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Application of CILP2 in preparation of medicine for improving heart aging and myocardial hypertrophy

A technology for cardiac hypertrophy and cardiac aging, applied in the field of biomedicine, can solve the problem of lack of NPP catalytic sites

Active Publication Date: 2020-10-30
WUHAN UNIV
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Problems solved by technology

The homology of the C-terminus and nucleotide pyrophosphohydrolase (NTPPHase) is as high as 90.9%, which may be related to the activity of nucleotide pyrophosphodiesterase (NPP), but it lacks NPP catalytic sites or bivalent cation binding site

Method used

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  • Application of CILP2 in preparation of medicine for improving heart aging and myocardial hypertrophy
  • Application of CILP2 in preparation of medicine for improving heart aging and myocardial hypertrophy
  • Application of CILP2 in preparation of medicine for improving heart aging and myocardial hypertrophy

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Embodiment Construction

[0026] In order to make the purpose of the present invention, technical solutions and advantages clearer, the present invention will be described in further detail below in conjunction with the examples, and the equipment and reagents used in each embodiment and test example can be obtained from commercial sources unless otherwise specified. The specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0027] From the information contained herein, various changes in the precise description of the invention will readily become apparent to those skilled in the art without departing from the spirit and scope of the appended claims. It should be understood that the scope of the present invention is not limited to the processes, properties or components defined, since these embodiments, as well as other descriptions, are only intended to illustrate certain aspects of the invention. In fact, various changes to the embod...

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Abstract

The invention belongs to the technical field of biomedicine, and particularly relates to application of CILP2 in preparation of a medicine for improving heart aging and myocardial hypertrophy. According to the invention, a mouse is used as an experimental object, an AAV9 virus is used for overexpression of the transcription level of a CILP2 gene, and comparative study is carried out by establishing a heart aging and myocardial hypertrophy model. Results show that compared with an aging wild type control group, the overexpression of the CILP2 can obviously reduce the index level of heart agingof aging mice, reduce the index level of myocarditis factors of the aging mice, improve the expression level of myocardial hypertrophy markers, reduce the thickness of the rear wall of the heart, weaken the fibrosis degree and reduce myocardial cells. The results prove that the expression level of the CILP2 can regulate and control the occurrence of heart aging and myocardial hypertrophy, has a protective effect on heart aging and myocardial hypertrophy, and can provide theoretical basis and clinical basis for researching new targets and new strategies for preventing and treating heart aging and myocardial hypertrophy.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of CILP2 in the preparation of drugs for improving heart aging and cardiac hypertrophy. Background technique [0002] Health, aging and longevity are the most concerned issues, and people have been exploring the mysteries since ancient times. As our country enters an aging society, the diseases brought about by age increase seriously threaten human health, but the current understanding of aging is still in its infancy. Among diseases caused by aging, cardiovascular disease has topped the list of causes of death over the years, and heart failure is one of the most common causes of death. Recently, at the protein level, GDF11 and TIMP2 were identified as potential antiaging factors. The application of anti-aging factors to aging organisms can slow down the progress of organ aging, and improve the functions of heart aging and cardiac hypertrophy and ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K45/00A61P9/04
CPCA61K38/1709A61K45/00A61P9/04
Inventor 王志华汤立许李丽莉罗强胡依萌
Owner WUHAN UNIV
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