78 results about "Terminalia chebula" patented technology

The present invention belongs to the field of traditional Chinese medicine technology and primarily relates to a traditional Chinese medicine composition, preparation method, and application for preventing and treating sea cucumber rotten skin syndrome. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-80 parts of Terminalia chebula, 3-20 parts of Galla chinensis, 10-50 parts of Andrographis paniculata, and 5-30 parts of Ligusticum chuanxiong. The traditional Chinese medicine composition can significantly enhance the immune function and disease resistance of sea cucumbers, reduce the inflammatory response and pathological damage caused by Vibrio splendens, slow the progression of sea cucumber disease caused by pathogenic bacteria, and reduce the morbidity and mortality of sea cucumbers suffering from rotten skin syndrome, thereby effectively preventing and treating sea cucumber rotten skin syndrome.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of anti-fatigue health care wine, and relates to the technical field of traditional Chinese medicine preparation and traditional Chinese medicine health care. The traditional Chinese medicine composition takes medicinal and edible traditional Chinese medicinal materials as raw materials, is prepared from herba cistanche, radix acanthopanacis semticosi, radix asparagi, fructus phyllanthi, pollen typhae, fructus canarii, herba cichorii, folium microcotis, semen canavaliae and fructus citri, and has the effects of tonifying kidney and spleen, tonifying qi and yin and combining clearing and tonifying. The traditional Chinese medicine composition and the health-care wine prepared from the traditional Chinese medicine composition provided by the invention have an excellent anti-fatigue effect, and can be used for remarkably prolonging the weight-bearing exhaustion swimming time of mice, remarkably reducing the plasma urea nitrogen content of the mice after exercise, remarkably improving the hepatic glycogen content of the mice and remarkably improving the blood lactic acid clearance of the mice after exercise; the obvious physical fatigue relieving effect is realized. The compound is expected to be developed into anti-fatigue medicines or health-care products.

The invention discloses a coffee-flavor plant extract and a preparation method thereof, and the coffee-flavor plant extract is refined by using lophatherum gracile, Chinese olive, folium cortex eucommiae, dendrobium officinale, astragalus membranaceus, codonopsis pilosula, dandelion and liquorice as composite plant raw materials through multi-strain synergistic fermentation and oak barrel aging and curing technologies. The dissolution rate and bioavailability of various bioactive components such as chlorogenic acid, ginsenoside, curcumin and dendrobium polysaccharides are effectively improved through multi-strain synergistic fermentation. The oak barrel ageing endows the product with unique baking, nut and vanilla flavors, the taste is mellow, and the flavor characteristic of coffee is effectively simulated. The plant extract prepared by the invention is rich in various functional components, and can assist in improving the memory ability. Meanwhile, a healthy, caffeine-free and rich-flavor herbaceous plant beverage is provided for consumers, a new solution is provided for product development of plant extracts, and huge market potential and economic value are achieved.

This invention discloses a Tibetan bath composition compound and its preparation method, relating to the field of daily chemical products technology. The Tibetan bath composition compound consists of a ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder, Bacillus subtilis, Tibetan medicine composition, starch, anhydrous citric acid, sodium bicarbonate, calcium citrate, crospovidone, and magnesium stearate. Bacillus subtilis is used to ferment the ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder to obtain a fermentation-modified porous carrier, which is then loaded with the Tibetan medicine composition to form a Tibetan medicine inclusion powder. This not only achieves efficient drug delivery through a triple mechanism of biomodification, metabolite synergy, and structural optimization, but also forms a quaternary system with Terminalia chebula. The effervescent effect also enhances the penetration of Tibetan medicine components, which is beneficial for better exerting the antibacterial and anti-inflammatory effects of active substances, and significantly improving fungal infections and eczema-related skin problems.

