1544results about "Supporting apparatus" patented technology

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master / copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

The invention belongs to the field of laboratory automation equipment, and discloses a control method and system of a task execution device for physical and chemical experiment operation, and the method comprises the steps: initializing and calibrating the device; receiving and analyzing an experiment task instruction; collecting object information through a visual sensor; the upper computer generates an execution scheme according to the strategy library; the electric control rotary clamping jaw is driven to complete operation; force and displacement parameters are monitored in real time, and dynamic adjustment actions are fed back through a closed loop; and judging that the operation is completed according to the threshold. The system comprises a visual sensor, a rotary driving body, an electric control rotary clamping jaw and an upper computer. By integrating visual identification and force sense feedback, fine operations such as clamping, taking and placing, bottle cap screwing and the like can be completed in a self-adaptive mode, the efficiency, precision and reliability of laboratory automatic operation are remarkably improved, manual operation errors are reduced, and good application prospects are achieved.

Methods for determining a location of a feature in a spatial array with features include: (a) providing an array with a first set of one or more features immobilized on a substrate, a first feature of the first set having a first barcoded oligonucleotide with a first spatial barcode and a first constant sequence, and a second set of one or more features immobilized on the substrate, a second feature of the second set having a second barcoded oligonucleotide with a second spatial barcode and a second constant sequence; (b) attaching the first constant sequence to the second constant sequence to generate a nucleic acid product; (c) determining all or a portion of a sequence of the nucleic acid product or a complement thereof; and (d) associating the second barcoded oligonucleotide with the first barcoded oligonucleotide in the nucleic acid product.

The utility model provides a magnetic frame, and relates to the technical field of biology and medical treatment. The magnetic frame comprises a magnetic frame body and a magnetic fixing piece, a placing space is arranged on one side of the magnetic frame body, and one end, away from the magnetic frame body, of the placing space is open; the two ends of the magnetic fixing piece are arranged on the left side and the right side of the opening of the containing space respectively. According to the magnetic frame, an existing magnetic frame structure is thoroughly changed, and one side of the magnetic frame body is provided with the containing space used for containing the magnetic bead incubation structure and the magnetic fixing belt used for fixing the magnetic bead incubation structure in the containing space, so that the magnetic bead incubation structure of a non-centrifugal tube is fixed.

The invention relates to a space experiment sample observation mechanism, a space experiment device and a fluid physics experiment cupboard, the space experiment sample observation mechanism comprises a plug connector, a sample sleeve and a first heating sheet, the first heating sheet is arranged on the sample sleeve, one end of the sample sleeve is fixed on the back side surface of the plug connector, and the other end of the sample sleeve is fixed on the back side surface of the plug connector; a sample clamping part is arranged at the other end of the sample sleeve; the sample clamping part comprises a circular-arc-shaped sample clamping piece with an opening in the upper side, a bottom connecting piece and a cylindrical sample clamping piece, the sample sleeve, the circular-arc-shaped sample clamping piece and the cylindrical sample clamping piece are coaxially arranged, and the sample sleeve, the circular-arc-shaped sample clamping piece, the bottom connecting piece and the cylindrical sample clamping piece are sequentially connected; the bottom of the arc-shaped sample clamping piece is fixedly connected with the bottom of the cylindrical sample clamping piece through a bottom connecting piece, a sample observation interval position is reserved between the arc-shaped sample clamping piece and the cylindrical sample clamping piece, and a sample observation opening position penetrating in the direction perpendicular to the axis of the cylindrical sample clamping piece is formed in the side wall of the cylindrical sample clamping piece.

A packaging for two pipette tip carriers comprising a peripheral side wall with two longitudinal and transverse sides providing a rectangular box with a passage connecting openings on the top and on the bottom of the box surrounded by a top rim vertically spaced apart from a bottom rim. The top rim is configured to support one of the two pipette tip carriers and the bottom rim is configured to support the other one of the two pipette tip carriers. At least one protrusion vertically extends from the top rim and at least one protrusion vertically extends from the bottom rim wherein each protrusion is configured to pass through a complementary passage in the two pipette tip carriers for horizontally positioning the two carriers on the rectangular shaped box with respect to each other.

