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Method for analyzing anti-cervical cancer action mechanism of corilagin based on network pharmacology and molecular docking

A technology of network pharmacology and molecular docking, which is applied in the field of analysis of the mechanism of Corilagin's anti-cervical cancer based on network pharmacology and molecular docking, and achieves the effect of narrowing the research and development scope and improving the efficiency.

Pending Publication Date: 2022-01-14
WUHAN POLYTECHNIC UNIVERSITY
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Problems solved by technology

At present, there is no research report on Corilagin's anti-cervical cancer in vivo

Method used

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  • Method for analyzing anti-cervical cancer action mechanism of corilagin based on network pharmacology and molecular docking
  • Method for analyzing anti-cervical cancer action mechanism of corilagin based on network pharmacology and molecular docking
  • Method for analyzing anti-cervical cancer action mechanism of corilagin based on network pharmacology and molecular docking

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Experimental program
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Embodiment

[0035] 1. Based on network pharmacology and molecular docking analysis method of corilagin anti-cervical cancer mechanism.

[0036] 1.1. Screening of Corylagin’s action targets

[0037] Using "Corilagin" as the keyword to search in the Pubchem database, the structural formula of Corilagin mol2 was obtained. The swisstargetprediction and PharmMapper databases respectively input the structure formula of Corylagin mol2 to obtain the target of Corylagin protein. After verification by the protein database Uniprot, the final eligible Corylatin gene target was obtained according to z'-score>0.

[0038] 1.2. Cervical cancer candidate target identification

[0039] With "Cervical cancer" as the keyword, the DisGeNET database, Genecard database and OMIM database were used to search for relevant disease targets, and the screening condition of the Genecard database was: Relevance score>1. Then, the disease target and the corilagin target obtained in 1.1 were processed by Venn diagram m...

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Abstract

The invention belongs to the field of biomedicine, and relates to a method for analyzing an anti-cervical cancer action mechanism of corilagin based on network pharmacology and molecular docking. The method comprises the following steps: S1, screening active component action targets; s2, identifying disease candidate targets; s3, constructing a component target-disease target network and screening core targets; s4, performing enrichment analysis on the core target spot to discuss the action mechanism of the medicinal components; s5, constructing and visualizing a 'component-target-pathway-disease' network; and S6, carrying out molecular docking on the corilagin anti-cervical cancer key target. A network pharmacology technology is utilized to construct the corilagin anti-cervical cancer'drug ingredient-target-disease' network diagram for the first time, and how the active ingredient corilagin performs the drug effect through 'multi-target, multi-path and multi-path' combined regulation and control is revealed.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a method for analyzing the anti-cervical cancer mechanism of corilagin based on network pharmacology and molecular docking. Background technique [0002] Cervical cancer refers to malignant tumors that occur at the intersection of squamous epithelial cells at the cervix or transition zone and columnar epithelial cells at the endocervical endometrium. Cervical cancer is one of the common gynecological malignancies, and its incidence rate ranks fourth among female malignancies in the world, and even ranks first in some developing countries. For patients with locally advanced and recurrent metastatic cervical cancer, surgery and concurrent radiotherapy and chemotherapy cannot completely eradicate tumor tissue. Therefore, it is urgent to find effective and low-toxic treatment methods to improve the efficacy of cervical cancer treatment and reduce cervical cancer mortality. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40G16H70/60G16H50/70G16C20/50G16C20/90
CPCG16H70/40G16H70/60G16H50/70G16C20/50G16C20/90
Inventor 王丽梅王宏勋易阳侯温甫闵婷艾有伟毕经会叶诗洁
Owner WUHAN POLYTECHNIC UNIVERSITY
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