This invention belongs to the field of biomedical technology, specifically relating to a Terminalia chebula active polypeptide, its preparation method, and its application. The preparation method uses Terminalia chebula slices as raw material, which are pulverized, homogenized with water, and then subjected to a series of enzymatic hydrolysis steps: a first hydrolysis with neutral protease, a second hydrolysis with pepsin, and a third hydrolysis with trypsin. Enzyme inactivation is performed after each hydrolysis. Subsequent steps include filtration, removal of alkaline proteins, ultrafiltration, and fine filtration to obtain the Terminalia chebula active polypeptide. The preparation method of this invention, through a three-step progressive enzymatic hydrolysis method, can efficiently prepare highly active Terminalia chebula polypeptides. The obtained Terminalia chebula active polypeptides have small molecular weight, are easily absorbed, and are non-toxic. These active polypeptides exhibit significant anti-tumor and liver fibrosis-improving effects, effectively reshaping the tumor microenvironment, enhancing anti-tumor immune responses, and repairing liver tissue damage. They have broad application prospects in the preparation of anti-tumor and liver fibrosis-improving drugs.

This invention relates to the field of traditional Chinese medicine analysis, and particularly to a method for determining the content of multiple components in Terminalia chebula and constructing its characteristic fingerprint spectrum. The method provided by this invention can simultaneously determine chebulin, gallic acid, 4-galloshikimic acid, 5-galloshikimic acid, punicalin (punicalin A&B), corilagin, 1,3,6-tri-O-galloyl-β-D-glucose, chebulin, urolithin M5, chebulin tannic acid, chebulin-lintannic acid, and ellagic acid in Terminalia chebula. It exhibits high sensitivity, good precision, repeatability, and stability, and can be used to detect the tannin content in the extract at each step of the tannin extraction process, as well as for related detection in the study and quality evaluation of tannin components in Terminalia chebula. It can also be used to construct the characteristic fingerprint spectrum of Terminalia chebula. This method can also be used for determining the content of tannin compounds and constructing their characteristic fingerprint spectrum in Terminalia chebula, which contains similar tannin compounds to Terminalia chebula.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine composition for treating rhinitis based on a fructus xanthii extract and a preparation method of the traditional Chinese medicine composition. 5%-7% of liquorice; 15%-20% of dark plum; 2%-5% of bighead atractylodes rhizome; 20%-25% of schisandra chinensis; 1%-3% of almonds; 5%-8% of cortex mori radicis; 4%-11% of centipeda minima; 4%-7% of fructus chebulae; 0.2%-0.5% of cassia twig; 1%-3% of radix saposhnikoviae and 4%-9% of 4%-7% of radix astragali; 3%-6% of radix ophiopogonis; the raw materials are processed and proportioned, and the traditional Chinese medicine ointment is prepared through the processes of decoction of the detoxifying and synergistic group, concentration of the orifice-opening and exterior-strengthening group, extraction of the qi-tonifying and yin-nourishing group, mixed light decoction and concentration. When the ointment is used, a cotton swab is coated with the ointment, the cotton swab coated with the ointment is fed into the nasal polyp part of a rhinitis patient and stays for about 20 minutes, after the drug effect of the ointment is slowly released, the nasal polyp necroses, part of the nasal polyp can fall off after about 15 days, and the treatment process can be repeated for multiple times and once every 15 days until the nasal polyp completely falls off. The ointment can effectively relieve nasal obstruction, running nose, rhinocnesmus and sneezing symptoms of rhinitis patients; the traditional Chinese medicine is not required to take medicine but is only externally used, is very safe to use and has no toxic or side effect.

The present invention discloses a pharmaceutical composition comprising more than 26 substances, obtained by mixing ethanol extracts of costus root, agarwood, jujube, terminalia chebula, nutmeg, kapok, and frankincense with travertine. The composition can improve myocardial ischemia in subjects; increase the ejection fraction of subjects with myocardial infarction; increase the fractional shortening of the heart; reduce the left ventricular end-diastolic diameter in subjects with myocardial infarction; reduce the left ventricular end-systolic diameter in subjects with myocardial infarction; shorten the sleep latency in subjects with insomnia; prolong the sleep duration in subjects; and upregulate the expression of GAD67 protein in the brain tissue of subjects.

The invention relates to the technical field of hair supplies, in particular to plant-extracted anti-hair-loss hair-growing liquid and a preparation method thereof. The plant extraction anti-hair loss hair growth liquid provided by the invention is prepared from hair growth factors, peppermint oil, isohexylene glycol, 1, 3-butanediol and water, the hair growth factor is obtained by extracting polygonum multiflorum, eclipta, white mulberry root-bark, rhizoma kaempferiae and fructus chebulae. The hair growth liquid obtained by the invention has the advantages of low irritation, moistening and transdermal effects, good compliance effect for a user and efficient hair loss prevention and hair growth effects, and hair growth active factors can be efficiently delivered and effectively play the hair loss prevention and hair growth effects.

