541 results about "Acetoxy group" patented technology

A method for depositing a silicon-containing film, the method comprising: placing a substrate comprising at least one surface feature into a flowable CVD reactor which is at a temperature of from about −20° C. to about 400° C.; introducing into the reactor at least one silicon-containing compound having at least one acetoxy group to at least partially react the at least one silicon-containing compound to form a flowable liquid oligomer wherein the flowable liquid oligomer forms a silicon oxide coating on the substrate and at least partially fills at least a portion of the at least one surface feature. Once cured, the silicon oxide coating has a low k and excellent mechanical properties.

The present invention relates to a new industrial process for the synthesis of solvate- free 17a-acetoxy-11ss-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17a-ethynyl-17ss-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17a-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11l); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5a,10a- and 5ss,10ss-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran.

An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17a-hydroxylase/C17, 20-lyase inhibitor, such as abiraterone acetate (i.e., 3beta-acetoxy-17-(3-pyridyl) androsta-5, 16-diene), in combination with at least one additional therapeutic agent such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising a 17a- hydroxylase/C17, 20-lyase inhibitor, and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid.

The invention relates to a coating flatting agent, in particular to a preparation of polyether terminal modified polydimethylsiloxane and an application of the polyether terminal modified polydimethylsiloxane serving as the flatting agent in coatings. The structural formula of a terminal modified organic silicone coating flatting agent is shown as follows, wherein m is equal to 0-100; and R is equal to - (CH2) 3-O-(C2H4O) x (C3H6O) y-R', wherein the x is equal to 0-100, the y is equal to 0-100, and R' is hydrogen (H) or alkyl, acetoxy group and epoxy group with one to ten carbon atoms. The flatting agent has the advantages that the surface tension of the coatings is reduced, the wettability of substrates is improved, the flowing and flatting of the coatings are increased, the surface defects are eliminated, the smoothness is improved, the surface friction coefficient of the coatings is lowered, and the scrath resistance and anti-blocking are improved.

A room temperature crosslinking, one component (RTV 1C) silicone rubber formulation with hydrophobic, silica featuring extremely low water absorption, a high level of whiteness, and fine-tunable, storage-stable rheological properties with a high reinforcing action in the silicone rubber vulcanizate contains A) from 0.5 to 60% by weight of a hydrophobic silica having the following properties: a carbon content of >3.1%; a methanol wettability of >60%; a reflectance of >94%; a BET/CTAB ratio of from >1 to <3; a DBP absorption of <230 g/100 g; a BET surface area of from 50 to 110 m²/g; a CTAB surface area of >30 m²/g; a water vapor absorption at 30° C. at an ambient humidity of 30 of <1.3; a water vapor absorption at 30° C. at an ambient humidity of 70 of <1.7; and B) 40-99.5% by weight of an organopolysiloxane of the formula

Z_nSiR_3-n—O—[SiR₂O]_x—SiR_3-n—Z′_n

wherein each R represents independently alkyl, acetoxy, oxime, alkoxy, amido, aryl or alkenyl radicals, each having from 1 to 50 carbon atoms, each unsubstituted or substituted identically or differently by O, S, F, Cl, Br or I; or R represents independently polystyrene, polyvinyl acetate, polyacrylate, polymethacrylate, or polyacrylonitrile radicals, each having 50-10 000 repeating units; wherein each Z represents independently OH, Cl, Br, acetoxy, amino, amido, amineoxy, oxime, alkoxy, alkenyloxy, acyloxy or phosphate radicals, wherein said acetoxy, amino, amido, amineoxy, oxime, alkoxy, alkenyloxy and acyloxy radicals each have up to 20 carbon atoms; wherein each Z′ represents independently oxime, alkoxy, amido or acetoxy radicals; wherein n is 1-3; and wherein x is 100-15 000.

A hydrophilic modification method comprising a step of forming a coat having a solid coat amount of 0.02 to 3 g/m2 on a heat exchanger with a modifier for hydrophilicity after treatment for rust prevention thereof wherein said modifier for hydrophilicity comprises a modified polyvinyl alcohol (A) having, on a side chain thereof, a group represented by the formula (I): in the formula, n represents an integer of 1 to 500, R1 represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R2 represents a hydrogen atom or a methyl group, and at least one member (B) selected from the group consisting of phosphorus compound salts and boron compound salts of Ca, Al, Mg, Fe and Zn, said group represented by the formula (I) accounting for 0.01 to 20 mole percent relative to hydroxyl and acetoxy groups contained in said modified polyvinyl alcohol.

