Medical hydrogel dressings and preparation method thereof

A hydrogel, medical technology, applied in the field of dressings and its preparation, can solve the inconvenience of observing wound healing and other problems, achieve excellent resistance to bacterial invasion, reduce production costs, non-irritating and sensitizing effects

Active Publication Date: 2011-03-02
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In addition, although commercially available hydrogel wound dressings solve the problems of exudate absorption, air permeability, bacteria barrier, waterproof, and wound comfort, in order to increase the strength of the hydrogel, strengthen the hydrogel and the waterproof and breathable back For the adhesiveness of the film, most fiber fabrics or non-woven fabrics are used as the reinforcement layer, and a complex multi-layer composite process is adopted, so that the resulting product is an opaque structure, which is not easy to observe the wound healing

Method used

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  • Medical hydrogel dressings and preparation method thereof
  • Medical hydrogel dressings and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Disperse 10g of polyvinyl alcohol powder and 5g of agar in 70g of deionized water, heat up to 85°C to dissolve, cool down to 40°C, wherein the degree of polymerization of polyvinyl alcohol is 2400, and the degree of alcoholysis is 99%; disperse 10g of wheat starch in Add 10g of deionized water to the above polyvinyl alcohol and agar solution, stir evenly, adjust the pH value of the system to 9 with 3wt% NaOH solution, then raise the temperature to 95°C and keep it for 20min, then cool down to 30°C; add 0.8g polytetramethylene Guanidine hydrochloride was formulated into an aqueous solution with a mass concentration of 2%, added to the reaction system, and stirred evenly; then 5g of epichlorohydrin was added, stirred to form a mixed solution, the mixed solution was poured into a mold, and placed at 60°C for 3 hours to react to obtain Antibacterial hydrogel dressing.

Embodiment 2

[0060] Disperse 10g of polyvinylpyrrolidone powder in 50g of deionized water, stir to dissolve, wherein the molecular weight of polyvinylpyrrolidone is 1000000; disperse 15g of potato starch in 30g of deionized water, add it to the above polyvinylpyrrolidone solution, stir well, and use 2wt Adjust the pH value of the system to 10 with % NaOH solution, then raise the temperature to 80°C and keep it for 30 minutes, then cool down to 40°C; prepare 1.6g of polyhexamethylene guanidine hydrochloride into an aqueous solution with a mass concentration of 5%, add it to the reaction system, and stir evenly Add 4g of ethylene glycol diglycidyl ether, stir to form a mixed solution, pour the mixed solution into a mold, and place it at 75°C for 3 hours to obtain an antibacterial hydrogel dressing.

Embodiment 3

[0062] Disperse 5g of polyvinyl alcohol powder and 2g of gelatin in 20g of deionized water, heat up to 85°C to dissolve, cool down to 40°C, wherein the degree of polymerization of polyvinyl alcohol is 8000, and the degree of alcoholysis is 91.5%; disperse 18g of soluble starch in Add 60g of deionized water to the above polyvinyl alcohol and gelatin solution, stir evenly, adjust the pH value of the system to 11 with 4wt% NaOH solution, then raise the temperature to 85°C and keep it for 15min, then cool down to 30°C; 3.0g of polyoctamethylene Guanidine hydrochloride is formulated into an aqueous solution with a mass concentration of 10% and added to the reaction system, and stirred evenly; then 6g of glycerol triglycidyl ether is added, stirred to form a mixed solution, the mixed solution is poured into a mold, and placed at 70°C for reaction 4h, get antibacterial hydrogel dressing.

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Abstract

The invention relates to a medical hydrogel dressings and a preparation method thereof. The hydrogel dressings is prepared by taking 10-30% by mass of starch and 2-15% by mass of water-soluble polymer as raw materials, utilizing a guanidinesalt polycondensate as an anti-bacterial agent, adding a cross-linking agent, and reacting at the temperature of 40-80 DEG C. The operation steps are as follows: adding the starch and the water-soluble polymer in a solvent to prepare into a solution, regulating the pH value of the solution by a NaOH solution, heating for gelatinization, cooling, adding the anti-bacterial agent and the cross-linking agent, stirring to form a mixed solution, pouring the mixed solution into a die, and reacting at the temperature of 40-80 DEG C to obtain the anti-bacterial hydrogel. Compared with the prior art, the hydrogel dressings in the invention has the advantages of good swelling property, high transparency, moderate mechanic strength, excellent bacteria invasion resistance, wide raw material sources, cheap raw materials, good tissue compatibility and favorable medical application prospect, and can effectively prevent wound infection.

Description

technical field [0001] The invention relates to a dressing for burns, scalds and traumatic wounds and a preparation method thereof, in particular to a medical hydrogel dressing and a preparation method thereof. Background technique [0002] The skin is a barrier to maintain the stability of the internal environment and prevent the invasion of microorganisms. Extensive damage to the skin may result from trauma, abrasions, burns, and skin ulcers. It is common knowledge that wounds are prone to infection, which is caused by pathogens such as Staphylococcus aureus, Candida and E. coli that easily multiply on the wound. Infected wounds are not easy to heal, can easily cause fluid loss and cause various complications. Although traditional dressings have a protective effect on the wound surface, it is generally not considered to promote wound healing. If the granulation tissue is damaged when the dressing is changed, the wound healing will be delayed. The bacterial resistance cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/22A61L15/24A61L15/32A61L15/42A61L15/44C08L3/02
Inventor 管涌方媛郑安呐危大福李书召
Owner EAST CHINA UNIV OF SCI & TECH
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