117 results about "Liquid Specimen" patented technology

A disposable liquid specimen collector and testing device can be manipulated to distribute a quantified portion of a liquid specimen to separate chromatographic strip-mounting testing stations while shielding the remainder of the specimen from cross-contamination by the immunoassay reagents present in the testing strips. In the resting state, the device exposes the testing station to a desiccant. A separate test station provides for a quick revelation of any adulterating component in the sample specimen. The geometry of the test station and fluid distribution channels assures isobaric conditions throughout the testing areas.

The present invention provides a concentration method and apparatus for preparing a liquid specimen for a trace element analysis system. A holder positions a thin film that is prepared to have a liquid repellency so that a liquid sample containing a specimen can be uniformly evaporated to be concentrated at one location. An irradiation source of energy can be applied to enable a detector to determine the trace element.

A container assembly provides for the collection, transporting, and dispensing of a fluid specimen. The container assembly includes a cup-shaped container having an open end for collecting the fluid specimen. A lid is attachable to the container to close the open end thereof. The lid includes an access port for providing communication with the collected fluid specimen through the cover and for permitting extraction of a sample therefrom. A self-sealing closure member is supported by the lid in the access port and seals the access port preventing fluid leakage. The extraction device may be used to extract a sample of the fluid specimen. The extraction device is insertable through the self-sealing closure to permit such extraction. Upon removal of the extraction device, the self-sealing closure recloses the access port.

A centrifugal micro-fluidic device detecting analytes in a liquid specimen and a method of detection of analytes from a liquid specimen using the micro-fluidic device are provided. Reaction efficiency is increased using a repetitive flow of the liquid specimen induced by an alternating combination of capillary force and centrifugal force, thereby enhancing detection sensitivity.

The invention of Integrated Versatile and Systems Preparation of Specimens relates an open module technology which integrates synchronously the methods of protection, isolation and alteration of specimens into the “One for All” product or kit. The product or kit comprises a core module without or with Plug-in modules and a set of comprehensive protocols which can simultaneously or individually isolate systems biomolecules including DNA / ccfDNA, Large RNA / mRNA / ccfRNA, Small RNA / miRNA / ccfmiRNA, Protein, Lipid, Carbohydrates, and Metabolite versatilely from a vast variety of specimens including solid specimens and liquid specimens. The product or kit can accept new and custom Plug-in modules to expand functions and applications. The product or kit prepares specimens and biomolecules with features and benefits of high quality, easy, fast, no toxicity, safe to user and environment, low demanding, cost-effective, reducing waste, saving nature resources and protecting environment, and leads to a low-carbon and Green economy in preparation of specimens.

A centrifugal micro-fluidic device detecting analytes in a liquid specimen and a method of detection of analytes from a liquid specimen using the micro-fluidic device are provided. Reaction efficiency is increased using a repetitive flow of the liquid specimen induced by an alternating combination of capillary force and centrifugal force, thereby enhancing detection sensitivity.

The present invention provides a reagent composition for detecting β-lactamase including as a β-lactamase detection substrate 3-[2,4-dinitrostyryl]-7-(2-thienylacetamido]-3-cephem-4-carboxylic acid, or 7-[2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxy-imino)acetamido]-3-(2,4-dinitrostyryl)-3-cephem-4-carboxylic acid, and at least one β-lactamase inhibitor selected from the group consisting of clavulanic acid, aztreonam, ethylenediaminetetraacetic acid, and cloxacillin, which composition can detect β-lactamases rapidly and easily with high sensitivity. The present invention also provides a detection kit including the detecting reagent composition. Further, the present invention provides a β-lactamase detection method where a liquid specimen containing a target substance to be analyzed is brought into contact with the composition.

The invention of Integrated Versatile and Systems Preparation of Specimens relates an open module technology which integrates synchronously the methods of protection, isolation and alteration of specimens into the “One for All” product or kit. The product or kit comprises a core module without or with Plug-in modules and a set of comprehensive protocols which can simultaneously or individually isolate systems biomolecules including DNA / ccfDNA, Large RNA / mRNA / ccfRNA, Small RNA / miRNA / ccfmiRNA, Protein, Lipid, Carbohydrates, and Metabolite versatilely from a vast variety of specimens including solid specimens and liquid specimens. The product or kit can accept new and custom Plug-in modules to expand functions and applications. The product or kit prepares specimens and biomolecules with features and benefits of high quality, easy, fast, no toxicity, safe to user and environment, low demanding, cost-effective, reducing waste, saving nature resources and protecting environment, and leads to a low-carbon and Green economy in preparation of specimens.

