86 results about "Acetoxy group" patented technology

The application discloses a PAG bonding type photosensitive photoresist resin and a preparation method and application thereof. The photoresist resin is as follows: formula. The PAG bonding type resin is prepared through the following reaction process: 1) performing a RAFT polymerization reaction on p-acetoxystyrene, p-styrene sulfonamide trifluoromethyl potassium salt and a RAFT chain transfer agent under the action of an initiator to obtain an intermediate I, 2) performing a hydrolysis reaction on the intermediate I to obtain an intermediate II, 3) performing a protection group introduction reaction on the intermediate II and di-tert-butyl dicarbonate to obtain an intermediate III; and 4) performing an ion exchange reaction on the intermediate III and triphenylsulfonium bromide. The application realizes the bonding of the PAG into the resin skeleton, and improves the problems of poor compatibility between the PAG and the resin, phase separation, uneven distribution of the PAG and the like. Therefore, the photoresist prepared from the resin has the photo-generated acid bound by the polymer main chain and limited diffusion, the resolution is improved, and the photoetching effect is excellent.

This invention provides a compound for recognizing chiral amino alcohols, a fluorescent probe, its preparation method, and its application. Naphthol and sodium hydride are weighed and dissolved separately in ultra-dry tetrahydrofuran, mixed, and then reacted with bromomethyl methyl ether. The mixture is extracted with ethyl acetate, and the organic phases are combined to obtain product (R)-1. This product is dissolved in ultra-dry tetrahydrofuran, and n-butyllithium is added. The reaction system changes from colorless to brown, and the reaction is allowed to return to room temperature. Ultra-dry N,N-dimethylformamide solution is then added, and the reaction is quenched by adding saturated ammonium chloride solution under ice-water bath conditions. The product is then extracted with ethyl acetate to obtain product (R)-2. Product (R)-2 is dissolved in a mixed solvent of tetrahydrofuran and anhydrous methanol, and sodium triacetoxyborohydride is added. The product is then extracted with ethyl acetate to obtain reduced product (R)-3. Product (R)-3 is dissolved in a mixed solvent of dichloromethane and anhydrous ethanol, and concentrated hydrochloric acid is added. After the reaction is complete, the reaction is quenched with sodium bicarbonate, and then extracted with dichloromethane to finally obtain compound (R)-4, which recognizes chiral amino alcohols.

The invention discloses a method and a system for preparing a 4-AA medical intermediate through continuous flow ozone oxidation. The method comprises the following steps: continuously introducing a raw material solution containing (3R)-3-((R)-1-((tert-butyldimethylsilyl) oxy) ethyl)-1-(4-methoxyphenyl)-4-oxo azetidine-2-yl acetate and a gas containing ozone into a microreactor for reaction; after the reaction liquid is subjected to reduction quenching, the (3R, 4R) 4-acetoxyl-3-[R-(tert-butyldimethylsiloxy) ethyl]-2-azetidinone is obtained. On one hand, the reaction time is shortened from the hour level to the minute level, and the production efficiency is remarkably improved; and on the other hand, the reaction temperature is increased to 10-30 DEG C from deep cooling, so that the refrigeration energy consumption and the equipment requirement are greatly reduced. According to the invention, local peroxidation is fundamentally avoided, byproducts are obviously reduced, the product purity is improved, the method is suitable for continuous operation, the reaction process is controllable, and the method is safe and reliable.

The invention belongs to the technical field of resveratrol synthesis, and particularly relates to a preparation method of resveratrol and application of resveratrol in meat preservation. The method comprises the following steps: taking 3, 5-dimethoxybenzoic acid as a raw material, and carrying out acylation reaction to obtain 3, 5-dimethoxybenzoyl chloride. Then reacting with p-acetoxystyrene to generate 3, 3 '-dihydroxy-3, 3'-dihydroxy-3 The preparation method comprises the following steps: taking 1, 5-dimethoxy-4 '-acetoxystilbene as a raw material, hydrolyzing and demethylating to obtain resveratrol, and preparing resveratrol lipid nanoparticle suspension by taking resveratrol, a ZIF-8 / chitosan compound, compound lipid, cholesterol, epsilon-polylysine, ascorbyl palmitate and phosphate buffer saline as raw materials. High load and controlled release of resveratrol are achieved, and the problems that resveratrol is poor in water solubility and prone to oxidation are solved.

