Liver protection composition and preparation method thereof

Abstract

The invention discloses a liver protection composition and a preparation method thereof. The liver protection composition comprises the following raw materials in parts by mass: 10-20 parts of pseudo-ginseng, 20-30 parts of origanum vulgare, 40-50 parts of Chinese dates, 20-30 parts of glossy privet fruits, 40-50 parts of red peony roots and 5-10 parts of Chinese magnoliavine fruits. Animal experiments find that in the raw materials of the liver protection composition, the combination of pseudo-ginseng, origanum vulgare, jujube, glossy privet fruit, red peony root and schisandra chinensis greatly increases the GSH value and CAT value, and significantly reduces the TG value and MDA value, so that the liver protection composition has a significant liver protection effect. The raw materials adopted by the liver protection composition provided by the invention are non-toxic and harmless to a human body, and the generated medicine effect is mild and safe. The liver protection composition provided by the invention is simple and convenient in preparation process, low in preparation cost and high in production efficiency.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a liver protection composition and a preparation method thereof. Background Art

[0002] As one of the most important metabolic organs in the human body, the liver is an important site for metabolic activities. It participates in many important life activities such as human metabolism, detoxification, secretion, and excretion, and is essential for maintaining the balance and health of the body. However, due to the fast pace of life in today's society, the liver is burdened with excessive stress, lack of sleep, excessive body fat, excessive smoking and drinking, and greasy diet, which can cause liver damage. In recent years, the number of people suffering from liver diseases such as fatty liver and alcoholic liver that affect health has gradually increased. Therefore, it is particularly important to nourish and protect the liver. The main methods of common liver protection are: (1) taking Western medicine liver protection drugs, but they usually have more side effects, and their metabolites will also put a certain burden on the liver. In addition, taking Western medicine is prone to dependence and drug resistance; (2) taking traditional Chinese medicine liver protection drugs, but the existing traditional Chinese medicine liver protection drugs have some problems with unsatisfactory ratios and components, resulting in certain limitations in the efficacy of liver protection. Therefore, it is of practical significance to provide a liver protection drug that is non-toxic to the human body, has few side effects, and has a reasonable composition ratio. Summary of the invention

[0003] In view of the deficiencies in the above-mentioned prior art, the present invention provides a liver protection composition, which is synergistic between the components by combining a specific mass ratio of Panax notoginseng, oregano, jujube, Ligustrum lucidum, red peony root, and Schisandra chinensis, greatly improving the GSH value and CAT value, significantly reducing the TG value and MDA value, and having a significant liver protection effect. The liver protection composition provided by the present invention has no obvious toxic and side effects on the human body, a simple preparation process, and a low preparation cost.

[0004] The object of the present invention is to provide a liver protection composition, which comprises the following raw materials in parts by weight: 10 to 20 parts of Panax notoginseng, 20 to 30 parts of oregano, 40 to 50 parts of jujube, 20 to 30 parts of Ligustrum lucidum, 40 to 50 parts of red peony root, and 5 to 10 parts of Schisandra chinensis.

[0005] In some embodiments of the present invention, the liver protection composition also includes the following raw materials in parts by weight: 12-18 parts of Panax notoginseng, 23-30 parts of oregano, 40-47 parts of jujube, 23-29 parts of Ligustrum lucidum, 40-46 parts of red peony root, and 5-8 parts of Schisandra chinensis.

[0006] In some embodiments of the present invention, the liver protection composition further includes the following raw materials in parts by weight: 12 parts of Panax notoginseng, 27 parts of oregano, 45 parts of jujube, 28 parts of Ligustrum lucidum, 46 parts of red peony root, and 8 parts of Schisandra chinensis.

[0007] In some embodiments of the present invention, the liver protection composition also includes the following raw materials in parts by weight: 20-30 parts of artificial bezoar, 40-50 parts of pig bile, 10-20 parts of tricholoma aconitifolia, 20-30 parts of eucommia, 10-20 parts of gardenia, 40-50 parts of capillaris, and 20-30 parts of curcuma.

[0008] Another object of the present invention is to provide a method for preparing the above-mentioned liver protection composition, comprising the following steps:

[0009] S1. 20 to 30 parts by mass of artificial bezoar, 40 to 50 parts by mass of pig bile, 10 to 20 parts by mass of hairy chicken bone grass, 20 to 30 parts by mass of Eucommia ulmoides, 10 to 20 parts by mass of Gardenia jasminoides, 40 to 50 parts by mass of Artemisia capillaris, 20 to 30 parts by mass of Curcuma aromatica were extracted with water, filtered, and the filtrate was retained to obtain an extract;

[0010] S2. boiling the extract, filtering, and concentrating the filtrate to obtain an extract;

[0011] S3. Mix the extract with 10-20 parts by mass of Panax notoginseng, 20-30 parts by mass of oregano, 40-50 parts by mass of jujube, 20-30 parts by mass of Ligustrum lucidum, 40-50 parts by mass of Ligustrum lucidum, and 5-10 parts by mass of Schisandra chinensis, add auxiliary materials, dry, and grind into fine powder to obtain a liver protection composition.