The invention belongs to the technical field of bioengineering, and particularly relates to myrobalan fruit nano-vesicles, a preparation method and application of the myrobalan fruit nano-vesicles in skin aging resisting products. The preparation method comprises the following steps: firstly, carrying out enzymolysis on a myrobalan fruit raw material by adopting a compound enzyme preparation containing feruloyl esterase, and adding sodium alginate and a calcium chloride solution into enzymatic hydrolysate after enzymolysis to carry out precipitation treatment on nano-vesicles; and finally, treating the precipitate by adopting a sodium carbonate or sodium bicarbonate solution, fully stirring, centrifuging, and collecting the supernatant, thereby obtaining the purified product of the myrobalan fruit nano-vesicle. The preparation method of the myrobalan fruit nano-vesicle is efficient and low in cost, the content of miRNA in the obtained nano-vesicle is high, animal experiments show that the nano-vesicle can reduce the content of IL-6 inflammatory factors in experimental animal skin tissue and reduce collagen loss caused by ultraviolet rays, and the nano-vesicle has remarkable anti-aging and light aging relieving effects and can be used for preparing the nano-vesicle. The method can be applied to functional skin care products.

Antimicrobial compositions and methods for making and using the same are disclosed. The compositions comprise an effective amount of one or more of a Cryptolepis sanguinolenta tincture, a Sida acuta tincture, a Terminalia chebula tincture, an Alchornea cordifolia tincture, a Phyllanthus emblica tincture, a Curcuma longa tincture, an Olea europaea tincture, an Embelia ribes tincture, a Tinospora cordifolia tincture, and an Ocimum tenuiflorum tincture.

The invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application, and particularly belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition comprises the following components in parts by weight: 7-11 parts of champignon, 19-29 parts of aloe, 10-14 parts of fructus chebulae immaturus, 5-7 parts of rhizoma zingiberis, 5-7 parts of rhizoma nardostachyos, 4-6 parts of fructus chebulae and 2-4 parts of halite. The traditional Chinese medicine composition can improve the activity of SOD, inhibit the content of MDA, reduce damage of oxygen free radicals to gastric mucosa, effectively relieve inflammatory response, achieve anti-inflammation, improve ulcer surface blood flow, improve gastric mucosa damage, reduce ulcer surfaces and promote ulcer healing, and therefore the protective effect on gastric ulcer is achieved. The results of network pharmacology, molecular docking speculation and Western blot method verification show that the FMST plays an anti-inflammatory role through a TLR4 / MyD88 / NF-kappa B signal channel.

The application provides a traditional Chinese medicine composition and application thereof in preparation of a drug for treating reflux esophagitis, and relates to the technical field of traditional Chinese medicine pharmacy.The traditional Chinese medicine composition takes Fritillaria thunbergii Miq., Evodia rutaecarpa, Citrus medica L. as monarch drugs, Inula japonica, Terminalia chebula Retz., Nardostachys chinensis, Syzygium aromaticum, Amomum subulatum, Phoenix tree as minister drugs, mother-of-pearl, Cortex Fraxini, Gentiana scabra Bunge, Osmanthus fragrans as auxiliary drugs, and Glycyrrhiza uralensis as a servant drug, and the drugs are combined to have the effects of dispersing the liver and harmonizing the stomach, reducing adverse and acid, and regulating cold and heat.The traditional Chinese medicine composition can significantly improve the esophagitis index of RE rats, has obvious inhibitory effect on inflammatory damage, can significantly improve the pathological morphology of the esophageal tissue of the RE rats, and realizes better anti-inflammatory and therapeutic effect on the RE rats.Meanwhile, the traditional Chinese medicine composition can significantly improve and alleviate the clinical symptoms of the patients with reflux esophagitis, such as acid reflux, heartburn, abdominal distension and belching, and reduce the frequency of the clinical symptoms.The traditional Chinese medicine composition is expected to be further developed and popularized as a drug for treating reflux esophagitis.

