47 results about "Benzene derivatives" patented technology

A biphenyl derivative, its preparation method and its use in preparing drugs for treating related diseases, specifically relating to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

The present invention relates to the preparation of cyantraniliprole, comprising the preparation of 8-methyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carbonitrile key intermediate via 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid. Wherein hydroxylamine attacks a benzylic formyl group, to obtain the 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid, that undergoes simultaneously or by consecutive steps dehydrogenation and cyclization to obtain the benzo[d][1,3]oxazine group and the cyano group of the desired product. In addition, an improved method for the synthesis of the benzylic formyl group is also displayed.

The application discloses a kind of high level dipole orientation tetraphenyl benzene derivatives and its preparation method and application, the tetraphenyl benzene derivative has structure shown in formula (I):In formula (I), any two of R1, R2, R3, R4 Four groups are each independently selected from N-containing electron-donating group, and the other two are each independently selected from electron-withdrawing group.The tetraphenyl benzene derivative is prepared using two-step suzuki coupling reaction.The tetraphenyl benzene derivative of the application has excellent solid-state light emitting efficiency and high molecular level dipole orientation, and can be used as non-doped light-emitting layer to prepare non-doped blue light organic electroluminescent device with high efficiency, low degree of efficiency roll-off, low start voltage, with maximum external quantum efficiency reaching 8.32%, which is greatly improved compared with prior art, and has wide application prospect in the field of organic optoelectronics.

The invention provides a covalent organic framework material as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, adding 4 ', 4' '-(1, 3, 5-triazine-2, 4, 6-triyl) triphenylamine and a polyformyl benzene derivative into a mixed organic solvent A, and uniformly mixing to obtain a mixture B; s2, adding a catalyst glacial acetic acid into the mixture B to obtain a mixture C; s3, the mixture C is subjected to a reaction under heating, and a reaction product D is obtained; and S4, cleaning the reaction product D, and drying to obtain the covalent organic framework material. The preparation method is simple and easy to implement, and the prepared catalytic material is large in specific surface area, dispersed in active sites and stable in property. Moreover, the catalytic material prepared by the invention can improve the regeneration rate of the CO2-rich amine solution, catalyze and regenerate the absorbent, reduce the regeneration temperature and energy consumption of the absorbent, and realize the purposes of energy conservation and emission reduction.

The present invention provides a strain of Bifidobacterium breve BX-18 and its application, and belongs to the field of biotechnology. The deposit number of Bifidobacterium breve (Bifidobacterium breve) BX-18 provided by the present invention is CGMCCNo.28446. The Bifidobacterium breve BX-18 can synthesize active substances such as amino acids and metabolites thereof, benzene derivatives, flavonoids, and its metabolites have broad-spectrum antibacterial activity and have good antibacterial effect on foodborne pathogens or spoilage bacteria. The present invention provides a new idea for the in-depth study and utilization of probiotics with functional active substances, which has huge research and application value.

The present invention relates to the process of preparation of cyano-benzene derivatives including cyantraniliprole, comprising the preparation of cyano-group via cyanation reagent, wherein the cyanation reagent reacts with benzene derivatives, to form the cyano-benzene derivatives. The present invention provides one-step, high yield, high efficiency, and low-cost cyanation synthesis of cyano substituted substances including common pesticides such as cyantraniliprole.

The application discloses a mild synthesis method of a selenium-containing urea-based benzimidazole derivative, and the method is characterized by that 1,2-diisocyanobenzene derivative, secondary amine and elemental selenium (Se powder) are used as reaction raw materials, one-pot cyclization reaction is carried out in the presence of a solvent and an additive at room temperature in an air atmosphere, and after reaction, the selenium-containing urea-based benzimidazole derivative is prepared through separation and purification, wherein R 1 is H, 4-Me, 4-CO2Me, 4,5-di-Cl, 4,5-di-Me, R 2 is C6H5, 4-MeC6H4, 4-NH2C6H4, 4-CF3C6H4, 1-naphthyl, 2-pyridyl, i-Pr, R 3 is Me, i-Pr, Bn. The synthesis method disclosed by the application is characterized by simple reaction steps, excellent yield of target products and wide application range of substrates.

An electrolyte composition for lithium secondary batteries contains a lithium salt and an organic solvent. The organic solvent includes an aromatic solvent with fluorinated toluene derivatives (such as 2,3-difluorotoluene) and an ether solvent. The lithium salt may contain compounds such as Li(CF3SO2)2N, Li(SO2F)2N, LiPF6, and others. The aromatic solvent is present in the electrolyte at a concentration of approximately 30–90 vol%, and the molarity of the lithium salt ranges from 0.1 to 3.0 M. This composition improves battery performance by increasing stability, conductivity, and compatibility with lithium-metal or lithium-ion electrodes, making it suitable for high-energy-density applications in lithium secondary batteries.

