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Loaded drug sustained release composite tissue repairing material and preparation method thereof

A technology for repairing materials and composite tissues, applied in the fields of medical science, prostheses, coatings, etc., can solve the problems of cytotoxicity, lack of clinical application prospects, unknown biological safety, etc., and achieve the effect of good histocompatibility

Inactive Publication Date: 2017-11-17
EXCELLENCE MEDICAL TECH SUZHOU CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the nanoparticles involved in these two patents is complicated, and the biological safety is unknown. Nanoparticles with small particle size (<50nm) may have certain cytotoxicity and lack clinical application prospects.
Therefore, the drug loading method of biomaterials still needs to be improved.

Method used

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  • Loaded drug sustained release composite tissue repairing material and preparation method thereof
  • Loaded drug sustained release composite tissue repairing material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Porcine small intestinal submucosa decellularized matrix (SIS) and SIS fluidized composition were prepared, and the latter was added with 10 mM antibacterial agent as drug-loading medium. SIS is prepared in a staggered way with an area of ​​10×10cm 2 The upper and lower surfaces of the drug-loaded medium are respectively covered with two layers of SIS sheets, and the layers are bonded together by vacuum lamination and pressure of -200mmHg. Scanning electron microscope images can observe the inner ultrastructure of the material, and the antibacterial agent has been combined with SIS collagen fibers.

[0029] In vitro release: Cut the composite tissue repair material to 1cm×1cm and place it in an agarose petri dish, culture it for 1-24 days, extract the agarose, and identify the concentration of the released drug. The results show that the composite tissue repair material can maintain stability for at least 14 days Release, the release amount is about 30% of the total dr...

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Abstract

The invention relates to a loaded drug sustained release composite tissue repairing material and a preparation method thereof. The repairing material comprises a material having a three dimensional structure, porosity, and permeability, a drug or a drug loading medium. The repairing material can sustained release loaded drugs. Moreover, the release curve is controllable. The tissue compatibility and host-material immune reaction type of the repairing material are not changed. The repairing material is biocompatible, nontoxic, and harmless. The biological functions and special functions of the repairing material are enhanced, and the clinical application prospect is good.

Description

technical field [0001] The invention belongs to the field of composite tissue repair material and its preparation, in particular to a drug-loaded slow-release composite tissue repair material and a preparation method thereof. Background technique [0002] Enhancing the functionality of materials by drug loading is one of the possible ways to improve biomaterials. According to the purpose of the repair material, functional drugs are added in a targeted manner to achieve tissue repair while improving efficacy, while maintaining effective drug concentration while reducing drug dosage, reducing toxicity and side effects, and reducing adverse reactions. In addition, the drug-loaded prosthetic material that can be released slowly can avoid the trouble of repeated medication and dressing change, and is suitable for the site where it is inconvenient to take medication directly. There are various types of drugs to choose from, including drugs that are not suitable for systemic admin...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/28A61L27/50A61L27/36A61L27/24
CPCA61L27/24A61L27/28A61L27/3633A61L27/50A61L27/54A61L2300/404A61L2300/602
Inventor 张剑周海洋胡志前
Owner EXCELLENCE MEDICAL TECH SUZHOU CO LTD
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