The present invention relates to the beneficial effect of Chebulinic acid (CA) and its enriched standardized fraction (CAEF) isolated / prepared from the fruits of Terminalia chebula for the management of Benign Prostatic Hyperplasia respectively. Further, it relates to a novel, convenient and economically viable method for the isolation of chebulinic acid (CA) and ellagic acid (EA) from the dried and powdered fruits of T. chebula without using any expensive and tedious chromatographic techniques such as HPLC, column chromatography, resins etc.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine for treating pain symptoms and a preparation process thereof. The traditional Chinese medicine product is prepared from lycopodium clavatum, berba aristolochiae mollissimae, fructus chebulae, semen strychni, codonopsis pilosula, eucommia ulmoides, radix achyranthis bidentatae, angelica sinensis, elm bark, radix paeoniae alba and moutan bark through boiling, hot water extraction, serrapeptase enzymolysis, ethanol extraction, concentration, composite extraction of a composite extraction phase and secondary concentration, and the prepared traditional Chinese medicine is rich in active ingredient variety, high in concentration and few in impurity; the effect of treating pain symptoms is obviously improved. The preparation process is simple, the comprehensive effect of the product is excellent, and the application prospect is wide.

The Invention provides an enhanced Polyherbal Nano-admixture to retain and regain metabolic health with balanced detoxification, synergistic effect and preparation method thereof. The present invention discloses a polyherbal composition comprising a Andrographis paniculata herb extract; a Boerhavia diffusa herb extract; a Abelia triflora herb extract; a Terminalia bellerica herb extract; a Picrorhiza kurroa herb extract; a Tinospora cordifolia herb extract; a Phyllanthus emblica herb extract; a Acalypha fructicosa herb extract; a Phyllanthus niruri herb extract; a Terminalia chebula herb extract; and a Abutilon persicum herb extract.

The invention provides a Chinese herbal compound for treating or improving anxiety disorder and application thereof, and relates to the technical field of Chinese herbal medicines. According to the traditional Chinese medicine compound, cortex albiziae, longan pulp and citron are used as monarch materials, zedoary, buckeye and scirpus yagara are used as ministers, cortex fraxini, fructus chebulae, cortex dictamni, selfheal, lithospermum and liquorice are used as assistants and guides, all the medicines are combined to regulate qi activity, invigorate qi and blood, dissipate stasis and clear away toxin, and the whole formula has the effects of resolving depression, soothing the nerves, soothing the liver, regulating qi, tonifying heart and spleen, activating blood and clearing heat. The traditional Chinese medicine compound can effectively relieve anxiety mood of a patient, refresh sleep quality and improve anxiety expression such as body symptoms of the patient, is remarkable in curative effect, has huge application potential in the aspect of treating or improving anxiety disorder, and is worthy of popularization.

The invention relates to the technical field of Tibetan medicines, in particular to a preparation containing Tibetan medicine musk, a preparation method of the preparation and application of the preparation in preparation of liver cancer medicines. The preparation is prepared from the following raw materials: musk, swertia mussotii, rheum tanguticum, dracocephalum tanguticum, delphinium delphinium, phyllanthus emblica, salviae miltiorrhizae, herpetospermum pedunculosum, saussurea hypoglauca, saffron crocus, trogopterus dung, fructus chebulae and plantago asiatica. According to the invention, a plurality of medicinal materials are compatible, all the raw materials have a synergistic effect, the effects of compound components are effectively exerted, and the traditional Chinese medicine composition can resist cancer, protect liver, clear away heat and toxic materials and inhibit tumor growth, has a good anti-liver cancer effect and does not generate an immunosuppressive effect on a body.

This invention relates to the field of Mongolian medicine preparation technology, and discloses an Erdun-7 granule preparation and its preparation method, which is made from the following raw materials in parts by weight: 1 part of *Inula japonica* and 1.3-1.8 parts of *Rubus idaeus*, used to regulate qi, relieve exterior symptoms and reduce fever; 1.6-2.4 parts of *Sophora flavescens*, 0.7-1.3 parts of *Gardenia jasminoides*, and 0.7-1.3 parts of *Terminalia chebula*, used to enhance the heat-clearing, fire-purging, detoxifying and blood-cooling effects of *Inula japonica* and *Rubus idaeus*; 0.8-1.2 parts of *Uncaria rhynchophylla* and 0.8-1.2 parts of *Cicada slough*, used to calm the liver, extinguish wind, and stop spasms; and 0.7-1.3 parts of *Kaempferia galanga* and 0.7-1.3 parts of *Melia azedarach*. This Erdun-7 granule preparation and its preparation method target the anticonvulsant effect of the granules, prolonging the latency period and reducing the incidence and severity, which is significantly better than traditional preparations, demonstrating the synergistic effect of clearing heat and relieving exterior symptoms and extinguishing wind and stopping spasms.

