65 results about "Benzene derivatives" patented technology

A biphenyl derivative, its preparation method and its use in preparing drugs for treating related diseases, specifically relating to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

The present invention relates to the preparation of cyantraniliprole, comprising the preparation of 8-methyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carbonitrile key intermediate via 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid. Wherein hydroxylamine attacks a benzylic formyl group, to obtain the 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid, that undergoes simultaneously or by consecutive steps dehydrogenation and cyclization to obtain the benzo[d][1,3]oxazine group and the cyano group of the desired product. In addition, an improved method for the synthesis of the benzylic formyl group is also displayed.

The application discloses a kind of high level dipole orientation tetraphenyl benzene derivatives and its preparation method and application, the tetraphenyl benzene derivative has structure shown in formula (I):In formula (I), any two of R1, R2, R3, R4 Four groups are each independently selected from N-containing electron-donating group, and the other two are each independently selected from electron-withdrawing group.The tetraphenyl benzene derivative is prepared using two-step suzuki coupling reaction.The tetraphenyl benzene derivative of the application has excellent solid-state light emitting efficiency and high molecular level dipole orientation, and can be used as non-doped light-emitting layer to prepare non-doped blue light organic electroluminescent device with high efficiency, low degree of efficiency roll-off, low start voltage, with maximum external quantum efficiency reaching 8.32%, which is greatly improved compared with prior art, and has wide application prospect in the field of organic optoelectronics.

The invention provides a covalent organic framework material as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, adding 4 ', 4' '-(1, 3, 5-triazine-2, 4, 6-triyl) triphenylamine and a polyformyl benzene derivative into a mixed organic solvent A, and uniformly mixing to obtain a mixture B; s2, adding a catalyst glacial acetic acid into the mixture B to obtain a mixture C; s3, the mixture C is subjected to a reaction under heating, and a reaction product D is obtained; and S4, cleaning the reaction product D, and drying to obtain the covalent organic framework material. The preparation method is simple and easy to implement, and the prepared catalytic material is large in specific surface area, dispersed in active sites and stable in property. Moreover, the catalytic material prepared by the invention can improve the regeneration rate of the CO2-rich amine solution, catalyze and regenerate the absorbent, reduce the regeneration temperature and energy consumption of the absorbent, and realize the purposes of energy conservation and emission reduction.

The present application relates to 4-sec-butoxy-1-benzaldehyde and related compounds, methods of making them, and methods of using them as flavor and fragrance ingredients in food, cosmetic, pharmaceutical, consumer, and other compositions and products.

The present invention provides a strain of Bifidobacterium breve BX-18 and its application, and belongs to the field of biotechnology. The deposit number of Bifidobacterium breve (Bifidobacterium breve) BX-18 provided by the present invention is CGMCCNo.28446. The Bifidobacterium breve BX-18 can synthesize active substances such as amino acids and metabolites thereof, benzene derivatives, flavonoids, and its metabolites have broad-spectrum antibacterial activity and have good antibacterial effect on foodborne pathogens or spoilage bacteria. The present invention provides a new idea for the in-depth study and utilization of probiotics with functional active substances, which has huge research and application value.

The present invention relates to the process of preparation of cyano-benzene derivatives including cyantraniliprole, comprising the preparation of cyano-group via cyanation reagent, wherein the cyanation reagent reacts with benzene derivatives, to form the cyano-benzene derivatives. The present invention provides one-step, high yield, high efficiency, and low-cost cyanation synthesis of cyano substituted substances including common pesticides such as cyantraniliprole.

The present invention discloses an inorganic-organic hybrid carbonyl radical luminescent material, its preparation method and application, belonging to the technical field of luminescent materials. In the inorganic-organic hybrid carbonyl radical luminescent material provided by the present invention, the common feature is that the tris-carbonyl substituted benzene derivative molecule after weak coordination with metal is used as the guest, and a series of imidazolium salt ionic liquid molecules are used as the host, and a supramolecular assembly is formed by the way of host-guest doping; the electrostatic interaction and electron delocalization effect generated in the system protect the carbonyl radical to emit stable light; the metal ions coordinated with the radical molecules in the assembly regulate the photophysical properties of the inorganic-organic hybrid carbonyl radical luminescent material through charge transfer. The synergistic effect of the three components enables the inorganic-organic hybrid carbonyl radical luminescent material of this type to obtain the property of adjustable emission color and realize the dual-mode detection of Cd<supgt;3+< / supgt; (turn off type) and Pb<supgt;3+< / supgt; (turn on type).

