2350results about "Supporting apparatus" patented technology

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master / copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master / copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

The invention belongs to the field of laboratory automation equipment, and discloses a control method and system of a task execution device for physical and chemical experiment operation, and the method comprises the steps: initializing and calibrating the device; receiving and analyzing an experiment task instruction; collecting object information through a visual sensor; the upper computer generates an execution scheme according to the strategy library; the electric control rotary clamping jaw is driven to complete operation; force and displacement parameters are monitored in real time, and dynamic adjustment actions are fed back through a closed loop; and judging that the operation is completed according to the threshold. The system comprises a visual sensor, a rotary driving body, an electric control rotary clamping jaw and an upper computer. By integrating visual identification and force sense feedback, fine operations such as clamping, taking and placing, bottle cap screwing and the like can be completed in a self-adaptive mode, the efficiency, precision and reliability of laboratory automatic operation are remarkably improved, manual operation errors are reduced, and good application prospects are achieved.

Methods for determining a location of a feature in a spatial array with features include: (a) providing an array with a first set of one or more features immobilized on a substrate, a first feature of the first set having a first barcoded oligonucleotide with a first spatial barcode and a first constant sequence, and a second set of one or more features immobilized on the substrate, a second feature of the second set having a second barcoded oligonucleotide with a second spatial barcode and a second constant sequence; (b) attaching the first constant sequence to the second constant sequence to generate a nucleic acid product; (c) determining all or a portion of a sequence of the nucleic acid product or a complement thereof; and (d) associating the second barcoded oligonucleotide with the first barcoded oligonucleotide in the nucleic acid product.

The utility model provides a magnetic frame, and relates to the technical field of biology and medical treatment. The magnetic frame comprises a magnetic frame body and a magnetic fixing piece, a placing space is arranged on one side of the magnetic frame body, and one end, away from the magnetic frame body, of the placing space is open; the two ends of the magnetic fixing piece are arranged on the left side and the right side of the opening of the containing space respectively. According to the magnetic frame, an existing magnetic frame structure is thoroughly changed, and one side of the magnetic frame body is provided with the containing space used for containing the magnetic bead incubation structure and the magnetic fixing belt used for fixing the magnetic bead incubation structure in the containing space, so that the magnetic bead incubation structure of a non-centrifugal tube is fixed.

The invention relates to a space experiment sample observation mechanism, a space experiment device and a fluid physics experiment cupboard, the space experiment sample observation mechanism comprises a plug connector, a sample sleeve and a first heating sheet, the first heating sheet is arranged on the sample sleeve, one end of the sample sleeve is fixed on the back side surface of the plug connector, and the other end of the sample sleeve is fixed on the back side surface of the plug connector; a sample clamping part is arranged at the other end of the sample sleeve; the sample clamping part comprises a circular-arc-shaped sample clamping piece with an opening in the upper side, a bottom connecting piece and a cylindrical sample clamping piece, the sample sleeve, the circular-arc-shaped sample clamping piece and the cylindrical sample clamping piece are coaxially arranged, and the sample sleeve, the circular-arc-shaped sample clamping piece, the bottom connecting piece and the cylindrical sample clamping piece are sequentially connected; the bottom of the arc-shaped sample clamping piece is fixedly connected with the bottom of the cylindrical sample clamping piece through a bottom connecting piece, a sample observation interval position is reserved between the arc-shaped sample clamping piece and the cylindrical sample clamping piece, and a sample observation opening position penetrating in the direction perpendicular to the axis of the cylindrical sample clamping piece is formed in the side wall of the cylindrical sample clamping piece.

A packaging for two pipette tip carriers comprising a peripheral side wall with two longitudinal and transverse sides providing a rectangular box with a passage connecting openings on the top and on the bottom of the box surrounded by a top rim vertically spaced apart from a bottom rim. The top rim is configured to support one of the two pipette tip carriers and the bottom rim is configured to support the other one of the two pipette tip carriers. At least one protrusion vertically extends from the top rim and at least one protrusion vertically extends from the bottom rim wherein each protrusion is configured to pass through a complementary passage in the two pipette tip carriers for horizontally positioning the two carriers on the rectangular shaped box with respect to each other.

The invention relates to the technical field of oil product detection, in particular to a full-automatic condensation point determinator and a determination method.The full-automatic condensation point determinator comprises a base and a test tube, the top of the base is fixedly connected with a mounting base, the surface of the base and the surface of the mounting base are provided with a test bath mechanism and a supporting mechanism, and the test bath mechanism enables a motor to drive a test bath to rotate; the rotation angle of the motor is controlled through a preset program, precise positioning is achieved, the tedious operation of hole-by-hole adjustment of the original structure is avoided, the rotating shaft is locked through mechanical clamping, angle deviation in the testing process is prevented, then manual adjustment is replaced by the motor and the electric push rod, and the test efficiency is improved. The double locking effect is achieved, accidental displacement can be prevented, and precision and efficiency are improved; according to the clamping mechanism, the four arc-shaped clamping plates apply uniform radial pressure through the first springs to clamp the outer wall of the test tube, the inner diameters of the clamping plates are gradually increased from top to bottom, and the clamping mechanism is compatible with test tubes with different outer diameters.

