209 results about "Acetoxy group" patented technology

The present disclosure provides methods of manufacturing psilocybin and crystalline psilocybin via a reaction of psilocin and tetrabenzylpyrophosphate in the presence of lithium chloride complex Grignard reagent, which is followed by hydrogenation. Methods of producing psilocin from 4-hydroxyindole or 4-acetoxyindole are also provided.

The invention discloses a synthetic method of glabridin with optical purity, which comprises the following steps: by taking (R)-3-acetoxyl-2-(2, 4-dimethoxyphenyl) propanol and 2-isopentenyl resorcinol as raw materials, carrying out Mitsunobu reaction to obtain a key intermediate compound I, then carrying out hydrolysis and iodination to obtain an intermediate compound II, and then carrying out cyclization to obtain the glabridin with optical purity. Reducing and removing a protecting group to obtain glabridin. By introducing the isopentene side chain, the reaction activity of an olefin functional group is reserved, a key site is provided for subsequent cyclization conversion, the precise spatial configuration of the product is ensured, and finally glabridin with optical purity is prepared. The method is short in route, low in cost, mild in reaction condition and suitable for industrial production.

The present invention relates to the technical field of liquid crystal polymer modification, and particularly relates to a crosslinked liquid crystal polymer, a preparation method thereof and an application. The crosslinked liquid crystal polymer is formed by crosslinking an aromatic liquid crystal polyester and a polyfunctional polyester oligomer in a mass ratio of 100:(0.4 - 5); the repeating unit of the polyfunctional polyester oligomer has the structure shown in formula (I) or formula (II), wherein the end groups of R1 - R6 are each independently selected from a carboxyl group and an acetoxy group, and at least one of R1, R2 and R3 in formula (I) or at least one of R4, R5 and R6 in formula (II), and its molecular chain contains a -C(O)-Ar-C(O)- link; Ar represents an aromatic ring. The crosslinked liquid crystal polymer has the advantages of high modulus and high temperature resistance, and can also maintain good flexibility and film-forming property, and thus can be formed into a diaphragm by diaphragm forming to prepare a diaphragm material. #imgabs0#

The invention discloses a preparation method of 4-(acetoxy) phenyl-2-methyl-2-acrylate, which takes mild DMAP as a reaction catalyst, produced phenolic ester is not easy to hydrolyze due to weak alkalinity, and the dripping speed and the reaction temperature are controlled at the same time, so that simultaneous esterification of two hydroxyls of hydroquinone can be effectively avoided, and the yield of 4-(acetoxy) phenyl-2-methyl-2-acrylate is improved. And generation of by-products can be reduced. According to the method, the ethyl acetate and petroleum ether mixed solvent with the ratio of 1: 2 is adopted for recrystallization, hot filtration operation is carried out, insoluble substances are by-products, solids separated out after filtrate is cooled are target products, operation is simple, high-yield target product powder solids can be directly obtained, and the purity can reach 80% or above. The method is simple and rapid in process, short in production period, low in production cost, high in total yield of target products and suitable for industrial production.

The application discloses a PAG bonding type photosensitive photoresist resin and a preparation method and application thereof. The photoresist resin is as follows: formula. The PAG bonding type resin is prepared through the following reaction process: 1) performing a RAFT polymerization reaction on p-acetoxystyrene, p-styrene sulfonamide trifluoromethyl potassium salt and a RAFT chain transfer agent under the action of an initiator to obtain an intermediate I, 2) performing a hydrolysis reaction on the intermediate I to obtain an intermediate II, 3) performing a protection group introduction reaction on the intermediate II and di-tert-butyl dicarbonate to obtain an intermediate III; and 4) performing an ion exchange reaction on the intermediate III and triphenylsulfonium bromide. The application realizes the bonding of the PAG into the resin skeleton, and improves the problems of poor compatibility between the PAG and the resin, phase separation, uneven distribution of the PAG and the like. Therefore, the photoresist prepared from the resin has the photo-generated acid bound by the polymer main chain and limited diffusion, the resolution is improved, and the photoetching effect is excellent.