Provided are a device and a method for pre-treating and injecting a liquid specimen. The device includes a first syringe comprising: a first tube having an open top and a first hole in the bottom; and protrusions formed in a lower and outer wall of the first tube; a second syringe comprising: a second tube having an open top and a second hole in the bottom and having an inner diameter greater than an outer diameter of the first tube; a second piston capable of moving along an inner wall of the second tube and having a third hole; and a communication channel providing a fluid communication between the first hole of the first tube and the third hole of the second piston and fixing the second piston to the first tube; and a joint portion being attachable to and detachable from a top of the second tube and having an opening having a shape which corresponds to a transverse cross-section of the first tube and grooves having a shape which corresponds to the shape of the protrusions such that the first tube can pass through the joint portion when the protrusions are matched with the grooves.

It is intended to provide a reagent composition for detecting beta-lactamase which contains 3-[2,4-dinitrostyryl]-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid or 7-[2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-(2,4-dinitrostyryl)-3-cephem-4-carboxylic acid as a substrate for detecting beta-lactamase together with at least one beta-lactamase inhibitor selected from among clavulanic acid, aztreonam, ethylenediaminetetraacetic acid and cloxacillin and by which beta-lactamase can be quickly and easily identified at a high sensitivity. Moreover, a detection kit containing the above detection reagent composition and a method of detecting beta-lactamase comprising contacting a liquid specimen containing the subject to be analyzed with the above composition are provided.

Provided herein are methods and devices for rapid testing of solid, semi-solid, or liquid specimens, such as stool, blood, urine, saliva, or swab specimens of the cervix, urethra, nostril, and throat, and for environmental testing.

The present invention provides an improved, leak proof, air tight, cost-effective, plastic liquid specimen container device and methods of use, comprised of a container, a lid, a lid groove containing a gasket therein that is configured to cover and tighten over the rim of the container, a lid flange, and a thin hook in the container containing a second gasket that is compressed by the lid flange when the lid is closed over the container. The improved container device of the present invention thus provides two, independent, internal seals that protect the liquid contents therein for extended periods of time, even if the plastic undergoes deformation, during transport, especially air transport, and under varying temperature and atmospheric pressure.

A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided.

A specimen box for an electron microscope capable of observing a general specimen or a live cell is formed of a housing. The housing includes a receiving chamber formed therein and at least one view hole formed on each of a top side thereof and a bottom side thereof and communicating with the receiving chamber and coaxially aligned with the other. The distance between a bottom end of the view hole located on the top side of the housing and a top end of the view hole located on the bottom side of the housing is smaller than 50 μm. The housing is ultra-thin to enable penetration of the electron beam therethrough even though a liquid specimen is injected into the housing. A general specimen or a live cell can be put into the housing for the microscopic observation under the electron microscope.

The present invention relates to a device for automatic pipetting of a liquid specimen, essentially comprising: a) at least one means for sampling-dispensing the liquid specimen; b) at least one compartment for receiving the liquid specimen, intended to receive all or part of the liquid specimen sampled by said sampling-dispensing means; c) at least one data acquisition means; d) at least one data processing means integrated within said pipetting device and / or delocalized, able to process the data acquired by the data acquisition means; e) at least one means for communication between the pipetting device and a data retrieval device, said communication means being able to transfer the data between said data acquisition means and said data processing means, when the latter is delocalized; and f) at least one power supply means; the data acquisition means being a means for identifying the liquid specimen and / or the container or containers intended to receive all or part of said liquid specimen.

A method capable of easily collecting microorganisms or cells in a short time without using a special device, comprising the steps of preparing a centrifugal tube (1) in which the inside thereof is divided into upper and lower parts by a filter (14) and water absorbing resin particles (15) are disposed on the filter (14), pouring liquid specimen in the centrifugal tube (1) so that the liquid specimen touches the water absorbing resin particles (15) to absorb the liquid specimen by the resin particles so as to arrest microorganisms or cells on the surfaces of the particles, pouring collecting liquid into the centrifugal tube (1) to collect the microorganisms or cells with the collecting liquid and, by centrifugal separation, accumulating the collecting liquid at the bottom part of the centrifugal tube (1) through the filter (14).