The present application relates to a kind of recycling method of avibactam intermediate production waste liquid, belong to pharmaceutical chemical technology field;The present application will be in the 5-benzyloxyamine piperidin-2S-formic acid ethyl ester oxalate in avibactam intermediate production waste liquid by desalination into free state, under the condition of ethyl acetate as solvent, using the dilute solution of m-chloroperbenzoic acid drop, homogeneous reaction in organic solvent, effectively improve the utilization of raw material, with the advantage of less by-product, and have higher recovery rate than prior art, in addition, the present application also prepares a kind of activated carbon loaded sodium triacetoxyborohydride, can play the role of catalytic sodium triacetoxyborohydride reduction amination reaction, improve the utilization of sodium triacetoxyborohydride, and prevent sodium triacetoxyborohydride from contacting with water.

The application discloses a kind of polymer resin for photoresist, negative photoresist and recycling method.The preparation method of polymer resin is: using functional polycarbonate, p-acetyl oxystyrene, initiator, star-shaped RAFT agent to prepare polymer resin.Using 2-benzyl (methyl) amino-9H-thioxanthene-9-ketone, 3-chloropropyl triethoxysilane, potassium carbonate, triethoxysilane compound and 1,1,1,1,3,3,3-hexamethyl disiloxane to prepare photo initiator.Photolithography is compounded by polymer resin, photo initiator and additive, solvent.The negative photoresist has good thermal stability, and can be recycled by specific filter film, and the recovery rate is 79-83%.The application combines chain free volume design and mobility control, and improves the glass transition temperature of material;And photoresist waste liquid can be recycled.The negative photoresist can be used in wafer level advanced packaging, micro-nano processing, high-end optics and other fields.

This invention provides a high-transmittance UV ink and its preparation method, belonging to the field of novel ink preparation technology. This application proposes a high-transmittance, high-refractive-index UV ink system: by introducing an active zirconium-oxygen nanocluster solution and synergistically combining it with a side-chain flexible acrylic bisphenol A type epoxy resin prepolymer, a balance between refractive index and transparency is achieved; the zirconium clusters are generated under the stepwise coordination stabilization of acetyl acetoxyethyl methacrylate and methacrylic acid, and are stably dispersed into the curing system by replacing and removing low-boiling byproducts with a high-refractive-index monomer carrier, reducing agglomeration, whitening, and haze caused by powder dispersion; the flexible side chains slow down the curing shrinkage stress, reducing brittleness and microcracks, and improving coating integrity; the composite polymerization inhibitor and coordination buffer monomer reduce the tendency for storage thickening and microgel formation, which is beneficial for improving processing window and batch consistency; thus, a UV ink with high transparency, low haze, high refractive index, and stable film formation is obtained.

This invention discloses a system and method for preparing 4-acetoxybutyraldehyde by hydroformylation of allyl acetate. The system includes a reaction unit, a separation unit, and a product tank connected in sequence, as well as a dynamic dehydration unit that forms a loop with the reaction unit through pipelines and pumps, a catalyst regeneration unit connected to the organic phase outlet of the heating unit, and a circulating dehydration unit connected between the catalyst regeneration unit and the reaction unit. The method employs a carbonyl metal catalytic system, using a bypass molecular sieve to dynamically adsorb the self-condensing water of the reaction. After separating the aldehyde product, the remaining organic phase is deeply dehydrated by the molecular sieve and recycled. This invention reduces the water content in the reaction system by setting up a closed-loop dehydration system throughout the entire process. Through the combined strategy of "dynamic adsorption by molecular sieve + deep dehydration of the circulating phase," it achieves multiple benefits, including "reduced corrosion, reduced highly toxic byproducts, and increased yield."