The present invention relates to a production method capable of producing an optically active α-hydroxyphosphonic acid and its derivatives with sufficiently high enantioselectivity not only for aromatic aldehydes but also for aliphatic aldehydes, and more specifically to a method of producing an optically active α-hydroxyphosphonic acid and its derivatives, characterized in that an optically active aluminum(salalen) complex represented by any one of the following formulae (I), (I′), (II) and (II′):

[wherein R¹s are each alkyl group or aryl group independently; R²s are each alkyl group or aryl group independently; R³s are each alkyl group or aryl group independently, and two R³s may bond with each other to form a ring; R⁴s are each hydrogen atom, halogen atom, alkyl group, alkoxy group, nitro group, or cyano group independently; R⁵ is alkyl group; and X¹ is halogen atom, alkyl group, alkoxy group, acetoxy group or toluenesulfonyloxy group] is used as a catalyst to asymmetrically hydrophosphonylate an aldehyde with phosphonic acid or its derivatives.

Provided is a toner comprising a toner particle including a toner base particle and fine particles present on a surface of the toner base particle, wherein each of the fine particles includes a core fine particle and a condensate of at least one organosilicon compound selected from the group consisting of organosilicon compounds represented by specific structural formulas, the condensate coating the surface of the core fine particle, and in a wettability test of the toner with respect to a methanol/water mixed solvent, a methanol concentration, when a transmittance of light having a wavelength of 780 nm is 50%, is 5.0 to 20.0% by volume:

The invention discloses a preparation method for imipenem medicine intermediate 4AA. The preparation method comprises making 4-substituted aniline into an intermediate A, perform epoxidation on L-threonine to produce (2R, 3R)-epoxy butyric acid; enabling (2R, 3R)-epoxy butyric acid and the intermediate A to undergo a coupling reaction, obtaining an intermediate B, enabling the intermediate B to undergo a cyclization reaction, obtaining an intermediate C, enabling the intermediate C to undergo a hydroxyl protection reaction, obtaining an intermediate D, enabling the intermediate D to be oxidized to form an acetoxy group, and enabling an oxidized product to undergo an ozonation reaction, wherein G is H, F, Cl, Br, a methoxy group, oxethyl or an amino group; and R is H, straight chain alkyl of C1-C6, cyclopropyl, isopropyl, tert-butyl, a phenyl group, p-chlorophenyl, o-chlorophenyl, p-bromophenyl, o-bromophenyl, p-methoxyphenyl, o-methoxyphenyl or m-methoxyphenyl. According to the preparation method, raw materials are cheap and easy to obtain, reaction conditions are mild, the conversion rate and the yield rate are high, and the preparation method is suitable for industrial production.

The invention discloses a method of acquiring high-purity 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, comprising the following steps: a) putting the acquired crude 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione in a proper solvent system to generate a pure 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione solid; b) separating the 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione solid; and c) carrying out recrystallization on the acquired solid. The compound used as a new oral emergency contraception can be taken in 120 h after unprotected sexual intercourse of women without a reduction of emergency contraception effect with the delay of the time of using drugs, and has good safety and survivability simultaneously.

The invention discloses a quinaldine derivative b fluorescent and colorimetric reagent as well as a preparation method and an application thereof and belongs to the field of organic synthesis and analytical chemistry. 8-hydroxyquinaldine serving as a raw material has a Knoevenagel condensation reaction with 2,4-dihydroxy benzaldehyde to obtain an intermediate a, wherein the chemical name of the intermediate a is (E)-2-(2,4-didiacetoxylphenyl)ethenyl-8-acetoxyquinoline; the intermediate a is hydrolyzed in a mixed medium of pyridine and water to obtain a derivative b, wherein the chemical name of the derivative b is (E)-2-(2,4-dihydroxylphenyl)ethenyl-8-hydroxyquinoline. The reaction materials are easily available; the synthesis method is simple; a target product can be obtained by two-step reaction. In a special solvent medium, the derivative b can act as fluorescent and colorimetric reagent for detecting Al<3+> and F-. The structural formula of the derivative is shown in the specification.