The invention discloses a pyrrole biphenyl derivative compound as well as a preparation method and application thereof in pharmacy, and belongs to the technical field of chemical medicine raw material medicine and preparation manufacturing. The compound has a structure as shown in # imgabs0 #. The compound is specifically combined with SGLT-2 protein through a pyrrole-benzene conjugated system, the glucose transport function of the SGLT-2 protein is inhibited, and the IC50 value of the SGLT-2 protein reaches 15-105 nM. The traditional Chinese medicine composition is suitable for preparing medicines for treating non-alcoholic liver diseases, solid tumors, hematological malignant tumors and autoimmune diseases, and especially has a remarkable effect on abnormal glycolipid metabolism of liver cells and energy deprivation of tumor cells. The compound has deuterated group enhanced metabolic stability, and can be prepared into dosage forms such as tablets, capsules, injection and the like.

1. The name of this design product: Volatile organic compound online monitoring system. 2. Application of this product design: Mainly used for online monitoring of various volatile organic compounds such as VOCs, total hydrocarbons (THC), non-methane hydrocarbons (NMHC), benzene and benzene derivatives. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

This invention discloses a pyrrolobenzene derivative compound, its preparation method, and its pharmaceutical application, belonging to the field of chemical pharmaceutical raw materials and formulation manufacturing technology. The compound has the structure shown. This compound specifically binds to the SGLT-2 protein through a pyrrolobenzene conjugated system, inhibiting its glucose transport function and affecting the IC50 of SGLT-2. 50 Values ​​range from 15 to 105 nM. Suitable for preparing drugs to treat non-alcoholic liver disease, solid tumors, hematological malignancies, and autoimmune diseases, especially effective against abnormal glucose and lipid metabolism in hepatocytes and energy deprivation in tumor cells. The compound possesses enhanced metabolic stability due to its deuterated group and can be formulated into tablets, capsules, injections, and other dosage forms.

The present disclosure provides novel benzothienopyrrole (Bt)-cyanine (Cy) fluorescent compounds, water soluble BtCy fluorescent dyes, water soluble BtCy binding partner conjugates, and tandem dyes thereof. Yellow, orange, red, NIR or IR wavelengths can be used to excite the BtCy fluorescent compounds, conjugates, and tandem dyes. The fluorescent dyes can be conjugated to a binding partner for detecting a target analyte in a biological sample, and are suitable for flow cytometry assays. These dyes have the general formula wherein Ar1 is selected from the group consisting of substituted or unsubstituted benzene, benzene derivatives, monocyclic aryl, polycyclic aryl, monocyclic heteroaryl and polycyclic heteroaryl.

The invention discloses an intelligent water-retaining agent based on nonionic amide and a preparation method of the intelligent water-retaining agent, and belongs to the technical field of functional polymer materials. The water-retaining agent is prepared from the following raw materials in percentage by mass: 50 to 70 percent of PHEAA; 20 to 25 percent of PVP (Polyvinyl Pyrrolidone); 5 to 8% of HPG; 10 to 15% of PEGDA (polyethylene glycol diacrylate); 3-5% of a composite pore channel; 2 to 3% of up-conversion nano particles; 2-4% of an azobenzene derivative; 1 to 2 percent of PDA; 0.5 to 1.0 percent of CMC (Carboxymethyl Cellulose 0.3% to 0.5% of Fe3O4 nano particles; wherein the composite pore channel is a ferriprotein-Al < 3 + > composite pore channel, and the up-conversion nanoparticles are NaYF4: Yb < 3 + > / Tm < 3 + >. According to the material, the salt resistance and water retention are improved through cooperation of a nonionic network and bionic pore channels, dynamic controlled release of moisture is triggered by near-infrared light, the material has the magnetic recovery characteristic and cycling stability, the preparation process is environmentally friendly, and the material is suitable for intelligent agriculture and ecological restoration engineering in a complex environment.

The invention relates to the technical field of adhesives, and discloses a hot melt adhesive based on a high polymer material and a preparation method thereof.The hot melt adhesive is prepared by taking polyester glycol as a soft segment and binary isocyanate as a hard segment, conducting prepolymerization under the action of a catalyst and then conducting chain extension polymerization through a chain extender and a composite functional flame retardant, wherein the chain extender is a tert-butylbenzene derivative, a tert-butyl structure can be introduced into a polyurethane molecular chain, the water resistance of the polyurethane hot melt adhesive can be greatly improved, the composite functional flame retardant is prepared by modifying the surface of boehmite with nitrogen-containing heterocyclic rings and phytic acid, the uniformly dispersed composite functional flame retardant can utilize the special effect of boehmite, and the flame retardancy of the polyurethane hot melt adhesive is improved. The flame retardant can improve the mechanical strength of the polyurethane hot melt adhesive, also can form a stable physical barrier effect, and can cooperate with nitrogen-containing heterocyclic rings and phytic acid to achieve the effect of greatly enhancing the flame retardant property of the hot melt adhesive by adding a small amount of the flame retardant.

