Hydroxylapatite coating magnesium alloy medical inner implantation material and method of preparing the same

A hydroxyapatite and implant material technology, applied in medical science, prosthesis and other directions, can solve the problems of poor binding ability of bone and surrounding soft tissue, poor surface biological activity, affecting wide application, etc., to slow down the degradation rate, The effect of good compatibility and good histocompatibility

Inactive Publication Date: 2008-09-03
BEIJING ALLGENS MEDICAL SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of the existing magnesium alloy materials is still too fast to meet the clinical requirements for orthopedic internal fixation materials, and the su

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Magnesium alloy AZ31 was ultrasonically cleaned in acetone for 10 min, then in ethanol for 10 min, and finally in deionized water for 10 min, and dried.

[0022] The cleaned magnesium substrate was treated with biomimetic solution (Ca(NO 3 ) 2 : 5mmol / l, NaH 2 PO 4 : 5mmol / l) for 48 hours, rinsed in deionized water after taking out, and dried. After the obtained coated magnesium substrate was heated to 500°C, it was naturally cooled to room temperature.

[0023] The thickness of the surface hydroxyapatite is 30μm, and the bonding strength with the matrix is ​​30Mpa.

[0024] The material after coating and the material before coating were placed in 0.9% NaCl solution in vitro, and the degradation rate was measured. The results showed that the degradation rate of magnesium alloy material with hydroxyapatite coating slowed down by 60%. .

Embodiment 2

[0026] The magnesium alloy AZ31 substrate was ultrasonically cleaned in acetone for 10 min, then in ethanol for 10 min, and finally in deionized water for 10 min, and dried.

[0027] Pure hydroxyapatite was sintered at 1250°C as a target.

[0028] In a vacuum of 1×10 -5 Under the vacuum degree of Pa, the target is bombarded with argon ions under the condition of 60KeV, and the density of argon ions is 3×10 16 ions / cm 2 .

[0029] Put the magnesium alloy AZ31 which has been bombarded by argon ions into a high-temperature furnace, heat it to 500°C, and then cool it down to room temperature naturally.

[0030] The thickness of the surface hydroxyapatite is 35 μm, and the bonding strength with the matrix is ​​80Mpa.

[0031] The material after coating and the material before coating were placed in 0.9% NaCl solution in vitro, and the degradation rate was measured, and the degradation rate of the magnesium alloy material with the hydroxyapatite coating slowed down by 70%.

Embodiment 3

[0033] The magnesium alloy AZ91 substrate was ultrasonically cleaned in acetone for 10 min, then in ethanol for 10 min, and finally in deionized water for 10 min, and dried.

[0034]High-purity hydroxyapatite is used as the powder material, which is wet ground for 10 hours and passed through a 300-mesh sieve. The particle size distribution range of the hydroxyapatite powder is 0.4-50 μm. Disperse the hydroxyapatite powder in an ethanol solvent, add appropriate polyvinyl alcohol, and fully disperse the powder, immerse the magnesium alloy AZ91 substrate in it for 0.5h, take it out, put it in a high-temperature furnace, and heat it at 1050°C Sintering at temperature for 3 hours.

[0035] The thickness of the surface hydroxyapatite is 5μm, and the bonding strength with the matrix is ​​35Mpa.

[0036] The material after coating and the material before coating were placed in 0.9% NaCl solution in vitro, and the degradation rate was measured, and the degradation rate of the magnesiu...

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Abstract

The invention relates to a hydroxyapatite coating magnesium alloy medical implantation material and a preparation method thereof. The hydroxyapatite coating magnesium alloy medical implantation material is characterized in that: the surface of a magnesium alloy substrate is attached with a hydroxyapatite coating layer. The preparation method of the hydroxyapatite coating magnesium alloy medical implant material can adopt the bionic solution growing method, the ion beam deposition method, the coating and sintering process, the plasma spray method, the discharge plasma sintering method or the electrophoresis deposition method. The magnesium alloy material with the hydroxyapatite coating structure which is provided by the invention can effectively slow down the degradation rate of the magnesium alloy; at the same time, the coating layer can not only have great tissue compatibility, but can also be conductive to connective tissue attachment and the growth of the bone tissues, improve the bone healing rate and shorten the healing time.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a magnesium alloy medical implant material with a hydroxyapatite coating on the surface, especially an internal fixation or implant material for bone surgery or plastic surgery and a preparation method thereof. Background technique [0002] Magnesium alloy is a biodegradable metal material. Pure magnesium was first used in bone tissue repair and plastic surgery in the 1930s. However, due to the rapid degradation rate of pure magnesium and the generation of a large amount of hydrogen gas, it is limited. its application. However, with the development of alloy technology, more alloy elements have been discovered and applied, so that degradable magnesium alloys have been re-recognized by people. [0003] Studies have shown that magnesium alloys have good biocompatibility and excellent mechanical properties. The addition of some other alloying elements, especially rare earth eleme...

Claims

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Application Information

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IPC IPC(8): A61L27/42
Inventor 崔菡焦延鹏张余尹庆水王本学
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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