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Application of icariin to preparation of medicaments for preventing and treating pulmonary artery hypertension and complications thereof

A technology of pulmonary arterial hypertension and icariin, which is applied in the application field of medicine to achieve the effect of improving right ventricular hypertrophy

Inactive Publication Date: 2011-11-23
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the effect of icariin on the prevention or treatment of pulmonary hypertension and its complications

Method used

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  • Application of icariin to preparation of medicaments for preventing and treating pulmonary artery hypertension and complications thereof
  • Application of icariin to preparation of medicaments for preventing and treating pulmonary artery hypertension and complications thereof
  • Application of icariin to preparation of medicaments for preventing and treating pulmonary artery hypertension and complications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Get 100g of commercially available icariin, 40g of sildenafil, mix with 10g of starch, pack into capsules, and make 1000 capsules to obtain capsules.

[0056] Dosage: Take orally, 3 times a day, 1 capsule each time.

[0057] Function and Indications: For pulmonary hypertension and right ventricular hypertrophy caused by pulmonary hypertension, cor pulmonale and pulmonary vascular remodeling, etc.

Embodiment 2

[0059] Take icariin, dissolve it with water for injection and fill it in a corresponding container, sterilize it by autoclaving at 115°C for 30 minutes, after cooling, filter it with suction, dilute the filtrate with water for injection, filter it with a vertical melting filter ball, and seal it at 115°C Then autoclave for 30 minutes to prepare an injection solution.

[0060] Icariin was purchased from Suzhou Baozetang Pharmaceutical Technology Co., Ltd. with a purity of 98%.

[0061] Usage and dosage: intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 50mg based on icariin.

[0062] Function and Indications: For pulmonary hypertension and right ventricular hypertrophy caused by pulmonary hypertension, cor pulmonale and pulmonary vascular remodeling, etc.

Embodiment 3

[0064] The icariin is taken, dissolved in water for injection, added with 2% mannitol, dried, and prepared into freeze-dried powder for injection.

[0065] Icariin was purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd. with a purity of 98%.

[0066] Usage and dosage: intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 100mg based on icariin.

[0067] Function and Indications: For pulmonary hypertension and right ventricular hypertrophy caused by pulmonary hypertension, cor pulmonale and pulmonary vascular remodeling, etc.

[0068] Icariin was purchased from Suzhou Baozetang Pharmaceutical Technology Co., Ltd. with a purity of 98%.

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Abstract

The invention provides application of icariin to the preparation of medicaments for preventing or treating pulmonary artery hypertension and complications thereof. The icariin can reduce pulmonary artery pressure and improve right ventricular hypertrophy, pulmonary heart disease and pulmonary vascular remodeling which are caused by pulmonary artery pressure increase.

Description

technical field [0001] The invention relates to the application of icariin, in particular to the application of icariin in the preparation of medicines for preventing or treating pulmonary hypertension and its complications. technical background [0002] Pulmonary hypertension (PH) has complex etiology and is caused by a variety of heart, lung or pulmonary vascular diseases. It is manifested by increased pulmonary circulation pressure and resistance, increased right ventricular load, right ventricular insufficiency, and reduced pulmonary blood flow, which can cause a series of clinical manifestations. Pulmonary hypertension often develops progressively during the course of the disease. It is a serious and potentially fatal chronic pulmonary circulation disease, especially idiopathic arterial pulmonary hypertension, which can only be diagnosed about 2 years after the onset of symptoms, and the natural course of the disease after diagnosis is mostly 2.5-3.4 years. [0003] Pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/12A61P11/00
Inventor 李利生龚其海刘娟
Owner ZUNYI MEDICAL UNIVERSITY
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