157 results about "Acetoxy group" patented technology

The present disclosure provides methods of manufacturing psilocybin and crystalline psilocybin via a reaction of psilocin and tetrabenzylpyrophosphate in the presence of lithium chloride complex Grignard reagent, which is followed by hydrogenation. Methods of producing psilocin from 4-hydroxyindole or 4-acetoxyindole are also provided.

The application discloses a PAG bonding type photosensitive photoresist resin and a preparation method and application thereof. The photoresist resin is as follows: formula. The PAG bonding type resin is prepared through the following reaction process: 1) performing a RAFT polymerization reaction on p-acetoxystyrene, p-styrene sulfonamide trifluoromethyl potassium salt and a RAFT chain transfer agent under the action of an initiator to obtain an intermediate I, 2) performing a hydrolysis reaction on the intermediate I to obtain an intermediate II, 3) performing a protection group introduction reaction on the intermediate II and di-tert-butyl dicarbonate to obtain an intermediate III; and 4) performing an ion exchange reaction on the intermediate III and triphenylsulfonium bromide. The application realizes the bonding of the PAG into the resin skeleton, and improves the problems of poor compatibility between the PAG and the resin, phase separation, uneven distribution of the PAG and the like. Therefore, the photoresist prepared from the resin has the photo-generated acid bound by the polymer main chain and limited diffusion, the resolution is improved, and the photoetching effect is excellent.

The invention discloses a method for preparing methyltriacetoxysilane from acetic anhydride-containing acetyl chloride distillation tailings, and relates to the technical field of organic silicon synthesis, the method comprises the following steps: adding methyl trichlorosilane and acetic anhydride-containing acetyl chloride distillation tailings into a reaction kettle, stirring and heating; after a total reflux condition is reached, maintaining total reflux for a period of time, and then starting to collect acetyl chloride; continuously heating until the collection of acetyl chloride is completed, stopping heating, and when the temperature of the kettle is reduced to room temperature, heating again and starting vacuum negative pressure; when the kettle temperature reaches a set value, stopping heating, stopping stirring, and closing vacuum negative pressure; and after the kettle temperature is reduced to room temperature, adding pretreated activated carbon, carrying out decoloration reaction, and carrying out suction filtration after the reaction is completed, thereby obtaining the product. According to the method, a large amount of acetic anhydride in the acetyl chloride distillation tailings is used as a raw material and directly reacts with methyl trichlorosilane to prepare methyltriacetoxysilane, and the quality of the obtained product is remarkably higher than that of a product prepared by a normal process.

The present invention provides a hair dyeing method which comprises a step 1 and a step 2 in this order, and does not comprise a step for rinsing hair between the step 1 and the step 2, and comprises a step for rinsing hair after the step 2: step 1: a step for applying an agent A to hair, the agent A having a pH value of 8-11 and containing the following components (a1) and (a2): (a1) a compound represented by general formula (1) or a salt thereof; the dashed line represents the presence or absence of a pi bond, R1 represents a hydroxyl group or an acetoxy group, R2 represents a hydrogen atom or-COOR (R represents a hydrogen atom, a methyl group or an ethyl group), and R3 represents a hydrogen atom, an acetyl group, a methyl group or an ethyl group); (a2) an alkaline agent; step 2: A step for applying agent B to hair, said agent B containing the following component (b): (b) alkali metal salt or alkaline earth metal salt selected from among organic acid salts or inorganic salts having 6 or less carbon atoms # imgabs0 #

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

This invention provides a compound for recognizing chiral amino alcohols, a fluorescent probe, its preparation method, and its application. Naphthol and sodium hydride are weighed and dissolved separately in ultra-dry tetrahydrofuran, mixed, and then reacted with bromomethyl methyl ether. The mixture is extracted with ethyl acetate, and the organic phases are combined to obtain product (R)-1. This product is dissolved in ultra-dry tetrahydrofuran, and n-butyllithium is added. The reaction system changes from colorless to brown, and the reaction is allowed to return to room temperature. Ultra-dry N,N-dimethylformamide solution is then added, and the reaction is quenched by adding saturated ammonium chloride solution under ice-water bath conditions. The product is then extracted with ethyl acetate to obtain product (R)-2. Product (R)-2 is dissolved in a mixed solvent of tetrahydrofuran and anhydrous methanol, and sodium triacetoxyborohydride is added. The product is then extracted with ethyl acetate to obtain reduced product (R)-3. Product (R)-3 is dissolved in a mixed solvent of dichloromethane and anhydrous ethanol, and concentrated hydrochloric acid is added. After the reaction is complete, the reaction is quenched with sodium bicarbonate, and then extracted with dichloromethane to finally obtain compound (R)-4, which recognizes chiral amino alcohols.

