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Phyllanthus niruri medicinal material fingerprint establishing method and standard fingerprint thereof

A standard fingerprint and fingerprint technology, which is applied in the field of pharmaceutical analysis, can solve the problems of patents on fingerprints of herbal medicinal materials such as pearls, and achieve the effects of easy realization of chromatographic conditions, simple production, good stability and reproducibility

Inactive Publication Date: 2012-01-25
中国医学科学院药用植物研究所云南分所
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AI Technical Summary

Problems solved by technology

[0004] So far, most of the reports on Zhuzicao focus on pharmacology, and there is no patent related to the fingerprint of Zhuzicao.

Method used

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  • Phyllanthus niruri medicinal material fingerprint establishing method and standard fingerprint thereof
  • Phyllanthus niruri medicinal material fingerprint establishing method and standard fingerprint thereof
  • Phyllanthus niruri medicinal material fingerprint establishing method and standard fingerprint thereof

Examples

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Effect test

Embodiment

[0025] EXAMPLE Establishment of HPLC fingerprints of herbal medicinal materials of beads.

[0026] This example is a method for establishing the fingerprints of 15 batches of cultivated C. chinensis and the standard fingerprints obtained therefrom, and using this method to evaluate the quality of the various batches of C. chinensis.

[0027] The 15 batches of bead herbal medicinal materials were obtained after planting seeds from different sources in Xishuangbanna Prefecture, Yunnan Province. The sources of medicinal materials are shown in Table 2.

[0028] Table 2 Sources of bead herbs

[0029] Sample serial number source S1 Xiamen City, Fujian Province S2 Zhangzhou City, Fujian Province S3 Maoming City, Guangdong Province S4 Wanning County, Hainan Province S5 Nanning City, Guangxi Province S6 Dehong Prefecture, Yunnan Province S7 Honghe Prefecture, Yunnan Province S8 Yuxi City, Yunnan Province S9 Xishuangbanna...

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Abstract

The invention discloses a phyllanthus niruri medicinal material efficient liquid phase fingerprint establishing method and a standard fingerprint thereof. Gallic acid and Corilagin are used as comparison products, HPLC (High Performance Liquid Chromatography) detection is carried out to a comparison product solution and a test sample solution under the same chromatograph condition, gradient elution is carried out, and a chromatogram is recorded to obtain the standard fingerprint. Through the comparison of the HPLC fingerprints of 15 batches of phyllanthus niruri medicinal materials, 26 common characteristic peaks are determined, and the common characteristic peaks constitute the fingerprint characteristics of the phyllanthus niruri medicinal materials and can be used as the standard fingerprints of the phyllanthus niruri medicinal materials. The invention has the characteristics of simple method, good repeatability, a large number of characteristic peaks, good accuracy and reliability and the like, and the established standard fingerprints can effectively represent the quality of the phyllanthus niruri medicinal materials and provide theoretical and practical foundations for perfecting the quality evaluation system of the phyllanthus niruri medicinal materials.

Description

technical field [0001] The present invention relates to a method for establishing fingerprints of traditional Chinese medicinal materials, especially a method for establishing fingerprints of pearl herbal materials with high performance liquid chromatography (HPLC), and the HPLC standard fingerprints of pearl herbal materials obtained by the method, which belong to drug analysis technology field. Background technique [0002] Pearl grass is Euphorbiaceae Phyllostachys genus Pearl grass ( Phyllanthus niruri Linn ), as a traditional Dai medicine, has a history of thousands of years of application. "Zhuzi Gantai Capsule" produced with Zhuzicao as the main raw material is currently the first choice of Chinese patent medicine for the treatment of liver diseases. Since the drug was successfully launched in 1999, its sales volume has doubled, and it has also been recommended by the country as one of the 18 drugs for the treatment of liver diseases. However, the production of hig...

Claims

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Application Information

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IPC IPC(8): G01N30/86G01N30/02
Inventor 牛迎凤李学兰唐德英陈曦
Owner 中国医学科学院药用植物研究所云南分所
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