The invention relates to the technical field of oil product detection, in particular to a full-automatic condensation point determinator and a determination method.The full-automatic condensation point determinator comprises a base and a test tube, the top of the base is fixedly connected with a mounting base, the surface of the base and the surface of the mounting base are provided with a test bath mechanism and a supporting mechanism, and the test bath mechanism enables a motor to drive a test bath to rotate; the rotation angle of the motor is controlled through a preset program, precise positioning is achieved, the tedious operation of hole-by-hole adjustment of the original structure is avoided, the rotating shaft is locked through mechanical clamping, angle deviation in the testing process is prevented, then manual adjustment is replaced by the motor and the electric push rod, and the test efficiency is improved. The double locking effect is achieved, accidental displacement can be prevented, and precision and efficiency are improved; according to the clamping mechanism, the four arc-shaped clamping plates apply uniform radial pressure through the first springs to clamp the outer wall of the test tube, the inner diameters of the clamping plates are gradually increased from top to bottom, and the clamping mechanism is compatible with test tubes with different outer diameters.

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

Methods for determining a location of a feature on an array include: (a) providing a first array with a first plurality of features immobilized on a first substrate; (b) providing a second array with a second plurality of features immobilized on a second substrate; (c) aligning the first array with the second array; (d) hybridizing a first barcoded oligonucleotide of the first array to a second barcoded oligonucleotide of the second array, thereby producing a combined nucleic acid that includes first and second spatial barcodes; (e) determining all or a portion of the sequence of the combined nucleic acid; and (f) identifying the second barcoded oligonucleotide associated with the first barcoded oligonucleotide in the combined nucleic acid, and determining the location of a second feature in the second array.

The invention relates to a space microscopic sample support, a space experiment device and a fluid physics experiment cupboard, the space microscopic sample support comprises a support body and a heating sheet, one side surface of the support body is provided with the heating sheet, the other side surface of the support body is recessed to form a sample slot, and the heating sheet is arranged in the sample slot. And an observation light path penetrating through the bottom of the sample slot is arranged on the bracket body. According to the space microscopic sample support, a microscopic sample is taken out by an astronaut and placed on the sample support during observation, the sample support can maintain the liquid state of the microscopic sample during observation, and temperature uniformity is ensured.

The invention relates to a space experiment sample temperature processing device and a space fluid physics experiment cabinet, and the space experiment sample temperature processing device comprises a housing, an alternating temperature on-orbit sample drawer, a constant temperature on-orbit sample drawer, an alternating temperature descending sample drawer and a constant temperature descending sample drawer. An alternating temperature on-orbit sample cavity, a constant temperature on-orbit sample cavity, an alternating temperature descending sample cavity and a constant temperature descending sample cavity are arranged in the shell, an alternating temperature on-orbit sample drawer is arranged in the alternating temperature on-orbit sample cavity, and a constant temperature on-orbit sample drawer is arranged in the constant temperature on-orbit sample cavity; the alternating temperature descending sample drawer is arranged in the alternating temperature descending sample cavity, and the constant temperature descending sample drawer is arranged in the constant temperature descending sample cavity; the shell is provided with a temperature regulating mechanism for regulating and controlling the temperature of the alternating temperature on-orbit sample drawer, the constant temperature on-orbit sample drawer, the alternating temperature descending sample drawer and the constant temperature descending sample drawer.

Methods for determining a location of a feature on a spatial array include (a) providing an array of features on a substrate, where a feature of the array includes a barcoded oligonucleotide having, in a 5′ to 3′ direction, a spatial barcode, a cleavage domain, and a constant sequence; (b) hybridizing a priming oligonucleotide to the constant sequence; (c) extending the priming oligonucleotide using the barcoded oligonucleotide as a template; and (d) determining all or a portion of a sequence of the extended priming oligonucleotide corresponding to the spatial barcode, or a complement thereof, and a location of the extended priming oligonucleotide, and using the location of the extended priming oligonucleotide to determine the location of the feature on the spatial array.