The invention relates to the technical field of chemical intermediates, and particularly discloses a preparation method of a givelastat intermediate.According to the preparation method, an initiator compound 5 can be synthesized by adopting cheap 2-hydroxy-6-naphthoic acid (CAS: 16712-64-4, 141 yuan / kg), and the preparation method is different from a method in the prior art. A gemvelastat intermediate compound 4 is synthesized from a compound 5 through a three-step reaction, compared with the prior art, the yield is high, industrial amplification production is more facilitated, in the process of synthesizing a compound 6 from the compound 5, acetonitrile can be adopted as a cyanide source in a reaction system, activated hydroxyl is subjected to a coupling reaction, and the yield is high. In the process of synthesizing a compound 6 from a compound 7 instead of a traditional metal cyanide, or in the process of synthesizing a compound 6 from another compound 5, a cheap cuprous cyanide and cuprous iodide system is adopted for a coupling reaction, and in the process of synthesizing a compound 4 from a compound 7, an acetic acid and sodium triacetoxyborohydride reaction system is adopted, so that the compound 6 is synthesized. And the important intermediate of the givelastat can be obtained with high yield.

The invention relates to the field of pharmacy, and provides a crystal form B of a compound cis-(+)-5-[(2-dimethylamino) ethyl]-2-(4-methoxyphenyl)-3-acetoxy-2, 3-dihydro-1, 5-benzothiaza # imgabs0 #-4 (5H)-ketone hydrochloride, which can meet the pharmaceutical requirements of convenient production, processing, transportation, storage and the like. The invention also relates to a preparation method of the crystal form B of the compound, a raw material medicine containing the crystal form B, a composition containing the crystal form B and application of the crystal form B in preparation of medicines for treating angina pectoris, hypertension, coronary heart disease and / or arrhythmia.

The invention relates to a core-shell polyacrylamide nano flocculant as well as a preparation method and application thereof, the flocculant is of a core-shell structure, the shell is a water-soluble polyacrylamide polymer, and the core is cross-linked poly (p-hydroxystyrene); the preparation method comprises the following steps: preparing a poly (p-tert-butoxystyrene-b-polyacrylate) block polymer or a poly (4-acetoxystyrene-b-polyacrylate) block polymer; carrying out hydrolysis and self-assembly on poly (p-tert-butoxystyrene) or poly (4-acetoxystyrene) on the block polymer at the same time in the presence of a trifluoroacetic acid hydrolysis reagent by utilizing a modification induced self-assembly process, and carrying out in-situ crosslinking on poly (p-hydroxystyrene) obtained by hydrolysis by using formaldehyde; and in the presence of a 1, 5, 7-triazabicyclo [4.4. 0] decene-5-ene catalyst, modifying the polyacrylate block by using an amination reagent to prepare the flocculant. Compared with the prior art, the flocculant provided by the invention has the advantages of controllable morphology, stable cross-linkable property and the like.

The invention discloses a method for preparing methyltriacetoxysilane from acetic anhydride-containing acetyl chloride distillation tailings, and relates to the technical field of organic silicon synthesis, the method comprises the following steps: adding methyl trichlorosilane and acetic anhydride-containing acetyl chloride distillation tailings into a reaction kettle, stirring and heating; after a total reflux condition is reached, maintaining total reflux for a period of time, and then starting to collect acetyl chloride; continuously heating until the collection of acetyl chloride is completed, stopping heating, and when the temperature of the kettle is reduced to room temperature, heating again and starting vacuum negative pressure; when the kettle temperature reaches a set value, stopping heating, stopping stirring, and closing vacuum negative pressure; and after the kettle temperature is reduced to room temperature, adding pretreated activated carbon, carrying out decoloration reaction, and carrying out suction filtration after the reaction is completed, thereby obtaining the product. According to the method, a large amount of acetic anhydride in the acetyl chloride distillation tailings is used as a raw material and directly reacts with methyl trichlorosilane to prepare methyltriacetoxysilane, and the quality of the obtained product is remarkably higher than that of a product prepared by a normal process.

