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Prosoma liposome preparation, its production method and using method

A technology of prolipid and body preparation, applied in liposome delivery and other directions, can solve the problems of easy aggregation of particles, easy leakage of drugs, easy hydrolysis reaction, etc., so as to avoid the preparation process, solve the stability problem, and improve the biological The effect of utilization

Active Publication Date: 2005-11-23
新疆维吾尔自治区包虫病临床研究所 +2
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0008] However, the liposomes disclosed in the above-mentioned patents and documents all exist in a microparticle dispersion system, and have the following stability problems: 1) physical stability problems, that is, the microparticles are easy to aggregate, settle, and medicine is easy to leak; 2) chemical stability Sexual problems, that is, membrane material phospholipids are prone to hydrolysis in aqueous suspensions, resulting in lysophospholipids and fatty acids
[0013] Although the above patents have solved the stability problem of liposomes, they all need to be completed through complex preparation processes, and the preparation process involves the use of organic solvents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1, the novel proliposome preparation contains by weight percentage: 1% of drug, 10% of phospholipid, 1% of surfactant and the balance of solvent.

Embodiment 2

[0027] Example 2, the novel proliposome preparation contains by weight percentage: 30% of drug, 30% of phospholipid, 15% of surfactant and the balance of solvent.

Embodiment 3

[0028] Example 3, the novel proliposome formulation contains by weight percentage: 1% of drug, 30% of phospholipid, 15% of surfactant and the balance of solvent.

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PUM

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Abstract

Disclosed is a prosoma liposome preparation, its production method and using method, wherein the preparation comprises medicament, solvent, phosphatide and adjunct, the solvent is non-aqueous solvent with hydrophilous nature, the adjunct is surface active agent. The solvent can be non-aqueous solvent having hydrophilous nature and good dissolving property to medicament, phosphatide and adjunct. the surface active solvent can be anionic or non-ionic surface active agent. The production method consists of dissolving the medicament with solvent, charging phosphatide and adjunct, fully dissolving so as o obtain the end product.

Description

technical field [0001] The invention relates to a medical preparation and a production method thereof, and is a novel proliposome preparation and a production method thereof. The novel proliposome preparation is especially used as an antitumor drug for treatment. Background technique [0002] In 1965, British Bangham et al. dispersed phospholipids in water and found that they could form a bilayer vesicle in water and automatically encapsulated drugs. They called this ultramicro spherical carrier preparation liposome. Subsequently, the study of liposomes became a hot spot in passive targeting formulations. The application of liposome formulations requires better quality control and a certain encapsulation efficiency on the basis of certain stability. [0003] Deamer et al. (Biochem Biophys Acta, 1976, 443:629) reported the preparation of liposomes by injection. Dissolve lipidoids and fat-soluble drugs in an organic solvent (oil phase), then inj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127
Inventor 高晓黎温浩季新梅王建华
Owner 新疆维吾尔自治区包虫病临床研究所
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