixture can be freeze-dried in less than 24 hours due to the high specific surface area of the small balls, the cost is reduced through liquid nitrogen circulation, and the flux and particle diameter can be controlled through multi-parameter adjustment, so that the device is suitable for the preparation of silk fibroin and composite materials.

The invention discloses a nano emulsion loaded with terpinen-4-ol. The nano emulsion is prepared from the following components in percentage by mass: 3 to 4 percent of terpinen-4-ol, 6 to 8 percent of an amino acid surfactant, 5 to 6 percent of a cosurfactant, 0.1 to 1 percent of sorbitan fatty acid ester, 0 to 0.5 percent of N-isopropylacrylamide, 0 to 1 percent of vitamin E and the balance of water, the amino acid surfactant is prepared from one or more of sodium lauroyl sarcosinate, sodium lauroyl glutamate, N-oleoyl sodium methyl taurate and sodium cocoyl glycinate. The particle size of the nano-emulsion is 50-100 nm, the nano-emulsion is uniform in distribution and high in stability at room temperature, N-isopropylacrylamide is introduced under the action of hydrogen bonds in a two-time freeze-drying and redissolving mode, vitamin E can form a protective film on the surface of liposome, the stability of the emulsion is enhanced, and the stability of the nano-emulsion is improved. The terpinen-4-ol is loaded into the side chain of the amino acid surfactant by adopting the amino acid surfactant, so that the toxicity and irritation are reduced, and the adverse reaction of the system is reduced.

This invention relates to the field of lyophilized formulation technology and discloses a method for preparing controllable molecular weight silk fibroin lyophilized spheres, comprising the following steps: preparing a mixture of a lyophilization protectant, a protein conformation stabilizer, and silk fibroin solutions of different molecular weights. The lyophilization protectant includes sugars and sugar alcohols, and the protein conformation stabilizer is a polyol. After pre-freezing the mixture into spheres, a surface coating modification is performed by adding an ethanol solution containing cellulose, followed by a second pre-freezing in liquid nitrogen, and finally, the lyophilized product is controlled by a specific program in a vacuum freeze dryer. This invention employs specific lyophilization protectants, protein conformation stabilizers, surface coating modification techniques, and freeze-drying techniques, enabling the prepared silk fibroin lyophilized spheres to have a better appearance and improving their resistance to moisture absorption and shrinkage, as well as their rapid reconstitution.

The invention discloses a multi-effect repairing polypeptide composition and application thereof in cosmetics, and relates to the technical field of cosmetics. The natural plant essential oil such as the camellia-seed oil, the jojoba oil, the rose essential oil, the geranium essential oil and the neroli essential oil are compounded, good whitening and repairing effects are achieved, the natural plant essential oil serves as a core material, the polypeptide compound, the modified chitosan and the hyaluronic acid are sequentially coated, the stimulation effect on skin can be greatly reduced, and the skin care effect is achieved. According to the present invention, the polypeptide compound and the whitening essential oil are added, the active components in the polypeptide compound and the whitening essential oil are substantially absorbed under the permeation promoting effect of the hyaluronic acid and the chitosan so as to well provide the whitening and repairing effects, in addition, the polypeptide compound contains oligopeptide-1, tripeptide-3 and carnosine, such that the skin barrier is efficiently repaired in multiple ways, the antioxidant peptide is adopted to modify the chitosan so as to provide the skin whitening and repairing effect, and the skin whitening and repairing effects are further provided; the antioxidant effect of the polypeptide composition is improved, so that the whitening and repairing effects of the polypeptide composition are indirectly improved.