44results about How to "Promote hypertrophy" patented technology

The present invention discloses a coronary artery medicine coating scaffold for inhibiting endometrial hyperplasia and preventing restenosis in the scaffold. It includes dilating scaffold base body and inner coating layer coated on the dilating scaffold base body, the above-mentioned inner coating layer is formed from medicine carrier and ligustrazine, their mass ratio is 3:1-1:3, the above-mentioned inner coating layer is one of methyl acrylate, methyl methacrylate copolymer, polylactic acid, polyglycollic acid, polymonoracemic lactic acid, polylactide-diglycolide polymer, phosphorylcholine, ethyl polyurethane inorganic micropore aluminium oxide and cellulose or their composite.

The invention provides a Chinese patent medicine for treating prostatitis, which comprises the following raw medicines: aweto, American ginseng, antler, Chinese yam, epimedium, broomrape, Chinese wolfberry, common cnidium fruit, prepared rehmannia root, cynomorium, teasel root, shiandra, angelica, euryale seed, safflower, tuckahoe, moutan bark, rhizoma anemarrhenae, dogwood, dodder, lotus seed, oyster, phellodendron bark, deglued antler, achyranthes, peach kernel, milk vetch, plantain seed and licorice. The Chinese patent medicine is prepared from oral capsules and brewed medicated wine which are taken together, wherein the oral capsules are taken after breakfast per day, and the brewed medicated wine is drunk at night in the same day. In the invention, the oral capsules and the drinking medicated wine need to be taken together, wherein the oral capsules need to be taken in the morning, and the brewed medicated wine needs to be drunk at night. The Chinese patent medicine provided by the invention can be used for treating both principal and secondary aspects of diseases, can be used for treating prostatitis, conditioning internal secretion and improving sleep quality, has the advantages of short course of treatment, good treatment effect, no side effects and low treatment cost, and is convenient to use. Traditional capsules and medicated wine are adopted in the invention, thus the Chinese patent medicine is convenient to prepare, store and use clinically.

The invention discloses a loofah high-yield culture technique in greenhouse. By adopting the technique, fresh loofah can be provided for the market in midwinter, and the loofah is smooth in fruit stem and has little fuzz and soft peel. The technique is realized by the following technical scheme: growing seedlings in nutrition bowl or nutrition soil block; soaking seeds in warm water and accelerating germination; flatly putting 1 germinated seed in each pot; providing enough water and base fertilizer before field planting; performing the field planting in the first ten days of November, and using the mixture of carbendazim and primary virus powder with soil as bottom and disinfecting; and after planting, enhancing management on water, fertilizer, temperature and humidity, paying attention to pruning, flower thinning, pollination and loofah protection, and harvesting in proper time.

The invention discloses a Gannan potentilla anserine efficient planting method. The method comprises the steps of land selection, land preparation and fertilization, plant disease and insect pest controlling and digging at a proper time; the planting method is characterized by five aspects of a planting season and seed selection, planting pattern, planting density and seeding quantity, an irrigation method and irrigation quantity and foliage application; according to an efficient planting technology of potentilla anserine in areas in hostile natural conditions which is high and cold and high in altitude and the like, scale and standardized potentilla anserine planting in the Gannan plateau area is achieved, the potentilla anserine industry is developed, and service guarantee is provided for economy development, targeted poverty alleviation, and income increase of farmers and herdsmen in high and cold areas in hostile natural environment conditions.

The invention provides application of a nuclear receptor ROR alpha in the preparation of anti-heart failure drugs. The nuclear receptor ROR alpha is a nuclear receptor ROR alpha 1 subtype; the gene sequence of the nuclear receptor ROR alpha 1 is as shown in SEQ ID NO. 1; and the amino acid sequence of the nuclear receptor ROR alpha 1 is as shown in SEQ ID NO. 2. Experiments find that the expression of the nuclear receptor ROR alpha provided by the invention in hypertrophic and failing myocardial tissues is down-regulated, and the loss of ROR alpha can aggravate cardiac hypertrophy and cardiacfailure. The overexpression of myocardial-specific ROR alpha can alleviate TAC-induced myocardial interstitial fibrosis and improve the cardiac hypertrophy and cardiac failure. The nuclear receptor ROR alpha has an effect against cardiac hypertrophy and cardiac failure.

