55results about How to "Protect heart function" patented technology

The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.

The invention discloses a function and application of ubiquitin specific protease 4 (USP4) in treating cardiac hypertrophy, and belongs to the field of gene functions and application. The mutual relation between the expression of the USP4 and cardiac hypertrophy is determined; research results show that in a cardiac hypertrophy occurrence model, the expression of the USP4 is significantly reduced compared with a normal group; by restraining the expression of the USP4, the cardiac hypertrophy and fibrosis are significantly promoted, and the cardiac function is deteriorated; by promoting the expression of the USP4, cardiac hypertrophy and fibrosis are significantly restrained, and the cardiac function is protected. Accordingly, the USP4 can be used as a target gene for screening and preparing the medicine which protects the cardiac function, resists cardiac fibrosis and/or prevents, relieves and/or treats cardiac hypertrophy, and an effective new way is provided for treating cardiac hypertrophy.

The invention discloses a function and application of activin receptor-like kinase7 (ALK7) in treatment of a cardiac hypertrophy disease. According to the invention, the relationship between an ALK7 gene and the cardiac hypertrophy is determined: when the cardiac hypertrophy occurs, the expression of ALK7 is obviously reduced; the interference of ALK7 and over-expressed adenovirus are respectively used for promoting and inhibiting cardiomyocyte hypertrophy; ALK7 gene knockout has the effect of remarkably enhancing the activation of MEK1/2/ERK1/2 and Smad2/Samd3 signal channels so that the cardiac hypertrophy and fibrosis are promoted and the heart function is worsened; over-expression of the ALK7 gene has the effect of remarkably reducing the activation of MEK1/2/ERK1/2 and Smad2/Samd3 signal channels so that the cardiac hypertrophy and fibrosis are inhibited and the heart function is improved. Therefore, the ALK7 gene can be used as a target gene in gene therapy and can be used for preparing a medicine for protecting the heart function and/or preventing, relieving and/or treating the cardiac hypertrophy, thus providing a new way for treating the cardiac hypertrophy.

The invention discloses a function and application of a dual-specificity phosphatase 14 (DUSP 14) in curing cardiac hypertrophy, belonging to the field of gene function and application. The mutual relation between the expression of the DUSP 14 and cardiac hypertrophy is determined, and research results show that in a model with cardiac hypertrophy, compared with a normal group, the expression of the DUSP 14 is remarkably reduced; inhibiting the expression of the DUSP 14 remarkably promotes cardiac hypertrophy and fibrosis and deteriorates a cardiac function, and promoting the overexpression of the DUSP 14 remarkably inhibits cardiac hypertrophy and fibrosis and protects the cardiac function. Therefore, the DUSP 14 can serve as a target gene for screening drugs capable of protecting the cardiac function, resisting cardiac fibrosis and/or preventing, relieving or curing cardiac hypertrophy, and for preparing the drugs capable of protecting the cardiac function, resisting cardiac hypertrophy and/or preventing, relieving or curing cardiac hypertrophy, thus providing an effective new approach for the curing of cardiac hypertrophy.

The invention belongs to the technical field of health care product, and especially relates to a traditional Chinese medicine composition capable of relieving autonomic nervous dysfunction, and a preparation method and a product thereof. The traditional Chinese medicine composition is composed of, by weight, 10 to 100 parts of poria cocos and 10 to 100 parts of spine date seed. It is confirmed byexperiments that the traditional Chinese medicine composition is capable of improving depression anxiety symptoms effectively, protecting autonomic nerve and cardiac functions, improving neuronal celldamages, and relieving autonomic nervous dysfunctions such as anxiety, depression, attention-deficit disorders, impaired study and memory capacity, and functional gastrointestinal disorders caused bylong term pressure or endocrine dyscrasia; the effect is better than that of independent using of poria cocos or spine date seed. The raw materials which can be taken as both food and medicine are adopted, simplification and optimization of ancient prescription < wild jujube seed decoction> is realized, the application range of Chinese herbal medicines in improvement of autonomic nervous dysfunctions is widened, the traditional Chinese medicine composition is safe and stable, and is suitable for long term eating.

