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New geranium extract

An extract, the technology of geranium, applied in the field of diseases, can solve the problems of excessive, unsuitable for large-scale clinical use, and high cost of treatment, and achieve the effect of simple preparation process, good hyperacidity, and increased healing percentage

Inactive Publication Date: 2009-12-30
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since gastric ulcer is a chronic disease, and the acid pump metabolizes quickly, it is necessary to insist on taking omeprazole for a long time, which leads to high cost of treatment and exceeds the affordability of many patients. Therefore, this drug is not yet suitable for large-scale use in China. scale clinical use

Method used

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  • New geranium extract
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  • New geranium extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1 prepares the geranium extract containing corilagin

[0051] Take 2000g of Geranium macrorrhizum, pulverize it, add 7 times the amount of water, heat and decoct twice for 1.5 hours each time, combine the extracts, filter, collect the filtrate, pass the above sample solution through the processed HPD400 50kg macroporous adsorption resin column for dynamic adsorption. After the column loading is completed, the resin column is washed with 5 times the amount of resin in water, and then eluted with 2 times the amount of resin in 95% ethanol until the end of the eluate, and the alcohol eluate is collected. The ethanol eluate was partially concentrated to dryness under reduced pressure, and then precipitated with an appropriate amount of 95% ethanol overnight. Filtrate and concentrate to dryness to obtain 44 g of geranium extract containing corilagin, in which the content of corilagin is 37% as detected by high performance liquid chromatography.

Embodiment 2

[0052] Embodiment 2 prepares the geranium extract containing corilagin

[0053] Take 2000g of Geranium dahuricum DC, pulverize it, add 8 times the amount of water, heat and decoct 3 times for 1.5 hours each time, combine the extracts, filter, collect the filtrate, pass the above sample solution through the processed HPD400 50kg macroporous adsorption resin column for dynamic adsorption. After the column loading is completed, the resin column is washed with 8 times the amount of resin in water, and then eluted with 4 times the amount of resin in 90% ethanol until the end of the eluate, and the alcohol eluate is collected. The ethanol eluate was partially concentrated to dryness under reduced pressure, and then precipitated with an appropriate amount of 95% ethanol overnight. Filtrate and concentrate to dryness to obtain 38 g of geranium extract containing corilagin, in which the content of corilagin is 23% as detected by high performance liquid chromatography.

Embodiment 3

[0054] Embodiment 3 prepares the geranium extract containing corilagin

[0055] Get wild geranium (Geranium caroliniznum) and pulverize, add 10 times the amount of water, heat and decoct 3 times, each time for 1.5 hours, combine the extracts, filter, collect the filtrate, pass the above-mentioned filtrate through the processed HPD40050kg macroporous adsorption resin column for dynamic adsorption. After the column loading is completed, the resin column is washed with 6 times the resin volume of water, and then eluted with 2 times the resin volume of 70% ethanol to the end of the eluate, and the ethanol eluate is collected. The ethanol eluate was partially concentrated to dryness under reduced pressure, and then precipitated with an appropriate amount of 95% ethanol overnight. Filtration and concentration to dryness obtained 40 g of geranium extract containing corilagin, and the content of corilagin in it was 29% as detected by high performance liquid chromatography.

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Abstract

The invention relates to a new geranium extract and a preparation method thereof, in particular to the geranium extract containing corilagin, and application of the geranium extract in medicaments for treating or preventing gastroxia and related diseases.

Description

technical field [0001] The present invention relates to a new geranium extract and a preparation method thereof, in particular to a geranium extract containing corilagin, and to the use of the geranium extract to inhibit gastric acid secretion and reduce gastric juice acidity, And the use of treating or preventing hyperacidity, peptic ulcer, chronic gastritis and other diseases. Background technique [0002] Geranium is a commonly used medicinal material in my country, and it has a wide variety, including Erodium stephanianum Willd (Erodium stephanianum Willd) and Geranium wilfordii Maxim (Geranium wilfordii Maxim). Geranium nepalense Sweet., Geranium nepalense Sweet., Geranium dahuricum DC, Geranium sibiricum L., Geranium nepalense L., Geranium mullein (G.eriostemon Fisch.ex.DC.), Geranium vlassovianum, Geranium tsingtauense Yabe, Geranium macrorrhizum and Geranium thunbergii Sieb. et Zucc.) and so on. There are many chemical components in geranium, mainly including tannins...

Claims

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Application Information

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IPC IPC(8): C07H13/08A61K36/185A61K31/7024A61P1/04
Inventor 李洋徐宏江杨永安张喜全李新祝王鸯宋伟
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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