According to the present invention, a positive electrode 23 has an antifluorite crystal structure and contains lithium oxide in which a transition metal is solid-solved, and an electrolyte solution 29 contains an additive. The additive includes at least one substance that is selected from the group consisting of a phosphoric acid ester, a sulfonic acid ester, a cyclic carbonic acid ester, a benzene derivative, and a radical scavenger. The concentration of the additive in the electrolyte solution is, for example, 0.01 mol / liter to 2.0 mol / liter inclusive.

The application provides application of a hyperbranched conjugated fluorescent high polymer in fluorescence detection of gasoline, diesel and kerosene, and relates to the technical field of organic synthesis and fluorescence sensing. The hyperbranched conjugated fluorescent high polymer has a structure shown in general formula (I), and is characterized in that a triethynylbenzene structure in the center of the polymer is subjected to a sonogashira coupling reaction with a hydroxyl-substituted benzene derivative to form a two-dimensional network structure, thereby bringing excellent sensing performance to a sensitive film; the sensitive film has on-site rapid detection sensitivity and sub-second (less than 1s) rapid response capability for gasoline, diesel and kerosene, meets on-site emergency detection requirements, and can realize effective anti-interference capability for various substances, and realizes high selectivity detection in a complex matrix environment.

The application belongs to the technical field of organic afterglow crystal materials, and particularly relates to an electron-rich material co-constructed organic long afterglow crystal material and a preparation method and application thereof. The electron-rich diphenylamine material which is easy to crystallize and cheap and easy to obtain is selected as a host material, and the electron-rich halogenated benzene derivative which is cheap and easy to obtain is introduced as a guest material, so that a series of crystal materials with regular structure are constructed, and a long afterglow luminescent new material with long afterglow time and adjustable color is obtained. The experiment proves that the electron-rich material co-constructed organic long afterglow crystal material provided by the application can be excited by ultraviolet light, has the characteristics of environmental stability, the afterglow time is more than 2s, and the crystal morphology can be regular, the afterglow color can also be adjusted, which shows the application potential in the information encryption and anti-counterfeiting fields, and can provide a theoretical basis and material basis for data encryption, anti-counterfeiting and other practical applications.

Compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, are described (see Formula), where Q, z, R2, R3, and m are as defined in the description. Compositions containing the compounds of Formula (1) and methods for controlling unwanted vegetation, comprising bringing the unwanted vegetation or its environment into contact with an effective amount of a compound or composition of the invention, are also described.

The present invention relates to zinc oxide-on-carbon core-shell nanoparticles. These particles are prepared by adding a benzene derivative or pyridine derivative substituted with at least one amino and / or carboxyl group, or a small silane molecule capable of undergoing a coupling reaction with zinc oxide, as a carbon source to a nano-zinc oxide methanol solution, followed by a solvothermal reaction at 150-200°C. The zinc oxide-on-carbon core-shell nanoparticles are coated with a nanocarbon material to suppress surface defects in zinc oxide. When used in the electron transport layer of organic solar cells, they can inhibit the photocatalytic reaction between zinc oxide and non-fullerene materials, reduce the number of oxygen adsorption sites on zinc oxide, and minimize the occurrence of the "light bathing" phenomenon, thereby improving the device's air and UV stability.

The invention relates to the field of intelligent high polymer materials, in particular to a preparation method of an azobenzene derivative modified chitosan-based photosensitive shape memory composite material. The composite material is prepared by compounding modified chitosan and polyvinyl alcohol, wherein the modified chitosan is prepared by grafting 4-acryloyloxy azobenzene onto maleic anhydride modified chitosan; by optimizing the ratio of the modified chitosan to the PVA and the grafting ratio of the azobenzene, the composite material with excellent photosensitive shape memory performance is successfully obtained; the most preferable CSMCF-3 sample (CSM / PVA = 3 / 7, and the grafting rate is 0.5%) has a shape fixation rate of 97.2% and a shape recovery rate of 93.3% under 365nm ultraviolet irradiation, and the recovery time is shorter than 300 seconds. The composite material also has the advantages of good biocompatibility, biodegradability and the like, and has wide application prospects in the fields of food packaging, biomedical engineering and the like.

