Application of anti-allergy composition in production of preparation and/or medicine for reducing irritation of azelaic acid

A composition, technology of azelaic acid, applied in the direction of drug combination, allergic diseases, plant/algae/fungus/moss components, etc., to achieve the effect of improving product competitiveness, high acne cure rate, and increasing compliance

Inactive Publication Date: 2021-06-25
谢志辉生物医药研究院(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are no relevant reports on the use of chrysanthemum, bletilla striata, and gastrodia elata to relieve the irritation of azelaic acid

Method used

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  • Application of anti-allergy composition in production of preparation and/or medicine for reducing irritation of azelaic acid
  • Application of anti-allergy composition in production of preparation and/or medicine for reducing irritation of azelaic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0058] Embodiment 1-3 A kind of acne-removing ointment and preparation method thereof

[0059] The weight percent content of the acne-removing ointment formula in Examples 1-3 and Comparative Examples 1-3 is shown in Table 1 below.

[0060] Acne-removing ointment formula in table 1 embodiment 1-3, comparative example 1-3

[0061]

[0062] The preparation method of embodiment 1-3 anti-acne ointment comprises the following steps:

[0063] S1. Stir and heat the solid oil and emulsifier to 85°C to obtain solution A;

[0064] S2. Add water and polyol, stir and heat to 85°C to obtain solution B;

[0065] S3. Add solution A to solution B, stir and homogenize to obtain solution C;

[0066] S4. Cool solution C to 50°C, add azelaic acid and stir evenly to obtain solution D;

[0067] S5. Cool the solution D to 40°C, add the extracts of Chrysanthemum chrysanthemum, Bletilla striata and Gastrodia elata, stir evenly and cool to room temperature to obtain the acne-removing ointment. ...

Embodiment 4-6

[0073] Embodiment 4-6 A kind of acne-removing gel and its preparation method

[0074] The weight percent content of the anti-acne gel formula in Examples 4-6 and Comparative Examples 4-6 is shown in Table 3 below.

[0075] Table 3 embodiment 4-6, comparative example 4-6 in the anti-acne gel formula

[0076]

[0077] The preparation method of embodiment 4-6 acne gel, comprises the following steps:

[0078] S1. Uniformly disperse azelaic acid in some polyols, stir and heat to 85°C to obtain solution A;

[0079] S2. Uniformly disperse the thickener in the remaining polyol, and add water to obtain solution B;

[0080] S3. Add solution A to solution B, and stir evenly at 65°C to obtain solution C;

[0081] S4. Cool the solution C to 45° C., add the extracts of chrysanthemum chrysanthemum, bletilla striata and gastrodia elata, and stir evenly to obtain the acne-removing gel.

[0082] The preparation method of the acne-removing gel in Comparative Example 4-6 is similar to the ...

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Abstract

The invention belongs to the technical field of skin medicines, and particularly relates to application of an anti-allergy composition in the production of a preparation and / or a medicine for reducing irritation of azelaic acid. The anti-allergy composition provided by the invention contains, by weight, 2-6% of a helichrysum extract, 0.3-2% of a bletilla striata extract and 0.3-2% of a gastrodia elata extract. The anti-allergy composition can obviously reduce erythema, pruritus, scales, burning sensation and other adverse reactions caused by azelaic acid ointment products, the effective rate reaches 90% or above, and the compliance of patients is improved, so that the product competitiveness is improved. The anti-allergy composition can be used for preparing acne-removing gel or ointment containing azelaic acid, the irritation of azelaic acid in the product can be relieved, the repairing speed of damaged skin can be increased, and the good acne-removing effect is achieved.

Description

technical field [0001] The invention relates to the technical field of skin medicines, in particular to the application of an anti-allergic composition in the preparation of preparations and / or medicines for reducing the irritation of azelaic acid. Background technique [0002] Azelaic acid, commonly known as rhododendronic acid, is a naturally occurring straight-chain saturated dicarboxylic acid with nine carbon atoms. Relevant studies have shown that azelaic acid has good antibacterial properties and has significant permeability on the surface of the skin. It can treat acne, acne and other skin problems. It can also balance oil secretion, stimulate hair growth, and inhibit the activity of tyrosinase. Lightens pigmentation and effectively fades acne marks. Azelaic acid has no systemic adverse reactions, but it has local skin irritation, mainly erythema, itching, scales and burning sensation, and its stimulation mechanism is still unclear. These shortcomings make most cons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61K9/06A61K47/10A61P17/00A61P37/08A61P17/10
CPCA61K36/28A61K36/898A61K36/8988A61K9/06A61K47/10A61P17/00A61P37/08A61P17/10A61K2300/00
Inventor 谢志辉许亮吴超锐胡振永陈永培林伟俊李懿枭
Owner 谢志辉生物医药研究院(广州)有限公司
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