26 results about "Benzene derivatives" patented technology

The present invention relates to the preparation of cyantraniliprole, comprising the preparation of 8-methyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carbonitrile key intermediate via 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid. Wherein hydroxylamine attacks a benzylic formyl group, to obtain the 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid, that undergoes simultaneously or by consecutive steps dehydrogenation and cyclization to obtain the benzo[d][1,3]oxazine group and the cyano group of the desired product. In addition, an improved method for the synthesis of the benzylic formyl group is also displayed.

The application discloses a kind of high level dipole orientation tetraphenyl benzene derivatives and its preparation method and application, the tetraphenyl benzene derivative has structure shown in formula (I):In formula (I), any two of R1, R2, R3, R4 Four groups are each independently selected from N-containing electron-donating group, and the other two are each independently selected from electron-withdrawing group.The tetraphenyl benzene derivative is prepared using two-step suzuki coupling reaction.The tetraphenyl benzene derivative of the application has excellent solid-state light emitting efficiency and high molecular level dipole orientation, and can be used as non-doped light-emitting layer to prepare non-doped blue light organic electroluminescent device with high efficiency, low degree of efficiency roll-off, low start voltage, with maximum external quantum efficiency reaching 8.32%, which is greatly improved compared with prior art, and has wide application prospect in the field of organic optoelectronics.

The present invention relates to the process of preparation of cyano-benzene derivatives including cyantraniliprole, comprising the preparation of cyano-group via cyanation reagent, wherein the cyanation reagent reacts with benzene derivatives, to form the cyano-benzene derivatives. The present invention provides one-step, high yield, high efficiency, and low-cost cyanation synthesis of cyano substituted substances including common pesticides such as cyantraniliprole.

The application discloses a mild synthesis method of a selenium-containing urea-based benzimidazole derivative, and the method is characterized by that 1,2-diisocyanobenzene derivative, secondary amine and elemental selenium (Se powder) are used as reaction raw materials, one-pot cyclization reaction is carried out in the presence of a solvent and an additive at room temperature in an air atmosphere, and after reaction, the selenium-containing urea-based benzimidazole derivative is prepared through separation and purification, wherein R 1 is H, 4-Me, 4-CO2Me, 4,5-di-Cl, 4,5-di-Me, R 2 is C6H5, 4-MeC6H4, 4-NH2C6H4, 4-CF3C6H4, 1-naphthyl, 2-pyridyl, i-Pr, R 3 is Me, i-Pr, Bn. The synthesis method disclosed by the application is characterized by simple reaction steps, excellent yield of target products and wide application range of substrates.

An electrolyte composition for lithium secondary batteries contains a lithium salt and an organic solvent. The organic solvent includes an aromatic solvent with fluorinated toluene derivatives (such as 2,3-difluorotoluene) and an ether solvent. The lithium salt may contain compounds such as Li(CF3SO2)2N, Li(SO2F)2N, LiPF6, and others. The aromatic solvent is present in the electrolyte at a concentration of approximately 30–90 vol%, and the molarity of the lithium salt ranges from 0.1 to 3.0 M. This composition improves battery performance by increasing stability, conductivity, and compatibility with lithium-metal or lithium-ion electrodes, making it suitable for high-energy-density applications in lithium secondary batteries.

This invention discloses a pyrrolobenzene derivative compound, its preparation method, and its pharmaceutical application, belonging to the field of chemical pharmaceutical raw materials and formulation manufacturing technology. The compound has the structure shown. This compound specifically binds to the SGLT-2 protein through a pyrrolobenzene conjugated system, inhibiting its glucose transport function and affecting the IC50 of SGLT-2. 50 Values ​​range from 15 to 105 nM. Suitable for preparing drugs to treat non-alcoholic liver disease, solid tumors, hematological malignancies, and autoimmune diseases, especially effective against abnormal glucose and lipid metabolism in hepatocytes and energy deprivation in tumor cells. The compound possesses enhanced metabolic stability due to its deuterated group and can be formulated into tablets, capsules, injections, and other dosage forms.

