The invention belongs to the technical field of medicines, and particularly relates to a medicine for preventing closed-fracture early-stage tension vesicles from being generated and developed. The medicine comprises, by weight, 4-6 parts of Chinese fan palm seeds, 4-6 parts of fewflower lysionotus herbs, 4-6 parts of roots of candolle pimpinella, 4-6 parts of roots of champion pentasacme, 4-6 parts of tubers of serrate sikoku jackinthepulpit, 4-6 parts of nude pronephrium rhizomes, 4-6 parts of all-grass of winkled marshweed, 4-6 parts of roots of perny germander, 4-6 parts of herbs of pilose bushclover and 4-6 parts of leaves of lance coreopsis. All the medicinal materials are combined to jointly achieve the effects of clearing heat, removing toxicity, activating blood, relieving swelling, regulating qi, eliminating stagnation, dispersing blood stasis and relieving pain, the medicine is used for preventing closed-fracture early-stage tension vesicles from being generated and developed, and the total effective rate is up to 97.7%.