The invention discloses an antithrombotic drug derived carbon dot as well as a preparation method and application thereof. Comprising the steps that an antithrombotic drug is selected as a precursor, the antithrombotic drug comprises at least one of an antiplatelet drug with a pharmacodynamic group, an anticoagulant drug with a pharmacodynamic group and a fibrinolytic drug with a pharmacodynamic group, the molecular weight of the antithrombotic drug is 100-2000 Da, and the thermal stability decomposition temperature is larger than or equal to 200 DEG C; the pharmacodynamic groups comprise at least one of sulfonic acid groups, acetoxy groups, indole rings and coumarin structures; performing gradient carbonization treatment on the precursor in a plurality of temperature zones, wherein the plurality of temperature zones comprise a low-temperature zone capable of retaining pharmacodynamic groups, a medium-temperature zone for regulating and controlling a carbon hybridization ratio and a high-temperature zone for performing heteroatom doping; and performing purification and drying treatment to obtain the antithrombotic drug derived carbon dots. Through the preparation method, the antithrombotic drug derived carbon dots with a thrombolysis function and high safety can be obtained, and the problem that the curative effect and safety of an existing antithrombotic drug are unbalanced is solved.

The invention discloses a preparation method of 3, 4-diacetoxy-1-butene, and belongs to the technical field of chemical engineering. Comprising the following steps: mixing raw materials containing 1, 4-diacetoxyl-2-butene, a catalyst and an auxiliary agent, heating, and carrying out a rearrangement reaction to obtain 3, 4-diacetoxyl-1-butene; the catalyst is selected from compounds of VIII group metals of transition metals; the auxiliary agent is selected from nitrile compounds. The auxiliary agent can form a relatively stable complex with the catalyst, so that the catalyst is not inactivated after long-time use, and the complex has very strong stability and chemical activity, thereby solving the problems that the catalyst is easy to inactivate and cannot be used mechanically in the rearrangement process; due to the addition of the auxiliary agent, the selectivity and the comprehensive yield of the rearrangement reaction are greatly improved; the product purity reaches 99% or above, the once-through yield reaches about 45%, and the catalyst is high in stability and suitable for continuous industrial production.

The invention relates to the technical field of synthesis, in particular to Sieber resin and a preparation method and application thereof. The preparation method comprises the following steps: under the catalysis of a first catalyst, (9H-xanth-9-one-3-oxymethyl) resin and fluorenylmethoxycarbonyl amide are subjected to a first reaction in a first solvent, and Sieber resin is prepared; wherein the first catalyst comprises triacetoxyborohydride alkali metal salt and acetic acid, the general formula of the triacetoxyborohydride salt is M [BH (OAc) 3], and M is selected from Li, Na, K, Rb and Cs. According to the preparation method of the Sieber resin provided by the embodiment of the invention, the reaction steps are simplified, the synthesis efficiency is improved, the reaction conditions are mild and controllable, and the prepared Sieber resin is good in swelling property, stable in product performance and suitable for large-scale industrial production.

This invention discloses a method for preparing p-acetoxystyrene, comprising the following steps: mixing [4-(1-hydroxyethyl)phenyl]acetate, organophosphoric acid, and a polymerization inhibitor, and reacting them thoroughly to obtain the desired p-hydroxystyrene. The method of this invention utilizes organophosphoric acid as a catalyst for the dehydration reaction of [4-(1-hydroxyethyl)phenyl]acetate, thus achieving the preparation of p-acetoxystyrene. Compared with traditional methods for preparing p-acetoxystyrene, this method does not require large amounts of acidic and alkaline dehydrating agents, generates less wastewater, and the organophosphoric acid catalyst can be recycled. Therefore, the method of this invention for preparing p-acetoxystyrene has advantages such as low waste, high yield, and environmental friendliness, and thus has good application value.

The application discloses a cannabidiol derivative and application thereof, and belongs to the technical field of medicinal chemistry. The structural general formula of the cannabidiol derivative is shown as formula (I): (I) R1 is selected from one of hydrogen, chlorine, bromine, a hydroxyl group, a cyano group, an acetoxy group, an acryloyloxy group, a benzoyl group, an acetamide group, an acrylamide group, a propiolamide group, an ethyl thiourea group, a 3-chloro-2,2-dimethylpropionyl group, a 2-ethylsulfonamide acetyl group, a 2-ethylsulfonamide-N-(2-amino-2-oxoethyl) acetyl group, a methylsulfonyl group, an ethylsulfonyl group, a vinylsulfonyl group, an alkyne propylsulfonyl group, a phenylsulfonyl group and a styrylsulfonyl group; and R2 is selected from one of C2-C5 alkyl groups. The cannabidiol derivative disclosed by the application has significantly improved anti-neuroinflammatory activity, significantly reduced cytotoxicity, and a generally improved treatment index of more than 10 times, or even more than 260 times, compared with cannabidiol.

