Compound lumbricus extract, and preparation process and composition thereof

Abstract

The invention relates to a compound lumbricus extract, and a preparation process and a composition thereof. The compound lumbricus extract comprises, by weight, 25 parts of a fresh product of lumbricus, 3.5 parts of Ligusticum wallichii, 3 parts of Radix Astragali and 2 parts of achyranthes root. The preparation process comprises the following steps: 1) preparing lumbricus powder, that is, taking 25 parts of the fresh product of lumbricus, cleaning and draining the fresh product of lumbricus, adding water with a weight equal to that of the fresh product of lumbricus, carrying out stirring and homogenization at a temperature of 37 DEG C, carrying out centrifugation, taking a supernatant for membrane filtration, condensing obtained filtrate, and carrying out freeze drying on obtained concentrate; 2) preparing extracts of Ligusticum wallichii, achyranthes root and Radix Astragali, that is, taking Ligusticum wallichii, achyranthes root and Radix Astragali by above-mentioned corresponding weight percentage, adding 6 to 10 times of an ethanol solution with a concentration of 50 to 90%, carrying out reflux extraction twice, each lasting 2 hours, carrying out filtration, merging alcohol liquid, recovering the alcohol liquid, condensing the alcohol liquid until relative density of the alcohol liquid is about 1.1 to 1.5, and drying the alcohol liquid; 3) preparing the compound lumbricus extract, that is, uniformly mixing the lumbricus powder prepared in step 1) and extracts of Ligusticum wallichii, achyranthes root and Radix Astragali prepared in step 2).

Description

technical field [0001] The invention relates to the field of medicines, in particular to a compound dilong extract, a preparation process and a composition thereof. Background technique [0002] Compound Dilong Capsules is listed in Volume 37 of "National Drug Standards for New Drugs". The parts by weight of the components are: 25 parts of fresh earthworm, 3.5 parts of Chuanxiong, 3 parts of astragalus, and 2 parts of Achyranthes bidentata. [0003] Compound Dilong Capsule has the functions of removing blood stasis, dredging collaterals, replenishing qi and activating blood circulation, and is mainly used to treat ischemic cerebrovascular diseases. It is used for the treatment of qi deficiency and blood stasis in the meridian recovery period of ischemic stroke. Symptoms include hemiplegia, crooked tongue, and speech difficulty Astringent or speechless, partial body numbness, fatigue, palpitations, shortness of breath, salivation, spontaneous sweating, etc. The active ingre...

AI Technical Summary

Problems solved by technology

[0012] 1) Part of Astragalus is used as medicine by powdering, it is difficult to ensure its crushing particle size, and astragalus powder is added to other extracts to dry together, it is difficult to guarantee the curative effect, and the operation is cumbersome;

[0013] 2) The activity of dried earthworm is much lower than that of fresh product, and it is difficult to guarantee its curative effect when it is powdered into medicine;

[0014] 3) The solubility of the compound Dilong extract is not good, and its content is slightly soluble in the solvent. Suspending agents and other auxiliary materials must be added, and then uniformly mixed with a colloid mill to complete the preparation. This method will cause the temperature of the content to rise. And cause the degradation of active ingredient to affect the activity of compound Dilong extract;

[0015] 4) When the soft capsule is prepared by dripping or pressing, the rubber and the contents need to be heated, and the heating will cause the degradation of the active ingredient and affect the activity of the compound Dilong extract;

[0016] 5) Capsules tend to emit bad smells such as the fishy smell of medicines, which are not easy for patients to accept, and the active ingredients in the capsules are absorbed slowly in the human body, which affects the bioavailability of compound dilong extract;

[0017] 6) The hygroscopicity of the compound Dilong extract powder is very strong, and it is easy to absorb water to increase the viscosity, and cause the moisture absorption and deterioration of the active ingredients, reduce the disintegration performance of the disintegrating agent, and prolong the disintegration time; the compound Dilong extract powder The fluidity is poor, and it is difficult to control the difference in the loading of capsule drugs; not only affects the preparation of the preparation, but also affects the effectiveness, stability and safety of the drug due to the degradation of the active ingredients in the extract caused by moisture absorption;

[0018] 7) The process is not optimized enough, resulting in the low content of active ingredients in the compound Dilong extract. For example, the original quality standard only limited the content of ferulic acid to not less than 30 μg / grain

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