The present invention provides a hair dyeing method which comprises a step 1 and a step 2 in this order, and does not comprise a step for rinsing hair between the step 1 and the step 2, and comprises a step for rinsing hair after the step 2: step 1: a step for applying an agent A to hair, the agent A having a pH value of 8-11 and containing the following components (a1) and (a2): (a1) a compound represented by general formula (1) or a salt thereof; the dashed line represents the presence or absence of a pi bond, R1 represents a hydroxyl group or an acetoxy group, R2 represents a hydrogen atom or-COOR (R represents a hydrogen atom, a methyl group or an ethyl group), and R3 represents a hydrogen atom, an acetyl group, a methyl group or an ethyl group); (a2) an alkaline agent; step 2: A step for applying agent B to hair, said agent B containing the following component (b): (b) alkali metal salt or alkaline earth metal salt selected from among organic acid salts or inorganic salts having 6 or less carbon atoms # imgabs0 #

The present invention discloses a catalyst for synthesizing 1,4-diacetoxy-2-butene, its preparation method and application. The catalyst includes a carrier, a main active metal, and a co-active metal; the main active metal includes Pd, the co-active metal includes Te and / or Sn, and the carrier is silica modified with carbon quantum dots. The catalyst provided by the present invention is used in the synthesis reaction of 1,4-diacetoxy-2-butene, and has the characteristics of high selectivity of 1,4-diacetoxy-2-butene and few by-products.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

This invention provides a compound for recognizing chiral amino alcohols, a fluorescent probe, its preparation method, and its application. Naphthol and sodium hydride are weighed and dissolved separately in ultra-dry tetrahydrofuran, mixed, and then reacted with bromomethyl methyl ether. The mixture is extracted with ethyl acetate, and the organic phases are combined to obtain product (R)-1. This product is dissolved in ultra-dry tetrahydrofuran, and n-butyllithium is added. The reaction system changes from colorless to brown, and the reaction is allowed to return to room temperature. Ultra-dry N,N-dimethylformamide solution is then added, and the reaction is quenched by adding saturated ammonium chloride solution under ice-water bath conditions. The product is then extracted with ethyl acetate to obtain product (R)-2. Product (R)-2 is dissolved in a mixed solvent of tetrahydrofuran and anhydrous methanol, and sodium triacetoxyborohydride is added. The product is then extracted with ethyl acetate to obtain reduced product (R)-3. Product (R)-3 is dissolved in a mixed solvent of dichloromethane and anhydrous ethanol, and concentrated hydrochloric acid is added. After the reaction is complete, the reaction is quenched with sodium bicarbonate, and then extracted with dichloromethane to finally obtain compound (R)-4, which recognizes chiral amino alcohols.

The invention provides S-fluoroalkyl substituted amino acid, polypeptide and a preparation method of the S-fluoroalkyl substituted amino acid, and belongs to the technical field of fluorinated amino acid. The chemical structural formula of the compound is shown in the specification. Wherein Ar is 4-phenyl phenyl, 4-acetyl phenyl, 4-methoxycarbonyl phenyl, 4-acetoxyphenyl, 4-cyano phenyl, 4-(N, N-dicarboxamide) phenyl, 4-(N, N-dicarboxamide) phenyl, 4-(N, N-dicarboxamide) phenyl, 4-(N, N-dicarboxamide) phenyl, 4-(N, N- Ar'is phenyl, 4-iodophenyl, 4-bromophenyl, 3-methoxycarbonyl phenyl, 2-naphthyl or 3-thienyl, and R1 and R2 are methyl or H. According to the preparation method of the S-fluoroalkyl substituted amino acid and polypeptide, the adopted raw materials are low in cost, simple and easy to obtain, glassware cannot be corroded like other methods, and the tedious and functionalization steps are omitted in the preparation method.

The invention provides a synthesis method of L-acetoxypropionyl chloride, and belongs to the field of medical intermediates and fine chemical engineering. The preparation method comprises the following steps: mixing L-lactic acid and acetyl chloride for first reaction; then adding trichlorotoluene and a catalyst to carry out a second reaction; and then rectifying and separating to obtain the product L-acetoxypropionyl chloride. According to the method, two raw materials react to generate two products, no sulfur dioxide or acidic mixed waste gas is generated, the utilization rate of the raw materials reaches 100% theoretically, and the method completely conforms to an environment-friendly and pollution-free green process. The safety of the used trichlorotoluene is far higher than that of thionyl chloride and phosgene, the reaction is mild, the reaction speed can be controlled by controlling the temperature and the input amount of the catalyst, the production operation is relatively safe, and the purity of the prepared L-acetoxypropionyl chloride product is greater than 99%, and the yield is greater than 90%.

