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Antivirus compound formulation, preparation process, quality control method and use thereof

A compound preparation, antiviral technology, applied in antiviral agents, pill delivery, pharmaceutical formulations, etc., can solve the problems of western medicine with large side effects, slow onset of effect, and large dosage of patients.

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many medicines for treating colds on the market, Western medicines generally have the problem of large side effects, while Chinese patent medicines are medicines that are used to treat diseases according to different causes and combined with TCM theory, such as wind-cold cold, wind-heat cold, etc. choose different drugs for treatment
Moreover, there are disadvantages such as dizziness, drowsiness, and weakness of limbs in Western medicine cold medicines currently on the market; while pure Chinese medicine cold medicines have disadvantages such as slow onset of action.
In order to achieve better prevention and control purposes, many inventors and pharmaceutical companies have done a lot of research, and also provided some excellent therapeutic products; such as: patent application number: 200410048399.7, named "an antiviral orally disintegrating tablet and Its preparation method" patent application, it is used for cold diseases and has a quick effect; but in-depth research has found that the use of large prescriptions with many medicinal flavors has complicated ingredients in the preparation, and the patient takes a large amount of medicine. On this basis, the applicant has adopted the effective parts or monomer compatibility of Scutellaria baicalensis, Epimedium, and Houttuynia cordata, which can not only reduce the dosage of patients, but also remove some components with strong toxic and side effects in the extracts of medicinal materials, and improve the efficacy of the preparation. The controllability of safety and quality greatly improves the curative effect and is more conducive to the molding of preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1 of the present invention: Baicalin 50g Epimedium total flavonoids 25g Houttuynia cordata extract 25g

[0061] Take the baicalin, total flavonoids of Epimedium, and Houttuynia cordata extract in the above parts by weight, add 1800ml of water for injection, add mannitol according to the dosage ratio of medicine and auxiliary materials 1: 2.6, and adjust the pH value to 5.5~ with saturated sodium hydroxide solution. 8.0, add water for injection to 2000ml, mix well, add 0.3% activated carbon for needles, boil for 30 minutes, coarse filter, then filter with 0.45μm and 0.22μm microporous membranes, divide the filtrate, 2.0ml per bottle, freeze Drying, when the equilibrium freezing temperature of the first stage is 0°C, the equilibrium time is 4 hours, that is, the time when the shelf temperature is basically consistent with the product temperature; in the second stage, when the freezing temperature is from 0°C to the lowest eutectic temperature -18°C, The balance ti...

Embodiment 2

[0065] Example 2 of the present invention: Baicalin 50g Epimedium total flavonoids 25g Houttuynia cordata extract 25g

[0066] Take the extracts of the above-mentioned baicalin, total flavonoids of Epimedium, and Houttuynia cordata extract in parts by weight, add 5% citric acid, 15% mannitol, and 25% polyvinylpyrrolidone K30, pass through a 30-mesh sieve, and add an appropriate amount of Talcum powder and micropowder silica gel are mixed evenly, and pressed into tablets to obtain sublingual lozenges. 2 sticks at a time, once a day, dissolved in 250ml of 0.9% normal saline before use. Calculated in percent by weight, the sum of flavonoid components and all other measurable components in the preparation is 60% of the total solid content of the preparation after deducting the amount of auxiliary materials and moisture.

[0067] Among them, baicalin can be obtained from the market or prepared by the following method: crush Scutellaria baicalensis, add 8 times the volume of 70% et...

Embodiment 3

[0070] Embodiment 3 of the present invention: Baicalin 40g Epimedium total flavonoids 60g

[0071]Take the above weight parts of baicalin and total flavonoids of Epimedium, add 1800ml of water for injection, add mannitol according to the dosage ratio of drug and auxiliary materials 1:2.6, adjust the pH value to 5.5-8.0 with saturated sodium hydroxide solution, add water for injection to 2000ml , mix well, add 0.3% activated carbon for needles, boil for 30 minutes, coarsely filter, then filter with 0.45μm and 0.22μm microporous membranes, divide the filtrate, 2.0ml per bottle, freeze-dry, the first stage of equilibrium The equilibrium time when the freezing temperature is 0°C is 4 hours, that is, the time when the shelf temperature is basically consistent with the product temperature; in the second stage, when the freezing temperature is from 0°C to the lowest eutectic temperature -18°C, the shelf temperature and product temperature are balanced The time is 2 hours; the third s...

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PUM

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Abstract

The invention discloses a compound preparation which comprises two or more of extracts of baikal skullcap root glycosides, barren wort flavones and houttuynia cordata, and can be prepared into injections, capsules, tablets, dispersible tablets, sublingual tablets, granules, oral liquid preparations, drop pills and other pharmacologically allowable dose forms. The preparation can be used for treating pneumonia, respiratory tract infection, influenza, avian Influenza, SARS, asthma, and low body immunity.

Description

technical field [0001] The invention relates to an antiviral compound preparation and its preparation method, quality control method and application, belonging to the technical field of traditional Chinese medicine. technical background [0002] A cold is an upper respiratory tract infection caused by a variety of viruses, commonly known as "cold", and is a common respiratory disease that can occur in all seasons. Viral influenza is upper respiratory tract infection, also referred to as upper flu, which is a common respiratory infectious disease caused by multiple viruses. Although there are many medicines for treating colds on the market, Western medicines generally have the problem of large side effects, while Chinese patent medicines are medicines that are used to treat diseases according to different causes and combined with TCM theory, such as wind-cold cold, wind-heat cold, etc. Choose different drugs for treatment. Moreover, there are disadvantages such as dizziness...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K31/7048A61K9/08A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61P31/12
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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