The invention discloses a high-flux automatic chemical synthesis workstation, which relates to the technical field of chemical synthesis, and comprises a base, the base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-flux chemical reaction module, a gun head box, a cover plate and a liquid storage tank, and the negative pressure suction filter and the magnetic stirring reactor can be replaced by other detection instruments. The cover plate is in lap joint with a screw, the base is further provided with a moving device, the moving device is provided with a button assembly, a clamping jaw assembly and a pipetting assembly, the pipetting assembly is used for pipetting, and the clamping jaw assembly drives the cover plate to the high-flux chemical reaction module for sealing. The sealing module is driven to the reactor through the clamping jaw assembly after being fastened through the fastening assembly, and real-time observation can be carried out during remote operation. By means of the technical scheme, it is guaranteed that high-throughput chemical synthesis experiments including pipetting, reaction system sealing, reaction starting, gradient dilution and suction filtration are completed in one work station.

The utility model relates to the technical field of water conservancy projects, and discloses a water conservancy project water quality detection device which comprises a working table, a rotating table is arranged on the upper side of the working table, an L-shaped connecting plate is fixedly connected to the upper surface of the working table, and a water quality detector body is arranged on the surface of the L-shaped connecting plate. The water quality detector body comprises a detection probe arranged on the lower surface of a transverse plate of an L-shaped connecting plate, a positioning groove is formed in the surface of a rotating table, a detection cup can be conveniently placed through the positioning groove, a gear makes contact with a tooth groove through rotation of the rotating table, a sealing plate rotates subsequently, and then the detection cup is exposed; the water quality detection device is simple in structure and convenient to use, subsequent water quality detection is facilitated, the situation that a detected sample is polluted by the external environment is avoided as much as possible, the accuracy of subsequent water quality detection is guaranteed, meanwhile, the situation that the sample in the detection cup is scattered is avoided, the safety of the device is greatly improved, and the quality and effect of subsequent water quality detection are guaranteed. And the practicability is high.

A semiconductor biosensor diagnostic system is provided. The semiconductor biosensor diagnostic system includes a diagnostic cartridge and a cartridge diagnostic base. The diagnostic cartridge includes a biosensor device and a fluid-guide body over the biosensor device. The fluid-guide body includes a first pumping opening, a second pumping opening, a buffer reservoir, a sample reservoir, and a plurality of channels configured to provide a first loop including the first pumping opening and the buffer reservoir, and a second loop including the second pumping opening and the sample reservoir. The first loop and the second loop sharing a common channel passing through the biosensor device. The cartridge diagnostic base includes a plurality of micro pumps coupled to the first pumping opening and the second pumping opening, and a sensing structure configured to receive a sensing information from the biosensor device.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

The utility model relates to the technical field of chromatographic instruments, in particular to a high-precision liquid chromatograph which mainly comprises a placement assembly fixedly mounted at the top end of a chromatographic instrument body, a position adjusting assembly is clamped on the inner side of the placement assembly, and extrusion buffer assemblies are fixedly mounted on the left side and the right side of the position adjusting assembly; the clamping adjusting assembly is fixedly connected to the inner side of the extrusion buffering assembly, and the stable adjusting assembly is fixedly installed at the bottom ends of the left side and the right side of the chromatograph body and makes contact with the ground to be adsorbed and fixed. According to the high-precision liquid chromatograph, position adjustment is carried out through sliding of the position adjusting assembly in the placing assembly, telescopic extrusion adjustment is carried out through the extrusion buffering assembly arranged on the inner side, the clamping range of the inner side can be controlled, reagent bottles can be conveniently fixed in multiple ranges in cooperation with the multi-size detachable design of the clamping adjusting assembly, and the stability of the high-precision liquid chromatograph is improved. And the stable adjusting assembly is used for connecting and fixing, and pressing adsorption can be adjusted in the using process.