The invention discloses (E)-1, 4-diether olefin and a preparation method thereof, and the (E)-1, 4-diether olefin is obtained by using 1, 3-diene as a raw material and carrying out electrochemical reaction in the presence of an electrolyte and a solvent, wherein the 1, 2, 4-trimethyl-1, 3- The structural formula of the 1, 3-diene is as follows: R1 is phenyl, p-fluorophenyl, p-chlorphenyl, p-bromophenyl, p-methylphenyl, p-methoxyphenyl, p-trifluoromethylphenyl, p-trifluoromethoxyphenyl, p-acetoxyphenyl, p-methyl formate phenyl, p-cyanophenyl, p-pinacol borate phenyl, p-phenylphenyl, o-oxybenzyl phenyl and o-methoxyphenyl; r1 is one of 1, 2-naphthyl; the solvent is a mixed solvent containing methanol. The preparation method of (E)-1, 4-diether olefin has high E-selectivity and 1, 4-selectivity, and an electro-catalysis mode is adopted, so that the use of a stoichiometric toxic, expensive or dangerous oxidant is avoided.

Poly (catechol-styrene) (PCS) is a novel material having a variety of industrial and biomedical uses. For example, PCS acts as a binder that acts in a humid or underwater environment, and thus can be used in biomedical applications. The present disclosure provides a method of forming a poly (catechol-styrene) polymer. The method includes the step of polymerizing 3, 4-diacetoxystyrene and styrene in an emulsion polymerization to form a poly (3, 4-diacetoxystyrene-co-styrene) polymer. The polymer has acetate groups deprotected from an alcohol, thereby forming a poly (catechol-styrene) polymer. The poly (catechol-styrene) polymer has improved strength at a higher molecular weight.

The invention discloses a method and a system for preparing a 4-AA medical intermediate through continuous flow ozone oxidation. The method comprises the following steps: continuously introducing a raw material solution containing (3R)-3-((R)-1-((tert-butyldimethylsilyl) oxy) ethyl)-1-(4-methoxyphenyl)-4-oxo azetidine-2-yl acetate and a gas containing ozone into a microreactor for reaction; after the reaction liquid is subjected to reduction quenching, the (3R, 4R) 4-acetoxyl-3-[R-(tert-butyldimethylsiloxy) ethyl]-2-azetidinone is obtained. On one hand, the reaction time is shortened from the hour level to the minute level, and the production efficiency is remarkably improved; and on the other hand, the reaction temperature is increased to 10-30 DEG C from deep cooling, so that the refrigeration energy consumption and the equipment requirement are greatly reduced. According to the invention, local peroxidation is fundamentally avoided, byproducts are obviously reduced, the product purity is improved, the method is suitable for continuous operation, the reaction process is controllable, and the method is safe and reliable.

The invention discloses bio-based polyamide with low water absorption and a preparation method thereof, and belongs to the technical field of polyamide preparation. The bio-based polyamide with the low water absorption rate is prepared from the following components in parts by weight: 30 to 50 parts of pentamethylene diamine, 15 to 30 parts of sebacic acid, 5 to 12 parts of citric acid, 5 to 10 parts of hexamethylenediamine, 2 to 5 parts of a hydrophobic auxiliary agent and 1 to 5 parts of a modified high-temperature-resistant additive, the hydrophobic additive is prepared from acetoxybenzoic acid, nonadecanoic acid, m-dimethoxybenzene, trifluoroacetic anhydride and methyl tert-butyl ether as raw materials, and the modified high-temperature-resistant additive is prepared from o-phenylenediamine, chloroacetic acid, vanillin, benzoyl bromide and thiourea as raw materials. The bio-based polyamide prepared from the substances has low water absorption and excellent thermal stability.

