24 results about "Damages skin" patented technology

The application discloses a multifunctional biomaterial with light protection and repair functions, which comprises the following components in percentage by mass: 4-8% of methacrylated gelatin, 0.5-2% of nanomicelles of ferulic acid, 0.5-1% of adhesive peptides, 0.5-1.5% of hyaluronic acid and 0.5-1% of ekdromicin. The application further discloses a preparation method of the multifunctional biomaterial and application thereof. The multifunctional biomaterial realizes a trinity synergistic effect of 'protection-repair-regeneration', target enrichment of active ingredients to damaged parts, and can stimulate vascular regeneration, improve skin microcirculation, has antioxidant, anti-inflammatory and healing functions, and promotes repair of light-damaged skin.

The application provides a water-soluble breathable skin protection film composition and a preparation method and application thereof, relates to the technical field of skin care products and functional coating, and the water-soluble breathable skin protection film composition contains the following components in percentage of total weight: (a) 5-30% of a film-forming polymer component, the film-forming polymer component is a combination of polyvinylpyrrolidone / vinyl acetate copolymer and partially alcoholized polyvinyl alcohol; (b) 5-25% of C2-C4 lower alcohol and / or C2-C10 aliphatic diol; (c) 0.01-10% of a polyether-modified silicone surfactant; (d) 0.01-18% of a functional auxiliary agent; (e) the balance is water. The composition can form a breathable film with a water vapor transmission rate greater than 500 g / (m 2 ·24h) on the skin, which can be removed within 90 seconds by using 25-30 DEG C normal temperature water. When used in medical treatment, the composition does not contain lower alcohol and has no irritation to damaged skin.

This invention provides a liquid crystal biomimetic water-locking and oxygen-permeable skincare composition, its preparation method, and its application, belonging to the field of cosmetic technology. It comprises the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The liquid crystal biomimetic water-locking and oxygen-permeable skincare composition provided by this invention can better form a breathable protective film on the skin surface, reduce skin moisture loss, and help repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable skincare.

This invention discloses a repair composition containing multiple ceramides and its preparation method, belonging to the field of cosmetic technology. The repair composition, by mass parts, comprises ceramide AP, ceramide EOP, ceramide NP, phytosphingosine, Centella asiatica extract, Portulaca oleracea extract, Hydrangea macrophylla extract, ectoine, and tripeptide-1. This invention utilizes multiple ceramides and phytosphingosine to biomimetically replenish the lipids of the stratum corneum, combined with the synergistic effects of various plant active ingredients and active peptides, to effectively achieve multiple effects such as skin barrier repair, soothing and anti-inflammatory properties, and anti-allergy. This invention also provides a barrier repair serum containing this repair composition and its preparation method. The serum has stable physicochemical properties and, verified by in vitro cell experiments and human efficacy tests, can rapidly repair damaged skin barriers, improve sensitive symptoms such as redness and stinging, and is gentle and non-irritating, suitable for daily skincare use by people with sensitive skin and damaged skin barriers.

The application relates to a skin repair essence and a preparation method thereof. The skin repair essence comprises the following raw materials in percentage by weight: 0.2-0.6% gold-coated magnetic nanoparticles, 75-92% skin repair culture medium, 0.4-1.2% antioxidant and 0.1-1.3% humectant, and the rest is deionized water; wherein the skin repair culture medium comprises a cell in-vitro culture medium, a sturgeon caviar extract, a lactobacillus fermentation product and a brown algae extract; the cell in-vitro culture medium comprises low-sugar DMEM, RPMI-1640, MEM and protein peptides; the antioxidant comprises green tea extract, vitamin C, oat kernel extract and yeast extract; and the humectant comprises trehalose, xanthan gum and sodium hyaluronate. The scheme provided by the application can achieve the purpose of relieving aging by repairing damaged skin cells, and effectively improves the skin repair effect in a safe and effective manner.

The application discloses a skin protective agent containing a bioactive composition, which comprises an A agent freeze-dried powder and a B agent solvent liquid, the A agent freeze-dried powder comprises a liposome-encapsulated animal umbilical cord extract, an active peptide composition and an excipient, wherein the liposome-encapsulated animal umbilical cord extract and the active peptide composition constitute the bioactive composition; and the B agent solvent liquid comprises a humectant, a soothing agent, a repairing agent and a stabilizer. The skin protective agent can efficiently stimulate the cell activity of the dermis layer in an endogenous manner, promote the regeneration of collagen and elastin, and increase the barrier; and can significantly reduce the transdermal water loss and build a moisturizing barrier and soothe and repair the damaged barrier in an exogenous manner. Tests show that the skin protective agent has excellent moisturizing, repairing, exfoliating and firming effects. All components of the skin protective agent are EWG all-green components, and are mild and non-irritating; all subjects agree that there is no adverse reaction, and the skin protective agent is particularly suitable for daily skin care, maintenance of damaged skin and post-medical beauty repair.

