Medicinal composition

A composition and drug technology, applied in the field of antiviral drug compositions and antiviral therapeutic drug compositions, can solve the problem that 1-deoxynojirimycin cannot be absorbed into the blood, etc., and achieve stable, controllable and automated origin and origin. The effect of high degree and reducing adverse reactions

Inactive Publication Date: 2010-12-29
辽宁科泰生物基因制药股份有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although 1-deoxynojirimycin showed excellent broad-spectrum antiviral effect in vitro antiviral test, the unique chemical structure of 1-deoxynojirimycin makes it competitive with The combination of multiple glucosidases on the microvilli of small intestinal brush border cells is not enough to saturate the huge amount of glucosidases in the usual doses, so 1-deoxynojirimycin is almost ineffective when administered orally in the gastrointestinal tract. Absorb into blood, can not bring into play its good antiviral effect in human body and limit the application of 1-deoxynojirimycin in antiviral field, therefore need to solve the existing problem, make 1-deoxynojirimycin composition can enter blood and play an antiviral role

Method used

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Experimental program
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Effect test

Embodiment 11

[0031] The preparation of embodiment 1.1-deoxynojirimycin raw material

[0032] 20kg of dried mulberry leaves (place of origin: Zhejiang, 1-DNJ content 0.286%) were crushed into coarse powder, added 10 times the amount of deionized purified water, stirred and extracted at 80°C for 3 times, each time for 1.5 hours, filtered, combined filtrates, 70°C Concentrate under reduced pressure to a relative density of 1.2g / ml to obtain the water extract extract, take the water extract extract and dry it under reduced pressure and vacuum at 70°C for 12 hours to obtain 4.28kg of dry extract (1-DNJ content 1.323%), pulverize, and take 50 Double the amount of methanol or ethanol, add extract powder under stirring, heat up to 90°C, stir and reflux for extraction for 1 hour, filter, operate in the same way 3 times, combine the filtrate, concentrate under reduced pressure at 70°C to a relative density of 1.1g / ml, 70°C Vacuum drying under reduced pressure for 8 hours yielded 0.46 kg of purified ...

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Abstract

The invention discloses a solid or liquid medicinal composition for non-gastrointestinal administration. The medicinal composition contains 1-deoxynojirimycin component and / or pharmaceutically acceptable salt thereof, and the 1-deoxynojirimycin component and / or the pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient are prepared into the medicinal composition for non-gastrointestinal administration together. The medicinal composition for non-gastrointestinal administration can be injection, pills, sublingual tablets, oral patches, buccal tablets, respiratory inhalation aerosol, powder for inhalation, suppository and capsules for rectums and transdermal preparations. The medicinal composition can be used for preventing and / or treating virus infection of mammals comprising human in a non-gastrointestinal administration mode, and the composition has good broad-spectrum antivirus effect and high safety.

Description

technical field [0001] The invention relates to an antiviral pharmaceutical composition, which belongs to the technical field of pharmaceutical preparations, and specifically relates to an antiviral drug composition suitable for administration through injection, absorption through oral mucosa, absorption through sublingual vein, inhalation through the respiratory tract, administration through rectum, and administration through nasal mucosa. Absorption, absorption through the skin, and an antiviral therapeutic pharmaceutical composition for parenteral use such as eye medication. Background technique [0002] Viral infection and transmission have always been an important health problem threatening the world, and how to find effective broad-spectrum antiviral drugs for the prevention and treatment of viral infections has always been a hot topic in the medical field. Although there are a large number of antiviral drugs, their antiviral spectrum is broad However, there are very f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61P31/12A61K9/20A61K9/70A61K9/72A61K9/02A61K9/48
Inventor 胡晓阳
Owner 辽宁科泰生物基因制药股份有限公司
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