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Construction method and application of characteristic maps of Myrobalan and Myrobalan tomentosa

A technology of characteristic map and construction method, applied in the field of construction of characteristic map of Myrobalan and Myrobalan tomentosa medicinal materials

Active Publication Date: 2022-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The two basic medicinal materials of Myrobalan (collectively referred to as) are not distinguished in clinical application at present, and there is still a lack of research on whether there is a difference in the quality of the two. Comparative Study on the Quality of Myrobalan and Myrobalan

Method used

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  • Construction method and application of characteristic maps of Myrobalan and Myrobalan tomentosa
  • Construction method and application of characteristic maps of Myrobalan and Myrobalan tomentosa
  • Construction method and application of characteristic maps of Myrobalan and Myrobalan tomentosa

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] 1 Instruments and reagents

[0102] 1.1 Instruments Waters H-Class ultra-high performance liquid chromatography (Waters Co., Ltd., USA), WatersCORTECS T3 chromatographic column (2.1mm×150mm, 1.6μm), KQ-500DE ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd. ), ME204E one-millionth balance, XP26 one-millionth balance (Mettler-Toledo), Milli-QDirect ultrapure water system (Merck Co., Ltd.).

[0103] 1.2 Test Drugs 30 batches of Myrobalan (collectively referred to as) medicinal materials were identified by Wei Mei, chief pharmacist of Guangdong Yifang Pharmaceutical Co., Ltd., as the dried and mature fruits of the Junziaceae plants Terminalia chebula Retz. and Terminalia chebula Retz.var.tomentella Kurt. . See Table 1 for sample numbers and details.

[0104] Gallic acid (batch number: 110831-201805, content: 90.8%); Corilagin (batch number: 29111623-200301, content: 100%), provided for China Food and Drug Control Institute; -5, content: 97%) is Shanghai Shidan...

Embodiment 2

[0139] The present embodiment provides a kind of detection method of chebula (collectively referred to as) medical material, and the steps are as follows:

[0140] Preparation of the sample solution to be tested Take about 0.25 g of the chebula to be tested (generally referred to as) medicinal material powder (passed through a No. 3 sieve), accurately weighed, put in a stoppered Erlenmeyer flask, accurately add 25 ml of 70% methanol, weigh, and ultrasonically Treat (power 250W, frequency 40kHz) for 30 minutes, let cool, weigh again, make up the lost weight with 70% methanol, shake well, filter, and take the filtrate to obtain the final product.

[0141] Determination According to the chromatographic conditions in item 2.1 of Example 1, the samples were injected into an ultra-high performance liquid chromatograph.

[0142] The result is as Figure 5 As shown, compared with the characteristic maps of the medicinal material Myrobalan and the medicinal material Myrobalan versicol...

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Abstract

The invention relates to a construction method and application of a characteristic map of Myrobalan and Myrobalan officinalis medicinal materials. The construction method of the characteristic map of the chebula medicinal material comprises the following steps: using gallic acid, ethyl gallate, corilagin, chebula acid, chebulic acid and chebulinic acid as reference substances, preparing a reference substance solution; taking chebula Medicinal material, solubilized and dissolved, ultrasonically extracted, the extract was filtered, and the filtrate was taken to obtain the test solution of Myrobalan; the reference substance solution and the test solution of Myrobalan were respectively carried out by ultra-high performance liquid chromatography; the ultra-high performance liquid The chromatographic conditions of the phase chromatography include: mobile phase A is acetonitrile, mobile phase B is phosphoric acid aqueous solution with a volume fraction of 0.1% to 0.3%, and the elution method is gradient elution. The invention provides a relatively comprehensive, effective and fast method for the quality control and evaluation of the medicinal materials of Myrobalan (collectively referred to as).

Description

technical field [0001] The invention relates to the technical field of drug analysis and drug quality control, in particular to a construction method and application of a characteristic map of myrobalan and myrobalan tomentosa medicinal materials. Background technique [0002] Myrobalan (collectively referred to as) is a commonly used medicine of traditional Chinese medicine, and also a commonly used medicine of ethnic medicines such as Tibetan medicine and Mongolian medicine. According to the first part of the 2015 edition of "Chinese Pharmacopoeia", Myrobalan (collectively referred to as) is the Junziceae plant Terminalia chebula Retz .Or the dry ripe fruit of Terminalia chebula Retz.var.tomentella Kurt. Myrobalan (collectively) is bitter, sour, puckery in nature, flat, returns lung, large intestine meridian. It has the effects of astringing the intestines to relieve diarrhea, astringing the lungs to relieve cough, reducing fire and pharynx, and is clinically used for chr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8679G01N30/8686
Inventor 李国卫吴文平邓淙友索彩仙邱韵静何嘉莹程学仁魏梅孙冬梅陈向东
Owner GUANGDONG YIFANG PHARMA
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