The invention discloses (E)-1, 4-diether olefin and a preparation method thereof, and the (E)-1, 4-diether olefin is obtained by using 1, 3-diene as a raw material and carrying out electrochemical reaction in the presence of an electrolyte and a solvent, wherein the 1, 2, 4-trimethyl-1, 3- The structural formula of the 1, 3-diene is as follows: R1 is phenyl, p-fluorophenyl, p-chlorphenyl, p-bromophenyl, p-methylphenyl, p-methoxyphenyl, p-trifluoromethylphenyl, p-trifluoromethoxyphenyl, p-acetoxyphenyl, p-methyl formate phenyl, p-cyanophenyl, p-pinacol borate phenyl, p-phenylphenyl, o-oxybenzyl phenyl and o-methoxyphenyl; r1 is one of 1, 2-naphthyl; the solvent is a mixed solvent containing methanol. The preparation method of (E)-1, 4-diether olefin has high E-selectivity and 1, 4-selectivity, and an electro-catalysis mode is adopted, so that the use of a stoichiometric toxic, expensive or dangerous oxidant is avoided.

Poly (catechol-styrene) (PCS) is a novel material having a variety of industrial and biomedical uses. For example, PCS acts as a binder that acts in a humid or underwater environment, and thus can be used in biomedical applications. The present disclosure provides a method of forming a poly (catechol-styrene) polymer. The method includes the step of polymerizing 3, 4-diacetoxystyrene and styrene in an emulsion polymerization to form a poly (3, 4-diacetoxystyrene-co-styrene) polymer. The polymer has acetate groups deprotected from an alcohol, thereby forming a poly (catechol-styrene) polymer. The poly (catechol-styrene) polymer has improved strength at a higher molecular weight.

The present technology relates to a process useful for preparing the crystalline (S)-1,1-bis(4-fluorophenyl)propan-2-yl (3-acetoxy-4-methoxypicolinoate)-L-alaninate compound (I), which comprises distilling a mixture, which comprises distilling a mixture containing an aprotic organic solvent, a protic organic solvent, the compound (I), and a seed crystal of the compound (I), or which comprises distilling a mixture containing an aprotic organic solvent and the compound (I) and crystallizing the compound (I) by preparing a second mixture containing a protic organic solvent, the compound (I), and a seed crystal of the compound (I). The process disclosed herein describes a more stable and storage-compatible preparation of the compound (I). Preparations of the compound (I) having fewer (trace) impurities are also disclosed.

The invention discloses a method and a system for preparing a 4-AA medical intermediate through continuous flow ozone oxidation. The method comprises the following steps: continuously introducing a raw material solution containing (3R)-3-((R)-1-((tert-butyldimethylsilyl) oxy) ethyl)-1-(4-methoxyphenyl)-4-oxo azetidine-2-yl acetate and a gas containing ozone into a microreactor for reaction; after the reaction liquid is subjected to reduction quenching, the (3R, 4R) 4-acetoxyl-3-[R-(tert-butyldimethylsiloxy) ethyl]-2-azetidinone is obtained. On one hand, the reaction time is shortened from the hour level to the minute level, and the production efficiency is remarkably improved; and on the other hand, the reaction temperature is increased to 10-30 DEG C from deep cooling, so that the refrigeration energy consumption and the equipment requirement are greatly reduced. According to the invention, local peroxidation is fundamentally avoided, byproducts are obviously reduced, the product purity is improved, the method is suitable for continuous operation, the reaction process is controllable, and the method is safe and reliable.

The invention discloses bio-based polyamide with low water absorption and a preparation method thereof, and belongs to the technical field of polyamide preparation. The bio-based polyamide with the low water absorption rate is prepared from the following components in parts by weight: 30 to 50 parts of pentamethylene diamine, 15 to 30 parts of sebacic acid, 5 to 12 parts of citric acid, 5 to 10 parts of hexamethylenediamine, 2 to 5 parts of a hydrophobic auxiliary agent and 1 to 5 parts of a modified high-temperature-resistant additive, the hydrophobic additive is prepared from acetoxybenzoic acid, nonadecanoic acid, m-dimethoxybenzene, trifluoroacetic anhydride and methyl tert-butyl ether as raw materials, and the modified high-temperature-resistant additive is prepared from o-phenylenediamine, chloroacetic acid, vanillin, benzoyl bromide and thiourea as raw materials. The bio-based polyamide prepared from the substances has low water absorption and excellent thermal stability.