The invention relates to the technical field of adhesives, and discloses a hot melt adhesive based on a high polymer material and a preparation method thereof.The hot melt adhesive is prepared by taking polyester glycol as a soft segment and binary isocyanate as a hard segment, conducting prepolymerization under the action of a catalyst and then conducting chain extension polymerization through a chain extender and a composite functional flame retardant, wherein the chain extender is a tert-butylbenzene derivative, a tert-butyl structure can be introduced into a polyurethane molecular chain, the water resistance of the polyurethane hot melt adhesive can be greatly improved, the composite functional flame retardant is prepared by modifying the surface of boehmite with nitrogen-containing heterocyclic rings and phytic acid, the uniformly dispersed composite functional flame retardant can utilize the special effect of boehmite, and the flame retardancy of the polyurethane hot melt adhesive is improved. The flame retardant can improve the mechanical strength of the polyurethane hot melt adhesive, also can form a stable physical barrier effect, and can cooperate with nitrogen-containing heterocyclic rings and phytic acid to achieve the effect of greatly enhancing the flame retardant property of the hot melt adhesive by adding a small amount of the flame retardant.

The application provides application of a hyperbranched conjugated fluorescent high polymer in fluorescence detection of gasoline, diesel and kerosene, and relates to the technical field of organic synthesis and fluorescence sensing. The hyperbranched conjugated fluorescent high polymer has a structure shown in general formula (I), and is characterized in that a triethynylbenzene structure in the center of the polymer is subjected to a sonogashira coupling reaction with a hydroxyl-substituted benzene derivative to form a two-dimensional network structure, thereby bringing excellent sensing performance to a sensitive film; the sensitive film has on-site rapid detection sensitivity and sub-second (less than 1s) rapid response capability for gasoline, diesel and kerosene, meets on-site emergency detection requirements, and can realize effective anti-interference capability for various substances, and realizes high selectivity detection in a complex matrix environment.

The application belongs to the technical field of organic afterglow crystal materials, and particularly relates to an electron-rich material co-constructed organic long afterglow crystal material and a preparation method and application thereof. The electron-rich diphenylamine material which is easy to crystallize and cheap and easy to obtain is selected as a host material, and the electron-rich halogenated benzene derivative which is cheap and easy to obtain is introduced as a guest material, so that a series of crystal materials with regular structure are constructed, and a long afterglow luminescent new material with long afterglow time and adjustable color is obtained. The experiment proves that the electron-rich material co-constructed organic long afterglow crystal material provided by the application can be excited by ultraviolet light, has the characteristics of environmental stability, the afterglow time is more than 2s, and the crystal morphology can be regular, the afterglow color can also be adjusted, which shows the application potential in the information encryption and anti-counterfeiting fields, and can provide a theoretical basis and material basis for data encryption, anti-counterfeiting and other practical applications.

Compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, are described (see Formula), where Q, z, R2, R3, and m are as defined in the description. Compositions containing the compounds of Formula (1) and methods for controlling unwanted vegetation, comprising bringing the unwanted vegetation or its environment into contact with an effective amount of a compound or composition of the invention, are also described.

The invention relates to the field of intelligent high polymer materials, in particular to a preparation method of an azobenzene derivative modified chitosan-based photosensitive shape memory composite material. The composite material is prepared by compounding modified chitosan and polyvinyl alcohol, wherein the modified chitosan is prepared by grafting 4-acryloyloxy azobenzene onto maleic anhydride modified chitosan; by optimizing the ratio of the modified chitosan to the PVA and the grafting ratio of the azobenzene, the composite material with excellent photosensitive shape memory performance is successfully obtained; the most preferable CSMCF-3 sample (CSM / PVA = 3 / 7, and the grafting rate is 0.5%) has a shape fixation rate of 97.2% and a shape recovery rate of 93.3% under 365nm ultraviolet irradiation, and the recovery time is shorter than 300 seconds. The composite material also has the advantages of good biocompatibility, biodegradability and the like, and has wide application prospects in the fields of food packaging, biomedical engineering and the like.

This invention discloses a method for preparing a diarylcarbazole material, relating to the field of organic light-emitting device technology. The method includes: obtaining intermediate A through a nitration reaction of 4-bromo-2-chloro-1-fluorobenzene; obtaining coupling intermediate B through a Suzuki coupling reaction of intermediate A and 1-naphthoboric acid; preparing intermediate C through a nitro cyclization reaction of intermediate B; coupling intermediate C with iodobenzene or iodobenzene derivative D to form intermediate E; preparing pinacol borate intermediate F using intermediate E; obtaining intermediate H through a Suzuki coupling reaction of intermediate F and o-bromoaniline or o-bromoaniline derivative G; cyclizing intermediate H under alkaline conditions to obtain intermediate I; and coupling intermediate I with a haloaryl derivative J to obtain the diarylcarbazole material. The preparation route provided by this invention has high reaction selectivity, produces a single product, has no obvious reaction defects, and avoids the problems of isomers in cyclization reactions and polybromination in bromination reactions.