The invention belongs to the technical field of resveratrol synthesis, and particularly relates to a preparation method of resveratrol and application of resveratrol in meat preservation. The method comprises the following steps: taking 3, 5-dimethoxybenzoic acid as a raw material, and carrying out acylation reaction to obtain 3, 5-dimethoxybenzoyl chloride. Then reacting with p-acetoxystyrene to generate 3, 3 '-dihydroxy-3, 3'-dihydroxy-3 The preparation method comprises the following steps: taking 1, 5-dimethoxy-4 '-acetoxystilbene as a raw material, hydrolyzing and demethylating to obtain resveratrol, and preparing resveratrol lipid nanoparticle suspension by taking resveratrol, a ZIF-8 / chitosan compound, compound lipid, cholesterol, epsilon-polylysine, ascorbyl palmitate and phosphate buffer saline as raw materials. High load and controlled release of resveratrol are achieved, and the problems that resveratrol is poor in water solubility and prone to oxidation are solved.

The invention discloses a method for synthesizing 4-acetoxy-2-methylbutyraldehyde. 4-hydroxy-2-butanone is used as a starting raw material, and condensation, hydrolysis, and esterification (or esterification, condensation, and hydrolysis) reactions are performed to prepare the 4-acetoxy-2-methylbutyraldehyde. The condensation is performed under the catalytic action of an alkaline substance and a halogenated acetate is used as one of the reaction raw materials. The esterification uses acetic acid and / or acetic anhydride as one of the reaction raw materials. The reaction process is highly safe and easy to operate, and the yield is high. In particular, the raw materials are simple and readily available, and no noble metal catalyst is required in the reaction process, thereby significantly reducing the preparation cost. Compared with the prior art, the method is more suitable for large-scale industrial production.

The invention particularly relates to 4 '-thiosugar and a preparation method thereof. The preparation method comprises the following steps: taking D-ribose as a raw material, firstly carrying out methylation protection on C1-site hydroxyl, and then carrying out benzylation protection on other hydroxyl; the preparation method comprises the following steps: firstly, carrying out hydrolysis on a glucosidic bond at a C1 site, carrying out reduction through hydroboron to obtain open-loop ribitol (formula V), carrying out sulfonic acid esterification and bromination substitution on hydroxyl of the ribitol, forming a sulfur bridge bond by taking sodium sulfide as a nucleophilic reagent to obtain benzyl-protected thiosugar, oxidizing a thioether bond into sulfoxide, rearranging to obtain acetoxy thioether, and carrying out debenzylation reaction and hydroxybenzoylation reaction to obtain the high-purity acetoxy thioether. According to the present invention, the multi-step intermediate reaction only needs simple purification, the key intermediate can be obtained through recrystallization, the method is simple, the yield is high, the amplification production is convenient, and the obtained 4 '-thiosugar as the basic sugar can participate in the reaction with a variety of basic groups to form the sulfur-containing nucleoside so as to provide the good foundation for the subsequent drug development or activity screening.

A method for controlling phytopathogenic pests on cereals, wherein the pest, their habitat, breeding grounds, their locus or the plants to be protected against pest attack, the soil or plant propagation material are treated with an effective amount of a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one as compound I, and 2) one fungicidal compound II selected from [2, 2-bis(4-fluorophenyl)-1-methyl-ethyl]2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound 11-1) and [(1S)-2,2-bis(4-fluorophenyl)-1-methyl-ethyl](2S)-2-[(3-acetoxy-4-methoxy-pyridine-2-carbonyl)amino]propanoate (compound II-2).

The present invention provides 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate of the following formula (1). The present invention further provides the aforesaid 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate (1), the process comprising the step of subjecting an organic magnesium compound (2) of the following general formula (2), wherein X1 represents a halogen atom or a 3-(2-butyl-1,3-dioxolan-2-yl)propyl group, to a nucleophilic addition reaction with propylene oxide of the following formula (3) and then reacting with an acetylating agent of the following general formula (4), wherein X2 represents a halogen atom, an acetoxy group, a methoxy group, or an ethoxy group, to form 5-(2-butyl-1,3-dioxolan-2-yl)-1-methylpentyl acetate (1).