The invention belongs to the technical field of production and cultivation of edible mushrooms and discloses nutritional supplementing liquid for multiple fruiting of pleurotus eryngii. The nutritional supplementing liquid contains the following components in parts by weight: 20-30 parts of urea, 15-25 parts of potassium dihydrogen phosphate, 5-15 parts of potassium chloride, 25-50 parts of organic substance mixed liquid, 20-40 parts of a nutrition additive, 2-6 parts of multivitamins, 1-5 parts of microelements, 5-10 parts of glucose, 2-10 parts of saccharose, 1.0-2.5 parts of corn germ oil,1-5 parts of citric acid and 500-1000 parts of water. The nutritional supplementing liquid is specially prepared according to the growth property of the pleurotus eryngii and can be used for promotingthe secondary fruiting and even multiple fruiting of the pleurotus eryngii and supplying comprehensive nutrients to the pleurotus eryngii, so that the total yield of the pleurotus eryngii can be increased; and the nutrients in a culture medium are adequately utilized, so that the environmental wasting is reduced, the feasibility is high, and the cultivation cost of the pleurotus eryngii is greatly saved.

The invention discloses a preparation method for an agent used for production of seedless grapes. The agent is prepared from certain amounts by weight of gibberellin, B9, forchlorfenuron and 2,4-dichlorphenoxyacetic acid and 10% of ethanol. After the agent is applied to flower clusters and fruit clusters, the seedless rate of grapes can reach 100%, seedless grapes are bigger in size, the period of keeping grapes on grapevines for fresh storage is prolonged, and a fruit setting rate is increased. The agent is simple to prepare and can be easily absorbed by the flower clusters and the fruit clusters.

The invention discloses water-soluble fertilizer for fruit swelling, coloring, yield increasing and disease resistance of fruits and vegetables and a preparation method of the water-soluble fertilizer. The water-soluble fertilizer is prepared from the following raw materials in parts by weight: 120 to 180 parts of zinc sulfate, 120 to 180 parts of manganese sulfate, 50 to 70 parts of potassium humate, 1.5 to 2.5 parts of S-abscisic acid, 1.5 to 2.5 parts of forchlorfenuron and 1.5 to 2.5 parts of triacontanol. The water-soluble fertilizer provided by the invention is used for strengthening andsupplementing zinc, manganese and potassium, has strong pertinence and also can be used for regulating the growth of the fruits and vegetables; and the water-soluble fertilizer has fruit swelling, coloring, yield increasing and disease resistance effects on the fruits and vegetables and has relatively low comprehensive utilization cost.

The invention relates to novel pharmacological action of traditional Chinese medicine salvianolic acid A and application thereof in the preparation of products for preventing, relieving and/or treating pulmonary arterial hypertension and its complications. The salvianolic acid A has the advantages that the salvianolic acid A has the pharmacological action of relieving pulmonary circulation pressure rise, the pharmacological actions of relieving right heart failure due to pulmonary arterial hypertension, improving right ventricular hypertrophy and right ventricular enlargement, improving heart injury due to pulmonary arterial hypertension, and restoring from heart failure, and the pharmacological actions of lowering endothelin-1 level in pulmonary tissues, relieving pulmonary arterial remodeling and improving pathologic damage of pulmonary tissues; the salvianolic acid A is a monomer compound extracted from Salvia miltiorrhiza, has low toxicity, has a wide source range of material, has promising application and development prospect, is an ideal novel traditional Chinese medicine monomer for treating pulmonary arterial hypertension and its complications, and may be applied to prepare products for preventing, relieving and treating pulmonary arterial hypertension and its complications, such as chronic obstructive pulmonary emphysema, chronic pulmonary heart disease and heart failure.

