Application of polyphenols in resisting coronavirus

Abstract

The invention discloses an application of various compounds such as polyphenols in resisting coronavirus. The invention relates to the application of one or more of a polyphenol substance, a proton pump inhibitor, p-benzoquinone and a derivative thereof, an active ingredient of sappan wood, TDZD-8, thiomersalate, alkannin, Tidelusib, protoflavin, rabeprazole sodium, PX-12, Dixanthophygen, methyl cholate, carbamofluorine, corilagin, dihydromyricetin, chloramine T, merbromin, gallocatechin, fraxetin, meisoindigo, a lactic acid ethacridine monohydrate and sousoprazole in preparation of drugs for treating and / or preventing diseases caused by coronavirus. In-vitro enzyme activity experiments show that various compounds such as 1, 4-naphthoquinone and the like can well inhibit the activity of main protease in the coronavirus, and the defect that diseases caused by the coronavirus cannot be treated in the prior art is overcome.

Description

technical field

[0001] The invention belongs to the technical field of biomedicine and relates to the application of polyphenols in anti-coronavirus, in particular to the application of compounds such as polyphenols in the preparation of medicines for treating and / or preventing diseases caused by coronaviruses. Background technique

[0002] Coronaviruses are a class of viruses that are closely related to humans and animals. Coronaviruses HCoV-229E and HCoV-OC43 cause the common cold (van der Hoek, L., Pyrc, K., Jebbink, M. et al. Identification of a newhuman coronavirus. Nat Med 2004, 10, 368–373). The recently circulating SARS-CoV-2 virus can cause COVID-19, clinically manifested as fever, dry cough and dyspnea, severe illness can cause death (Jeannette Guarner, MD, Three Emerging Coronaviruses in Two Decades: The Story of SARS, MERS, and NowCOVID-19, American Journal of Clinical Pathology,, aqaa029). Coronaviruses have a huge impact on animal husbandry: porcine epidemic ...

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