The present invention provides NOS inhibitors such as iNOS inhibitors, or a pharmaceutically acceptable salt, ester, prodrug, complex, solvate, hydrate, or isomer thereof, in any crystalline form or in amorphous form. The inhibitors include 1,1 or 1,2 substituted-ethyl carbamimido thioates, cyclic compounds substituted with a carbamimidoyl sulfanylethylphenyl group and a carbamimidoylsulfanyl group, compounds substituted with a carbamimidoyl sulfanylethyl phenylmethyl group, bis-carbamimidoylsulfanylethyl substituted compounds, 2-propoxypyridine derivatives, alkylamine or heteroalkylamine derivatives, n-aminoethyl n-phenyl amine derivatives, and saturated heterocyclic fused benzene derivatives. Pharmaceutical products comprising the NOS inhibitors such as iNOS inhibitors and the applications thereof in prophylaxis and / or treatment of inflammatory diseases, and proliferative diseases such as cancer including gastro-intestinal, colorectal, gynecological, pancreatic, head and neck, esophageal, breast, lung, and central nervous system tumors, among others, are also provided.

The application discloses a mild synthesis method of a selenium-containing urea-based benzimidazole derivative, and the method is characterized by that 1,2-diisocyanobenzene derivative, secondary amine and elemental selenium (Se powder) are used as reaction raw materials, one-pot cyclization reaction is carried out in the presence of a solvent and an additive at room temperature in an air atmosphere, and after reaction, the selenium-containing urea-based benzimidazole derivative is prepared through separation and purification, wherein R 1 is H, 4-Me, 4-CO2Me, 4,5-di-Cl, 4,5-di-Me, R 2 is C6H5, 4-MeC6H4, 4-NH2C6H4, 4-CF3C6H4, 1-naphthyl, 2-pyridyl, i-Pr, R 3 is Me, i-Pr, Bn. The synthesis method disclosed by the application is characterized by simple reaction steps, excellent yield of target products and wide application range of substrates.

An electrolyte composition for lithium secondary batteries contains a lithium salt and an organic solvent. The organic solvent includes an aromatic solvent with fluorinated toluene derivatives (such as 2,3-difluorotoluene) and an ether solvent. The lithium salt may contain compounds such as Li(CF3SO2)2N, Li(SO2F)2N, LiPF6, and others. The aromatic solvent is present in the electrolyte at a concentration of approximately 30–90 vol%, and the molarity of the lithium salt ranges from 0.1 to 3.0 M. This composition improves battery performance by increasing stability, conductivity, and compatibility with lithium-metal or lithium-ion electrodes, making it suitable for high-energy-density applications in lithium secondary batteries.

The invention discloses a pyrrole biphenyl derivative compound as well as a preparation method and application thereof in pharmacy, and belongs to the technical field of chemical medicine raw material medicine and preparation manufacturing. The compound has a structure as shown in # imgabs0 #. The compound is specifically combined with SGLT-2 protein through a pyrrole-benzene conjugated system, the glucose transport function of the SGLT-2 protein is inhibited, and the IC50 value of the SGLT-2 protein reaches 15-105 nM. The traditional Chinese medicine composition is suitable for preparing medicines for treating non-alcoholic liver diseases, solid tumors, hematological malignant tumors and autoimmune diseases, and especially has a remarkable effect on abnormal glycolipid metabolism of liver cells and energy deprivation of tumor cells. The compound has deuterated group enhanced metabolic stability, and can be prepared into dosage forms such as tablets, capsules, injection and the like.