The invention discloses a preparation method of poly (p-hydroxystyrene), poly (p-hydroxystyrene) and application, and relates to the technical field of organic synthesis. According to the preparation method, 4-acetoxystyrene, 4-hydroxyphenyl methacrylate, tert-butyl acrylate, tert-butyl methacrylate and 1-ethyl cyclopentyl methacrylate are taken as monomers, and the P (HSt-co-HADMA) copolymers with different HADMA proportions are obtained through RAFT (reversible addition-fragmentation chain transfer) polymerization. According to the copolymer, large-volume side groups are introduced, so that the glass-transition temperature of PHSt is effectively increased, the processing window of subsequent acid diffusion is improved, and the film-forming property of the copolymer is also effectively improved. Along with the increase of the HADMA content, the cracking condition of the film is improved, and the surface roughness is reduced.

Disclosed herein are various embodiments pertaining to continuous processes for making ethylene glycol diacetate, also known as 1,2-diacetoxyethane, by esterification of monoethylene glycol to 2-hydroxyethyl acetate and the esterification of 2-hydroxyethyl acetate to ethylene glycol diacetate. Various embodiments herein use reactive distillation in processes promising enhanced economic viability in the production of high-quality ethylene glycol diacetate.

The invention discloses 1, 3-bifunctional isobutyramide pyridinium salt, a preparation method and application of the 1, 3-bifunctional isobutyramide pyridinium salt in antiviral drugs, and belongs to the field of drug synthesis. The preparation method comprises the following steps: under the protection of argon, by taking (3-(2-fluorophenyl)-2, 2-dimethyl propionyl) (pyridine-2-yl) amide as a raw material and dichloroethane as a solvent, adding palladium acetate, iodobenzene diacetate, water and acetic acid, and reacting to obtain 1, 3-hydroxyl / acetoxy pyridinium salt; the preparation method comprises the following steps: by taking N-(3-((2-(2-fluoro-4-phenylbiphenyl-3-yl)-2-methylpropionyl) oxy)-2, 2-dimethyl propionyl) pyridinium as a raw material and toluene as a solvent, adding palladium acetate, 4, 5-diazafluorene-9-one, iodobenzene diacetate, potassium carbonate and acetic anhydride, and reacting to obtain the 1, 3-diacetoxypyridinium salt. The synthesis process of the 1, 3-bifunctional isobutyramide pyridinium salt is simple and convenient, and the reaction conditions are mild; meanwhile, the pyridinium salt has good anti-enterovirus activity and is expected to become a medicine for effectively treating EV-A71 infection.

To provide a novel circadian rhythm regulator. [Solution] A circadian rhythm regulator comprising a phthalide compound having at least one substituent R on a benzene ring as an active ingredient, wherein the at least one substituent R is independently selected from the group consisting of hydroxy, methoxy, ethoxy, propoxy, hydroxymethyl, and acetoxy.

The application discloses an expandase mutant SEQ ID NO:3 which can efficiently catalyze the expandase reaction of a substrate to generate phenylacetyl-7-amino deacetoxycephalosporanic acid in a reaction system with a penicillin G concentration of up to 10 mM, and can be used for industrial production of G-7-ADCA.

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

A film forming composition is provided. The film forming composition comprises a silicon precursor having a structure according to general Formula (1):wherein, Q1 is a substituent selected from an acetoxy group, an acryloyloxy group, a C1 to C6 alkoxy group, a silyloxy group, a germyloxy group, a phosphonooxy group, and an alkyl amine group; and Q2, Q3, and Q4 are each a substituent independently selected from a hydrogen atom, a C1-C6 alkyl group, and the substituent group of Q1. Methods for forming the film forming composition and methods and systems for using the film forming composition to deposit a carbon doped silicon containing film on a substrate are also provided.

The invention relates to the technical field of high-performance polymer fiber manufacturing, in particular to a low-processing-viscosity liquid crystal polyarylester fiber and a preparation method thereof.The preparation method comprises the steps that S1, p-hydroxybenzoic acid and 2-hydroxy-6-naphthoic acid serve as monomers, and an acetylation reaction is conducted in the presence of an acetylation reagent and a catalyst; the preparation method comprises the following steps: firstly, preparing LCP resin, then carrying out melt polycondensation reaction, adding 6-acetoxy-2-naphthoic acid at the later stage of the melt polycondensation reaction, stirring and dispersing, discharging, cooling and granulating to obtain the LCP resin; and S2, carrying out melt spinning and heat treatment on the LCP resin to obtain the liquid crystal polyarylate fiber. According to the preparation method, the melt processing viscosity of the resin can be remarkably reduced, the production smoothness is improved, the heat treatment time is shortened, the production energy consumption is reduced, the high molecular weight potential of the resin in spinning processing is not influenced, and the liquid crystal polyarylate fiber is ensured to have very good strength performance.