The invention relates to a preparation method for co-producing lithium oxalate and fluorobenzene-containing derivatives and application thereof, and belongs to the technical field of organic synthesis and battery materials. In order to solve the technical problems that in the prior art, a fluorobenzene preparation process is dangerous, synthesis steps of lithium oxalate-containing salt are tedious, and the yield is low, the invention provides an efficient and safe preparation method for co-producing lithium oxalate-containing salt and fluorobenzene derivatives. The method comprises the following steps: reacting fluorine-containing lithium salt with an oxalate compound in the presence of a non-aqueous acid catalyst under the protection of inert gas to generate the lithium oxalate-containing salt and fluorobenzene derivative. The preparation method provided by the invention realizes collaborative production of two products with high added values, has the advantages of simple process, high safety, good atom economy and high purity of the obtained product, and is especially suitable for the fields of lithium ion battery electrolytes and additives.

The present invention relates to a negative electrode for a lithium secondary battery comprising a protective layer. More specifically, the negative electrode comprises: a negative electrode current collector; and a protective layer on the negative electrode current collector, wherein the protective layer may include a first polymer. The first polymer includes a main chain comprising a chain-like hydrocarbon and a plurality of benzene derivatives connected to the main chain, wherein each of the plurality of benzene derivatives includes 2 to 4 benzene rings, and adjacent benzene rings may be connected by a single bond or may be fused by sharing carbon atoms.

The application discloses a high-temperature-resistant and high-voltage-resistant lithium ion battery electrolyte and a preparation method thereof, and comprises the following components in percentage by mass: a film forming agent 1-4%, a flame retardant 1-3%, an electrolyte lithium salt 8-12%, an auxiliary lithium salt 1-2%, a high-voltage stable solvent 15-25%, and the balance being a base solvent. The application improves the cycle performance of the electrolyte by compounding fluorine-containing cyano-substituted benzene derivatives, silicon-oxygen compounds and nitrogen-containing borate esters as the film forming agent, and compounding the fluorine-containing cyclotriphosphazene flame retardant, so that the high-temperature stability and the high-voltage resistance of the electrolyte are enhanced through the synergistic effect, and the high-nickel electrode is compatible, the cycle life, the rate performance and the safety performance of the NCM811 battery are significantly improved.

The invention relates to a synthesis method of a phenylmorpholine sulfonate derivative, which comprises the following steps: taking morpholine-4-sulfonic acid as an initial raw material, and reacting with a halogenated benzene derivative in the presence of an organic alkali, an inorganic alkali and a solvent to generate the phenylmorpholine sulfonate derivative in the formula I, in the formula I and the formula II, R is H, halogen or C1-C6 alkyl. The synthesis method is simple in synthesis raw materials, high in yield and suitable for industrial production.

This application relates to biphenyl derivatives, wherein the biphenyl derivatives have the structure represented by formula I, or are pharmaceutically acceptable salts, esters, amides, solvates, active metabolites, polymorphs, isotope-labeled, isomers, or prodrugs of the structure represented by formula I. Here, ring A is a methyl- or amino-substituted, or unsubstituted, five-membered ring, and the ring atoms of ring A contain one or two nitrogen atoms, R 1 It is a hydrogen bond donor or acceptor, and its structure contains one or more of the following: an amino group, an imino group, a hydroxyl group, and an ether bond. JPEG2026528760000075.jpg6154

The application provides a preparation method of acetophenone, acetophenone derivative or acetophenone analog. The preparation method comprises the following steps: mixing a reaction substrate, a catalyst, N-hydroxyphthalimide (NHPI), and performing an oxidation reaction under a solvent-free condition by taking oxygen as an oxidant to obtain an oxidation product; the reaction substrate comprises one of ethylbenzene, an ethylbenzene derivative and an ethylbenzene analog; wherein the raw material for preparing the catalyst is Mg2Fe layered double hydroxide (Mg2Fe-LDH) and an organic acid. The method can realize efficient oxidation of ethylbenzene, an ethylbenzene derivative and an ethylbenzene analog under a solvent-free reaction condition.