[0012] In some embodiments of the present invention, in S1, the mass ratio of the total mass of the artificial bezoar, pig bile, tricholoma aconiti lobata, eucommia bark, gardenia, capillaris and curcuma to water is 1:6-8.

[0013] In some embodiments of the present invention, in S1, the extraction temperature is 45-65° C., and the extraction time is 2-3 hours.

[0014] In some embodiments of the present invention, in S2, the decoction temperature is 80-100° C., and the decoction time is 4-6 hours.

[0015] Another object of the present invention is to provide an application of the liver protection composition in the preparation of liver protection drugs.

[0016] In some embodiments of the present invention, the liver protecting drug includes the liver protecting composition.

[0017] In some embodiments of the present invention, the liver protecting drug further comprises pharmaceutically acceptable excipients.

[0018] In some embodiments of the present invention, the auxiliary material is at least one of polyene phosphatidylcholine, corn oligopeptide powder, and organic selenium.

[0019] Another object of the present invention is to provide a method for preparing the drug, comprising the following steps:

[0020] S1. 20 to 30 parts by mass of artificial bezoar, 40 to 50 parts by mass of pig bile, 10 to 20 parts by mass of hairy chicken bone grass, 20 to 30 parts by mass of Eucommia ulmoides, 10 to 20 parts by mass of Gardenia jasminoides, 40 to 50 parts by mass of Artemisia capillaris, 20 to 30 parts by mass of Curcuma aromatica were extracted with water, filtered, and the filtrate was retained to obtain an extract;

[0021] S2. boiling the extract, filtering, and concentrating the filtrate to obtain an extract;

[0022] S3. Mix the extract with 20 parts by mass of Panax notoginseng, 30 parts by mass of oregano, 40 parts by mass of jujube, 20 parts by mass of Ligustrum lucidum, 50 parts by mass of Ligustrum lucidum, and 5 parts by mass of Schisandra chinensis, add auxiliary materials, dry, and grind into fine powder to make a drug in the form of tablets, capsules, granules, powders, suspensions or pills.

[0023] In some embodiments of the present invention, in S1, the mass ratio of the total mass of the artificial bezoar, pig bile, tricholoma aconiti lobata, eucommia bark, gardenia, capillaris and curcuma to water is 1:6-8.

[0024] In some embodiments of the present invention, in S1, the extraction temperature is 45-65° C., and the extraction time is 2-3 hours.

[0025] In some embodiments of the present invention, in S2, the decoction temperature is 80-100° C., and the decoction time is 4-6 hours.

[0026] In some embodiments of the present invention, in S3, the auxiliary material is at least one of polyene phosphatidylcholine, corn oligopeptide powder, and organic selenium.

[0027] In some embodiments of the present invention, in S3, the auxiliary materials are 290-310 parts by mass of polyene phosphatidylcholine, 30-40 parts by mass of corn oligopeptide powder and 290-310 parts by mass of organic selenium.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) The raw materials used in the liver protection composition of the present invention have no obvious toxic side effects on the human body, and the efficacy is mild and safe.

[0030] (2) In the liver protection composition described in the present invention, the combination of Panax notoginseng, oregano, jujube, Ligustrum lucidum, red peony root, and Schisandra chinensis greatly increased the GSH value and CAT value, and significantly reduced the TG value and MDA value, indicating that the present invention has a significant liver protection effect.

[0031] (3) Compared with the prior art, the liver protection composition of the present invention has a simpler preparation process and lower preparation cost, thereby effectively improving production efficiency. DETAILED DESCRIPTION

[0032] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0033] Example 1

[0034] This embodiment provides a liver protection drug, and the specific preparation steps are as follows:

[0035] S1. 30 parts by mass of artificial bezoar, 40 parts by mass of pig bile, 10 parts by mass of hairy chicken bone grass, 30 parts by mass of Eucommia ulmoides, 20 parts by mass of Gardenia jasminoides, 40 parts by mass of Artemisia capillaris, 30 parts by mass of Curcuma aromatica were mixed, 1200 parts by mass of water were added and extracted at 45 ° C for 3h, filtered, and the filtrate was retained to obtain an extract;

[0036] S2. The extract was boiled at 80°C for 6h, filtered, and the filtrate was concentrated to obtain an extract;

[0037] S3. Mix the extract with 10 parts by mass of Panax notoginseng, 20 parts by mass of oregano, 45 parts by mass of jujube, 30 parts by mass of Ligustrum lucidum, 40 parts by mass of Ligustrum lucidum, and 10 parts by mass of Schisandra chinensis, add 280 parts by mass of polyene phosphatidylcholine, 40 parts by mass of corn oligopeptide powder and 310 parts by mass of organic selenium, dry, and grind into fine powder to obtain a liver-protecting drug.