The invention discloses a medical tool capsule, which comprises a tool device and an in vitro wireless remote controller. The tool device comprises a tool power source, a tool switch circuit, a tool power, a tool, a signal receiver and a microprocessor, wherein, the tool switch circuit is connected with the microprocessor, the tool switch circuit is connected between the tool power and the tool power in series, the tool power drives the tool to carry out the drug application and the acquisition operations; the in vitro remote controller sends command to the microprocessor through a receiver-transmitter, to control the tool device to carry out drug application, collection, staining, and labeling. According to the in vitro remote operation, the medical tool capsule can carry out the collection of the liquid specimen, the staining for the dubious region, the labeling of the focus and the direct drug application and treatment to the focus, thereby the diagnostic accuracy rate of the disease and the therapeutic effective rate can be greatly enhanced, the treatment cycle is shortened, the structure is simple, and the manufacture cost is low.

An organism testing apparatus adapted to measure the organisms in a specimen in stable fashion is disclosed in which the organisms are stained, the specimen is concentrated and the information on the organisms contained in the specimen are acquired through a simple process. The apparatus includes a staining unit for staining the organisms having live cells existing in a flowing liquid specimen, a concentration unit for concentrating the organisms in a flowing stained specimen, an individual measuring unit for acquiring the image information on the individuals containing the organisms in the concentrated specimen, and a control unit for measuring the organisms based on the image information on the individuals output from the individual measuring unit.

Provided herein are methods and devices for rapid testing of solid, semi-solid, or liquid specimens, such as stool, blood, urine, saliva, or swab specimens of the cervix, urethra, nostril, and throat, and for environmental testing.

The present invention is an analyzer for analyzing a target substance contained in a sample using a reagent containing magnetic particles, the analyzer comprising: a magnetic capturing section that comprises a first holder configured to hold a container accommodating a liquid specimen containing a sample and the reagent containing the magnetic particles and that comprises a first magnetic force generating member configured to magnetically capture the magnetic particles in the container held by the first holder; a target substance separating section that comprises a second holder configured to hold the container and a second magnetic force generating member configured to magnetically capture the magnetic particles in the container held by the second holder, and that discharges a cleaning liquid into the container held by the second holder and aspirates a liquid in the container held by the second holder while magnetically capturing the magnetic particles in the container with the second magnetic force generating member; and a container transferring section configured to transfer the container from the magnetic capturing section to the target substance separating section, wherein the first magnetic force generating member of the magnetic capturing section is arranged on a lower side of the container held by the first holder and is configured to magnetically capture the magnetic particles in the container held by the first holder. The present invention is also to present an analyzing method for analyzing a target substance contained in a sample using a reagent containing magnetic particles.

The light scattering detector for in-situ microanalysis collects the Rayleigh scattering signal, which is mach greater than Raman scattering signal, for detection. In the design of optical path, theinterference caused by Raman scattering signal is non-significant. The liquid specimen to be detected needs no atomizing or evaporation in advance. The light scattering detector of the present invention may be used alone for microanalysis, together with capillary electrophoresis apparatus, or together with flow injection analyzer and liquid phase chromatograph for in-situ post-column detection and analysis.

A closed system for withdrawing, measuring, and isolating discrete quantities of liquid specimen for cryogenic preservation and recovery includes a fluoroplastic storage tube, an aspirating device, such as a syringe, and an impermeable barrier. The aspirating device can be used to meter exact amounts of specimen into the tube, and then to isolate the specimen within the confines of the tube during freezing, storage, thawing. The specimen in the tube can be withdrawn into the same syringe. While encapsulated, the specimen is protected from contact with air, gasses, and moisture in the cryogenic atmosphere. The specimen can be recovered from the frozen state without compromising sterility or exposure to any external environment.

