The invention relates to a compound lumbricus extract, and a preparation process and a composition thereof. The compound lumbricus extract comprises, by weight, 25 parts of a fresh product of lumbricus, 3.5 parts of Ligusticum wallichii, 3 parts of Radix Astragali and 2 parts of achyranthes root. The preparation process comprises the following steps: 1) preparing lumbricus powder, that is, taking 25 parts of the fresh product of lumbricus, cleaning and draining the fresh product of lumbricus, adding water with a weight equal to that of the fresh product of lumbricus, carrying out stirring and homogenization at a temperature of 37 DEG C, carrying out centrifugation, taking a supernatant for membrane filtration, condensing obtained filtrate, and carrying out freeze drying on obtained concentrate; 2) preparing extracts of Ligusticum wallichii, achyranthes root and Radix Astragali, that is, taking Ligusticum wallichii, achyranthes root and Radix Astragali by above-mentioned corresponding weight percentage, adding 6 to 10 times of an ethanol solution with a concentration of 50 to 90%, carrying out reflux extraction twice, each lasting 2 hours, carrying out filtration, merging alcohol liquid, recovering the alcohol liquid, condensing the alcohol liquid until relative density of the alcohol liquid is about 1.1 to 1.5, and drying the alcohol liquid; 3) preparing the compound lumbricus extract, that is, uniformly mixing the lumbricus powder prepared in step 1) and extracts of Ligusticum wallichii, achyranthes root and Radix Astragali prepared in step 2).