The invention discloses cake sandwiched coarse cereal bread and a preparation method thereof. The cake sandwiched coarse cereal bread is characterized by being composed of, by mass, 1-5 parts of dough, 1-2 parts of cakes, 1-2 parts of coarse cereal particles and 1-2 parts of salad dressing. Based on a traditional Chinese medicine health-preserving theory and a human body dietary structure, a breadoften eaten by people is selected as a carrier, coarse cereals or coarse cereal powder is added into a bread body, meanwhile, a cake with a fine and smooth taste is used as a sandwich in the bread, the defect that the coarse cereals are rough in taste is overcome greatly, and therefore the coarse cereal bread which is nutritional, healthy and fine and smooth in taste is prepared.

The invention discloses a method for preparing a nut soybean sauce, belonging to the technical field of food processing. The method comprises the following steps: I. preparing spice leach liquor, namely boiling anises, gingers and crude salt with water to prepare the spice leach liquor; and II. preparing sauce, namely mixing rice beans, black soyabeans, corns, aspergillus oryzae, flour, sunflower seed kernels, pumpkin seed kernels, apricot kernels, walnut kernels and the spice leach liquor, and fermenting to prepare the paste. The nut soybean sauce disclosed by the invention not only is abundant in natural nutrition, but also has heavy fragrance and crispy taste.

The invention discloses a Chinese medicinal composition for treating a myocardial ischemia heart disease and a preparation method thereof, and relates to the Chinese medicinal composition and the preparation method thereof. The Chinese medicinal composition for treating the myocardial ischemia heart disease is prepared from hypericum attenuatum and root of red-rooted salvia. The method 1 comprises the following steps of: taking the hypericum attenuatum and the root of red-rooted salvia; preparing hypericum attenuatum extract, drying under reduced pressure and then crushing into fine powder A; decocting the root of red-rooted salvia with water and performing reflux extraction to prepare the extract, drying under reduced pressure and then crushing into fine powder B; and mixing the fine powder A with the fine powder B. The method 2 comprises the following steps of: taking the hypericum attenuatum and the root of red-rooted salvia; preparing hypericum attenuatum extract, drying under reduced pressure and then crushing into fine powder A; performing reflux extraction on the root of red-rooted salvia to prepare the extract, drying under reduced pressure and then crushing into fine powder B; and mixing the fine powder A with the fine powder B. In the Chinese medicinal composition, compound compatibility of the hypericum attenuatum and the root of red-rooted salvia is adopted, the hypericum attenuatum and the root of red-rooted salvia can be cooperatively used for relieving symptoms of the myocardial ischemia heart disease, and the composition has an obvious effect, is safe and does not have a toxic or side effect; and the preparation method is simple, easy to operate, low in cost and is suitable for industrial production.

The invention discloses application of zinc finger protein 307 (ZNF307) in protecting heart function, resisting cardiac fibrosis and/or preventing and relieving and/or treating myocardial hypertrophy and belongs to the field of gene application. The circumstance that expression of ZNF307 in a model occurring myocardial hypertrophy is remarkably lowered when compared with that of a normal group is determined; inhibition of ZNF307 expression remarkably promotes myocardial hypertrophy and fibrosis and deteriorates the heart function while promotion of overexpression of the ZNF307 remarkably inhibits myocardial hypertrophy and fibrosis and protects the heart function. The ZNF307 can serve as a drug target to be used for screening drug for protecting heart function, resisting cardiac fibrosis and/or preventing and relieving and/or treating myocardial hypertrophy; the ZNF307 can serve as a target gene in gene treatment to be used for designing and preparing drug and/or biological preparations for protecting heart function, resisting cardiac fibrosis and/or preventing and relieving and/or treating myocardial hypertrophy, and a novel effective approach is provided for treatment of myocardial hypertrophy.

