12 results about "Cation binding" patented technology

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and / or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and / or in other diagnostic techniques and / or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

The invention provides preparation and application of an artificial peptide transporter for promoting transmembrane delivery of peptide drugs, the structural general formula of the artificial peptide transporter is as follows: # imgabs0 #. The compound involved in the invention is composed of three parts: (1) a bisamide structure as an anion binding unit which is bound with carboxyl anions of peptide molecules; (2) crown ether is used as a cation binding unit and is bound with amino positive ions of the peptide molecules; and (3) hydrophobic side chain: connecting the anion binding unit with the cation binding unit, so that the whole molecule can be used as molecular tweezers to form a stable compound with peptide drugs, and the stable compound is coated in a hydrophobic environment to promote transmembrane transportation of the peptide drugs. The obtained compound is cheap in raw material and easy to synthesize, the bioavailability of polypeptide drugs is remarkably improved, and the compound shows remarkable synergistic anti-cancer activity in in-vitro and in-vivo experiments, so that the compound has great potential as a pharmaceutical adjuvant.

This invention provides the preparation and application of a class of artificial peptide transporters for promoting transmembrane delivery of peptide drugs. The general structural formula is as follows: The compound involved in this invention consists of three parts: (1) a diamide structure as an anion-binding unit, which binds to the carboxyl anion of the peptide molecule; (2) a crown ether as a cation-binding unit, which binds to the amino cation of the peptide molecule; and (3) a hydrophobic side chain: connecting the anion-binding unit and the cation-binding unit, so that the whole molecule can act as molecular tweezers to form a stable complex with the peptide drug and encapsulate it in a hydrophobic environment to promote its transmembrane transport. The compound obtained in this application has inexpensive raw materials, is easy to synthesize, and significantly improves the bioavailability of peptide drugs. It has shown significant synergistic anticancer activity in both in vitro and in vivo experiments, and therefore has great potential as a pharmaceutical excipient.

The invention provides a composition with a whitening effect as well as a preparation method and application of the composition. The composition is prepared from ascorbic acid glucoside ionic liquid, a nicotinamide compound, a bisabolol inclusion compound and milk active peptide, the weight ratio of the ascorbic acid glucoside ionic liquid to the nicotinamide compound to the bisabolol clathrate compound to the milk active peptide is (3-8): (3-6): (0.3-1): (1-5); according to the preparation method, the ascorbic acid glucoside is combined with specific cations, so that the ascorbic acid glucoside derivative ionic liquid can be constructed, the chemical stability and skin permeability of the ascorbic acid glucoside can be remarkably improved, and the ascorbic acid glucoside derivative ionic liquid can also be used as a multifunctional carrier to synergistically load other active ingredients; all the components achieve the triple synergistic effect of permeation enhancement, multi-channel blackness inhibition and barrier repair through molecular-level compounding, and the multi-channel whitening effect is achieved.

The present invention provides a kind of ZSM 5 molecular sieve catalyst and its preparation method and application, ZSM 5 molecular sieve catalyst uses basic ionic liquid as template and is prepared by hydrothermal crystallization method, wherein, basic ionic liquid template is imidazole ionic liquid and tetrabutylammonium ionic liquid, ionic liquid is with bromide 1,3 dialkyl imidazole salt or quaternary ammonium salt as cation, prepared in conjunction with different anions, with silicon source, aluminum source, alkali source and water as raw material, through the preparation of template, the preparation of reaction mixture and hydrothermal crystallization three steps, then through solid-liquid separation, washing, ion exchange, drying and roasting, obtain hydrogen type ZSM 5 molecular sieve.The preparation process is simple, catalyst acid site is adjustable, and products obtained therefrom hydrothermal stability is good, activity is high, effect is good, so that the conversion rate of cyclohexene is high, cyclohexanol selectivity is good, and raw materials used are safe, process is simple, can be used for industrial production.

A method, comprising: disposing a plurality of layers on a plurality of nanocrystals (NCs) disposed on a substrate, wherein a given layer comprises a matrix material that includes a compound comprising an anionic species associated with a cationic species, the plurality of NCs optionally being core-shell NCs or quantum dots, and wherein the method is performed so as to give rise to interparticle fusion between at least some of the plurality of NCs and to completely fill interstitial gaps between NCs. Also provided is a composition, comprising: a plurality of NCs exhibiting interparticle fusion therebetween and the plurality of NCs defining interstitial spaces therebetween, the interstitial spaces being completely filled with a matrix material that comprises a plurality of layers, a given layer including an anionic species associated with a cationic species, and the plurality of NCs optionally being core-shell NCs or quantum dots.