An apparatus may include a microfluidic chip including at least one microfluidic channel and a first at least one electrical interconnect. An apparatus may include a circuit board having at least one interface interconnect and a second at least one electrical interconnect electrically coupled with the first at least one electrical interconnect of the microfluidic chip. An apparatus may include a cartridge enclosing the microfluidic chip and the circuit board, the cartridge including at least one opening allowing access to the at least one microfluidic channel on the microfluidic chip and the at least one interface interconnect.

The invention discloses an optical thermostat with comprehensive vibration reduction and low-temperature in-situ displacement functions, which adopts upper and lower opposite vibration absorbers and a large-mass base to realize first-order to second-order inertial vibration absorption, and further realizes thorough decoupling with an optical platform in a suspension type non-contact manner, and the vibration transmissibility can be reduced to be less than 10%. Resonant frequencies of two systems (a sample table system and a cold head system) are designed to achieve vibration decoupling. The technical problems that in the prior art, the high-grade vibration isolation capacity is insufficient, refrigerator noise is easily coupled to a measuring light path, the low-temperature in-situ precision displacement capacity is lacked, and the contradiction between heat isolation, convenience and cost is difficult to balance can be solved. Under the support of a conventional GM refrigerator, the comprehensive requirements of ultralow basic vibration, strong decoupling of a measurement light path, low-temperature in-situ micron-sized displacement, convenient sample replacement and efficient refrigeration / thermal control are met at the same time.

The utility model relates to a full-automatic all-in-one machine for NGS library building hybridization sequencing interpretation, which is used for sample adding and sequencing of a sequencing chip, and comprises a rack, a manipulator, a library preparation instrument and a sequencing device, the sequencing device comprises a gene sequencer, a sample adding clamping mechanism and a turnover mechanism, the library preparation instrument is used for sample adding of the sequencing chip, and the sample adding clamping mechanism is used for sample adding of the sequencing chip. The sample adding and clamping mechanism comprises a clamping tool and a clamping base, the clamping base is provided with a second positioning groove, the clamping tool is placed in the second positioning groove, the clamping tool clamps the sequencing chip, the overturning mechanism overturns the clamping tool to drive the sequencing chip for sample adding to overturn, the manipulator comprises an execution end and a clamping piece, the clamping piece is arranged at the execution end, and the clamping piece is arranged at the execution end. The clamping piece clamps the clamping tool, and the execution end moves among the library preparation instrument, the turnover mechanism and the gene sequencer, so that the sequencing chip is inserted into a preset position of the slot after being subjected to sample adding and turnover. The clamping tool clamps the sequencing chip, so that the sequencing chip is prevented from being overturned and falling off, automatic insertion of the sequencing chip is realized, and the sequencing efficiency is improved.

The invention relates to the field of space irradiation tests, and provides a multi-degree-of-freedom pose adjusting device for a space irradiation test. The device is formed by sequentially connecting a supporting base, a shear type lifting mechanism, a linear translation mechanism and a pitching mechanism, and can realize accurate translation of a test sample in X, Y and Z axis directions and pitching turnover around a horizontal axis in a vacuum environment. The device provided by the invention is compact in structure and high in adjustment precision, is especially suitable for performing multi-dimensional attitude control on a test sample in a vacuum irradiation environment, and remarkably improves the flexibility and stability of sample positioning and attitude adjustment in a space irradiation test; the problems of motion coupling, precision loss, large occupied space and the like existing in a traditional single-shaft or double-shaft mechanism are solved, high-precision multi-degree-of-freedom motion control under the complex vacuum environment is achieved, and the high-precision multi-degree-of-freedom motion control mechanism has the remarkable advantages of being high in structural integration degree, high in adaptability, high in repeated positioning precision and the like.

The invention relates to a modular floor platform and a laboratory installation based thereon for use in automated laboratories. The floor platform has several profile frame modules (1) and several base plates (3) mounted thereon, forming a platform floor for walking on and setting up laboratory equipment. In addition to the floor platform, the laboratory installation includes an industrial robot (6) and a traversing unit (7) for moving the industrial robot (6). A guide slot (4) in the platform floor allows the traversing unit (7) and the industrial robot (6) to be installed separately on either side of the platform floor by connecting the traversing unit (7) and the industrial robot (6) to each other by means of a connecting element (8) that passes through and is guided in the guide slot (4).The floor platform and the laboratory installation based on it are characterized by their modular and space-saving design, leveling capability and stability, protection against contamination, easy assembly, and adaptability to different laboratory spaces.

