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Novel use of corilagin

A kind of use, the technology of medicinal salt, which is applied in the new application field of corilagin, can solve the problems such as the inhibition of gastric acid by corilagin, and achieve the effect of treating or preventing gastric ulcer, reducing the acidity of gastric juice, and reducing the secretion of gastric acid

Inactive Publication Date: 2009-06-24
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, there have been no reports on the activity of corilagin in inhibiting gastric acid secretion, nor has there been any report on the treatment of hyperacidity, peptic ulcer and chronic gastritis related to hyperacidity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Effect of Corilagin on Gastric Acid Secretion in Rats

[0037] 1 material

[0038] 1.1 Reagents

[0039] Corilagin, prepared according to the method in Chinese patent ZL97104154.7

[0040] Ranitidine hydrochloride was provided by Jiangxi Huiren Pharmaceutical Co., Ltd.

[0041] Omeprazole is provided by AstraZeneca Pharmaceuticals Limited

[0042] Sodium carboxymethylcellulose (CMC-Na) was provided by Sinopharm Chemical Reagent Co., Ltd.

[0043] Penicillin Sodium for Injection was provided by North China Pharmaceutical Co., Ltd.

[0044] Chloral hydrate was provided by Sinopharm Chemical Reagent Co., Ltd.

[0045] Sodium hydroxide was provided by Nanjing Chemical Reagent No. 1 Factory

[0046] Phenolphthalein was provided by Haijing Analysis Chemical Technology Co., Ltd.

[0047] 1.2 Animals

[0048] Clean grade SD rats, male, weighing 180-200g, Shanghai Slack Experimental Animal Co., Ltd.

[0049] 1.3 Instruments

[0050] Sartorius BS110S Electroni...

Embodiment 2

[0074] Example 2 Corilagin anti-gastric ulcer animal experiment

[0075] 1 Experimental materials:

[0076] 1.1 Animals:

[0077] SD rats, male, 180-220g, provided by the Experimental Center of Yangzhou University

[0078] 1.2 Drugs and reagents:

[0079] Corilagin: prepared according to the method in Chinese patent ZL97104154.7

[0080] Positive drug; ranitidine hydrochloride capsules, provided by Zhongnuo Pharmaceutical Co., Ltd.

[0081] Acetic acid: provided by Shanghai Lingfeng Chemical Reagent Co., Ltd.

[0082] Sodium pentobarbital: provided by China Pharmaceutical Shanghai Chemical Reagent Co., Ltd.

[0083] 1.3 Equipment:

[0084] Rat fixation plate, surgical scissors, scalpel, tweezers, needle holder, micro syringe, balance

[0085] 1.4 Experimental conditions:

[0086] Experimental rats were kept in separate cages, fed with full price pellet feed, free to drink water, room temperature 20±2°C, humidity 50-70%

[0087] 2. Model of gastric ulcer in rats with p...

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PUM

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Abstract

The invention relates to novel application of corilagin or a pharmaceutically acceptable corilagin salt, in particular to application of the corilagin or the pharmaceutically acceptable corilagin salt in treating or preventing diseases related to gastric acid hypersecretion such as hyperchlorhydria, peptic ulcer and chronic gastritis.

Description

technical field [0001] The present invention relates to a new application of corilagin or a pharmaceutically acceptable salt thereof, in particular to the use of corilagin or a pharmaceutically acceptable salt thereof for treating or preventing diseases related to hypersecretion of gastric acid, such as hyperacidity, peptic ulcer, Chronic gastritis and other diseases. Background technique [0002] Hyperacidity refers to excessive secretion of gastric juice (including hydrochloric acid and pepsin and other components), which makes patients feel stomach discomfort, acid reflux, and heartburn (stomach burning sensation). Mild hyperacidity is mainly characterized by repeated gastric burning and acid reflux. If the gastric mucosa is damaged by excessive gastric acid, it will also cause symptoms such as stomach pain, nausea, and vomiting. Hyperacidity may further develop into peptic ulcer , and even ulcer perforation. [0003] Drugs for the treatment of hyperacidity can be divid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61K31/70A61P1/04
Inventor 李洋徐宏江杨永安张喜全李新祝王鸯宋伟
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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