A microplate holder comprises a top shell portion comprising a plurality of holes constructed and arranged to receive a pipette; and a bottom shell portion constructed and arranged to couple to the top shell portion, the top shell portion and the bottom shell portion configured to at least partially enclose a microplate having a plurality of wells vertically aligned with the plurality of holes of the top shell portion, the bottom shell portion having a bottom region that exposes a bottom surface of the microplate to a light generating source that provides backside illumination for a photoactivation process regarding liquid contents of the microplate.

A fluid loading module, a fluid loading system, a fluid loading method, and a gene sequencing device. The fluid loading module is configured to load fluid to a solid-phase slide. The solid-phase slide comprises a plurality of openings. The fluid loading system comprises a manifold block and a valve device. A first flow channel is disposed in the manifold block, and a first fluid inlet, a second fluid inlet, a first flow channel outlet and a plurality of slide interfaces are provided on the manifold block, both the first fluid inlet and the first flow channel outlet being connected to the first flow channel. Each slide interface is provided with a first hole, the first hole of each slide interface being connected to one opening of the solid-phase slide. The valve device comprises a plurality of first valves. Each first valve is connected to the first flow channel and the first hole of one slide interface, such that the first fluid inlet is in communication with a corresponding slide interface by means of one first valve. The second fluid inlet is in communication with another slide interface.

A microfluidic chip liquid inlet device disclosed by the present invention comprises a bottom plate and supporting legs, a liquid inlet structure is arranged above the bottom plate, the liquid inlet structure comprises a liquid inlet mechanism, a liquid injection mechanism and a feeding mechanism, and the liquid inlet mechanism comprises a first motor, a rotating rod, a mounting plate, a rotating rod and a first bearing plate. The output end of the first motor is connected with the bottom of the rotating rod, the top of the rotating rod is connected with the bottom of the mounting plate, and the bottom of the mounting plate is connected with the top of the rotating rod. According to the invention, micro-fluidic chips with different sizes can be rapidly and conveniently clamped and fixed, and a plurality of micro-fluidic chips can be subjected to liquid feeding work at the same time, so that the problem that the plurality of micro-fluidic chips cannot be rapidly and conveniently used at the same time is solved; and moreover, the problem that the micro-fluidic chips with different sizes cannot be quickly and conveniently clamped and fixed is solved, and the working efficiency of the liquid inlet device is improved.

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

Methods for determining a location of a feature on an array include: (a) providing a first array with a first plurality of features immobilized on a first substrate; (b) providing a second array with a second plurality of features immobilized on a second substrate; (c) aligning the first array with the second array; (d) hybridizing a first barcoded oligonucleotide of the first array to a second barcoded oligonucleotide of the second array, thereby producing a combined nucleic acid that includes first and second spatial barcodes; (e) determining all or a portion of the sequence of the combined nucleic acid; and (f) identifying the second barcoded oligonucleotide associated with the first barcoded oligonucleotide in the combined nucleic acid, and determining the location of a second feature in the second array.

The invention relates to a space microscopic sample support, a space experiment device and a fluid physics experiment cupboard, the space microscopic sample support comprises a support body and a heating sheet, one side surface of the support body is provided with the heating sheet, the other side surface of the support body is recessed to form a sample slot, and the heating sheet is arranged in the sample slot. And an observation light path penetrating through the bottom of the sample slot is arranged on the bracket body. According to the space microscopic sample support, a microscopic sample is taken out by an astronaut and placed on the sample support during observation, the sample support can maintain the liquid state of the microscopic sample during observation, and temperature uniformity is ensured.

The invention discloses a new material drier viscosity detection device, and relates to the technical field of new material drier detection.The new material drier viscosity detection device comprises a workbench and a switching assembly, a sample cup is arranged at one end of the top of the workbench, a detection assembly is arranged in the center of the top of the workbench, and the switching assembly is connected to the upper portion of the detection assembly; and the switching assembly comprises a rotating motor. The lifting motor drives the screw rod to drive the lifting seat to move downwards, so that the reset spring pushes the rotating ring to synchronously descend, automatic butt joint of the rotor and the viscometer main body and detection operation by immersing the rotor into a new material drier solution are realized, and the system stability is enhanced through a guide column limiting structure during detection; after detection is finished, when the lifting seat resets, the connecting fluted disc can be automatically separated, the rotor is automatically transferred to the ultrasonic cleaning machine in a detection gap through linkage of the rotating motor and the cleaning mechanism, and seamless connection of the detection process and the cleaning process is achieved in cooperation with rapid drying of an air heater.