1. The name of this design product: Volatile organic compound online monitoring system. 2. Application of this product design: Mainly used for online monitoring of various volatile organic compounds such as VOCs, total hydrocarbons (THC), non-methane hydrocarbons (NMHC), benzene and benzene derivatives. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

This invention discloses a pyrrolobenzene derivative compound, its preparation method, and its pharmaceutical application, belonging to the field of chemical pharmaceutical raw materials and formulation manufacturing technology. The compound has the structure shown. This compound specifically binds to the SGLT-2 protein through a pyrrolobenzene conjugated system, inhibiting its glucose transport function and affecting the IC50 of SGLT-2. 50 Values ​​range from 15 to 105 nM. Suitable for preparing drugs to treat non-alcoholic liver disease, solid tumors, hematological malignancies, and autoimmune diseases, especially effective against abnormal glucose and lipid metabolism in hepatocytes and energy deprivation in tumor cells. The compound possesses enhanced metabolic stability due to its deuterated group and can be formulated into tablets, capsules, injections, and other dosage forms.

The invention provides a preparation method and application of a covalent organic framework material TPA-COF.The preparation method of the covalent organic framework material TPA-COF comprises the steps that 1, a trisubstituted benzene derivative group and a first solvent are mixed and dissolved according to a certain proportion and then subjected to ultrasonic dispersion, and a clear solution is obtained; 2) adding a certain mass of acetic acid into the clear solution, freezing to below zero DEG C, and then performing vacuum freeze drying to obtain a dried product; (3) heating the dried product obtained in the step (2) to obtain a yellow product; washing and drying the yellow product, and collecting to obtain deep yellow powder; (4) dispersing the deep yellow powder obtained in the step (3) in a second solvent, and carrying out intermittent ultrasonic treatment to form a self-assembled dispersion liquid, and (5) collecting an upper suspension in the self-assembled dispersion liquid, and carrying out centrifugal concentration on the suspension to obtain the covalent organic framework material TPA-COF.

The present disclosure provides novel benzothienopyrrole (Bt)-cyanine (Cy) fluorescent compounds, water soluble BtCy fluorescent dyes, water soluble BtCy binding partner conjugates, and tandem dyes thereof. Yellow, orange, red, NIR or IR wavelengths can be used to excite the BtCy fluorescent compounds, conjugates, and tandem dyes. The fluorescent dyes can be conjugated to a binding partner for detecting a target analyte in a biological sample, and are suitable for flow cytometry assays. These dyes have the general formula wherein Ar1 is selected from the group consisting of substituted or unsubstituted benzene, benzene derivatives, monocyclic aryl, polycyclic aryl, monocyclic heteroaryl and polycyclic heteroaryl.

The invention belongs to the technical field of photoresponse materials, and provides an azobenzene photoresponse nanofiber film and a preparation method and application thereof.The preparation method includes the following steps that polyvinylidene fluoride, azobenzene derivatives and a solvent are mixed and stirred to obtain a spinning solution, and a fiber film is prepared through an electrostatic spinning method; the mass ratio of the azobenzene derivative to the polyvinylidene fluoride is (0.1-0.5): 1; the solvent is prepared from N, N-dimethylformamide and acetone in a volume ratio of 1: (1-1.5). The azobenzene photoresponse nanofiber film provided by the invention has good patterning performance and photoresponsiveness, and also has excellent mechanical property and thermal stability.

The invention discloses an intelligent water-retaining agent based on nonionic amide and a preparation method of the intelligent water-retaining agent, and belongs to the technical field of functional polymer materials. The water-retaining agent is prepared from the following raw materials in percentage by mass: 50 to 70 percent of PHEAA; 20 to 25 percent of PVP (Polyvinyl Pyrrolidone); 5 to 8% of HPG; 10 to 15% of PEGDA (polyethylene glycol diacrylate); 3-5% of a composite pore channel; 2 to 3% of up-conversion nano particles; 2-4% of an azobenzene derivative; 1 to 2 percent of PDA; 0.5 to 1.0 percent of CMC (Carboxymethyl Cellulose 0.3% to 0.5% of Fe3O4 nano particles; wherein the composite pore channel is a ferriprotein-Al < 3 + > composite pore channel, and the up-conversion nanoparticles are NaYF4: Yb < 3 + > / Tm < 3 + >. According to the material, the salt resistance and water retention are improved through cooperation of a nonionic network and bionic pore channels, dynamic controlled release of moisture is triggered by near-infrared light, the material has the magnetic recovery characteristic and cycling stability, the preparation process is environmentally friendly, and the material is suitable for intelligent agriculture and ecological restoration engineering in a complex environment.

