This invention belongs to the field of biomedical materials and relates to a method for preparing a multi-dynamically bonded hydrogel based on polysaccharides from the
traditional Chinese medicine *
Solanum nigrum* and its application. *
Solanum nigrum* is initially extracted and precipitated with
alcohol to obtain crude polysaccharides. The polysaccharides are then deproteinized using the Sevag method to obtain a crude
polysaccharide solution. After
dialysis and freeze-
drying, crude
polysaccharide is obtained. The crude product is separated and purified to obtain homogeneous polysaccharides. The homogeneous
polysaccharide solution is reacted with
sodium periodate solution in the dark, followed by
dialysis, purification, and freeze-
drying to obtain oxidized *
Solanum nigrum* polysaccharide OBY. OBY is dissolved in
boric acid solution to obtain solution A.
Carboxymethyl chitosan is dissolved in
polyvinyl alcohol solution to obtain solution B. After the solutions A and B have fully reacted, they are placed in a mold to obtain a multi-dynamically bonded hydrogel based on *
Solanum nigrum* polysaccharides. This hydrogel can be applied to the preparation of drugs for
chronic wound repair, providing a novel
material system and application strategy for developing new wound dressings with excellent physicochemical properties, intelligent
response characteristics, and active repair functions.