The application belongs to the field of
engineering technology and provides a preparation method of a
nucleic acid separation device. The preparation method of the application prepares a hydrogel
nucleic acid adsorption device through a photo-initiated
radical polymerization reaction, avoiding the cumbersome limitations of traditional
polymerization reactions which need to be carried out under anaerobic conditions. The preparation method is simple and fast, and does not depend on professional and precise instruments. The raw materials are cheap and easy to obtain. The method can efficiently load silica particles, effectively combine the
plasticity of the hydrogel with the high specific surface area of the silica particles and the
strong binding capacity of the
nucleic acid, and further obtain a handheld nucleic acid extraction device which can change shape, size and quantity at any time according to application requirements, has a high specific surface area and excellent nucleic acid extraction performance. Compared with traditional processes, the preparation process is simpler, the application range is wider, and the application requirements of
low resource environment are greatly met, and the application prospect in the field of outdoor and clinical nucleic acid extraction technology is broad.