The present application relates to a skin barrier repair composition containing a Prinsepia uniflora extract and application thereof, and the skin barrier repair composition comprises the Prinsepia uniflora extract, the Physella fructus extract, the Origanum vulgare extract and the Portulaca oleracea extract. The Prinsepia uniflora extract, the Physella fructus extract, the Origanum vulgare extract and the Portulaca oleracea extract are combined creatively to form a brand-new composition mode, and the four are scientifically matched and synergized, the composition has excellent skin repair efficacy and anti-aging efficacy, and the specific performance is that the composition can promote the increase of the epidermal layer thickness, reduce the water loss rate of the damaged skin, accelerate the wound healing speed, and has a remarkable effect on promoting the expression of the repair-related genes and promoting the expression of the elastin and the collagen. In addition, the safety has been well verified, and the composition can be safely applied to related products.

This invention belongs to the field of skincare product preparation technology and discloses a method for preparing skincare products containing butter. The method includes a Mongolian butter purification process and a skincare product molding process. The purification process involves separating the milk skin by allowing it to stand, fermenting to prepare sour cream, whipping to separate the raw butter, and boiling and purifying to obtain cosmetic-grade Mongolian butter. The molding process uses the purified Mongolian butter as the core, combined with natural moisturizing excipients and emulsifiers, and involves mixing, melting, emulsifying, low-temperature sterilization, cooling, and filling to obtain the finished product. Finally, after passing inspection, it is stored. This invention features a coherent process, strong feasibility, and can thoroughly remove allergenic impurities from the butter while retaining its natural nutritional activity. The prepared skincare product is natural, safe, gentle, and hypoallergenic, with excellent moisturizing, repairing, and antioxidant effects. It is suitable for dry, sensitive skin, as well as infant and post-cosmetic surgery damaged skin, and exhibits strong stability and a long shelf life.

The application provides a traditional Chinese medicine gel for treating stubborn skin color spots and a preparation method thereof, and the traditional Chinese medicine gel is prepared from the following raw materials in mass parts: aloe extract 25-30 parts, opuntia dillenii Haw extract 10-15 parts, safflower 5-10 parts, radix lithospermi 5-8 parts, herba portulacae 5-8 parts, purified water 60-65 parts, carbomer 1-5 parts, fish scale glue 5-8 parts, hydrogenated castor oil 100-110 parts, ethanol 120-140 parts and monoglyceride 4-10 parts. The prepared traditional Chinese medicine gel can clear heat and cool blood, remove blood stasis and remove spots, promote skin metabolism, repair damaged skin cells, and can treat stubborn skin color spots such as chloasma, melasma and age spots, and has no side effects.

This invention discloses a Pickering emulsion loaded with Stephania tetrandra extract, prepared by emulsifying an oil phase and an aqueous phase at a mass ratio of 1:2. The oil phase consists of camellia seed oil and Stephania tetrandra extract, with a mass ratio of camellia seed oil to Stephania tetrandra extract of 40:1 to 80:1.5. The aqueous phase is a 0.5% to 1.0% (w / w) aqueous solution of silk fibroin. This invention also discloses a method for preparing the Pickering emulsion described above. Furthermore, this invention discloses the application of the Pickering emulsion described above in the preparation of cosmetics for relieving acute or chronic atopic dermatitis. The Pickering emulsion prepared by this invention avoids irritation to damaged skin, while optimizing the emulsion particle size and achieving long-term sustained release of Stephania tetrandra extract, thus solving the problem of low bioavailability. This emulsion has high safety, excellent biological efficacy, no significant cytotoxicity, and can achieve biphasic regulation of acute and chronic atopic dermatitis.

This invention relates to cosmetic compositions comprising brewer's yeast extract and diol. These compositions selectively promote the growth of beneficial bacteria on the skin, thereby maintaining the balance of the skin microbiome. This contributes to skin health by improving damaged skin and other means. They can be used to maintain the skin's microecological balance and can improve or enhance the UV blocking effect of UV blockers, thus enabling UV blocking enhancement.

