Function and application of dual specificity phosphatase 14 (dusp14) in the treatment of cardiac hypertrophy

Abstract

The invention discloses a function and application of a dual-specificity phosphatase 14 (DUSP 14) in curing cardiac hypertrophy, belonging to the field of gene function and application. The mutual relation between the expression of the DUSP 14 and cardiac hypertrophy is determined, and research results show that in a model with cardiac hypertrophy, compared with a normal group, the expression of the DUSP 14 is remarkably reduced; inhibiting the expression of the DUSP 14 remarkably promotes cardiac hypertrophy and fibrosis and deteriorates a cardiac function, and promoting the overexpression of the DUSP 14 remarkably inhibits cardiac hypertrophy and fibrosis and protects the cardiac function. Therefore, the DUSP 14 can serve as a target gene for screening drugs capable of protecting the cardiac function, resisting cardiac fibrosis and / or preventing, relieving or curing cardiac hypertrophy, and for preparing the drugs capable of protecting the cardiac function, resisting cardiac hypertrophy and / or preventing, relieving or curing cardiac hypertrophy, thus providing an effective new approach for the curing of cardiac hypertrophy.

Description

technical field [0001] The invention belongs to the field of gene function and application, and particularly relates to the function and application of a dual-specificity phosphatase 14 (DUSP14) in the treatment of cardiac hypertrophy. Background technique [0002] Myocardial hypertrophy is the compensatory response of the myocardium to long-term biomechanical pressure or increased volume load, which is commonly seen in cardiovascular diseases such as hypertension and aortic stenosis. Increased and other characteristics [1-3]. Hypertension and senile degenerative aortic valve disease are on the rise year by year in our country. Cardiac hypertrophy and the incidence of hypertension and heart disease caused by hypertension and other diseases also increase thereupon. Although myocardial hypertrophy can initially increase myocardial cells and strengthen myocardial contractility, which is a compensatory mechanism to maintain normal cardiac output, long-term continuous pressure ...

AI Technical Summary

Problems solved by technology

Although myocardial hypertrophy can initially increase myocardial cells and strengthen myocardial contractility, which is a compensatory mechanism to maintain normal cardiac output, long-term continuous pressure or volume overload will cause myocardial remodeling, and at the same time due to myocardial Increased oxygen demand and relatively insufficient coronary blood supply lead to myocardial ischemia, myocardial cell apoptosis, and decompensation, leading to heart failure, malignant arrhythmia, and even sudden death[4,5]

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