The application provides a KrF resin, a preparation method thereof and a chemical amplification photoresist, and relates to the field of semiconductors. The KrF resin has a general structure as follows: the preparation method of the KrF resin comprises the following steps: mixing raw materials including 4-acetyloxy styrene, a first monomer compound, a second monomer compound and an initiator, and performing a first reaction; then adding an ammonium acetate-water suspension into the system, and performing a second reaction to obtain the KrF resin; the first monomer compound is a compound comprising a high ultraviolet absorption group, and the second monomer compound is a compound comprising a low-activation-energy deprotection acidic group. The chemical amplification photoresist comprises the KrF resin. The KrF resin provided by the application has the characteristics of controllable UV absorption and low deprotection activation energy. The chemical amplification photoresist has the ability to obtain good developing pattern results under different transmittance requirements.

A method of forming a film on a substrate includes providing the substrate to a reaction chamber and forming the film on the substrate by repeating cycles including supplying a first silicon source including acetoxy groups and supplying a hydrogen source while applying power from a power source to the reaction chamber, wherein the hydrogen source reacts with the acetoxy group of the first silicon source to form an adsorption site that is reactive with the acetoxy group, and wherein the film formed on the substrate comprises silicon oxycarbide (SiOC).

The present application relates to a kind of recycling method of avibactam intermediate production waste liquid, belong to pharmaceutical chemical technology field;The present application will be in the 5-benzyloxyamine piperidin-2S-formic acid ethyl ester oxalate in avibactam intermediate production waste liquid by desalination into free state, under the condition of ethyl acetate as solvent, using the dilute solution of m-chloroperbenzoic acid drop, homogeneous reaction in organic solvent, effectively improve the utilization of raw material, with the advantage of less by-product, and have higher recovery rate than prior art, in addition, the present application also prepares a kind of activated carbon loaded sodium triacetoxyborohydride, can play the role of catalytic sodium triacetoxyborohydride reduction amination reaction, improve the utilization of sodium triacetoxyborohydride, and prevent sodium triacetoxyborohydride from contacting with water.

The invention discloses a recyclable high-strength foamed polymer as well as a preparation method, a regeneration method and application thereof, and relates to the technical field of foamed materials. According to the recoverable high-strength foaming polymer provided by the invention, the covalent cross-linking agent and the dynamic cross-linking agent containing dynamic bonds are adopted to jointly cross-link and cure a polymer matrix with at least one polar branched chain of acetoxy, maleic anhydride group and vinyl; the polymer matrix has good mechanical strength suitable for foaming and good recoverability, meanwhile, the polymer can obtain a rich, uniform and compact foam structure after foaming, and the mechanical property and the structural stability of the obtained material are further improved.

The application discloses a kind of polymer resin for photoresist, negative photoresist and recycling method.The preparation method of polymer resin is: using functional polycarbonate, p-acetyl oxystyrene, initiator, star-shaped RAFT agent to prepare polymer resin.Using 2-benzyl (methyl) amino-9H-thioxanthene-9-ketone, 3-chloropropyl triethoxysilane, potassium carbonate, triethoxysilane compound and 1,1,1,1,3,3,3-hexamethyl disiloxane to prepare photo initiator.Photolithography is compounded by polymer resin, photo initiator and additive, solvent.The negative photoresist has good thermal stability, and can be recycled by specific filter film, and the recovery rate is 79-83%.The application combines chain free volume design and mobility control, and improves the glass transition temperature of material;And photoresist waste liquid can be recycled.The negative photoresist can be used in wafer level advanced packaging, micro-nano processing, high-end optics and other fields.

The present disclosure provides methods of manufacturing psilocybin and crystalline psilocybin via a reaction of psilocin and tetrabenzylpyrophosphate in the presence of lithium chloride complex Grignard reagent, which is followed by hydrogenation. Methods of producing psilocin from 4-hydroxyindole or 4-acetoxyindole are also provided.