The present application relates to the technical field of Mongolian medicine external preparation, in particular to a Mongolian medicine Sendeng-4 cream. The cream is prepared from Sendeng, Terminalia chebula, Gardenia jasminoides and Chinese Hopea as raw materials, and effective components are enriched by composite enzymolysis, supercritical CO2 two-phase extraction, gradient membrane separation and molecular imprinting purification. Then, the cream is prepared by adding composite penetration enhancer and plant source preservative after the pH-ROS response carrier targets drug loading and the temperature-sensitive composite matrix is microfluidic adapted. The present application solves the defects of traditional preparation, such as insufficient dissolution, poor stability and weak targeting, and has high cream purity, good skin permeability, excellent safety, stable long-term storage performance, and is suitable for skin inflammation, eczema, itching and other diseases. The cream has the advantages of traditional Mongolian medicine and modern preparation, and has a wide clinical application prospect.

The invention discloses a depression-relieving, fire-decreasing and mind-tranquilizing ointment formula and a preparation method thereof. The invention discloses a depression-relieving, fire-decreasing and mind-tranquilizing ointment formula. The traditional Chinese medicine composition comprises the following components in parts by weight: 5-15 parts of pericarpium citri reticulatae, 15-45 parts of poria cocos, 10-20 parts of rhizoma pinellinae praeparata, 5-15 parts of fructus aurantii immaturus, 5-15 parts of fructus chebulae, 10-20 parts of fried semen ziziphi spinosae, 3-10 parts of baked ginger, 5-15 parts of schisandra chinensis, 5-20 parts of angelica sinensis, 5-20 parts of raw rhizoma atractylodis macrocephalae, 3-15 parts of mangnolia officinalis, 5-20 parts of agastache rugosus, 3-10 parts of honey-fried licorice root, 5-15 parts of poria with hostwood, 5-15 parts of cassia twig, 5-15 parts of pericarpium citri reticulatae viride, 5-20 parts of rhizoma anemarrhenae, 5-20 parts of The traditional Chinese medicine is prepared from 15-45 parts of oyster, 5-20 parts of rhizoma acori graminei, 10-30 parts of radix ophiopogonis, 5-20 parts of radix salviae miltiorrhizae, 5-30 parts of rhizoma dioscoreae, 5-10 parts of herba menthae, 5-20 parts of radix paeoniae alba, 15-30 parts of light wheat, 5-15 parts of arillus longan and 100-200 parts of honey. The invention further provides a preparation method of the ointment capable of resolving depression, decreasing internal heat and tranquilizing mind. The traditional Chinese medicine composition is used for treating liver depression transforming fire and yin impairment and spleen deficiency, dampness obstruction and qi stagnation syndrome type chronic insomnia, and has the effects of soothing liver-qi stagnation, clearing away heart-fire, tonifying spleen, promoting qi circulation, reducing phlegm, soothing nerves, stabilizing mind and the like.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of radix fici simplicissimae, 15-25 parts of herba asari, 10-20 parts of fructus chebulae, 10-20 parts of discolor bulbophyllum herb, 10-20 parts of gecko, 10-20 parts of cortex magnoliae officinalis, 10-15 parts of kadsura longepedunculata, 5-10 parts of folium microcotis, 10-15 parts of semen coicis, 10-15 parts of achyranthes aspera, 10-15 parts of radix astragali and 10-15 parts of honey-fried licorice root. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to the formula dosage, then adding water which is 5-20 times of the total weight of the traditional Chinese medicine composition, and decocting for three times to obtain a traditional Chinese medicine decoction; combining the traditional Chinese medicine decoction, filtering, and concentrating until the relative density is 1.05-1.10 to obtain a traditional Chinese medicine extract; and adding clinically acceptable auxiliary materials into the traditional Chinese medicine extract, and preparing by adopting a conventional preparation mode. The traditional Chinese medicine can achieve the treatment purposes of simultaneously treating lung, spleen, kidney and heart, diminishing inflammation, relieving asthma, harmonizing yin and yang and eliminating lung distension.