[0038] Example 2

[0039] This embodiment provides a liver protection drug, and the specific preparation steps are as follows:

[0040] S1. 20 parts by mass of artificial bezoar, 48 parts by mass of pig bile, 20 parts by mass of hairy chicken bone grass, 20 parts by mass of Eucommia ulmoides, 10 parts by mass of Gardenia jasminoides, 50 parts by mass of Artemisia capillaris, 22 parts by mass of Curcuma acuminatum were mixed, 1520 parts by mass of water were added and extracted at 65 ° C for 2h, filtered, and the filtrate was retained to obtain an extract;

[0041] S2. boiling the extract at 100° C. for 4 h, filtering, and concentrating the filtrate to obtain an extract;

[0042] S3. Mix the extract with 20 parts by mass of Panax notoginseng, 30 parts by mass of oregano, 40 parts by mass of jujube, 20 parts by mass of Ligustrum lucidum, 50 parts by mass of Ligustrum lucidum, and 5 parts by mass of Schisandra chinensis, add 310 parts by mass of polyene phosphatidylcholine, 30 parts by mass of corn oligopeptide powder and 290 parts by mass of organic selenium, dry, and grind into fine powder to obtain a liver-protecting drug.

[0043] Example 3

[0044] This embodiment provides a liver protection drug, and the specific preparation steps are as follows:

[0045] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0046] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0047] S3. Mix the extract with 12 parts by mass of Panax notoginseng, 27 parts by mass of oregano, 50 parts by mass of jujube, 28 parts by mass of Ligustrum lucidum, 46 parts by mass of Ligustrum lucidum, and 8 parts by mass of Schisandra chinensis, add 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium, dry, and grind into fine powder to obtain a liver-protecting drug.

[0048] Comparative Example 1

[0049] This comparative example provides a liver-protecting drug, and the specific preparation steps are as follows:

[0050] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0051] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0052] S3. The extract was mixed with 171 parts by mass of Panax notoginseng, 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium were added, dried and crushed into fine powder to obtain a liver-protecting drug.

[0053] Comparative Example 2

[0054] This comparative example provides a liver-protecting drug, and the specific preparation steps are as follows:

[0055] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0056] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0057] S3. The extract is mixed with 171 parts by mass of oregano, 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium are added, dried, and crushed into fine powder to obtain a liver-protecting drug.

[0058] Comparative Example 3

[0059] This comparative example provides a liver-protecting drug, and the specific preparation steps are as follows:

[0060] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0061] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0062] S3. The extract is mixed with 171 parts by mass of jujube, 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium are added, dried, and crushed into fine powder to obtain a liver-protecting drug.

[0063] Comparative Example 4

[0064] This comparative example provides a liver-protecting drug, and the specific preparation steps are as follows:

[0065] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0066] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0067] S3. The extract is mixed with 171 parts by mass of Ligustrum lucidum, 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium are added, dried, and crushed into fine powder to obtain a liver-protecting drug.

[0068] Comparative Example 5

[0069] This comparative example provides a liver-protecting drug, and the specific preparation steps are as follows:

[0070] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0071] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0072] S3. The extract is mixed with 171 parts by mass of Ligusticum chuanxiong, 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium are added, dried, and crushed into fine powder to obtain a liver-protecting drug.

[0073] Comparative Example 6

[0074] This comparative example provides a liver-protecting drug, and the specific preparation steps are as follows:

[0075] S1. 25 parts by mass of artificial bezoar, 50 parts by mass of pig bile, 13 parts by mass of hairy chicken bone grass, 21 parts by mass of Eucommia ulmoides, 13 parts by mass of Gardenia jasminoides, 42 parts by mass of Artemisia capillaris, 20 parts by mass of Curcuma acuminatum were mixed, 1288 parts by mass of water were added and extracted at 50 ° C for 2.5h, filtered, and the filtrate was retained to obtain an extract;

[0076] S2. The extract was boiled at 90° C. for 5 h, filtered, and the filtrate was concentrated to obtain an extract;

[0077] S3. The extract is mixed with 171 parts by mass of Schisandra chinensis, 295 parts by mass of polyene phosphatidylcholine, 35 parts by mass of corn oligopeptide powder and 300 parts by mass of organic selenium are added, dried, and crushed into fine powder to obtain a liver-protecting drug.