This invention belongs to the field of organic chemical engineering, specifically relating to a method for preparing a homogeneous catalyst and a method for preparing 3-acetoxypropionate by using the homogeneous catalyst in the hydrogen esterification reaction of vinyl acetate. The method for preparing the homogeneous catalyst of this invention includes the following steps: (1) in a first organic solvent, a dihaloalkane and a dialkylphosphine borane complex are reacted under alkaline conditions to generate a dialkylphosphine ligand borane complex; (2) in a first alcohol, the dialkylphosphine ligand borane complex is heated to remove borane, yielding a dialkylphosphine ligand; (3) in a second organic solvent, the dialkylphosphine ligand and a metal precursor are mixed to obtain a solution containing the homogeneous catalyst. The homogeneous catalyst of this invention can be applied to the hydrogen esterification reaction of vinyl acetate, and the homogeneous catalyst and its ligands are easy to synthesize. Using the homogeneous catalyst of this invention to catalyze the hydrogen esterification reaction of vinyl acetate, the conversion rate of the reaction raw materials is >99%, the yield of the straight-chain ester product can reach 62%, and the selectivity can reach 71%.

A sulfonium salt represented by the following general formula (1). In formula, R1, R2, and R3 represent a fluorine atom, a hydroxy group, a trifluoromethyl group, a trifluoromethoxy group, a trifluoroacetyloxy group, a cyano group, a carbamoyl group, an amide group, or a linear, branched, or cyclic monovalent hydrocarbon group having 1 to 15 carbon atoms and optionally having a heteroatom; “r” represents integer of 0 to 4, “p” represents integer of 0 to 5, “q” represents integer of 0 to 5, “x” represents integer of 0 to 4, “y” represents integer of 0 to 5, “z” represents integer of 0 to 5, and “r”, “p”, “q”, “x”, “y”, and “z” satisfy x+y+z≥1, 4≥r+x≥0, 5≥p+y≥0, and 5≥q+z≥0. This can provide an acid diffusion inhibitor used for a chemically-amplified resist material that does not impair sensitivity in photolithography and is excellent in lithography performances such as CDU and LWR.

The present invention provides a composition for forming a carbon-doped silicon-containing film, a method for forming the composition, and a method and system for using the composition. [Solution] The film-forming composition is based on the general formula (1): JPEG2026060924000014.jpg26170 (In the formula, Q 1 Q is a substituent selected from an acetoxy group, an acryloyloxy group, a C1-C6 alkoxy group, a silyloxy group, a gelmyloxy group, a phosphonooxy group, and an alkylamine group. 2 Q 3 , and Q 4 These are a hydrogen atom, a C1-C6 alkyl group, and Q, respectively. 1 The substituent is independently selected from the substituents. The invention includes a silicon precursor having a structure due to ). Methods for forming a film-forming composition, as well as methods and systems for depositing a carbon-doped silicon-containing film on a substrate using the film-forming composition, are also provided.

The invention relates to the technical field of vinyltrimethoxysilane by-products, in particular to a method for modifying 1, 2-bis (trimethoxysilyl) ethane and application of the 1, 2-bis (trimethoxysilyl) ethane. The method comprises the following steps: dehydrating a vinyltrimethoxysilane by-product 1, 2-bis (trimethoxysilyl) ethane through a molecular sieve, mixing the vinyltrimethoxysilane by-product 1, 2-bis (trimethoxysilyl) ethane with acetoxysilane, and discharging water through the molecular sieve. Compared with 1, 2-bis (trimethoxysilyl) ethane, the obtained modified product is higher in hydrolysis speed, lower in acid value and longer in preservation time, so that the modified product can be better applied to the fields of buildings, sealants and the like, and due to the low acid value, the modified product is expected to be expanded to the fields with higher requirements, such as metals, electronic materials and the like.

