The invention discloses a method for preparing a moisture-cured multi-grafted solvent type adhesive. Rubber and a styrene type thermoplastic elastomer form a skeleton, and under the initiation of BPO, monomers methyl methacrylate (MMA), methacrylamide (AM) and glycidyl methacrylate (GMA) are grafted to a carbon doublebond of the skeleton, thereby changing the polarity of the adhesive with the modification of the monomers; and a silane coupling agent and epoxy groups undergo a cross linking reaction through silane to form three-dimensional net working so as to fulfill the aim of moisture curing, and enhance the bond strength and heat resistance of the adhesive. The moisture-cured multi-grafted solvent type adhesive prepared by using the method of the invention does not contain any toxic substance, such as benzene and the like, threatening human health, has high component stability, is secure and environmentally-friendly, simultaneously has high bonding power for polar materials and nonpolar materials, can bond a plurality of materials, such as rubber, leather, fabrics, foam, PVC leather, PU leather, plastics, colored printed product surface mount plastics and the like, and is widely applied to the vehicle material market and footwear industry.