The present invention provides an improved, leak proof, air tight, cost-effective, plastic liquid specimen container device and methods of use, comprised of a container, a lid, a lid groove containing a gasket therein that is configured to cover and tighten over the rim of the container, a lid flange, and a thin hook in the container containing a second gasket that is compressed by the lid flange when the lid is closed over the container. The improved container device of the present invention thus provides two, independent, internal seals that protect the liquid contents therein for extended periods of time, even if the plastic undergoes deformation, during transport, especially air transport, and under varying temperature and atmospheric pressure.

A specimen box for an electron microscope capable of observing a general specimen or a live cell is formed of a housing. The housing includes a receiving chamber formed therein and at least one view hole formed on each of a top side thereof and a bottom side thereof and communicating with the receiving chamber and coaxially aligned with the other. The distance between a bottom end of the view hole located on the top side of the housing and a top end of the view hole located on the bottom side of the housing is smaller than 50 μm. The housing is ultra-thin to enable penetration of the electron beam therethrough even though a liquid specimen is injected into the housing. A general specimen or a live cell can be put into the housing for the microscopic observation under the electron microscope.

Improved control of continuous processes that handle liquids. Data generated by this invention is used to control gas contents of liquids within optimum ranges, for instance in paper coating processes and in the manufacture of food products (ketchup), personal care products (shampoo), paints, and in any industry where information on entrained and / or dissolved gases, and related parameters such as true density of and gas solubility in process liquids, is employed to optimize processing. The amount of gas in a liquid is determined by subjecting a mixture of an incompressible liquid sample and a compressible gas to three or more different equilibrium pressure states, measuring the temperature and volume of the mixture at each of the pressure states, determining the changes in volume of the mixture between at least two different pairs of pressure states, and calculating the amount of gas in the liquid sample. The inventive apparatus includes: a reservoir for process fluid; piping through which fluid may be pumped, the piping being under the control of a pressure regulator which is capable of setting at least three different pressures P1, P2, and P3 in the apparatus; at least three fluid control valves V1, V2, and V3; a pressure gauge; a temperature gauge; and a density gauge.

A pipette comprises a pipette housing comprising an upper end and a lower end, a nipple configured to contact and retain a pipette tip, a drive apparatus configured to aspirate a liquid specimen into the pipette tip and expel the liquid specimen from the pipette tip, and an ejection apparatus. The ejection apparatus comprises a curved support rotatably mounted within the pipette housing, an ejection rod, a first sensing element positioned on the ejection rod and configured to be guided on a first curve on a perimeter of the curved support, and an operating element coupled to the curved support and configured to rotate relative to the pipette housing. The ejection apparatus is configured to rotate the curved support out of a start position by rotating the operating element. The first curve displaces the first sensing element downward a the ejection rod moves the pipette tip off of the nipple.

Provided are a biosensor and a method of manufacturing the same which can reduce an amount of liquid specimen required for measurement (a required amount of the liquid specimen), and conduct measurement with higher accuracy. In the biosensor, the liquid specimen is developed on a development layer by using chromatography and a test substance in the liquid specimen is measured. By reducing the thickness of the development layer (to 20 μm to 135 μm), the required amount of the liquid specimen is reduced. The thickness of the development layer is controlled to a smaller thickness thus, so that the required amount of the liquid specimen can be reduced in response to the measurement of a test substance in each liquid specimen in a state in which the accuracy of analysis is properly kept.

A method of operating liquid in a vacuum or low-pressure environment and observing the operation and a device for the operation and the observation respectively, including the steps of preparing a housing, putting the housing in the vacuum or low-pressure environment and keep a predetermined temperature difference between liquid, vapor, and buffer chambers, infusing vapor into the vapor chamber through a gas inlet and control the vapor pressure inside the vapor chamber to be equal to the saturated vapor pressure of a liquid specimen inside the liquid chamber under the same temperature to prevent the inside liquid from volatilization, and evacuating the buffer chamber through the pumping port to pump out the vapor and prevent the vapor from exhausting through outer apertures out of the housing. A probing source can pass through the outer, inner, and vapor apertures for observation and analysis of the liquid specimen inside the liquid chamber.

In order to prevent excess and deficiency of an amount of a liquid specimen injected into a biochemical reaction cartridge through eye observation, at least a portion of a chamber 7 for containing a liquid specimen B is constituted by a transparent portion 13 so that the amount of the light specimen B can be visually observed externally. The transparent portion 13 is provided with an indicator 14a for indicating a minimum required amount of the light specimen B.