The invention belongs to the technical field of resveratrol synthesis, and particularly relates to a preparation method of resveratrol and application of resveratrol in meat preservation. The method comprises the following steps: taking 3, 5-dimethoxybenzoic acid as a raw material, and carrying out acylation reaction to obtain 3, 5-dimethoxybenzoyl chloride. Then reacting with p-acetoxystyrene to generate 3, 3 '-dihydroxy-3, 3'-dihydroxy-3 The preparation method comprises the following steps: taking 1, 5-dimethoxy-4 '-acetoxystilbene as a raw material, hydrolyzing and demethylating to obtain resveratrol, and preparing resveratrol lipid nanoparticle suspension by taking resveratrol, a ZIF-8 / chitosan compound, compound lipid, cholesterol, epsilon-polylysine, ascorbyl palmitate and phosphate buffer saline as raw materials. High load and controlled release of resveratrol are achieved, and the problems that resveratrol is poor in water solubility and prone to oxidation are solved.

The invention discloses a method for synthesizing 4-acetoxy-2-methylbutyraldehyde. 4-hydroxy-2-butanone is used as a starting raw material, and condensation, hydrolysis, and esterification (or esterification, condensation, and hydrolysis) reactions are performed to prepare the 4-acetoxy-2-methylbutyraldehyde. The condensation is performed under the catalytic action of an alkaline substance and a halogenated acetate is used as one of the reaction raw materials. The esterification uses acetic acid and / or acetic anhydride as one of the reaction raw materials. The reaction process is highly safe and easy to operate, and the yield is high. In particular, the raw materials are simple and readily available, and no noble metal catalyst is required in the reaction process, thereby significantly reducing the preparation cost. Compared with the prior art, the method is more suitable for large-scale industrial production.

The invention discloses a synthesis method of m-acetoxystyrene, which is characterized by comprising the following steps: adding m-hydroxybenzaldehyde, vinyl ethyl ether and trifluoroacetic acid into an organic solvent A, and reacting in an inert gas atmosphere to obtain a reaction solution; dropwise adding the reaction solution into a Wittig reagent, carrying out a reaction, and carrying out post-treatment, so as to obtain 1-(1-ethyoxyl ethyoxyl)-3-vinyl benzene; the Wittig reagent is prepared by dispersing methyl triphenyl phosphorus bromide and sodium methoxide in an organic solvent B; the preparation method comprises the following steps: adding 1-(1-ethoxyethoxy)-3-vinylbenzene, an acid solution and an acetylation reagent into a solvent to react, and preparing m-acetoxystyrene after the reaction. The method is simple in process step, mild and controllable in reaction condition, high in equipment universality, low in comprehensive production cost, capable of effectively inhibiting side reactions and improving the product quality, suitable for industrial production and high in practicability.

The invention particularly relates to 4 '-thiosugar and a preparation method thereof. The preparation method comprises the following steps: taking D-ribose as a raw material, firstly carrying out methylation protection on C1-site hydroxyl, and then carrying out benzylation protection on other hydroxyl; the preparation method comprises the following steps: firstly, carrying out hydrolysis on a glucosidic bond at a C1 site, carrying out reduction through hydroboron to obtain open-loop ribitol (formula V), carrying out sulfonic acid esterification and bromination substitution on hydroxyl of the ribitol, forming a sulfur bridge bond by taking sodium sulfide as a nucleophilic reagent to obtain benzyl-protected thiosugar, oxidizing a thioether bond into sulfoxide, rearranging to obtain acetoxy thioether, and carrying out debenzylation reaction and hydroxybenzoylation reaction to obtain the high-purity acetoxy thioether. According to the present invention, the multi-step intermediate reaction only needs simple purification, the key intermediate can be obtained through recrystallization, the method is simple, the yield is high, the amplification production is convenient, and the obtained 4 '-thiosugar as the basic sugar can participate in the reaction with a variety of basic groups to form the sulfur-containing nucleoside so as to provide the good foundation for the subsequent drug development or activity screening.