The invention relates to the technical field of adhesives, and discloses a hot melt adhesive based on a high polymer material and a preparation method thereof.The hot melt adhesive is prepared by taking polyester glycol as a soft segment and binary isocyanate as a hard segment, conducting prepolymerization under the action of a catalyst and then conducting chain extension polymerization through a chain extender and a composite functional flame retardant, wherein the chain extender is a tert-butylbenzene derivative, a tert-butyl structure can be introduced into a polyurethane molecular chain, the water resistance of the polyurethane hot melt adhesive can be greatly improved, the composite functional flame retardant is prepared by modifying the surface of boehmite with nitrogen-containing heterocyclic rings and phytic acid, the uniformly dispersed composite functional flame retardant can utilize the special effect of boehmite, and the flame retardancy of the polyurethane hot melt adhesive is improved. The flame retardant can improve the mechanical strength of the polyurethane hot melt adhesive, also can form a stable physical barrier effect, and can cooperate with nitrogen-containing heterocyclic rings and phytic acid to achieve the effect of greatly enhancing the flame retardant property of the hot melt adhesive by adding a small amount of the flame retardant.

The invention relates to the technical field of dyes, and discloses a preparation method and application of an environment-friendly acidic color fixing agent, the preparation method comprises the following steps: S1) carrying out sulfonation reaction on tetramethyl biphenyl, acetic anhydride and 98% concentrated sulfuric acid in a first reaction temperature range to obtain a sulfonation product; preparing an intermediate mixture containing a monosulfonic acid biphenyl derivative and a disulfonic acid biphenyl derivative; and S2) dropwise adding deionized water and a 37% formaldehyde solution into the stirred intermediate mixture, heating to a second reaction temperature range, and terminating the condensation reaction when the viscosity is controlled to reach a viscosity threshold range, thereby obtaining the environment-friendly acidic color fixing agent. The prepared acidic color fixing agent does not contain phenol and bisphenol substances, is green and environment-friendly, and can meet the REACH regulation and the limit requirements of OEKO-TEX100. According to the application of the environment-friendly acidic color fixing agent, the color fastness of a nylon fabric or a nylon / spandex fabric can be improved.

The invention discloses a 1H-triazole biphenyl derivative as well as a preparation method and medical application thereof, and particularly relates to the 1H-triazole biphenyl derivative as shown in a general formula (I) and enantiomers, diastereoisomers, tautomers, N-oxides, solvates, physiologically hydrolyzable esters, preparations and pharmaceutically acceptable salts of the 1H-triazole biphenyl derivative. The invention discloses a 1H-triazole biphenyl derivative having an inhibition effect on S1PR1 and a pharmaceutically acceptable salt thereof, pharmacological experiments prove that the compound has a significant inhibition effect on S1PR1, has an effect of relieving pain, and is expected to become a novel analgesic molecule for replacing opioid drugs. # imgabs0 #

The present application provides a preparation method of a carbazole-based organic electroluminescent host material. Using inexpensive substrates 2-bromo-5-fluoro-nitrobenzene and 1-naphthylboronic acid, the coupling intermediate S1 is obtained through a Suzuki coupling reaction, and the ring-closing intermediate S2 is obtained by reduction with triphenylphosphine; the brominated product S3 is obtained by reacting with a brominating reagent in a suitable solvent; the intermediate S4 is synthesized using iodobenzene or an iodobenzene derivative; the intermediate S5 is obtained by reacting an arylamine with intermediate 4; the ring closure is achieved through C-H activation under Pd catalysis to obtain the intermediate S6; the 7,9-dihydrobenzo[g]indolo[2,3-b]carbazole derivative S7 is synthesized using iodobenzene or a benzene derivative.