The present application relates to the skin care technical field, and provides a sepiolite multifunctional mask and a preparation method thereof, raw materials including sepiolite composite material, synergist and water, wherein the sepiolite composite material includes sepiolite and antibacterial components. The mask prepared from the raw materials is green, safe, mild and non-irritating, can deeply clean the skin surface, has good antibacterial effect, can effectively inhibit the growth of surface bacteria, creates an antibacterial and bactericidal environment on the skin surface, and is beneficial to the maintenance of sensitive skin, the prevention of acne and the repair of damaged skin.

The invention also refers to a method of inducing, stimulating and / or promoting healing of a wound or a damaged skin area, wherein the method comprises topically treating the skin of a subject surrounding the wound or damaged skin area with conditioned medium derived from cultivation of mesenchymal stem cells of the umbilical cord. Equally, the invention relates to a method of preventing formation and / or recurrence of a wound or a damaged skin area in a subject being at risk of developing a wound or a damaged skin area, wherein the method comprises topically treating the skin of the subject with conditioned medium derived from cultivation of mesenchymal stem cells of the umbilical cord. Further, the invention relates to a method of treating rosacea, psoriasis, eczema, dermatitis, topical steroid withdrawal syndrome, epidermolysis bullosa, or skin damage caused by fragile skin, wherein the method comprises topically treating the skin of a subject surrounding the wound or damaged skin area to be treated with conditioned medium derived from cultivation of mesenchymal stem cells of the umbilical cord. The present invention is also directed to conditioned medium, uses thereof, compositions comprising the same, methods of producing the same as well as uses of these compositions.

The invention claimed herein relates to liquid crystalline lipid particles which are substantially free of ethoxylated emulsifiers without compromising skin and / or hair care performance. The liquid crystalline lipid particles of the present invention can provide skin protection benefits.

This invention discloses a single-domain antibody targeting phosphatidylserine, an engineered exosome based on this antibody, its preparation method, and its application in the preparation of skin repair products. The single-domain antibody has the amino acid sequence shown in SEQ ID NO:1. This invention further provides an engineered exosome whose surface is covalently linked to the single-domain antibody, and whose interior is enriched with mRNA encoding GPX4. This exosome is derived from human placental mesenchymal stem cells treated with a specific sequential induction protocol that can mimic the damaged microenvironment and upregulate the expression of specific functional molecules. The constructed engineered exosome can actively recognize and target the delivery of therapeutic molecules to damaged skin cells with everted phosphatidylserine, thereby effectively inhibiting ferroptosis, repairing UV-induced photoaging damage, and enhancing skin barrier function, providing a new technical solution to address the problem of insufficient targeting in existing exosome therapies.

This invention discloses a calamine composition, its preparation method, and its application. The calamine composition uses xanthan gum and sodium polyacrylamide dimethyl taurate as a composite thickener, and cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol and sorbitan stearate as emulsifiers to form an oil-in-water formulation. Practice shows that the calamine composition of this invention can achieve improved overall performance. It can not only stabilize high-content calamine in aqueous emulsion systems, but also can be stored for a long time over a wide temperature range. It can be used to prepare cosmetics that can soothe, calm, and repair damaged skin.

The application discloses a Bose anti-wrinkle cream and a preparation method thereof. The Bose anti-wrinkle cream comprises the following components in percentage by weight: 60-78% of Asian white birch juice, 6-8% of ginseng root water, 5-10% of a moisturizing agent, 0.4-1% of an emulsifying thickening agent, 5-10% of an emollient, 5-10% of a skin conditioner, and 0.6-1% of a preservative. The Bose anti-wrinkle cream of the application uses white birch juice as a solvent, adds high-content hydroxypropyl tetrahydropyran triol, and is matched with Schizochytrium limacinum ferment filtrate and superoxide dismutase, so that the skin is more delicate and has a brightening effect on the basis of improving wrinkles, skin inflammation and oxidative damage are reduced, and damaged skin is repaired.

This invention belongs to the field of cosmetics, specifically relating to an anti-chapped skin composition and its preparation method. The anti-chapped skin composition, by mass ratio, comprises the following components: 5.0–20.0% polyol, 0.1–1.0% allantoin, 2.0–10.0% petrolatum, 2.0–10.0% mineral oil, 0.1–3.0% tea seed oil, 0.1–2.0% tocopheryl acetate, 2.0–5.0% polyglycerol-3-methylglucose distearate, 1.0–8.0% fatty alcohol, 0.1–0.3% thickener, 0.1–0.3% potassium cetyl phosphate, and the balance being deionized water. The anti-chapped skin composition prepared by this invention effectively protects the skin from external factors, repairs damaged skin, and is gentle and non-irritating to the skin. It moisturizes the stratum corneum, locks in skin moisture for a long time, and prevents skin chapping.

