A kind of silk support and its preparation and application
A technology of silk and silk fibroin, applied in medical science, prosthesis, coating, etc., can solve problems such as curling, uneven structure, and affecting the use effect of silk stents, and achieve smooth structure, simple preparation method, and good body phase. capacitive effect
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Embodiment 1
[0036] Weaving thick silk into a mesh structure support, the specification is 100mm×20mm×0.5mm, and the mesh size is 1.0mm 2 , then with 0.2% Na 2 CO 3 Solution 200mL, boiled for 30min, repeated 3 times, rinsed 3 times with 200mL medical purified water, and dried at room temperature (25°C) for 12h to obtain the basic support; Sprayed on the basic support with 4% silk fibroin aqueous solution, the coating amount was 0.5 mL / cm 2 , and aired at room temperature (25°C) for 24 hours. After inner and outer packaging, it is sterilized by cobalt-60 irradiation to obtain the silk scaffold.
Embodiment 2
[0038] Weave the thick silk into a mesh structure support, the specification is 100mm×100mm×0.5mm, and the mesh size is 1.0mm 2 , then with 0.2% Na 2 CO 3 Solution 200mL, boil for 30min, repeat 3 times. Rinse 3 times with 200mL medical purified water, dry in an oven at 40°C for 4h, and set aside. Spray-coat the pre-prepared 10% chitosan aqueous solution on the silk support, and the coating amount is 1.5mL / cm 2 , after the coating is completed, it is dried in a constant temperature oven at 40°C for 4 hours, and after inner and outer packaging, it is sterilized by cobalt-60 radiation to obtain a silk scaffold.
Embodiment 3
[0040] Weave the thick silk into a mesh structure support, the specification is 100mm×100mm×0.5mm, and the mesh size is 4.0mm 2 , then with 0.2% Na 2 CO 3 Solution 200mL, boil for 30min, repeat 3 times. Rinse 3 times with 200mL medical purified water, dry at room temperature (25°C) for 24h, and set aside. Spray-coat the pre-prepared 20% chitosan aqueous solution on the silk support, and the coating amount is 0.5mL / cm 2 After coating, it is dried in a constant temperature oven at 30°C for 12 hours, and after packaging inside and outside, it is sterilized by cobalt-60 radiation to obtain a silk scaffold.
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