The emulsion composition of the present invention contains

• • (A) 0.001 to 10 wt. % of an organic compound having two or more hydroxyl groups, an inorganic value of 220 to 450, and an organic value of 300 to 1,000;
  • (B) 0.001 to 10 wt. % of an organic compound having one hydroxyl group, an inorganic value of 100 to 200, and an organic value of 280 to 700;
  • (C) 0.001 to 10 wt. % of a compound represented by formula (2):

wherein R¹ is a C4 to C30 hydrocarbon group; Z is a methylene group, a methine group, or an oxygen atom; X¹, X², X³ is a hydrogen atom, a hydroxyl group, or an acetoxy group; X⁴ is a hydrogen atom, an acetyl group, or a glyceryl group; each of R² and R³ a hydrogen atom, a hydroxyl group, a hydroxymethyl group, or an acetoxymethyl group; R⁴ is a C5 to C60 hydrocarbon group; and R⁵ is a hydrogen atom or a hydrocarbon group containing 1 to 30 carbon atoms in total;

(D) 0.00012 to 10 wt. % of at least one compound selected from the group consisting of a nonionic surfactant having a polyoxyethylene group and an HLB of 10 or higher, an ionic surfactant, and a sphingosine salt;

(E) 0.003 to 15 wt. % of at least one compound selected from the group consisting of a sugar alcohol selected from the group consisting of erythritol, threitol, xylitol, and mannitol, a disaccharide, and a trisaccharide; and

(F) water.

The present invention relates to a pharmaceutical composition, a food composition or a cosmetic composition, containing one or more kinds of a compound represented by the following formula (I′)

wherein R1 is a hydrogen atom, a hydroxyl group, a methoxy group or an ethoxy group, R2 is a hydroxyl group, a methoxy group or an acetoxy group, or R1 and R2 in combination optionally form a methylenedioxy group,

R is represented by the following formula

wherein Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=2 to 8, and R3 and R4 are each independently a hydrogen atom, a methyl group or an ethyl group,

provided that,

(1) when R1 is a methoxy group, then R2 is not a hydroxyl group; and

(2) when R1 is a hydroxyl group, then R2 is not a hydroxyl group and an acetoxy group.

According to the present invention, a stable capsinoid derivative is provided, and a pharmaceutical composition, a food composition, a cosmetic composition and the like containing the derivative as an active ingredient can be provided.

The invention relates to a method for hydroformylation of vinyl acetate. The method comprises the step of enabling the vinyl acetate to be in contact with carbon monoxide and hydrogen gas in the presence of a solvent and a catalyst system, wherein the catalyst system contains a rhodium complex and a phosphine ligand; the rhodium complex is one or more selected from rhodium(triphenylphosphine)carbonyl acetylacetonate, rhodium acetylacetone and chlorocarbonylbis(triphenylphosphine)rhodium; and the phosphine ligand is one or more selected from phosphine-containing organic matters represented by the following formulae shown in the description, wherein Ar in the formulae (1, 3 and 4) is substituted or unsubstituted aryl, M in the formula (2) is hydrogen, halogen element or substituted or unsubstituted alkyl, and t in the formula (3) is an integer from 2 to 10. According to the method, the selectivity to 3-acetoxypropanal in a hydroformylation reaction process of the vinyl acetate can be improved while a relatively high conversion ratio is guaranteed under the conditions of relatively low reaction temperature and reaction pressure.

The invention relates to a method for preparing a major midbody of a 19-bit dishorn methyl steroid compound, in particular to a method for preparing a compound 6beta, 19beta-epoxy-4-androstene-3, 17-diketone, which comprises the following steps of: 1, halogen alcoholization reaction: 3beta-acetoxyl-androstane-5-alkene-17-ketone takes halogen alcoholization reaction or chlorine alcoholization reaction to generate 3beta-acetoxyl-5alpha-bromo/chloro-6beta-hydroxyl-17-ketone; 2, illumination cyclization reaction: compounds obtained in the first step take cyclization reaction under the illumination condition in the existence of iodine, halide and catalysis quantity of radical initiators to obtain 3beta-hydroxyl-5alpha-halogenate-6beta, 19beta-epoxy-17-ketone; and 3, oxidation elimination reaction: (1) the compounds obtained in the second step take oxidation reaction under the effect of oxidizing agents to generate corresponding oxides; and (2) the obtained oxides take elimination reaction through being heated under the alkaline condition to generate 6beta, 19beta-epoxy-4-androstene-3, 17-diketone.

Acetal compounds in which a 5- or 6-membered ring acetal structure is connected to a norbornene structure through a linker represented by —(CH₂)_m— in which one hydrogen atom may be substituted with a hydroxyl or acetoxy group, and m is from 1 to 8 are novel. Using the acetal compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation and has excellent sensitivity, resolution, and etching resistance.