A system for clinical analysis by an analytical chip with an actuator device which, in turn, includes a computer module integrating all the signals received by the system and transforming them into analytical results, connectable through a connectivity module with a data processing module connected to an external large-scale clinical data system to generate patterns of diagnoses. A fluid drive module for the impulsion of fluids inside the analytical chip. A thermal module distinguishes thermal areas of the analytical chip. An artificial vision module of the processes is inside the analytical chip. An electronic interface communicates the sensors and actuators integrated in the analytical chip and the actuators of the actuator device with the computer module. A power management module to autonomously power the portable system inside an external container that protects all the previous modules of the actuator device and where the analytical chip is inserted.

A semiconductor biosensor diagnostic system is provided. The semiconductor biosensor diagnostic system includes a diagnostic cartridge (10) and a diagnostic cartridge base (30). The diagnostic cartridge (10) includes a biosensor device (104) and a fluid-guide body (108) over the biosensor device (104). The fluid-guide body (108) includes a first pumping opening (118), a second pumping opening (120), a buffer reservoir (112), a sample reservoir (124), and a plurality of channels (126) configured to provide a first loop including the first pumping opening (118) and the buffer reservoir (112), and a second loop including the second pumping opening (120) and the sample reservoir (124). The first loop and the second loop sharing a common channel passing through the biosensor device (104). The diagnostic cartridge base (30) includes a plurality of micro pumps (312A, 312B) coupled to the first pumping opening (118) and the second pumping opening (120), and a sensing structure (150) configured to receive a sensing information from the biosensor device (104).

The utility model provides a high performance liquid chromatograph for detecting the concentration of vitamin C in human serum. Comprising a degasser, a detector arranged above the degasser, an automatic sample injector arranged above the detector, a solvent frame arranged above the automatic sample injector, a column oven arranged on the automatic sample injector, a side door hinged to the outer side of the degasser, a valve body fixedly installed on the inner side of the degasser and a valve rod installed in the valve body. And an exhaust driving mechanism mounted on the valve body is fixedly mounted on the inner side of the degasser. According to the high performance liquid chromatograph for detecting the human serum vitamin C concentration, a two-way lead screw is automatically matched with thread transmission to drive a first clamping plate and a second clamping plate to move reversely, and then a solvent bottle located on the inner side of an avoiding hole is clamped and fixed through an anti-skid pad; the vibration generated when the high performance liquid chromatograph is used cannot cause the shaking of the solvent bottle, so that the high performance liquid chromatograph can well limit the solvent bottle.

Methods for determining a location of a feature in a spatial array with features include: (a) providing an array with a first set of one or more features immobilized on a substrate, a first feature of the first set having a first barcoded oligonucleotide with a first spatial barcode and a first constant sequence, and a second set of one or more features immobilized on the substrate, a second feature of the second set having a second barcoded oligonucleotide with a second spatial barcode and a second constant sequence; (b) attaching the first constant sequence to the second constant sequence to generate a nucleic acid product; (c) determining all or a portion of a sequence of the nucleic acid product or a complement thereof; and (d) associating the second barcoded oligonucleotide with the first barcoded oligonucleotide in the nucleic acid product.

A thermopneumatic interface includes one or more pneumatic inlet ports in fluid communication with one or more pneumatic outlet ports and a cooling loop extending through the thermopneumatic interface. The cooling loop is configured to maintain the thermopneumatic interface at a baseline temperature. The one or more pneumatic outlet ports are configured to contact a surface of a microfluidic chip. Each pneumatic inlet port is configured to receive a change in pressure and provide the change in pressure to a corresponding pneumatic outlet port. The thermopneumatic interface is configured to maintain the microfluidic chip at the baseline temperature.