Traditional Chinese medicinal recipe for inhibiting streptococcus

A technology of Chinese herbal medicine and streptococcus, which is applied in the direction of medical formulas, antibacterial drugs, and medical preparations containing active ingredients, etc., can solve problems such as the deterioration of the breeding environment, ecological balance imbalance, and water environment pollution, and achieve simple production processes and no The effect of developing drug resistance and reducing production costs

Inactive Publication Date: 2013-05-22
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term abuse of drugs or antibiotics will cause water environment pollution, which will lead to deterioration of the breeding environment, imbalance of ecological balance, and bacteria will develop drug resistance, and drug residues will pose a potential threat to consumers

Method used

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  • Traditional Chinese medicinal recipe for inhibiting streptococcus
  • Traditional Chinese medicinal recipe for inhibiting streptococcus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The invention relates to a Chinese herbal medicine formula for inhibiting streptococci, and the following 34 kinds of Chinese herbal medicines all have different degrees of antibacterial effects on streptococci.

[0012] First of all, pomegranate peel, catechin and Schisandra chinensis had the strongest antibacterial effect on streptococcus in vitro, and the minimum inhibitory concentration (MIC) reached 6.25 mg / ml; followed by ebony and papaya, which had stronger antibacterial effect on streptococcus, with the smallest The bacteriostatic concentration (MIC) reached 12.5mg / ml. Burnet also had a certain bacteriostatic effect on streptococci, and the MIC was 25mg / ml; the in vitro bacteriostatic effect of raspberry, myrobalan meat, araceae and cassia on streptococcus Weak, MIC is 50mg / ml; dry alum, crane lice, tiger stick slices, viola, rhubarb, myrrh, licorice, forsythia, gentian, houttuynia, mugwort, flavescens, torreya, angelica , white peony root, coptis, clove, hops, ...

Embodiment 2

[0016] The invention is a Chinese herbal medicine formula for inhibiting streptococcus. The Chinese herbal medicine is composed of the following raw materials and weight ratios: pomegranate peel, catechu, schisandra chinensis and black plum are mixed in a weight ratio of 1:1:2:2. The results showed that the formula has a significant antibacterial effect on streptococcus, which is more obvious than the antibacterial effect of single herbal medicine and other combinations of Chinese herbal medicine compound formula, and its minimum inhibitory concentration MIC is 2.34mg / ml. The minimum inhibitory concentration MIC of the Chinese herbal compound formula formed by mixing pomegranate peel, catechu, schisandra and ebony in a ratio of 1:1:1:1 by weight is 6.25mg / ml, and the pomegranate peel, catechin, schisandra and ebony The minimum inhibitory concentration MIC of the compound formula of Chinese herbal medicine mixed according to the weight ratio of 8:2:4:1 was 11.42 mg / ml, which was...

Embodiment 3

[0018] Bacteriostatic Test of Chinese Herbal Medicine on Streptococcus in Vitro

[0019] 1. Selection of Chinese herbal medicine and preparation of liquid medicine

[0020] The 86 kinds of Chinese herbal medicines selected in this study were all purchased from Beijing Tongrentang Pharmacy in Ningbo City. Schisandra, galla, ebony, clematis, catechu, dijincao, viola, dried alum, prunella, goose does not eat, myrobalan meat, perilla leaves, leaking reed seeds, cassia seeds, papaya, isatis root, berberine, Senecio, aloe vera, male clove, tallow, mugwort leaves, knotweed, crane lice, gentian, snakeberry, gong leaves, forsythia, myrrh, rhubarb, perrin, torreya, capillary, phellodendron, taro, andrographis paniculata , Perilla, Honeysuckle, Purslane, Astragalus, Licorice, Araceae, Artemisia annua, Lobelia, Paeoniae Alba, Icorus, Angelica, Radix, Aster, Hedyotis diffusa, Houttuynia, Sophora, Dandelion, Shouwu, Atractylodes atractylodes, Rhododendron, Perilla stalk, Raspberry, Baibu,...

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Abstract

The invention discloses a traditional Chinese medicinal recipe for inhibiting streptococcus. The recipe is characterized by comprising at least one of pericarpium granati, catechu, fructus schisandrae chinensis, chaenomeles speciosa, fructus mume, radix sanguisorbae, fructus rubi, terminalia chebula retz, rhizoma arisaematis, semen cassiae, aluminis usti, fructus carpesii, reynoutria japonica slice, herba violae, radix et rhizoma rhei, myrrha, radix glycyrrhizae, fructus forsythiae, gentiana scabra bunge, herba houttuyniae, folium artemisiae argyi, radix sophorae flavescentis slice, semen torreyae, radix angelicae dahuricae, white paeony root, coptis chinensis franch, flos caryophyllata, humulus lupulus, anemone chinensis, rhizoma atractylodis, radix scutellaria, radix clematidis, radix curcumae and cortex phellodendri chinensis, wherein a recipe which is formed by mixing the pericarpium granati, the catechu, the fructus schisandrae chinensis and the fructus mume according to the mass ratio of 1:1:2:2 has an optimal antibacterial effect. The recipe has the advantages of naturality, no toxity and residues, no tolerance and low price.

Description

technical field [0001] The invention relates to a Chinese herbal medicine formula, in particular to a Chinese herbal medicine formula for inhibiting streptococcus. Background technique [0002] At present, fish streptococcosis has become a worldwide disease, which has caused huge economic losses to the world's aquaculture industry. Streptococcus agalactiae in the genus Streptococcus ( Streptococcus agalactiae ) and Streptococcus iniae ( Streptococcus iniae ) are the main pathogenic bacteria that cause fish diseases. It is estimated that the economic loss of fish caused by dolphin streptococcosis alone has exceeded 150 million U.S. dollars each year, and streptococcus has become one of the main global fish pathogens. Streptococcus can infect a variety of marine and freshwater cultured fish (such as Japanese flounder, eel, rainbow trout, tilapia, tube basket fish, yellowtail, flounder, flat carp, bamboo carp, red fin Dongfang pure, sea bream, silver salmon, unicorn fish, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K36/8884A61K36/86A61K36/78A61K36/756A61K36/739A61K36/736A61K36/732A61K36/73A61K36/718A61K36/716A61K36/71A61K36/708A61K36/704A61K36/634A61K36/61A61K36/57A61K36/539A61K36/515A61K36/489A61K36/484A61K36/482A61K36/48A61K36/328A61K36/284A61K36/282A61K36/28A61K36/234A61K36/232A61K36/185A61K36/13A61K33/06A61P31/04
Inventor 龚一富王何瑜张文青章丽童丽娟赵群芬
Owner NINGBO UNIV
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