The invention relates to a synbiotic enzyme as well as a preparation method and application thereof, and belongs to the technical field of biological agriculture. The synbiotic enzyme is prepared from garlic, brown sugar, radix astragali, fructus schisandrae chinensis, fructus chebulae, lactobacillus hirsuti liquid and water. The synbiotic enzyme disclosed by the invention has a broad-spectrum antibacterial effect, and has a relatively strong inhibition effect on bacterial pathogenic bacteria such as vibrio alginolyticus, listonella anguillarum, edwardsiella ictaluri, aeromonas hydrophila, vibrio parahaemolyticus, aeromonas veronii and vibrio cholerae; the composition can be used for preventing and treating hemorrhagic ascites disease, necrotic canker and other aquaculture diseases caused by bacteria and pathogenic bacteria in aquaculture, can improve the feed conversion rate in aquaculture, and improves the growth and reproduction capability, immunity and culture benefits of aquatic animals.

The invention relates to the technical field of pharmaceutical analysis, in particular to a quantitative detection method for active components of fructus chebulae, which comprises the following steps: S1, collecting and pretreating a fructus chebulae sample, collecting fructus chebulae plant tissues, cleaning to remove surface impurities, drying to constant weight, drying under a dark condition, crushing to uniform powder after drying, and controlling the particle size of the powder by screening; s2, extracting active ingredients; s3, purifying and concentrating the extracting solution, namely purifying the extracting solution obtained in the S2 through a solid-phase extraction column to remove interfering substances, selecting the filler type of the solid-phase extraction column according to the adsorption characteristics of active ingredients of the fructus chebulae, concentrating the purified extracting solution to a preset volume under a reduced pressure condition, and controlling the concentration temperature within a stable range of the active ingredients; and S4, optimization and quantitative analysis of detection conditions. Through an optimized water-ethanol solvent ratio and an ultrasonic extraction technology, the extraction efficiency of active components is improved, and time and energy consumption is reduced.

The invention relates to the field of traditional Chinese medicine application, and discloses application of a loss-increasing real-person viscera-nourishing decoction in preparation of a medicine for treating critically ill antibiotic-associated diarrhea, and the loss-increasing real-person viscera-nourishing decoction comprises the following active ingredient raw materials in parts by weight: 13-17 parts of ginseng, 13-17 parts of charred angelica sinensis, 18-22 parts of roasted rhizoma atractylodis macrocephalae, 13-17 parts of myristica fragrans, 5-7 parts of cinnamon and 8-12 parts of honey-fried licorice root. , 18-22 parts of parched white peony root, 8-12 parts of roasted radix aucklandiae, 8-12 parts of roasted fructus chebulae and 18-22 parts of pomegranate rind. The loss-increasing real-person viscera-nourishing decoction shows a good curative effect in the treatment process of antibiotic-related diarrhea of critical patients, also shows a good curative effect in the aspects of improving the gastrointestinal function and the overall health condition of the patients, is relatively low in recurrence rate, has good safety, and is suitable for clinical application. The compound can be effectively used for preparing the medicine for treating the critically ill antibiotic-associated diarrhea and treating the critically ill antibiotic-associated diarrhea.

This invention relates to a compound gel for treating joint inflammation based on a modified ancient Chinese medicine formula, belonging to the fields of pharmaceutical preparations and traditional Chinese medicine. The compound gel consists of active ingredient extracts, a poloxamer thermosensitive gel matrix, a penetration enhancer, a humectant, and deionized water. The active ingredient extracts are obtained from *Terminalia chebula*, *Amla emblica*, lavender, wild watermelon, *Artemisia annua*, and chamomile through ultrasonic-microwave coupling extraction. Using ultrasonic-microwave coupling extraction combined with a low-temperature drying process, small-molecule active ingredients are obtained. A body temperature-responsive gel is constructed based on poloxamer 407 / 188, achieving in-situ phase transition on the skin surface and stable sustained release over 6-8 hours, significantly improving transdermal absorption. The gel is combined with an integrated medication container and biomimetic protective gear to form a synergistic drug delivery system, achieving closed-loop controlled release, leak-proof design, and motion adaptation. This gel is non-irritating and non-allergenic, suitable for topical treatment of osteoarthritis, rheumatoid arthritis, and soft tissue injuries caused by cold and dampness in high-altitude regions.