The invention relates to application of an oral hypoglycemic peptide. The application is used for preparing a medicine or a medicine composition for treating or preventing diabetes complicated with cardiovascular diseases. The oral hypoglycemic peptide is polypeptide OHP2. The polypeptide can effectively improve myocardial hypertrophy and fibrosis damage caused by the diabetes, reduce the contentof related myocardial enzymes, adjust the lipid metabolism level and improve myocardial cell oxidative stress and mitochondrial damage, so that the effect of protecting the heart is achieved; and therefore, the polypeptide can be used as a candidate molecule for treating or preventing the diabetes complicated with the cardiovascular diseases (especially diabetic cardiomyopathy), and has a good application prospect.

The invention discloses a function and application of SH2B adapter protein 1 (SH2B1) in myocardial hypertrophy treatment. According to the function and application, the mutual relation between SH2B1 genetic expression and myocardial hypertrophy is determined; the SH2B1 expression rises obviously when the myocardial hypertrophy happens; SH2B1 interference and overexpression adenovirus are used for restraining and promoting cardiomyocyte hypertrophy respectively; the SH2B1 gene defect and overexpression are used for restraining and obviously raising Jak2/Stat3 signal pathway activation respectively, so that cardiac hypertrophy and fibrosis are restrained and promoted, and the cardiac function can be protected and deteriorated. Hence, the SH2B1 gene can be used as a drug target to be used for screening drugs for protecting the cardiac function and/or preventing, relieving and treating cardiac hypertrophy; the SH2B1 gene can be used as a target gene in gene therapy to be used for designing and preparing the drugs for protecting the cardiac function and/or preventing, relieving and treating cardiac hypertrophy; a new path is provided for cardiac hypertrophy treatment.

The invention provides application of icariin to the preparation of medicaments for preventing or treating pulmonary artery hypertension and complications thereof. The icariin can reduce pulmonary artery pressure and improve right ventricular hypertrophy, pulmonary heart disease and pulmonary vascular remodeling which are caused by pulmonary artery pressure increase.

The invention provides Chinese chestnut fertilizer capable of promoting large fruits and a preparation method of the Chinese chestnut fertilizer and relates to the technical field of fertilizer. The Chinese chestnut fertilizer capable of promoting the large fruits is prepared from 10 to 18 parts of urea, 5 to 10 parts of attapulgite, 8 to 16 parts of calcium superphosphate, 5 to 10 parts of bone meal, 3 to 8 parts of sodium humate, 12 to 23 parts of fermented straw, 6 to 12 parts of lard residue, 7 to 14 parts of Chinese yam peel, 5 to 10 parts of jute, 6 to 12 parts of brown sugar, 5 to 9 parts of animal hair, 10 to 19 parts of mixed fungus chaff, 5 to 10 parts of sterilization liquid, 2 to 6 parts of a bacterium agent and a proper amount of water. By adopting the fertilizer provided by the invention, the problems of existing fertilizer that a water retention capability, a fertilizer retention capability and the permeability of soil are reduced when the soil is hardened, plants contain residual chemical fertilizer and the environment is polluted and the like are solved; the fruits of Chinese chestnuts are increased and the growth of the Chinese chestnuts also can be accelerated; meanwhile, the invasion of insect pests also can be prevented and the aim of green agriculture is realized.

The invention relates to application of PT2385 in preparation of a medicine for preventing and treating pulmonary hypertension, and belongs to the technical field of biomedicine. The invention provides a new medicinal application of PT2385, namely application of PT2385 in preparation of a medicine for preventing and treating pulmonary hypertension. The medicine prepared from PT2385 can be used for well preventing and treating pulmonary hypertension without obvious adverse reaction.

The invention discloses an application of DYZ-9 in preparation of an anti-cardiac hypertrophy product. Compared with the prior art, the DYZ-9 provided by the invention has the following advantages: (1) the DYZ-9 studied in the invention can be synthesized by known methods, has a mature preparation process, can provide a reliable compound source, and has the advantages of a reliable substance source, low production costs, a novel mechanism of action and good market prospects; (2) the DYZ-9 has the effects of inhibiting phosphorylation of AKT and adenosine cyclophosphate effector element bindingprotein caused by isoproterenol (ISO), reducing the levels of myocardial hypertrophy markers ANP and BNP and a cardiac weight index, and improving myocardial hypertrophy; and (3) the DYZ-9 contributes to the research and development of the novel anti-cardiac hypertrophy drug, can bring direct economic benefits, and the drug can reduce the possibility of forming heart failure and malignant arrhythmia caused by further deterioration of the myocardial hypertrophy, and can save a lot of health expenses from a long-term perspective.