This invention provides a high-transmittance UV ink and its preparation method, belonging to the field of novel ink preparation technology. This application proposes a high-transmittance, high-refractive-index UV ink system: by introducing an active zirconium-oxygen nanocluster solution and synergistically combining it with a side-chain flexible acrylic bisphenol A type epoxy resin prepolymer, a balance between refractive index and transparency is achieved; the zirconium clusters are generated under the stepwise coordination stabilization of acetyl acetoxyethyl methacrylate and methacrylic acid, and are stably dispersed into the curing system by replacing and removing low-boiling byproducts with a high-refractive-index monomer carrier, reducing agglomeration, whitening, and haze caused by powder dispersion; the flexible side chains slow down the curing shrinkage stress, reducing brittleness and microcracks, and improving coating integrity; the composite polymerization inhibitor and coordination buffer monomer reduce the tendency for storage thickening and microgel formation, which is beneficial for improving processing window and batch consistency; thus, a UV ink with high transparency, low haze, high refractive index, and stable film formation is obtained.

This invention discloses a system and method for preparing 4-acetoxybutyraldehyde by hydroformylation of allyl acetate. The system includes a reaction unit, a separation unit, and a product tank connected in sequence, as well as a dynamic dehydration unit that forms a loop with the reaction unit through pipelines and pumps, a catalyst regeneration unit connected to the organic phase outlet of the heating unit, and a circulating dehydration unit connected between the catalyst regeneration unit and the reaction unit. The method employs a carbonyl metal catalytic system, using a bypass molecular sieve to dynamically adsorb the self-condensing water of the reaction. After separating the aldehyde product, the remaining organic phase is deeply dehydrated by the molecular sieve and recycled. This invention reduces the water content in the reaction system by setting up a closed-loop dehydration system throughout the entire process. Through the combined strategy of "dynamic adsorption by molecular sieve + deep dehydration of the circulating phase," it achieves multiple benefits, including "reduced corrosion, reduced highly toxic byproducts, and increased yield."

The invention discloses an antithrombotic drug derived carbon dot as well as a preparation method and application thereof. Comprising the steps that an antithrombotic drug is selected as a precursor, the antithrombotic drug comprises at least one of an antiplatelet drug with a pharmacodynamic group, an anticoagulant drug with a pharmacodynamic group and a fibrinolytic drug with a pharmacodynamic group, the molecular weight of the antithrombotic drug is 100-2000 Da, and the thermal stability decomposition temperature is larger than or equal to 200 DEG C; the pharmacodynamic groups comprise at least one of sulfonic acid groups, acetoxy groups, indole rings and coumarin structures; performing gradient carbonization treatment on the precursor in a plurality of temperature zones, wherein the plurality of temperature zones comprise a low-temperature zone capable of retaining pharmacodynamic groups, a medium-temperature zone for regulating and controlling a carbon hybridization ratio and a high-temperature zone for performing heteroatom doping; and performing purification and drying treatment to obtain the antithrombotic drug derived carbon dots. Through the preparation method, the antithrombotic drug derived carbon dots with a thrombolysis function and high safety can be obtained, and the problem that the curative effect and safety of an existing antithrombotic drug are unbalanced is solved.

The invention discloses a preparation method of 3, 4-diacetoxy-1-butene, and belongs to the technical field of chemical engineering. Comprising the following steps: mixing raw materials containing 1, 4-diacetoxyl-2-butene, a catalyst and an auxiliary agent, heating, and carrying out a rearrangement reaction to obtain 3, 4-diacetoxyl-1-butene; the catalyst is selected from compounds of VIII group metals of transition metals; the auxiliary agent is selected from nitrile compounds. The auxiliary agent can form a relatively stable complex with the catalyst, so that the catalyst is not inactivated after long-time use, and the complex has very strong stability and chemical activity, thereby solving the problems that the catalyst is easy to inactivate and cannot be used mechanically in the rearrangement process; due to the addition of the auxiliary agent, the selectivity and the comprehensive yield of the rearrangement reaction are greatly improved; the product purity reaches 99% or above, the once-through yield reaches about 45%, and the catalyst is high in stability and suitable for continuous industrial production.