The utility model discloses an electrodeionization device for on-line anion trace monitoring, which is characterized in that a cation exchange membrane is arranged between a fresh water chamber and a concentrated water chamber, cation exchange resin is filled in the fresh water chamber and the concentrated water chamber, the fresh water chamber is used for removing cations in sample water, and the concentrated water chamber is used for removing the cation in the sample water. Then, outputting to the anion trace monitoring module for anion trace monitoring; the monitored sample water is output to a concentrated water chamber, water molecules are electrolyzed into hydrogen ions and hydroxyl ions by the concentrated water chamber, cation exchange resin is continuously regenerated by the hydrogen ions, and the hydroxyl ions are discharged after being combined with cations in the sample water; and the control module controls the power supply module to supply power to the electrodeionization module. According to the technical scheme of the utility model, the problems of frequent replacement and regeneration of cation exchange resin and waste liquid in trace monitoring of water sample anions are solved, sample water for removing cations can be continuously provided for monitoring the content of anions, and the use process and maintenance are simple and convenient.

The present invention relates to a preparation method of an efficient and stable perovskite solar cell. During the preparation of the perovskite solar cell, a perovskite thin film prepared by adding a passivation defect additive to a perovskite precursor solution is used as the perovskite light-absorbing layer. The small molecule structure of the passivation defect additive includes a carbonyl group, an amino group, a benzene ring, and a fluorine group. Among them, the carbonyl group can bind to Pb<supgt;2+< / supgt; ions with insufficient coordination in the perovskite solution, or bind to other defective state cations to form a Lewis complex, thereby passivating the film defects; the fluorine group has strong hydrophobicity, which can improve the stability of the perovskite solar device and is an effective charge transfer channel between the perovskite layer and the hole transport layer; and the amino group improves the coordination ability of C=O and Pb<supgt;2+< / supgt>, reduces the defects on the grain surface, improves the perovskite film formation quality, and the combination of the amino group and iodide can inhibit ion migration, further enhancing the passivation effect.

The invention relates to a method for stabilising limescale precipitation from drinking or service water in a drinking or service water installation, wherein the drinking or service water comprises dissolved Ca2+ ions and HCO3 - ions, wherein the method comprises the targeted catalytic deprotonation of HCO3 - ions and the continuous formation of CaCO 3 0 - ion pairs in the drinking or service water by contacting the drinking or service water with a polymeric granulate having functional groups, wherein the functional groups of the polymeric granulate comprise carboxylate groups which form cation-binding sites, wherein between 0.01% and 10%, preferably 0.5% to 5%, of the cation-binding sites formed by the carboxylate groups are occupied by at least one di- or trivalent metal cation different from Ca2+, less than 1.5% of the cation-binding sites are occupied by H+ ions, and wherein the remaining cation-binding sites are occupied by Ca2+ ions, with the proviso that the at least one di- or trivalent metal cation different from Ca2+ binds more strongly to the cation-binding sites than Ca2+.

A support comprising: a magnetic core; and a polymeric coating over at least a part of a surface of the core, wherein the polymeric coating comprises a cation-binding group containing at least one cyclic structure, and wherein the polymeric coating comprises a copolymer derived from an aliphatic cycloacrylate and at least one additional acrylate, and wherein the polymeric coating comprises at least one resin having a carbon / oxygen ratio of 3:1 to 8:1.

Disclosed herein are compositions comprising a solid substrate that is bound to a multivalent cation-binding ligand. The composition can be used to associate positively-charged ion species with the solid substrate so as to facilitate separation methods in the solid phase. Also disclosed are methods of making and using the composition.

The invention discloses a high-throughput calculation method of an electrolyte electrochemical window considering the influence of anions and cations, and belongs to the technical field of quantum chemistry calculation and new energy materials. A molecular structure is optimized, electrostatic potential of the molecular structure is calculated, a maximum value (minimum value) point of the electrostatic potential is combined with negative (positive) ions to construct a structure file in which a solvent is combined with the negative (positive) ions, the constructed structure file is imported in batches, high-flux optimization calculation is repeated, and energy corresponding to each structure file is output. An optimized structure combined with anions is obtained, the number of electrons is reduced by 1, and the number of spinning electrons is correspondingly modified; and obtaining an optimized structure combined with cations, adding 1 to the number of electrons, correspondingly modifying the number of spinning electrons, importing all structure files in batches, repeating high-throughput optimization calculation, and outputting energy corresponding to each structure file. And substituting the energy of the ground state, the oxidation state and the reduction state into a Nernst equation to calculate the oxidation-reduction potential of the molecule. According to the invention, beneficial help is provided for electrolyte design.