Bio-derived material with high tissue compatibility and long acting anti-infection as well as preparation method and application thereof

Abstract

The invention relates to a bio-derived material with high tissue compatibility and long acting anti-infection. The bio-derived material comprises the components of a cell-free matrix and absorbable anti-infective nanometer particles, wherein the amount of the absorbable anti-infective nanometer particles implanted into the cell-free matrix have the range of 100-1000 micrograms / cm<3> according to the content of the inorganic antibacterial agent. A preparation method of the bio-derived material comprises the following steps of: (1) preparing absorbable inorganic antibacterial agent nanometer particles; (2) carrying out cell-free modifying treatment on the bio-derived material; and (3) constructing a nanometer-modified bio-derived material by using a self-assembly technology. The bio-derivedmaterial has the advantages of directly contacting an abdominal cavity, long acting anti-infection, high tissue compatibility and strong ability to promote cell proliferation and can be used for contaminated wounds or infected wounds and the like; after implanted in vivo, the inorganic antibacterial nanometer particles burst a medicament within a short period (not more than 2 h) to quickly realize effective concentration so that the duration time of the effective blood concentration reaches 2 weeks to 3 months or even longer; and the invention has favorable application potential in the rehabilitation treatment of various tissue organs.

Description

Bio-derived materials with high tissue compatibility and long-acting anti-infection and their preparation and application technical field The invention belongs to the field of biologically derived materials and their preparation and application, in particular to a biologically derived material with high tissue compatibility and long-acting anti-infection, as well as its preparation and application. Background technique At present, surgical clinics urgently need repair materials with strong anti-infection ability, can be used in contaminated or infected wounds, and have high tissue compatibility. However, synthetic materials have many congenital defects, and it is difficult to meet this demand. Because synthetic materials improve anti-infection properties, anti-infection components are generally added on the surface, which cannot be implanted internally. The reason is that the incorporation of antibacterial agent molecules into the polymer structure of synthetic materials wi...

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Problems solved by technology

Bio-derived materials are not widely used as repair materials in China at present, and the reasons include: ①The anti-infection property still needs to be improved. Infectivity is still unsatisfactory. For example, foreign studies have shown that the failure rate of biologically derived materials is still >50% when used to repair polluted or infected body wall defects; And histocompatibility is affected by many factors, including the specific decellularization method, source material strain, age, location (such as the use of pig small intestine to prepare biological materials including jejunum and ileum), etc., so the product performance varies greatly between different batches (such as thickness, mechanical parameters and tissue compatibility, etc.), it is necessary to raise the standard

At present, there are no relevant literature reports on bio-derived materials with high tissue compatibility and long-term anti-infection and their preparation

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