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Application of Corilagin in preparation of medicine for treating burns and scalds

A drug and drug delivery technology, applied in the field of biomedicine, can solve the problems of large differences in the progress of the burn model

Inactive Publication Date: 2021-09-10
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In the past two decades, many burn animal models have been developed to elucidate the pathophysiological progress of burn injury, but in view of the constraints and limitations of various burn injury models, the pathological changes of burn injury models are different from the progression of clinical burn patients. larger

Method used

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  • Application of Corilagin in preparation of medicine for treating burns and scalds
  • Application of Corilagin in preparation of medicine for treating burns and scalds
  • Application of Corilagin in preparation of medicine for treating burns and scalds

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Embodiment 1

[0026] The application of the Corilagin of the present invention in the preparation of medicines for treating burns and scalds.

[0027] The Corilagin is one or a combination of Corilagin monomer or Corilagin salt.

[0028] The external application of the Corilagin reduces the growth of bacteria on burn and scald wounds by inhibiting the production and release of inflammatory mediators and alleviating wound inflammation.

[0029] The Corilagin advances the expression peaks of PDGF-BB and PDGFR-β by up-regulating the protein and gene expression levels.

[0030] The Corilagin can shorten the time of scab removal and hair growth in rats, and improve the healing rate of wounds.

[0031] The Corilagin is applied to treat burns and scalds and has a protective effect 7 days after administration.

[0032] The Corilagin is applied to treat burns and scalds for 21 days after administration.

[0033] Corilagin of the present invention has therapeutic and health-care effects in the pre...

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Abstract

The invention discloses application of Corilagin in preparation of a medicine for treating burns and scalds. The Corilagin is one of a Corilagin monomer or a Corilagin salt or a combination of the Corilagin monomer and the Corilagin salt. The Corilagin is externally used and reduces the growth of bacteria on the wound surfaces of burns and scalds by inhibiting the generation and release of inflammatory mediators to relieve the inflammatory response of the wound surfaces. Corilagin (8g / kg) reduces the inflammatory reaction of the wound surfaces by inhibiting the generation and release of inflammatory mediators, so as to reduce the growth of bacteria on the wound surfaces of the burns (scalds); and meanwhile, the protein and gene expression levels of PDGF-BB and PDGFR-beta are up-regulated, so that the expression peak is advanced, the decrustation and hair growing time of rats is shortened, and the healing rate of wound surfaces is improved. The Corilagin has an obvious treatment effect on the burns (scalds), and the curative effect of the Corilagin is even superior to that of a clinical first-line medicine 1% sulfadiazine silver.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Corilagin in the preparation of medicines for treating burns and scalds. Background technique [0002] Burn (scald) injury is a kind of acute skin injury, clinically, patients with small and medium-sized area, II° burn are in the majority. The skin is the largest and most easily damaged tissue and organ in the human body. After II° burn (scald) injury, the wound surface is often delayed or excessively repaired due to inappropriate treatment, resulting in a high rate of disability in patients. Therefore, how to timely and effectively deal with II° burn (scald) wounds is a common problem faced by all burn doctors. In the treatment of burn and scald patients in modern burn medicine, topical antimicrobial drugs are mainly chemical drugs such as antibiotics and silver salts to cover the wound surface in order to protect the remaining epithelial islands and prom...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P17/02
CPCA61K31/7024A61P17/02
Inventor 陈鹏张莉沈志强杨仁华李璠何波杨艳石佳宁
Owner KUNMING MEDICAL UNIVERSITY
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