The invention discloses loofah greenhouse high-yield cultivation technology. By utilizing the technology, fresh loofah can be provided for the market in the midwinter, and the loofah is smooth in fruit stem, fewer in fuzz and soft in fruit peel. The technology includes: adopting nutrition pots or nutrition soil blocks for seedling growing; using warm water for seed soaking and germination accelerating, and flatwise putting 1 germinated seed in each pot; irrigating sufficient water and applying sufficient fertilizer before field planting; performing field planting on early November, and using carbendazim and viral raw powder to be mixed with soil for bedding and disinfecting; enhancing management on water, fertilizer, temperature and humidity after planting, paying attention to branch pruning, flower thinning, pollination and fruit preservation, and harvesting at proper time.

A Chinese medicine for preventing and treating the irritable cardiovascular injury and improving cardiac function is prepared from coptis root, Chinese angelica root, rehmannia root and liquorice root through decocting and concentrating.

The invention relates to a food capable of regulating vigour and mood of human bodies and a making method. The food comprises the following components of ferment positioning enzymolysis micromoleculepeptide, soybean peptide, wheat peptide, whey protein, magnesium gluconate, zinc gluconate, calcium citrate, pine bark phytosterol, a pumpkin seed extract, arginine, a herba rhodiolae extract, a radixacanthopanacis senticosi extract, cornu cervi pantotrichum, a herba cistanch extract, a rhizoma polygonati extract, a ginseng extract, a tuber onion seed extract, a ligusticum wallichii extract, a radix puerariae extract, an arctium lappa root extract, selenium yeast and a common cnidium fruit extract. Through synergistic reaction of the components, the food can promote qi and blood circulation to improve micturition and cold hands and feet, can activate a metabolism and discharge mechanism, can tonify kidney qi, can build bodies, and can resist ageing.

The invention discloses application of a TRAF-associated NF-[Kappa]B activator (TANK) and inhibitors thereof in treatment of cardiac hypertrophy and belongs to the field of functions and application of genes. According to the application, the interrelationship between the expression of a TANK gene and the cardiac hypertrophy is determined; through inhibiting the expression of the TANK, the hypertrophy and fibrosis of cardiac muscles are inhibited remarkably, and cardiac functions are improved; and through promoting the expression of the TANK, the hypertrophy and fibrosis of the cardiac muscles are promoted remarkably, and the cardiac functions are deteriorated. Therefore, the TANK can be used for screening drugs for protecting the cardiac functions, preventing, relieving and/or treating the cardiac hypertrophy and resisting cardiac fibrosis as a drug target, and the inhibitors of the TANK can be used for preparing drugs for protecting the cardiac functions, preventing, relieving and/or treating the cardiac hypertrophy and resisting the cardiac fibrosis.

Compounds of formula I

are disclosed. The compounds are useful for promoting skeletal muscle hypertrophy or treating skeletal muscle atrophy.

The invention relates to a new pharmacological action of a traditional Chinese medicine simplex component-acetylshikonin, belonging to the technical field of medicines. The drug composition containingacetylshikonin comprises an effective dosage of acetylshikonin required for treatment and a carrier or an auxiliary material pharmaceutically acceptable, and further comprises a drug composition prepared together with other substances in any proportion and used in drugs preventing and relieving pulmonary artery hypertension and complications thereof. The acetylshikonin of the invention is a monomeric compound extracted from the wide raw material resource radix arnebiae, has low toxicity, has great application and development prospect, is an ideal, new traditional Chinese medicine monomer fortreating hypoxic pulmonary artery hypertension, and can be applied to preparation of products for preventing and treating pulmonary artery hypertension.