The invention relates to the use of an organometallic coordination complex or its phytopharmaceutically acceptable salt of a Mm+ metal and of at least one L ligand, where Mm+ is a transition metal having an oxidation number m, L is a ligand of general formula (VII) or its anion, wherein R1 is selected from the group consisting of oxygen, mono or polycyclic alkyl, naphthalene residue, anthracene residue and their hydroxylated or ketone derivatives; R2 and R3 are identical or different and are selected independently of each other from hydrogen, halogen, a hydroxyl group, an alkoxy group, a linear or branched alkyl group, a cycloalkyl group or R2 and R3 together forming a benzene derivative; R6, R7 and R8 are identical or different and independently of each other are selected from hydrogen, a hydroxyl group, an alkoxy group, a linear or branched alkyl group, a cycloalkyl group, a phenyl group, an aryl group in the treatment of Xylella fastidiosa in a plant. The invention also concerns the use of the compound of formula (VII) in the treatment of Xylella fastidiosa in a plant, also in combination with the organometallic coordination complex. Advantageously, the invention concerns the treatment of olive trees.

To provide compounds that have excellent therapeutic, preventive, or ameliorative effects on immune diseases selected from autoimmune diseases, transplant rejection, allergic diseases, and inflammatory diseases. [Solution] The present invention relates to novel benzene derivatives and their immunosuppressive applications. Specifically, the present invention relates to compositions comprising a compound of chemical formula 1, its stereoisomers, solvates, hydrates, crystalline forms, or pharmaceutically acceptable salts. The compositions have preventive or therapeutic applications for immune diseases such as autoimmune diseases, transplant rejection, allergic diseases, and inflammatory diseases.

The invention discloses a synthesis method of a polyhydroxy vinyl benzene derivative, which comprises the following steps: (1) in the presence of a solvent, reacting 3, 4, 5-trihydroxy benzaldehyde with a chlorinated substance under the action of N, N-diisopropylethylamine at 20-30 DEG C, and after the reaction is finished, extracting and concentrating to obtain an intermediate product; and (2) in tetrahydrofuran, reacting the intermediate product with methyltriphenylphosphonium bromide under the action of potassium tert-butoxide at 20-30 DEG C, and after the reaction is finished, carrying out quenching, acidification, extraction, drying, concentration and column chromatography purification to obtain the polyhydroxy vinyl benzene derivative. The synthesis of the polyhydroxy vinyl benzene derivative is realized, the operation is simple and convenient, and the cost is low.

The application belongs to the technical field of molecular machines, and particularly relates to a fluorine-containing rotaxane molecule and a preparation method and application thereof. The fluorine-containing rotaxane molecule of the application takes fluorine-containing crown ether as a cyclic molecule, and is also a fluorine-19 magnetic resonance signal source; takes a chain molecule containing a secondary ammonium salt cation as an axle, and can control the relaxation property of fluorine through the interaction with the fluorine-containing crown ether; and takes 3,5-substituted benzene derivatives as end-capping groups to prevent the fluorine-containing crown ether from falling off from the axle. The molecule can be used as a fluorine-19 magnetic resonance contrast agent, and based on the structure characteristics of the rotaxane, the motion of the molecule is limited to improve the sensitivity of magnetic resonance imaging, a paramagnetic metal is not needed, the fluorine signal is single and strong, and the structure is convenient for subsequent functionalization, so that a high-performance 19 F MRI contrast agent is provided.

The invention relates to a selenium-containing salvia lignan lactone analogue as well as a preparation method and application thereof. The selenium-containing salvia lignan lactone analogue has the following structural formula, R1 is selected from any one of Cl and H, R2 is selected from any one of H, Br and OCH3, R3 is selected from any one of phenyl, chlorphenyl, bromophenyl, cyanophenyl, trifluoromethylphenyl and naphthyl, and R4 is selected from CH3. The preparation method comprises the following steps: coupling aniline (or a halogenated aniline derivative) with a halogenated nitrobenzene derivative, carrying out methylation and reductive amination on a coupling product, then carrying out amidation, removing one molecule of water, and then carrying out cyclization reaction to obtain the salvia lignan lactone analogue. The selenium-containing salvia lignan lactone analogue provided by the invention can be used for preparing antitumor drugs.

The application provides a long acene derivative molecule containing a seven-membered ring and a preparation method thereof. The structure is shown in formula I, formula II or formula III. The application takes a cycloaddition reaction, a double coupling reaction and other reactions as key steps, and long acene derivative molecules containing a seven-membered ring shown in formula I, formula II and formula III are simply and efficiently synthesized. The method has the advantages of high efficiency and simplicity, short synthesis period, macro preparation of raw materials, synthesis of novel non-benzene polycyclic aromatic hydrocarbons containing a seven-membered ring which cannot be obtained by traditional methods and the like. The novel non-benzene polycyclic aromatic hydrocarbons containing a seven-membered ring synthesized by the application have unique optical physical and electrochemical properties and good photoelectric functions.