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Preparation method of Hydrophile ultra-slippery coating for medical apparatus

A medical device and hydrophilic technology, applied in the field of new medical materials, can solve the problems of affecting the anti-calcification and scaling performance of devices, cumbersome production process and related equipment, and inability to apply coatings, etc., to achieve high production efficiency and long-lasting hydrophilicity. Ultra-smooth, simple coating process

Active Publication Date: 2017-02-22
成都德信安创新医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this method are: the problem of initiator residue; for thick-walled medical devices and opaque internal surfaces of devices, ultraviolet rays cannot penetrate and cannot be cured, so the inner surface cannot be coated, which affects the anti-calcification scaling of devices performance, etc., and can only use a low-efficiency spraying process; at the same time, in order to control the thickness of the dry coating after coating, a solvent is usually added for regulation, so that the ultraviolet radiation can only be carried out after the volatile solvent is dried during coating, so that the production process and Related equipment is more cumbersome

Method used

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  • Preparation method of Hydrophile ultra-slippery coating for medical apparatus
  • Preparation method of Hydrophile ultra-slippery coating for medical apparatus
  • Preparation method of Hydrophile ultra-slippery coating for medical apparatus

Examples

Experimental program
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Effect test

Embodiment 1

[0029] First pour 30 mass parts of tetrahydrofuran into the reaction vessel, then mix 50 mass parts of N-vinylpyrrolidone and 1 mass part of hydroxyethyl acrylate in the head tank A; then mix 0.2 mass parts of initiator V -601 and 18.8 parts by mass of tetrahydrofuran are mixed evenly in the head tank B, and finally at the reaction temperature of 60°C, the head tank A and the head tank B are opened at the same time, and the uniform dropwise addition is completed within 4 hours; when all the materials are dropped , Insulation reaction for 2h to obtain hydroxyvinylpyrrolidone polymer.

Embodiment 2

[0031] First pour 45 parts by mass of methyl lactate into the reaction vessel, then mix 40 parts by mass of N-vinylpyrrolidone and 3 parts by mass of hydroxypropyl acrylate in the head tank A; then place 0.5 parts by mass of initiator Agent V-50 and 11.5 parts by mass of methyl lactate were mixed evenly in the head tank B, and finally at the reaction temperature of 70°C, the head tank A and the head tank B were opened at the same time, and the uniform dropwise addition was completed within 3 hours; when all the materials After the dropwise addition was completed, the reaction was incubated for 2 hours to obtain a hydroxyvinylpyrrolidone polymer.

Embodiment 3

[0033] First pour 50 parts by mass of ethyl lactate into the reaction vessel, then mix 30 parts by mass of N-vinylpyrrolidone and 5 parts by mass of hydroxyethyl methacrylate in the head tank A; then mix 1 part by mass of Initiator V-044 and 14 parts by mass of ethyl lactate were mixed evenly in head tank B, and finally at a reaction temperature of 80°C, head tank A and head tank B were opened at the same time, and the uniform dropwise addition was completed within 2 hours; After all the materials were added dropwise, the reaction was carried out for 2 hours to obtain the hydroxyvinylpyrrolidone polymer.

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Abstract

The invention discloses a preparation method of Hydrophile ultra-slippery coating for medical apparatus. The apparatus is characterized by being prepared, by mass, from the following material: 5-15 parts of hydroxy vinyl pyrrolidone polymer, 0.5-8 parts of isocyanate, 0.2-8 parts of isocyanate crosslinking agent, 0.05-0.5 parts of leveling agent and 73.5-94.25 parts of solvent A. The preparation method of the ultra-slippery coating comprises the steps of mixing the materials uniformly based on the ratio in normal temperature, and stirring for 3-6 hours to acquire the coating composition, conducting the dip-coating or spraying using the coating composition on the surface of the medical apparatus, drying under the temperature of 5-60 DEG C for 20-40 minutes to acquire the hydrophile ultra-slippery coating which possesses the good effect of the sustainable hydrophile and ultra-slippery properties. The hydrophile ultra-slippery coating prepared by the method is particularly suitable for the medical apparatuses made of polar materials such as polyvinyl chloride, polyurethane, nylon, acrylate and polyether ether ketone. The coating prepared based on the method can be used to produce the medical apparatuses such as urinary catheter, ureteral stent, guide wire, angiographic catheter, endoscopic sheath, balloon catheter, drainage tube and central venous catheter.

Description

technical field [0001] The invention belongs to the field of new medical materials, and relates to a medical device made of polyvinyl chloride, polyurethane, nylon, acrylate, polyether ether ketone, etc. Preparation method of hydrophilic super-slip coating on the surface of endoscopic inspection sheath, balloon catheter, drainage tube, central venous catheter, etc. Background technique [0002] Coating functional coatings on the surface of medical devices to make medical devices obtain hydrophilic, lubricating, antibacterial, anticoagulant, anti-tissue proliferation and other properties is an important step to improve the efficacy of medical devices, reduce patient discomfort, enhance treatment effects, and reduce infection rates. Technical solutions. With the advancement of medical technology, a large number of puncture needles, guide wires, catheters, catheter sheaths, stents, and balloons with super-smooth, antibacterial, anticoagulant, drug controlled release and other ...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/06A61L29/04A61L31/10A61L31/06A61L31/04A61L31/14
CPCA61L29/041A61L29/06A61L29/085A61L29/14A61L31/048A61L31/06A61L31/10A61L31/14C08L75/04C08L27/06
Inventor 唐文睿武迪蒙江时喜
Owner 成都德信安创新医疗技术有限公司
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