The invention discloses a Mongolian medicine composition for treating chronic kidney diseases and application of the Mongolian medicine composition, and belongs to the technical field of biological medicine. The Mongolian medicine composition is prepared from the following components in parts by weight: 35 to 45 parts of radix et rhizoma rhei, 30 to 40 parts of halite, 15 to 25 parts of rhizoma kaempferiae, 20 to 30 parts of pomegranate, 15 to 25 parts of semen cassiae torae, 20 to 30 parts of rhizoma kaempferiae, 10 to 20 parts of radix inulae and 15 to 25 parts of fructus chebulae. According to the Mongolian medicine three-root seven-element theory, the viscera theory, the turbid metabolism theory and the holistic view, the Mongolian medicine composition with the remarkable curative effect on the chronic kidney disease is developed by combining the intestinal renal axis theory. According to the invention, enema administration is adopted, so that the medicine directly acts on intestinal mucosa, the first-pass effect of liver is avoided, and the utilization rate of the medicine is improved; the drug administration scheme is optimized, the operation is simple and convenient, and the safety is high. And the composition is completely prepared from natural Mongolian medicine components, so that the toxic and side effects are small, the patient compliance is better, and a new treatment thought is provided for clinical treatment of the chronic kidney disease.

The quality evaluation method for determining the best processing technology of Mongolian medicine terminalia chebula-processed aconiti kusnezoffii of the present invention belongs to the technical field of traditional Chinese medicine analysis and detection. The quality evaluation method of the present invention takes the content changes of terminalia chebula and alkaloids in terminalia chebula-processed aconiti kusnezoffii as evaluation indicators, establishes an orthogonal optimization test to determine the best processing method of terminalia chebula-processed aconiti kusnezoffii; establishes a method for comprehensively evaluating the quality of terminalia chebula-processed aconiti kusnezoffii, which is also applicable to raw aconiti kusnezoffii, and evaluates the quality of processed aconiti kusnezoffii by multiple detection means, including impurities, moisture, total ash, thin layer, content determination involving high performance liquid chromatography, and fingerprint. It is proved by test examples that the method is stable and reliable, and can evaluate the quality of terminalia chebula-processed aconiti kusnezoffii in a relatively comprehensive manner. At the same time, the Mongolian medicine terminalia chebula-processed aconiti kusnezoffii processing method optimized by the evaluation method is suitable for scientific research and production practice.

The invention provides a pharmaceutical composition for pulmonary tuberculosis and a preparation method and application thereof, and the pharmaceutical composition comprises the following raw materials in parts by weight: 40-60 parts of fructus chebulae, 20-30 parts of acorus calamus, 10-20 parts of embelia laeta, 10-15 parts of fructus viticis, 10-15 parts of buchnera buxifolia, 10-15 parts of radix aucklandiae, 10-15 parts of travertine, 10-15 parts of frankincense, 10-15 parts of semen cassiae, 10-15 parts of abelmoschus esculentus, 10-15 parts of benzoin and 10-15 parts of safflower. The traditional Chinese medicine composition is prepared from 10-15 parts of clove, 10-15 parts of fructus amomi rotundus, 10-15 parts of fructus tsaoko, 10-15 parts of semen myristicae, 5-7 parts of catechu, 2-3 parts of zota and 1-2 parts of artificial musk. The raw materials are scientific in compatibility and reasonable in compounding, pure natural traditional Chinese medicines are used as the raw materials, and the traditional Chinese medicine composition is safe and mild, has the efficacy of treating pulmonary tuberculosis, is quick in efficacy, has no obvious side effect, does not cause damage to liver and kidney functions, does not generate drug resistance, can regulate the whole body of the lung, regulate the body and enhance the immunity, is low in recurrence rate and is convenient to take.