The invention discloses a method for synthesizing a pevitide key intermediate, and relates to the technical field of medicine synthesis. The specific preparation method comprises the following steps: firstly, reacting 2, 3, 4, 6-tetraacetoxy-alpha-D-glucopyranose bromide with 18-hydroxy tert-butyl octadecanoate under the action of a catalyst to generate a glycoside intermediate, and carrying out alkaline hydrolysis on the glycoside intermediate to remove an acetyl protecting group, so as to obtain the 2, 3, 4, 6-tetraacetoxy-alpha-D-glucopyranose. And finally, carrying out oxidation reaction and purification to obtain a target product 18-([beta-D-glucuronic acid-1-yl] oxy) tert-butyl octadecanoate, namely the pevitide key intermediate. According to the preparation method disclosed by the invention, the pevitide key intermediate with relatively high yield and purity can be finally obtained, and the preparation method is simple to operate and has a good application prospect.

The present application relates to the technical field of preparation of film-forming resins of photoresists, and discloses a film-forming resin of a KrF photoresist, a preparation method therefor, and a use thereof. The preparation method comprises the following steps: filtering a 4-acetoxystyrene monomer or a 4-acetoxystyrene monomer and another comonomer, then adding same into a dispersant, and adding an organic photocatalyst and a chain transfer agent for mixing to obtain a mixed solution; introducing an inert gas into the mixed solution, irradiating the mixed solution under the condition of visible light, and reacting to obtain a polymerization solution; and precipitating a polymer from the polymerization solution, performing drying, then adding an ammonia solution or a hydrazine hydrate solution, and upon completion of the reaction, removing residual metal ions to obtain a film-forming resin of a KrF photoresist having a molecular weight distribution of less than 1.2. The present application uses a photo-initiation mode, such that, on one hand, energy consumption during polymerization can be reduced, and the reaction conditions are mild; and on the other hand, a preparation process of a polymer can be well controlled in time and space, thereby ensuring batch-to-batch stability.

The invention discloses a preparation method of a fluorine bone triol intermediate, which comprises the following steps: (20S)-3beta-acetoxy-20-methyl-21-iodo-pregna-5-ene as shown in a formula II is taken as a raw material, and 26, 26, 26, 27, 27, 27-hexafluoro-25-hydroxycholesterol is prepared through four steps of reaction, namely coupling, ester hydrolysis, trifluoromethyl substitution and trifluoromethyl addition, and the reaction formula is as shown in the specification. The method has the advantages of simple process, cheap and easily available reagents, and suitableness for industrial production.

The application relates to the technical field of ceramic tiles, and particularly discloses a high-strength ceramic tile and a preparation method thereof. The high-strength ceramic tile is mainly made of the following raw materials in parts by weight: 20-30 parts of sodium feldspar, 15-25 parts of potassium feldspar, 10-20 parts of coal gangue, 2-8 parts of dolomite, 10-20 parts of kaolin, 5-15 parts of bentonite, 3-5 parts of superfine silicon powder, 3-5 parts of superfine titanium white powder, 1-3 parts of modified pre-oxidized fiber, and 0.2-0.8 parts of a dispersing agent; the modified pre-oxidized fiber is obtained by grafting acetoxypropyltrimethoxysilane and tetraethylenepentamine onto pre-oxidized fiber. The ceramic tile has the characteristics of high breaking strength, high modulus of rupture and high wear resistance, exhibits good comprehensive performance, and meets market demands.

This invention discloses a method for heterologous production of 7-aminodeacetoxycephalosporanic acid using *Aspergillus nidulans*. This invention targets a *Aspergillus nidulans* strain that heterologously produces 7-aminodeacetoxycephalosporanic acid. Genes derived from the biosynthetic gene clusters pcbAB / C, isopentine N-acetyltransferase gene, and cefE gene, or their mutants, are assembled into a *Aspergillus nidulans* expression vector. Co-expression is performed in a *Aspergillus nidulans* basal cell strain to obtain a recombinant strain, successfully achieving heterologous expression of 7-aminodeacetoxycephalosporanic acid in filamentous fungi. Experiments show that the yield can reach 0.13 g / L at the shake-flask level. The strain constructed in this invention provides a good heterologous expression system for studying the synthesis and regulatory mechanism of 7-aminodeacetoxycephalosporanic acid.