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Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts

A drug solution and drug technology, applied in medical science, pharmaceutical formulations, preparations for in vivo experiments, etc., can solve the problems of epileptic seizure activity cessation and prolongation

Inactive Publication Date: 2009-04-01
P·D·温施
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

iv. Initiation of treatment with diazepam injections results in prolonged cessation of seizure activity

Method used

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  • Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts
  • Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts
  • Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0343] A sterile aqueous solution containing atracurium besylate (10 mg) and fluorescein (10 mg) per milliliter (mL), wherein the pH of the solution was adjusted to 3.5 with besylate.

Embodiment 2

[0344]Sterile aqueous solution containing atracurium besylate (10 mg), benzyl alcohol (10 mg) and fluorescein (10 mg) per mL, wherein the pH of the solution was adjusted to 3.5 with benzenesulfonic acid.

Embodiment 3

[0345] Sterile aqueous solution containing rocuronium bromide (10 mg), sodium acetate trihydrate (2 mg), sodium chloride (3.3 mg) and fluorescein (50 mg) per mL, wherein the pH of the solution was adjusted to 4.0 with acetic acid .

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Abstract

The invention is directed to pharmaceutical compositions comprising colored solutions, colored emulsions, or colored powders of injectable pharmaceuticals wherein said pharmaceuticals are selected from the group consisting of muscle relaxants, hypnotics, induction agents, and anticholinergics. The formulations of the present invention may all be colored using fluorescein. Different colors may be achieved by either varying the concentration of fluorescein, or by combining fluorescein with another dye. The invention is also directed to methods involving the use of said pharmaceutical compositions.

Description

technical field [0001] The present invention relates to compositions and methods comprising colored solutions of injectable drugs and their pharmaceutically acceptable salts. Background technique [0002] The safety of drug delivery is of paramount importance in healthcare settings. It is estimated that 7000 Americans die each year from medication errors (1999 Institute of Medicine report, "To Erris Human: Building a Safer Health System,"). [0003] In the practice of anesthesiology, physicians and nurse practitioners prepare syringes of drugs that are used throughout the induction and maintenance of general anesthesia, sedation, and conscious sedation. Prepare the syringe by drawing the drug from a clear glass vial into a plastic disposable syringe. In current practice, implementers often place a pre-printed label or hand-crafted logo on the syringe, which details the contents. Labels are pre-printed with the drug name and color-coded by drug class. However, color-coded...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61B5/00A61B8/00
Inventor P·D·温施
Owner P·D·温施
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