[0078] Performance Testing:

[0079] 1. Effect on the body weight of mice

[0080] Mice were selected as experimental animals, and mice aged 6 weeks and weighing 14-18g were placed in separate ventilated cages of SPF level (10 mice per cage). Under constant temperature and humidity conditions (temperature 24-26°C; relative humidity 55-65%), mice had free access to food and distilled water, and were maintained at a light / dark cycle of 12h / 12h. Before the experiment, the mice were allowed to acclimate to the environment for one week. The mice were randomly divided into 11 groups (10 mice in each group). That is, the control group, the model group, the liver protection composition group of Examples 1 to 3, and the liver protection composition group of Comparative Examples 1 to 6. The specific operations are as follows:

[0081] Control group: mice were fed with normal diet for 12 weeks and given 5 mg / kg saline by gavage;

[0082] Model group: mice were fed with 45% high-fat diet for 12 weeks and given 5 mg / kg normal saline by gavage;

[0083] Group 1 of Example 1: mice were fed with 45% high-fat diet for 12 weeks and given 5 mg / kg of the liver protection composition of Example 1 by oral gavage;

[0084] Group 2 of Example 2: mice were fed with 45% high-fat diet for 12 weeks and given 5 mg / kg of the liver protection composition of Example 2 by oral gavage;

[0085] Group 3 of Example: mice were fed with 45% high-fat diet for 12 weeks and given 5 mg / kg of the liver protection composition of Example 3 by oral gavage;

[0086] Comparative Example 1 group: mice were fed with 45% high-fat feed for 12 weeks, and 5 mg / kg of the liver-protecting composition of Comparative Example 1 was administered by gavage;

[0087] Comparative Example 2 group: mice were fed with 45% high-fat feed for 12 weeks, and 5 mg / kg of the liver-protecting composition of Comparative Example 2 was administered by gavage;

[0088] Comparative Example 3 group: mice were fed with 45% high-fat feed for 12 weeks, and 5 mg / kg of the liver-protecting composition of Comparative Example 3 was administered by gavage;

[0089] Comparative Example 4 group: mice were fed with 45% high-fat feed for 12 weeks, and 5 mg / kg of the liver-protecting composition of Comparative Example 4 was administered by gavage;

[0090] Comparative Example 5 group: mice were fed with 45% high-fat feed for 12 weeks, and 5 mg / kg of the liver-protecting composition of Comparative Example 5 was administered by gavage;

[0091] Comparative Example 6 group: mice were fed with 45% high-fat feed for 12 weeks, and 5 mg / kg of the liver-protecting composition of Comparative Example 6 was administered by gavage;

[0092] The body weight (g) of mice in each group was recorded regularly every 4 weeks, and the average value was taken. The experimental results are shown in Table 1.

[0093] Table 1. Body weight changes of mice.

[0094]

[0095] As shown in Table 1, with the increase of feeding time, the weight of mice in each group increased to varying degrees. Among them, the model group had the largest weight change, indicating that the excess lipids produced by the high-fat diet are difficult to be metabolized by the liver, causing the liver to be burdened and damaged, and the weight of the mice is difficult to be well controlled. After intervention, the weight changes of the mice were all controlled to varying degrees. Among them, Example 1 to 3 groups had the best control effect on the weight of mice, and the weight of the mice gradually tended to the normal range, while the comparative example 1 to 6 groups did not produce a significant control effect on the weight of mice, indicating that the liver protection composition described in the present invention helps the metabolism of excess lipids in the liver and plays a significant liver protection effect.

[0096] After 12 weeks of feeding, the mice in each group were killed, and their livers were taken out. An appropriate amount of physiological saline was added to the livers and fully homogenized to prepare a 10% liver homogenate. The livers were centrifuged at 3000 r / min for 10 min in a low-temperature high-speed centrifuge, and the supernatant was taken to determine the contents of triglyceride (TG), catalase (CAT), malondialdehyde (MDA) and glutathione (GSH) in the liver tissues. The results are shown in Table 2.

[0097] Table 2. Effects on liver parameters in mice.

