Geranium extract

An extract and technology of geranium, applied in the field of diseases, can solve the problems of not being suitable for large-scale clinical use, exceeding the cost of treatment, etc., and achieve the effect of good peptic ulcer, simple preparation process, and increased healing percentage

Inactive Publication Date: 2009-06-24
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since gastric ulcer is a chronic disease, and the acid pump metabolizes quickly, it is necessary to insist on taking omeprazole for a long time, which leads to high cost of treatment and exceeds the affordability of many patients. Therefore, this drug is not yet suitable for large-scale use in China. scale clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of Corilagin-containing Geranium Extract

[0054] Take 2000 g of Geranium dahuricum, crush it, add 8 times the amount of 40% ethanol, and reflux three times for 2 hours each time. Filter off the medicinal residues and combine three extracts, concentrate under reduced pressure to obtain 280 g of extract, add an appropriate amount of water to dissolve, and then extract with petroleum ether (500ml×4) and ethyl acetate (500ml×4) successively. The ethyl acetate extracts were combined, concentrated to dryness under reduced pressure, and applied to a silica gel column in batches (100-200 mesh silica gel G for silica gel), followed by chloroform, chloroform:methanol=10:1, chloroform:methanol=8:1, Chloroform:methanol=5:1 for elution, followed by thin-layer chromatography for detection. The chloroform:methanol=5:1 eluents were combined and concentrated to dryness to obtain 25 g of geranium extract containing corilagin, and the content of corilagin in it was...

Embodiment 2

[0055] Example 2 Preparation of Corilagin-containing Geranium Extract

[0056] Take 2000 g of Geranium tsingtauense, crush it, add 8 times the amount of 40% ethanol, and reflux twice for 2 hours each time. Filter off the medicinal residues and combine the two extracts, concentrate under reduced pressure to obtain 220 g of extract, add an appropriate amount of water to dissolve, and then extract with petroleum ether (500ml×4) and ethyl acetate (500ml×4) successively. The ethyl acetate extracts were combined, concentrated to dryness under reduced pressure, and applied to a silica gel column in batches (100-200 mesh silica gel G for silica gel), followed by chloroform, chloroform:methanol=10:1, chloroform:methanol=8:1, Chloroform:methanol=5:1 for elution, followed by thin-layer chromatography for detection. The chloroform:methanol=5:1 eluents were combined and concentrated to dryness to obtain 18 g of geranium extract containing corilagin, and the content of corilagin in it was ...

Embodiment 3

[0057] Example 3 Preparation of Corilagin-containing Geranium Extract

[0058] Take 2000 g of Geranium vlassovianum, crush it, add 5 times the amount of 40% ethanol, and reflux extraction four times, each time for 2 hours. Filter off the medicinal residues and combine 4 extracts, concentrate under reduced pressure to obtain 250 g of extract, add an appropriate amount of water to dissolve, and then extract with petroleum ether (500ml×4) and ethyl acetate (500ml×4) successively. The ethyl acetate extracts were combined, concentrated to dryness under reduced pressure, and applied to a silica gel column in batches (100-200 mesh silica gel G for silica gel), followed by chloroform, chloroform:methanol=10:1, chloroform:methanol=8:1, Chloroform:methanol=5:1 for elution, followed by thin-layer chromatography for detection. The chloroform:methanol=5:1 eluents were combined and concentrated to dryness to obtain 16 g of geranium extract containing corilagin, and the content of corilagin...

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PUM

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Abstract

The invention relates to a novel heroubill geranium extract and a preparation method thereof, in particular to a heroubill geranium extract containing corilagin and application of the heroubill geranium extract in medicines for treating or preventing diseases related to gastric acid hypersecretion.

Description

technical field [0001] The present invention relates to a new geranium extract and a preparation method thereof, in particular to a geranium extract containing corilagin and a preparation method thereof, and to said geranium extract inhibiting gastric acid secretion, reducing gastric juice The use of acidity, and the use of treatment or prevention of hyperacidity, peptic ulcer, chronic gastritis and other diseases. Background technique [0002] Geranium is a commonly used medicinal material in my country, and it has a wide variety, including Erodium stephanianum Willd (Erodium stephanianum Willd) and Geranium wilfordii Maxim (Geranium wilfordii Maxim). Geranium nepalense Sweet., Geranium nepalense Sweet., Geranium dahuricum DC, Geranium sibiricum L., Geranium nepalense L., Geranium mullein (G.eriostemon Fisch.ex.DC.), Geranium vlassovianum, Geranium tsingtauense Yabe, Geranium macrorrhizum and Geranium thunbergii Sieb. et Zucc.) and so on. There are many chemical components ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/04C07H1/08
Inventor 李洋徐宏江杨永安张喜全李新祝王鸯宋伟
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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