The present invention relates to a process for purifying acetoxy siloxanes. A process for purifying acidified, preferably superacidified, in particular triflic acidified, end equilibrated acetoxy siloxanes is described, wherein acidified, preferably superacidified, in particular triflic acidified, acetic anhydride and optionally acetic acid containing equilibrated, preferably end equilibrated, acetoxy siloxanes are contacted with a base, after which the precipitate is filtered off, and the resulting filtrate is optionally purified by distillation, the acetoxy siloxanes optionally being dissolved in an inert solvent.

The invention relates to the technical field of synthesis, in particular to Sieber resin and a preparation method and application thereof. The preparation method comprises the following steps: under the catalysis of a first catalyst, (9H-xanth-9-one-3-oxymethyl) resin and fluorenylmethoxycarbonyl amide are subjected to a first reaction in a first solvent, and Sieber resin is prepared; wherein the first catalyst comprises triacetoxyborohydride alkali metal salt and acetic acid, the general formula of the triacetoxyborohydride salt is M [BH (OAc) 3], and M is selected from Li, Na, K, Rb and Cs. According to the preparation method of the Sieber resin provided by the embodiment of the invention, the reaction steps are simplified, the synthesis efficiency is improved, the reaction conditions are mild and controllable, and the prepared Sieber resin is good in swelling property, stable in product performance and suitable for large-scale industrial production.

The invention discloses a preparation method and application of a fluorine-free glass hydrophobing agent formula, and the specific steps are as follows: firstly, two solvents are prepared, an agent A takes a mixed system of alkyl trichlorosilane and 11-acetoxyundecyl trichlorosilane as a main agent, and an alcohol solvent is taken as a diluent; and the agent B takes acid as a catalyst and a mixed system of water and alcohols as a diluent. The preparation method comprises the following steps: preparing an agent A and an agent B, fully stirring the agent A and the agent B to form a uniform mixed system after preparation is finished, dropwise adding the agent B into the agent A, sealing the reaction system after dropwise adding is finished, and vigorously stirring again until a milky white uniform micelle system is formed, so as to obtain the target fluorine-free glass water repellent agent. The preparation method of the fluoride-free glass water repellent agent is simple, the water repellent agent is directly sprayed to the surface of cover plate glass in the later period, a high water drop angle can be achieved after heat treatment, and excellent hydrophobic performance is achieved.

This invention discloses a method for preparing p-acetoxystyrene, comprising the following steps: mixing [4-(1-hydroxyethyl)phenyl]acetate, organophosphoric acid, and a polymerization inhibitor, and reacting them thoroughly to obtain the desired p-hydroxystyrene. The method of this invention utilizes organophosphoric acid as a catalyst for the dehydration reaction of [4-(1-hydroxyethyl)phenyl]acetate, thus achieving the preparation of p-acetoxystyrene. Compared with traditional methods for preparing p-acetoxystyrene, this method does not require large amounts of acidic and alkaline dehydrating agents, generates less wastewater, and the organophosphoric acid catalyst can be recycled. Therefore, the method of this invention for preparing p-acetoxystyrene has advantages such as low waste, high yield, and environmental friendliness, and thus has good application value.

The application discloses a cannabidiol derivative and application thereof, and belongs to the technical field of medicinal chemistry. The structural general formula of the cannabidiol derivative is shown as formula (I): (I) R1 is selected from one of hydrogen, chlorine, bromine, a hydroxyl group, a cyano group, an acetoxy group, an acryloyloxy group, a benzoyl group, an acetamide group, an acrylamide group, a propiolamide group, an ethyl thiourea group, a 3-chloro-2,2-dimethylpropionyl group, a 2-ethylsulfonamide acetyl group, a 2-ethylsulfonamide-N-(2-amino-2-oxoethyl) acetyl group, a methylsulfonyl group, an ethylsulfonyl group, a vinylsulfonyl group, an alkyne propylsulfonyl group, a phenylsulfonyl group and a styrylsulfonyl group; and R2 is selected from one of C2-C5 alkyl groups. The cannabidiol derivative disclosed by the application has significantly improved anti-neuroinflammatory activity, significantly reduced cytotoxicity, and a generally improved treatment index of more than 10 times, or even more than 260 times, compared with cannabidiol.