The application discloses a kind of planar chiral iodometalate and its preparation method and the method for preparing polysubstituted planar chiral metallocene compound.The method uses simple N,N-dialkylaminomethyl metallocene (ferrocene, ruthenocene) as starting material, under the action of palladium catalyst, chiral amino acid, o-trifluoroacetyl iodobenzene derivative and base, under certain temperature in organic solvent, stirring reaction can obtain 1,2-disubstituted planar chiral iodometalate compound.The raw material used in the method is cheap and easy to obtain, the reaction condition is mild, substrate universality is good, yield is high, and the preparation process is simple.The prepared 1,2-disubstituted planar chiral iodometalate can be used for further synthesis of other functional group polysubstituted planar chiral metallocene compound.

The present invention relates to a novel benzene derivative and immunosuppressive-related use thereof. Specifically, it relates to a composition comprising a compound of Formula 1, its stereoisomer, solvate, hydrate, crystalline form, or pharmaceutically acceptable salt. The composition has preventive or therapeutic applications in immune disorders such as autoimmune diseases, transplant rejections, allergic diseases, and inflammatory conditions.

The present invention relates to a novel benzene derivative and immunosuppressive-related use thereof. Specifically, it relates to a composition comprising a compound of Formula 1, its stereoisomer, solvate, hydrate, crystalline form, or pharmaceutically acceptable salt. The composition has preventive or therapeutic applications in immune disorders such as autoimmune diseases, transplant rejections, allergic diseases, and inflammatory conditions.

This invention discloses a method for preparing a diarylcarbazole material, relating to the field of organic light-emitting device technology. The method includes: obtaining intermediate A through a nitration reaction of 4-bromo-2-chloro-1-fluorobenzene; obtaining coupling intermediate B through a Suzuki coupling reaction of intermediate A and 1-naphthoboric acid; preparing intermediate C through a nitro cyclization reaction of intermediate B; coupling intermediate C with iodobenzene or iodobenzene derivative D to form intermediate E; preparing pinacol borate intermediate F using intermediate E; obtaining intermediate H through a Suzuki coupling reaction of intermediate F and o-bromoaniline or o-bromoaniline derivative G; cyclizing intermediate H under alkaline conditions to obtain intermediate I; and coupling intermediate I with a haloaryl derivative J to obtain the diarylcarbazole material. The preparation route provided by this invention has high reaction selectivity, produces a single product, has no obvious reaction defects, and avoids the problems of isomers in cyclization reactions and polybromination in bromination reactions.

The invention relates to a preparation method for co-producing lithium oxalate and fluorobenzene-containing derivatives and application thereof, and belongs to the technical field of organic synthesis and battery materials. In order to solve the technical problems that in the prior art, a fluorobenzene preparation process is dangerous, synthesis steps of lithium oxalate-containing salt are tedious, and the yield is low, the invention provides an efficient and safe preparation method for co-producing lithium oxalate-containing salt and fluorobenzene derivatives. The method comprises the following steps: reacting fluorine-containing lithium salt with an oxalate compound in the presence of a non-aqueous acid catalyst under the protection of inert gas to generate the lithium oxalate-containing salt and fluorobenzene derivative. The preparation method provided by the invention realizes collaborative production of two products with high added values, has the advantages of simple process, high safety, good atom economy and high purity of the obtained product, and is especially suitable for the fields of lithium ion battery electrolytes and additives.

The present invention relates to a negative electrode for a lithium secondary battery comprising a protective layer. More specifically, the negative electrode comprises: a negative electrode current collector; and a protective layer on the negative electrode current collector, wherein the protective layer may include a first polymer. The first polymer includes a main chain comprising a chain-like hydrocarbon and a plurality of benzene derivatives connected to the main chain, wherein each of the plurality of benzene derivatives includes 2 to 4 benzene rings, and adjacent benzene rings may be connected by a single bond or may be fused by sharing carbon atoms.

The application discloses a high-temperature-resistant and high-voltage-resistant lithium ion battery electrolyte and a preparation method thereof, and comprises the following components in percentage by mass: a film forming agent 1-4%, a flame retardant 1-3%, an electrolyte lithium salt 8-12%, an auxiliary lithium salt 1-2%, a high-voltage stable solvent 15-25%, and the balance being a base solvent. The application improves the cycle performance of the electrolyte by compounding fluorine-containing cyano-substituted benzene derivatives, silicon-oxygen compounds and nitrogen-containing borate esters as the film forming agent, and compounding the fluorine-containing cyclotriphosphazene flame retardant, so that the high-temperature stability and the high-voltage resistance of the electrolyte are enhanced through the synergistic effect, and the high-nickel electrode is compatible, the cycle life, the rate performance and the safety performance of the NCM811 battery are significantly improved.