The application discloses a kind of compositions with multiple soothing repair and its application, belong to cosmetic technical field.The composition includes the following components by weight parts: Machi extract 3-10 parts, grape extract 5-10 parts, date extract 10-16 parts.The application also provides the preparation method of the composition and its application in the preparation of cosmetics.The composition takes natural plant extract as core, three synergies build "anti-inflammatory-repair-barrier reinforcement" complete repair link, has multiple effects such as significant anti-inflammatory, soothing redness, repairing skin barrier, improving water-locking capacity, and high safety, no irritation, suitable for sensitive skin, barrier damaged skin and other types of skin long-term care.The composition can be widely applied in emulsion, cream, essence and other cosmetics, and has good market prospect.

The application discloses a kind of plant extract compositions and its application of photothermal damage skin resistance, the composition is by following weight parts Each raw material is mixed to form: Forsythia suspensa flower extract 60-90 parts, Saururus chinensis extract 5-15 parts, Eucommia bark extract 3-10 parts;Wherein, Forsythia suspensa flower extract total lignans content ≥8wt%;Saururus chinensis extract total lignans content ≥15wt%, total triterpenes content ≥25wt%;Eucommia bark extract coralwood glycoside content ≥8wt%, gardenia jasminoides content ≥2wt%.Advantages are, the synergistic effect of three plant extracts in composition on different key pathways that cause skin photothermal damage, form a complete theoretical logic closed, can synergistically solve the skin redness problem caused by capillary relaxation due to photothermal damage, good safety, can be widely applied in cosmetics and external medicine.

This invention relates to the technical field of cosmetics, and discloses the preparation and application of a supramolecular composition with moisturizing and soothing effects. Using extracts of kava (PIPER METHYSTICUM) leaf / root / stem, milk thistle (SILYBUM MARIANUM) extract, and oat (AVENA SATIVA) extract as core active ingredients, supramolecular encapsulation and spray drying technologies are employed to encapsulate these poorly soluble soothing active ingredients with an encapsulation material. This solves the technical pain points of poor solubility, low transdermal absorption efficiency, and easy loss of activity of single active ingredients. The encapsulated supramolecular composition can deeply penetrate to the basal layer of the skin, soothe damaged skin barrier, and synergistically exert a powerful moisturizing and soothing effect. When applied to cosmetics, it can nourish the skin from the inside out, replenish skin moisture, enhance skin barrier function, and help the skin restore a hydrated, radiant, smooth, and healthy state. Compared with existing single active ingredients, the supramolecular composition of the present invention has significant advantages such as high transdermal absorption efficiency, strong stability of active ingredients, and synergistic effect. It can be widely used in various skin care products such as creams, lotions, emulsions, and masks, as well as related cosmetic systems such as scalp care and body wash.

The present application relates to a kind of aircraft surface damage area segmentation method based on adaptive multi-modal fusion, belong to nondestructive testing technical field, solve the technical problem of low precision of aircraft skin surface peeling damage area segmentation, it includes collecting aircraft skin damage data, obtains the gray scale chart, depth chart and point cloud chart of aircraft surface damage skin;Synthesis is carried out to gray scale chart, depth chart and point cloud chart, and the steps of obtaining the total edge probability chart of skin damage are carried out to the pre-processing, feature extraction, feature conversion, image display and projection, weighted fusion of synthesized gray scale chart, synthesized depth chart and synthesized point cloud chart;Total edge probability chart is screened, continuity detection, connectedness detection, constructs convex hull, marks, and divides the steps of skin peeling damage area.This application is used for aircraft skin health monitoring, maintenance support and operation.

This invention discloses a shower gel with antibacterial function, specifically relating to the technical field of shower gels. This shower gel aims to solve the problems of existing shower gels being unsuitable for damaged skin and hindering wound healing with long-term use. The shower gel of this invention contains the following components by weight percentage: 0.05%-0.2% hinoki alcohol; 1.0%-5.0% psoralen extract; 1.0%-8.0% Tween 20; 3.0%-10.0% propylene glycol; 0.5%-3.0% phospholipids; 0.01%-0.15% benzalkonium chloride; appropriate amount of pH adjuster; and the balance being purified water. This invention achieves a gentle and non-irritating cleansing effect through the selection and proportioning of specific components, while also exhibiting a significant inhibitory effect on common pathogenic bacteria. It is particularly suitable for the cleansing and care of skin around postoperative wounds and sensitive skin. This shower gel does not contain alcohol, fragrance, pigments, or irritating surfactants, avoiding secondary damage to damaged skin caused by traditional products. It has good system stability and biocompatibility, providing a safe and effective whole-body cleansing solution for postoperative patients.