The invention relates to a space experiment sample temperature processing device and a space fluid physics experiment cabinet, and the space experiment sample temperature processing device comprises a housing, an alternating temperature on-orbit sample drawer, a constant temperature on-orbit sample drawer, an alternating temperature descending sample drawer and a constant temperature descending sample drawer. An alternating temperature on-orbit sample cavity, a constant temperature on-orbit sample cavity, an alternating temperature descending sample cavity and a constant temperature descending sample cavity are arranged in the shell, an alternating temperature on-orbit sample drawer is arranged in the alternating temperature on-orbit sample cavity, and a constant temperature on-orbit sample drawer is arranged in the constant temperature on-orbit sample cavity; the alternating temperature descending sample drawer is arranged in the alternating temperature descending sample cavity, and the constant temperature descending sample drawer is arranged in the constant temperature descending sample cavity; the shell is provided with a temperature regulating mechanism for regulating and controlling the temperature of the alternating temperature on-orbit sample drawer, the constant temperature on-orbit sample drawer, the alternating temperature descending sample drawer and the constant temperature descending sample drawer.

Methods for determining a location of a feature on a spatial array include (a) providing an array of features on a substrate, where a feature of the array includes a barcoded oligonucleotide having, in a 5′ to 3′ direction, a spatial barcode, a cleavage domain, and a constant sequence; (b) hybridizing a priming oligonucleotide to the constant sequence; (c) extending the priming oligonucleotide using the barcoded oligonucleotide as a template; and (d) determining all or a portion of a sequence of the extended priming oligonucleotide corresponding to the spatial barcode, or a complement thereof, and a location of the extended priming oligonucleotide, and using the location of the extended priming oligonucleotide to determine the location of the feature on the spatial array.

The invention discloses a high-flux automatic chemical synthesis workstation, which relates to the technical field of chemical synthesis, and comprises a base, the base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-flux chemical reaction module, a gun head box, a cover plate and a liquid storage tank, and the negative pressure suction filter and the magnetic stirring reactor can be replaced by other detection instruments. The cover plate is in lap joint with a screw, the base is further provided with a moving device, the moving device is provided with a button assembly, a clamping jaw assembly and a pipetting assembly, the pipetting assembly is used for pipetting, and the clamping jaw assembly drives the cover plate to the high-flux chemical reaction module for sealing. The sealing module is driven to the reactor through the clamping jaw assembly after being fastened through the fastening assembly, and real-time observation can be carried out during remote operation. By means of the technical scheme, it is guaranteed that high-throughput chemical synthesis experiments including pipetting, reaction system sealing, reaction starting, gradient dilution and suction filtration are completed in one work station.

Described herein are various fluid provision systems that may be used in a laboratory setting. The fluid provision systems minimize waste of pipetted liquid sample or reagents and may be used, e.g., in combination with a multi-well plate such as in NGS processes. Other systems include those configured for compatibility with centrifuge rotors or multichannel pipettes with 12 or more channels.

The utility model relates to the technical field of water conservancy projects, and discloses a water conservancy project water quality detection device which comprises a working table, a rotating table is arranged on the upper side of the working table, an L-shaped connecting plate is fixedly connected to the upper surface of the working table, and a water quality detector body is arranged on the surface of the L-shaped connecting plate. The water quality detector body comprises a detection probe arranged on the lower surface of a transverse plate of an L-shaped connecting plate, a positioning groove is formed in the surface of a rotating table, a detection cup can be conveniently placed through the positioning groove, a gear makes contact with a tooth groove through rotation of the rotating table, a sealing plate rotates subsequently, and then the detection cup is exposed; the water quality detection device is simple in structure and convenient to use, subsequent water quality detection is facilitated, the situation that a detected sample is polluted by the external environment is avoided as much as possible, the accuracy of subsequent water quality detection is guaranteed, meanwhile, the situation that the sample in the detection cup is scattered is avoided, the safety of the device is greatly improved, and the quality and effect of subsequent water quality detection are guaranteed. And the practicability is high.

A holder device for holding a plurality of vials to be moved in a processing line. The holder device includes a plate having a plurality of housing seats for housing the vials and a plurality of rigid spacer elements arranged within the housing seats and configured to maintain the vials in a suspended position with respect to a substantially horizontal operating surface of the processing line. Each housing seat includes an open base intended to face towards the operating surface.

A semiconductor biosensor diagnostic system is provided. The semiconductor biosensor diagnostic system includes a diagnostic cartridge and a cartridge diagnostic base. The diagnostic cartridge includes a biosensor device and a fluid-guide body over the biosensor device. The fluid-guide body includes a first pumping opening, a second pumping opening, a buffer reservoir, a sample reservoir, and a plurality of channels configured to provide a first loop including the first pumping opening and the buffer reservoir, and a second loop including the second pumping opening and the sample reservoir. The first loop and the second loop sharing a common channel passing through the biosensor device. The cartridge diagnostic base includes a plurality of micro pumps coupled to the first pumping opening and the second pumping opening, and a sensing structure configured to receive a sensing information from the biosensor device.