[0098] Group TG (mmol / L) MDA (mmol / L) GSH (mmol / L) CAT (mmol / L) Control group 1.03 5.98 165.93 60.14 Model Group 2.35 11.98 91.25 28.97 Example 1 Group 1.44 7.62 125.84 42.85 Example 2 Group 1.47 7.67 125.43 42.41 Example 3 Group 1.45 7.65 125.07 42.54 Comparative Example 1 1.92 9.13 111.42 37.46 Comparative Example 2 1.89 9.42 110.63 35.81 Comparative Example 3 1.93 9.37 109.89 36.89 Comparative Example 4 1.99 9.24 108.93 36.62 Comparative Example 5 1.82 9.50 107.92 37.83 Comparative Example 6 1.81 9.35 111.53 35.90

[0099] As can be seen from Table 2, after being fed with a high-fat diet, the liver indicators of mice all fluctuated to varying degrees, indicating that a high-fat diet can easily increase the burden on the liver, leading to abnormal liver lipid metabolism and increased liver oxidative damage. After intervention, all indicators of the mouse liver were significantly improved. Among them, the changes in the various indicators of the mouse liver in Examples 1 to 3 groups tended to be normal, while the improvements in the various indicators in Comparative Examples 1 to 6 groups were relatively less obvious, indicating that the combination of Panax notoginseng, oregano, jujube, Ligustrum lucidum, red peony root, and Schisandra chinensis greatly increased the GSH value and CAT value, and significantly reduced the TG value and MDA value. Combined with the experimental results in Table 2, it is shown that the liver protection composition of the present invention has obvious liver protection effect.

[0100] The above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the same. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in the relevant field should understand that after reading the specification of this application, the technicians can still modify or replace the specific implementation methods of the present invention with equivalents, but these modifications or changes do not deviate from the scope of protection of the pending claims of the present application.

Claims

1. A liver protection composition, characterized in that: The liver protection composition comprises the following raw materials in parts by weight: 10-20 parts of Panax notoginseng, 20-30 parts of oregano, 40-50 parts of jujube, 20-30 parts of Ligustrum lucidum, 40-50 parts of red peony root, and 5-10 parts of Schisandra chinensis.

2. The liver protection composition according to claim 1, characterized in that The liver protection composition also includes the following raw materials in parts by weight: 20-30 parts of artificial bezoar, 40-50 parts of pig bile, 10-20 parts of tricholoma aconitifolia, 20-30 parts of eucommia bark, 10-20 parts of gardenia, 40-50 parts of capillaris, and 20-30 parts of curcuma.

3. A method for preparing a liver protection composition, characterized in that: The steps include: S1. 20-30 parts by weight of artificial bezoar, 40-50 parts by weight of pig bile, 10-20 parts by weight of tricholoma, 20-30 parts by weight of eucommia, 10-20 parts by weight of gardenia, 40-50 parts by weight of capillaris, and 20-30 parts by weight of curcuma are extracted with water, filtered, and the filtrate is retained to obtain an extract; S2. decoct the extract, filter, and concentrate the filtrate to obtain an extract; S3. Mix the extract with 10-20 parts by mass of Panax notoginseng, 20-30 parts by mass of oregano, 40-50 parts by mass of jujube, 20-30 parts by mass of Ligustrum lucidum, 40-50 parts by mass of red peony root, and 5-10 parts by mass of Schisandra chinensis, dry, and crush to obtain a liver protection composition.

4. Use of the liver protection composition according to any one of claims 1 to 2 in the preparation of liver protection drugs.

5. A liver-protecting drug, characterized in that: The liver protection composition comprises the liver protection composition according to any one of claims 1 to 2.

6. The drug according to claim 5, characterized in that Pharmaceutically acceptable excipients are also included.

7. The drug according to claim 6, characterized in that The auxiliary material is at least one of polyene phosphatidylcholine, corn oligopeptide powder and organic selenium.

8. The drug according to claim 5, characterized in that The dosage form of the medicine is tablet, capsule, granule, powder, suspension or pill.

9. The method for preparing the drug according to any one of claims 5 to 8, characterized in that: The steps include: S1. 20-30 parts by weight of artificial bezoar, 40-50 parts by weight of pig bile, 10-20 parts by weight of tricholoma, 20-30 parts by weight of eucommia, 10-20 parts by weight of gardenia, 40-50 parts by weight of capillaris, and 20-30 parts by weight of curcuma are extracted with water, filtered, and the filtrate is retained to obtain an extract; S2. decoct the extract, filter, and concentrate the filtrate to obtain an extract; S3. Mix the extract with 10-20 parts of Panax notoginseng, 20-30 parts of oregano, 40-50 parts of jujube, 20-30 parts of Ligustrum lucidum, 40-50 parts of red peony root, and 5-10 parts of Schisandra chinensis, add auxiliary materials, dry, and crush to make a medicine in the form of tablets, capsules, granules, powders, suspensions or pills.

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