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Traditional Chinese medicinal recipe for inhibiting Edwardsiella tarda

A Chinese herbal medicine composition and technology of Chinese herbal medicine, applied in the directions of antibacterial drugs, pharmaceutical formulations, plant raw materials, etc., can solve the problems of deterioration of the breeding environment, imbalance of ecological balance, threats to consumers, etc., and achieve simple production process and no drug resistance. , the effect of low price

Inactive Publication Date: 2014-11-05
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term abuse of drugs or antibiotics will cause water environment pollution, which will lead to deterioration of the breeding environment, imbalance of ecological balance, and bacteria will develop drug resistance, and drug residues will pose a potential threat to consumers

Method used

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  • Traditional Chinese medicinal recipe for inhibiting Edwardsiella tarda
  • Traditional Chinese medicinal recipe for inhibiting Edwardsiella tarda
  • Traditional Chinese medicinal recipe for inhibiting Edwardsiella tarda

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The invention relates to a Chinese herbal medicine composition for inhibiting Edwardsiella, and the following 21 kinds of Chinese herbal medicines all have different degrees of antibacterial effects on Edwardsiella.

[0011] First of all, Coptidis Rhizome has the strongest antibacterial effect on Edwardsiella in vitro, and its minimum inhibitory concentration (MIC) is 6.25 mg / ml; secondly, Schisandra, catechin, Artemisia argyi and alum also have strong antibacterial effect on Edwardsiella in vitro The effect of its minimum inhibitory concentration is 25mg / ml; Gallnut, ebony, and parsnip have moderate antibacterial effects on Edwardsiella in vitro, and its minimum inhibitory concentration is 50mg / ml; crane lice, papaya, knotweed slices, purple flower The minimum inhibitory concentration of Diding, Senecio, Myrrh, Houttuynia cordata, Su Ye, Solanum nigrum, raspberry, clove, Clematis and paeonol to Edwardsiella is 100mg / ml. Therefore, at least one of the above-mentioned 21...

Embodiment 2

[0016] The invention is a Chinese herbal medicine composition for inhibiting Edwardsiella, which is composed of the following raw materials and weight ratios: mugwort leaves, catechins, schisandra chinensis and coptis chinensis are mixed in a weight ratio of 4:1:2:1. The results showed that the formula has a significant antibacterial effect on Edwardsiella, which is more obvious than the antibacterial effect of single herbal medicine and other combinations of Chinese herbal medicine compound formula, and its minimum inhibitory concentration MIC is 3.125mg / ml. The minimum inhibitory concentration MIC of the compound formula of Chinese herbal medicine in the ratio of 1:1:1:1 by weight of mugwort leaf, catechu, schisandra and coptis was 6.25mg / ml, and the MIC of mugwort leaf, catechu, schisandra and coptis by weight ratio of 8 :8:4:1 The minimum inhibitory concentration MIC of the compound formula of Chinese herbal medicine is 65.63mg / ml, which is not as good as the antibacterial ...

Embodiment 3

[0018] Antibacterial test of Chinese herbal medicine on Edwardsiella in vitro

[0019] 1. Selection of Chinese herbal medicine and preparation of liquid medicine

[0020] The 86 kinds of Chinese herbal medicines selected in this study were all purchased from Beijing Tongrentang Pharmacy in Ningbo City. Schisandra, galla, ebony, clematis, catechu, dijincao, viola, dried alum, prunella, goose does not eat, myrobalan meat, perilla leaves, leaking reed seeds, cassia seeds, papaya, isatis root, berberine, Senecio, aloe vera, male clove, tallow, mugwort leaves, knotweed, crane lice, gentian, snakeberry, gong leaves, forsythia, myrrh, rhubarb, perrin, torreya, capillary, phellodendron, taro, andrographis paniculata , Perilla, Honeysuckle, Purslane, Astragalus, Licorice, Araceae, Artemisia annua, Lobelia, Paeoniae Alba, Icorus, Angelica, Radix, Aster, Hedyotis diffusa, Houttuynia, Sophora, Dandelion, Shouwu, Atractylodes atractylodes, Rhododendron, Perilla stalk, Raspberry, Baibu, M...

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Abstract

The invention discloses a traditional Chinese medicinal recipe for inhibiting Edwardsiella tarda. The recipe is characterized by comprising coptis chinensis franch, fructus schisandrae chinensis, catechu, folium artemisiae argyi, aluminis usti, galla chinensis, fructus mume, siegesbeckia pubescens mak, fructus carpesii, chaenomeles speciosa, reynoutria japonica slice, herba violae, senecio scandens, myrrha, herba houttuyniae, folium perillae, solanum nigrum, fructus rubi, flos caryophyllata, radix clematidis and cortex moutan radicis, wherein a recipe which is formed by mixing the folium artemisiae argyi, the catechu, the fructus schisandrae chinensis and the coptis chinensis franch according to the mass ratio of 4:1:2:1 has an optimum antibacterial effect. The recipe has the advantages of naturality, no toxity and residues, no tolerance and low price.

Description

technical field [0001] The invention relates to a Chinese herbal medicine formula, in particular to a Chinese herbal medicine composition for inhibiting Edwardsiella. Background technique [0002] Edwardsiella is a common pathogen that infects aquaculture animals. It is prevalent in spring and autumn. It has a wide range of hosts and can infect a variety of sea and freshwater fish, such as mullet, sea bream, flounder, yellowtail, and channel catfish. , eel, tilapia, crucian carp, goldfish, rainbow trout, chinook salmon, black bass and flounder, etc. Since it was first reported in 1962 that the bacteria infected Japanese eel, Edwardsiella has been a very harmful pathogen in aquaculture, and it has infected fish, amphibians, reptiles and mammals, including humans. According to reports, it has caused a large number of diseases in many species of fish farming, causing huge losses. [0003] At present, the prevention and treatment of the disease mainly utilizes chemicals, antib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61K36/81A61K36/78A61K36/736A61K36/732A61K36/73A61K36/718A61K36/716A61K36/704A61K36/61A61K36/57A61K36/535A61K36/48A61K36/328A61K36/282A61K36/28A61K35/64A61K33/06A61P31/04
Inventor 龚一富潘益芳张文青章丽王何瑜童丽娟
Owner NINGBO UNIV
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