A method for controlling phytopathogenic pests on cereals, wherein the pest, their habitat, breeding grounds, their locus or the plants to be protected against pest attack, the soil or plant propagation material are treated with an effective amount of a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one as compound I, and 2) one fungicidal compound II selected from [2, 2-bis(4-fluorophenyl)-1-methyl-ethyl]2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound 11-1) and [(1S)-2,2-bis(4-fluorophenyl)-1-methyl-ethyl](2S)-2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound II-2).

The present invention provides 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate of the following formula (1). The present invention further provides the aforesaid 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate (1), the process comprising the step of subjecting an organic magnesium compound (2) of the following general formula (2), wherein X1 represents a halogen atom or a 3-(2-butyl-1,3-dioxolan-2-yl)propyl group, to a nucleophilic addition reaction with propylene oxide of the following formula (3) and then reacting with an acetylating agent of the following general formula (4), wherein X2 represents a halogen atom, an acetoxy group, a methoxy group, or an ethoxy group, to form 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate (1).

An emollient blend comprising or consisting of (a) ethylhexyl acetoxystearate; (b) 2, 6-diethylhexyl naphthalate and / or dimethyl isosorbide (DMI), and a solvent; and (c) propylene glycol di (octoate / caprate). A sunscreen composition comprising or consisting of the following components: (a) ethylhexyl acetoxystearate; (b) 2, 6-diethylhexyl naphthalate and / or dimethyl isosorbide (DMI), and a solvent; and (c) propylene glycol di (octoate / caprate), and (d) at least one crystalline UV filter. The invention relates to the use of an emollient blend for dissolving an oil-soluble crystalline UV filter in an oil phase or emulsion, said emollient blend comprising or consisting of (a) ethylhexyl acetoxystearate; (b) 2, 6-diethylhexyl naphthalate and / or dimethyl isosorbide (DMI), and a solvent; and (c) propylene glycol di (octoate / caprate).

The application provides a KrF resin, a preparation method thereof and a chemical amplification photoresist, and relates to the field of semiconductors. The KrF resin has a general structure as follows: the preparation method of the KrF resin comprises the following steps: mixing raw materials including 4-acetyloxy styrene, a first monomer compound, a second monomer compound and an initiator, and performing a first reaction; then adding an ammonium acetate-water suspension into the system, and performing a second reaction to obtain the KrF resin; the first monomer compound is a compound comprising a high ultraviolet absorption group, and the second monomer compound is a compound comprising a low-activation-energy deprotection acidic group. The chemical amplification photoresist comprises the KrF resin. The KrF resin provided by the application has the characteristics of controllable UV absorption and low deprotection activation energy. The chemical amplification photoresist has the ability to obtain good developing pattern results under different transmittance requirements.

A method of forming a film on a substrate includes providing the substrate to a reaction chamber and forming the film on the substrate by repeating cycles including supplying a first silicon source including acetoxy groups and supplying a hydrogen source while applying power from a power source to the reaction chamber, wherein the hydrogen source reacts with the acetoxy group of the first silicon source to form an adsorption site that is reactive with the acetoxy group, and wherein the film formed on the substrate comprises silicon oxycarbide (SiOC).

The present application relates to a kind of recycling method of avibactam intermediate production waste liquid, belong to pharmaceutical chemical technology field;The present application will be in the 5-benzyloxyamine piperidin-2S-formic acid ethyl ester oxalate in avibactam intermediate production waste liquid by desalination into free state, under the condition of ethyl acetate as solvent, using the dilute solution of m-chloroperbenzoic acid drop, homogeneous reaction in organic solvent, effectively improve the utilization of raw material, with the advantage of less by-product, and have higher recovery rate than prior art, in addition, the present application also prepares a kind of activated carbon loaded sodium triacetoxyborohydride, can play the role of catalytic sodium triacetoxyborohydride reduction amination reaction, improve the utilization of sodium triacetoxyborohydride, and prevent sodium triacetoxyborohydride from contacting with water.