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New geranium extract

An extract, the technology of geranium, applied in the field of diseases, can solve the problems of not being suitable for large-scale clinical use, exceeding the cost of treatment, etc., and achieve the effect of good hyperacidity, simple preparation process, and increase the healing rate

Inactive Publication Date: 2012-06-27
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since gastric ulcer is a chronic disease, and the acid pump metabolizes quickly, it is necessary to insist on taking omeprazole for a long time, which leads to high cost of treatment and exceeds the affordability of many patients. Therefore, this drug is not yet suitable for large-scale use in China. scale clinical use

Method used

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  • New geranium extract
  • New geranium extract
  • New geranium extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Preparation of geranium extract containing corilagin

[0051] Take 2000g of Geranium macrorrhizum, crush it, add 7 times the amount of water, heat and decoct 2 times for 1.5 hours each time, combine the extracts, filter, collect the filtrate, pass the above sample liquid through the processed HPD400 50kg macroporous adsorption resin column for dynamic adsorption. After loading the column, the resin column is washed with 5 times the amount of resin water, and then eluted with 2 times the amount of resin with 95% ethanol to the end of the eluent, and the alcohol eluent is collected. Part of the alcohol eluate was concentrated to dryness under reduced pressure, and then precipitated with an appropriate amount of 95% ethanol overnight. After filtering and concentrating to dryness, 44 g of geranium extract containing corilagin was obtained, and the content of corilagin was determined to be 37% by high performance liquid chromatography.

Embodiment 2

[0052] Example 2 Preparation of geranium extract containing corilagin

[0053] Take 2000g of Geranium dahuricum DC, crush it, add 8 times the amount of water, heat and cook 3 times, 1.5 hours each time, combine the extracts, filter, collect the filtrate, pass the above sample solution through the processed HPD400 50kg macroporous adsorption resin column for dynamic adsorption. After loading the column, the resin column is washed with 8 times the amount of resin water, and then eluted with 4 times the amount of resin with 90% ethanol to the end of the eluent, and the alcohol eluent is collected. Part of the alcohol eluate was concentrated to dryness under reduced pressure, and then precipitated with an appropriate amount of 95% ethanol overnight. After filtering and concentrating to dryness, 38 g of geranium extract containing corilagin was obtained, and the content of corilagin was 23% by high performance liquid chromatography.

Embodiment 3

[0054] Example 3 Preparation of geranium extract containing corilagin

[0055] Take wild geranium (Geranium caroliniznum) and crush it, add 10 times the amount of water, heat and cook 3 times, 1.5 hours each time, combine the extracts, filter, collect the filtrate, pass the filtrate through the processed HPD400 50kg macroporous adsorption resin Column for dynamic adsorption. After the column loading is completed, the resin column is washed with 6 times the resin volume of water, and then eluted with 2 times the resin volume of 70% ethanol to the end of the eluent, and the alcohol eluent is collected. Part of the alcohol eluate was concentrated to dryness under reduced pressure, and then precipitated with an appropriate amount of 95% ethanol overnight. After filtering and concentrating to dryness, 40 g of geranium extract containing corilagin was obtained, and the content of corilagin was determined to be 29% by high performance liquid chromatography.

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Abstract

The invention relates to a new geranium extract and a preparation method thereof, in particular to the geranium extract containing corilagin, and application of the geranium extract in medicaments for treating or preventing gastroxia and related diseases.

Description

Technical field [0001] The invention relates to a new geranium extract and a preparation method thereof, in particular to a geranium extract containing corilagin, and also relates to the use of the geranium extract to inhibit gastric acid secretion and reduce the acidity of gastric juice. And the use of treating or preventing hyperacidity, peptic ulcer, chronic gastritis and other diseases. Background technique [0002] Geranium is a commonly used medicinal material in China. There are many kinds of medicinal materials, including Erodium stephanianum Willd (Erodium stephanianum Willd) and Geranium (Geraniumwilfordii Maxim) of the same family. Geranium (Geranium nepalense Sweet.), Thick-rooted Geranium (G.dahuricum DC), Geranium (G.sibiricum L.), Wild Geranium (G.caroliniznum L.), Geranium Verbascum (G.eriostemon Fisch.ex.DC.), Geranium vlassovianum, Geranium tsingtauense Yabe, Geranium macrorrhizum and G.thunbergii Sieb.et Zucc.) and so on. There are many chemical components i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H13/08A61K36/185A61K31/7024A61P1/04
Inventor 李洋徐宏江杨永安张喜全李新祝王鸯宋伟
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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