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Application of sanguinarine in inhibiting growth of multi-drug-resistant enterobacter horbiae

A technology for treating Enterobacter horii and Enterobacter horii is applied in the application field of sanguinarine in inhibiting the growth of Enterobacter horii, to achieve the effect of reducing the fatality rate, wide application value, and solving drug resistance and infection problems

Active Publication Date: 2020-04-03
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the use of sanguinarine as an active bacteriostatic ingredient to inhibit the growth of multidrug-resistant Enterobacter hallii

Method used

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  • Application of sanguinarine in inhibiting growth of multi-drug-resistant enterobacter horbiae
  • Application of sanguinarine in inhibiting growth of multi-drug-resistant enterobacter horbiae
  • Application of sanguinarine in inhibiting growth of multi-drug-resistant enterobacter horbiae

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of Enterobacter hallii

[0016] The present invention uses multiple strains of human Enterobacter hallii (strain samples taken from a hospital in Beijing) as starting strains, and selects piperacillin, levofloxacin, gentamicin, broguementin, imipenem, and ofloxacin , nitrofurantoin, ceftaquine, azithromycin, nalidixic acid 10 kinds of commonly used antibiotic susceptibility test strips for drug susceptibility test.

[0017] Pick and culture a single colony for 18-24 hours and evenly dissolve it in 2-5 mL sterile saline, adjust its turbidity to be equal to that of a 0.5 McFarland turbidimetric tube. Draw up 50-200 μL of bacterial solution under sterile conditions, spread the bacterial solution evenly on the plate w...

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Abstract

The invention discloses application of sanguinarine in inhibiting growth of multi-drug-resistant enterobacter horbiae. The sanguinarine has a good in-vitro killing effect on the multi-drug-resistant enterobacter horbiae of piperacillin, levofloxacin, bromgrantine, imipenem, ofloxacin, furadantin, cefathiaquine, azithromycin and naphthyridine acid, and can inhibit the growth of the multi-drug-resistant enterobacter horbiae, the minimum inhibitory concentration is 0.12 mg / mL, and the minimum bactericidal concentration is 0.24 mg / mL. The invention provides the inhibition effect of the sanguinarine on the multi-drug-resistant enterobacter horbiae, and the sanguinarine has wide application value in the fields of medicines and the like.

Description

technical field [0001] The invention relates to the application of sanguinarine, an active ingredient of traditional Chinese medicine, as an inhibitor of enterobacteriaceae, in particular to the application of sanguinarine in inhibiting the growth of enterobacteria hallii. Background technique [0002] Enterobacter hormaechei is a Gram-negative enteric bacterium (Enterobacteriaceae Enterobacter genus), the main source of this bacterium is humans, animals and food, food sources include dairy products, dried meat, milk and fruits, vegetables, rice, etc., and Enterobacter hallii was also isolated from infant milk powder. Analysis [J]. Chinese Journal of Veterinary Medicine (12): 78-82.) According to the mouse infection test, it was verified that Enterobacter hallii had certain conditional pathogenicity. And there are reports that Enterobacter hallii infection can also cause bacteremia including stroke, premature birth and frail infants. Enterobacter hallii is the main pathoge...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东李鑫辰杨敏刘淼付玉婷王文静孙照欢张家宁
Owner SHAANXI UNIV OF SCI & TECH
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