Method for preparing biodegradable filling materials, product prepared by aid of method and application of product

A filling material and biological technology, applied in the field of materials, can solve the problems of slow degradation, easy to cause inflammation or foreign body granuloma, poor cell affinity, etc., to achieve slow degradation, environmentally friendly preparation process, and good tissue compatibility Effect

Active Publication Date: 2017-03-15
重庆瑞凡德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when pure PLLA is used in tissue materials, it has poor cell affinity, slow degradation rate, and long-term existence in the body, which is easy to cause inflammation or foreign body granuloma and other application limitations.

Method used

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  • Method for preparing biodegradable filling materials, product prepared by aid of method and application of product
  • Method for preparing biodegradable filling materials, product prepared by aid of method and application of product
  • Method for preparing biodegradable filling materials, product prepared by aid of method and application of product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Mixing the matrix material and the dispersed phase material at a mass ratio of 10:0 and dissolving them in hexafluoroisopropanol to obtain a polymeric organic solvent; the matrix material is polydioxanone;

[0037] (2) Dry the polymeric organic solvent at 60°C and a vacuum of 94KPa for 6h, remove the hexafluoroisopropanol, extrude it with a plastic extruder and freeze it quickly, at -20°C, the power is 45kW , the pulverization fineness is 60 mesh low-temperature pulverizers and low-temperature pulverization to obtain microspheres with a particle size of 250 μm.

Embodiment 2

[0039] (1) Mixing polydioxanone and polylactic acid in a mass ratio of 9:1 and dissolving them in dimethyl sulfoxide to obtain a polymeric organic solvent;

[0040] (2) Dry the polymeric organic solvent at 63°C and a vacuum of 95KPa for 5h, remove dimethyl sulfoxide, extrude it with a plastic extruder and freeze it quickly, at -60°C, the power is 55kW , the pulverization fineness is 400 mesh low-temperature pulverizers and low-temperature pulverization to obtain microspheres with a particle size of 38 μm.

Embodiment 3

[0042] (1) Mixing polydioxanone and polycaprolactone at a mass ratio of 8:2 and dissolving them in N,N-dimethylformamide to obtain a polymeric organic solvent;

[0043] (2) Dry the polymeric organic solvent at 65°C and a vacuum of 96KPa for 4 hours, remove N,N-dimethylformamide, extrude it with a plastic extruder and freeze it quickly, and store it at -80°C , the power is 60kW, and the crushing fineness is 800 mesh low-temperature pulverizers to pulverize at low temperature to obtain microspheres. The microspheres are magnified 3000 times under a scanning electron microscope, and the results are as follows figure 1 shown by figure 1 It can be seen that the size of the microspheres is 18 μm.

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Abstract

The invention relates to a method for preparing biodegradable filling materials, a product prepared by the aid of the method and application of the product. The method mainly includes steps of (1), mixing matrix materials and dispersion-phase materials according to a mass ratio of 10:0-6:4 with one another and dissolving the matrix materials and the dispersion-phase materials in organic solvents to obtain high-polymer organic solvents; (2), treating the high-polymer organic solvents by the aid of a mechanical process or an emulsification process to obtain a micro-sphere. The matrix materials comprise polydioxanone; the dispersion-phase materials comprise a type of or a plurality of types of poly-L-lactic acid, polycaprolactone, polylactic acid and polyglycolic acid. The method, the product and the application have the advantages that the method is easy to implement, low in cost and good in repeatability, the product comprises tiny and stable particles, and the micro-sphere prepared by the aid of the method has similar and controllable particle sizes, is good in filling performance and tissue compatibility and is safe and degradable; the product can be degraded slowly, the degradation time can be regulated and controlled according to selection of the types and the adding proportions of the dispersion-phase materials; the micro-sphere can be used for preparing freeze-dried powder preparations and gel preparations, and the product is convenient to transport, store and clinically use.

Description

technical field [0001] The invention belongs to the field of material technology, and in particular relates to a preparation method of a biodegradable filling material and its product and application. Background technique [0002] With the development of society and the improvement of living standards, more and more people begin to pay attention to facial wrinkles and aging problems. The plastic surgery industry is rising rapidly. In 2009, China has become the third largest plastic surgery country in the world. At present, the scale of China's medical beauty market exceeds 500 billion, with an annual growth rate of nearly 20%. It is expected to exceed 800 billion yuan in 2018 and break through one trillion yuan in 2019. Among them, the total output value of China's medical aesthetics market in 2014 was 553 billion yuan, of which injection cosmetics accounted for a considerable proportion of plastic surgery, and because of the advantages of immediate effect of injection cos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/50A61L27/52A61L27/58A61L27/20A61K9/16A61K9/06A61K9/19A61K47/36A61K47/34
CPCA61K9/06A61K9/1647A61K9/19A61K47/36A61L27/20A61L27/48A61L27/50A61L27/52A61L27/58C08L67/04C08L5/08
Inventor 王秋玉李世荣李晓格
Owner 重庆瑞凡德生物科技有限公司
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