Sulphonyl benzene derivatives, in particular to fluorinated sulphonyl benzene derivatives. A compound of formula I or general formula IAwhere X is fluorine; A is either O or NH; B is an amino acid- or peptide-containing group and Y is a secondary or tertiary amine group or a thioether group.

According to the present invention, a positive electrode 23 has an antifluorite crystal structure and contains lithium oxide in which a transition metal is solid-solved, and an electrolyte solution 29 contains an additive. The additive includes at least one substance that is selected from the group consisting of a phosphoric acid ester, a sulfonic acid ester, a cyclic carbonic acid ester, a benzene derivative, and a radical scavenger. The concentration of the additive in the electrolyte solution is, for example, 0.01 mol / liter to 2.0 mol / liter inclusive.

The invention discloses a preparation method of a diuron slow-release composite material, and belongs to the technical field of herbicide preparation. Comprising the following steps: S1, cleaning straw, airing, crushing, drying, grinding and sieving to obtain a biochar precursor; performing pyrolysis, acid leaching, washing, drying, grinding and sieving on the biochar precursor under vacuum to obtain biochar; s2, mixing the biochar, diuron and deionized water, oscillating, and filtering to obtain diuron-adsorbed biochar; stirring the diuron-adsorbed biochar, an azobenzene derivative, pectin, EDC, NHS and absolute ethyl alcohol overnight, and performing centrifugal washing and freeze-drying to obtain the diuron slow-release composite material. The preparation method of the azobenzene derivative comprises the following steps: mixing and stirring 4-aminoazobenzene and triethylamine, adding chloralkane, refluxing and stirring, filtering and washing to obtain the azobenzene derivative.

The application provides application of a hyperbranched conjugated fluorescent high polymer in fluorescence detection of gasoline, diesel and kerosene, and relates to the technical field of organic synthesis and fluorescence sensing. The hyperbranched conjugated fluorescent high polymer has a structure shown in general formula (I), and is characterized in that a triethynylbenzene structure in the center of the polymer is subjected to a sonogashira coupling reaction with a hydroxyl-substituted benzene derivative to form a two-dimensional network structure, thereby bringing excellent sensing performance to a sensitive film; the sensitive film has on-site rapid detection sensitivity and sub-second (less than 1s) rapid response capability for gasoline, diesel and kerosene, meets on-site emergency detection requirements, and can realize effective anti-interference capability for various substances, and realizes high selectivity detection in a complex matrix environment.

The present application relates to 4-sec-butoxy-1-benzaldehyde and related compounds, methods of making them, and methods of using them as flavor and fragrance ingredients in food, cosmetic, pharmaceutical, consumer, and other compositions and products.

The application belongs to the technical field of organic afterglow crystal materials, and particularly relates to an electron-rich material co-constructed organic long afterglow crystal material and a preparation method and application thereof. The electron-rich diphenylamine material which is easy to crystallize and cheap and easy to obtain is selected as a host material, and the electron-rich halogenated benzene derivative which is cheap and easy to obtain is introduced as a guest material, so that a series of crystal materials with regular structure are constructed, and a long afterglow luminescent new material with long afterglow time and adjustable color is obtained. The experiment proves that the electron-rich material co-constructed organic long afterglow crystal material provided by the application can be excited by ultraviolet light, has the characteristics of environmental stability, the afterglow time is more than 2s, and the crystal morphology can be regular, the afterglow color can also be adjusted, which shows the application potential in the information encryption and anti-counterfeiting fields, and can provide a theoretical basis and material basis for data encryption, anti-counterfeiting and other practical applications.

Compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, are described (see Formula), where Q, z, R2, R3, and m are as defined in the description. Compositions containing the compounds of Formula (1) and methods for controlling unwanted vegetation, comprising bringing the unwanted vegetation or its environment into contact with an effective amount of a compound or composition of the invention, are also described.