The invention discloses an interferon regulatory factor 6(IRF6) and application of an inhibitor of the factor in treatment of myocardial hypertrophy and belongs to the fields of gene function and application. The mutual relation between IRF6 gene expression and the myocardial hypertrophy is determined, wherein the myocardial hypertrophy and fibrosis are remarkably inhibited and cardiac functions are improved by inhibiting the IRF6 expression, and the myocardial hypertrophy and fibrosis are remarkably promoted and the cardiac functions deteriorate by promoting the IRF6 expression. Therefore, the IRF6 can serve as a drug target for screening drugs for protecting the cardiac functions, preventing, relieving and/or treating the myocardial hypertrophy or resisting myocardial fibrosis, the inhibitor of the IRF6 can be used for preparing the drugs for protecting the cardiac functions, preventing, relieving and/or treating the myocardial hypertrophy or resisting myocardial fibrosis.

The invention discloses a function and an application of angiotensin invertaste (ACE3) in treating cardiac hypertrophy, and belongs to the field of function and application of genes. An interrelation between the expression of ACE3 and cardiac hypertrophy is determined, a research result shows that in a model having the cardiac hypertrophy, the expression of the ACE3 is remarkably decreased compared with that of a normal group; the cardiac hypertrophy, fiberization and heart function deteriorate are remarkably promoted by inhibiting the expression of ACE3, the cardiac hypertrophy and fiberization are remarkably inhibited by promoting the over-expression of the ACE3, and the heart function is protected. Therefore, ACE3 can be used as a target gene to screen a drug for protecting the heart function, resisting the fiberization of the heart and/or preventing, alleviating and/or treating cardiac hypertrophy, to prepare a drug for protecting the heart function, resisting the cardiac hypertrophy and/or preventing, alleviating and/or treating cardiac hypertrophy, and an effective new way is provided for treating the cardiac hypertrophy.

The invention discloses application of a TRAF-associated NF-[Kappa]B activator (TANK) and inhibitors thereof in treatment of cardiac hypertrophy and belongs to the field of functions and application of genes. According to the application, the interrelationship between the expression of a TANK gene and the cardiac hypertrophy is determined; through inhibiting the expression of the TANK, the hypertrophy and fibrosis of cardiac muscles are inhibited remarkably, and cardiac functions are improved; and through promoting the expression of the TANK, the hypertrophy and fibrosis of the cardiac muscles are promoted remarkably, and the cardiac functions are deteriorated. Therefore, the TANK can be used for screening drugs for protecting the cardiac functions, preventing, relieving and/or treating the cardiac hypertrophy and resisting cardiac fibrosis as a drug target, and the inhibitors of the TANK can be used for preparing drugs for protecting the cardiac functions, preventing, relieving and/or treating the cardiac hypertrophy and resisting the cardiac fibrosis.

The invention discloses an application of ZNF418 (zinc finger protein 418) to protection of cardiac functions, resistance to cardiac fibrosis and/or prevention, relief and/or treatment of myocardial hypertrophy, and belongs to the application field of genes. In a myocardial hypertrophy model, the expression of the ZNF418 is ensured to be significantly lower than that of a normal group; myocardial hypertrophy and fibrosis are significantly promoted and cardiac functions are deteriorated by inhibiting expression of the ZNF418, and the myocardial hypertrophy and fibrosis are significantly inhibited and the cardiac functions are protected by promoting overexpression of the ZNF418. The ZNF418 can be used as a drug target and used for screening of drugs for protecting the cardiac functions, resisting the cardiac fibrosis and/or preventing, relieving and/or treating the myocardial hypertrophy; the ZNF418 can be used as a target gene for gene therapy and used for designing and preparing drugs and/or biological reagents for protecting the cardiac functions, resisting the myocardial hypertrophy and/or preventing, relieving and/or treating the myocardial hypertrophy, and a new and effective way is provided for treatment of the myocardial hypertrophy.