Vitamin b12 compositions

a technology of compositions and vitamins, applied in the field of vitamin b12 compositions, can solve the problems of inconvenient self-administration for patients, inability to and existing vitamin bsub>12/sub>compositions to provide convenient self-administration for patients in a readily absorbable form, etc., to achieve superior absorbability and administration, improve vitamin b12 absorption, and efficiently metabolize and absorb vitamin

Inactive Publication Date: 2013-05-23
BEBAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]Many patients require vitamin B12 supplementation to combat vitamin B12 deficiency associated with anemia, pernicious anemia, immune system disorders, nerve damage, partial removal of the stomach or small intestine, or administration of drugs known to impair vitamin B12 absorption. Because of the large size of vitamin B12, the body neither efficiently metabolizes nor absorbs the vitamin. Existing vitamin B1

Problems solved by technology

Because of the large size of vitamin B12, the body neither efficiently metabolizes nor absorbs the vitamin.
Existing vitamin B12 compositions fail to provide convenient self-administrat

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Composition

[0099]A lozenge is prepared. The components of the composition, and their respective amounts, by weight, are listed in Table 1.

TABLE 1MaterialMilligram per Unit DoseCyanocobalamin, Hydroxocobalamin,Equal amounts of eachMethylcobalaminIsomalt galenIQ ™ 721182.750Polyethylene Glycol 800062.500Flavoring0.500Magnesium Searate1.250

example 2

Manufacture of Vitamin B12 Composition

[0100]About 5 grams of cyanocobalamin, about 5 grams of hydroxycobalamin acetate and about 5 grams of methylcobalamin are passed through a #20 mesh stainless steel screen.

[0101]About 15 grams of isomalt is passed through a #20 mesh screen and combined with the methyl-, cyano- and hydroxy-cobalamin mixture. Pre-blend 1 is mixed until a substantially homogenous mixture is observed.

[0102]About 90 grams of isomalt is passed through a #20 mesh screen and combined with pre-blend 1. Pre-blend 2 is mixed until a substantially homogenous mixture is observed.

[0103]About 360 grams of isomalt is passed through a #20 mesh screen and combined with pre-blend 2. Pre-blend 3 is mixed until a substantially homogenous mixture is observed. Pre-blend 3 is transferred into a blender.

[0104]About 448.75 grams of isomalt, about 312.5 grams of PEG-8000 and about 2.5 grams of cherry flavoring are passed through a #20 mesh screen and transferred into the blender with pre-b...

example 3

Treating Vitamin B12 Deficiency with Vitamin B12 Described Herein

[0107]A human presents with vitamin B12 deficiency associated with pernicious anemia, including impaired perception of deep touch and deep muscle-tendon reflexes. The patient self-administers a vitamin B12 lozenge according to Example 1. The human's symptoms of vitamin B12 deficiency are decreased.

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Abstract

This disclosure provides compositions of vitamin B12, and methods of treatment or amelioration of a disease associated with vitamin B12 deficiency. The composition can take the form of a solid, semi-solid, gummy, or chewable lozenge. The composition can also take the form of a troche, a candy, a wafer, an orally disintegrating tablet, a sublingual tablet, a buccal tablet, a buccal patch, an oral dissolvable film, an aerosol or spray, a lip balm, and chewing gum.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This application is a continuation-in-part of copending U.S. application Ser. No. 11 / 219,794 filed on Sep. 7, 2005, herein incorporated by reference in its entirety.FIELD OF INVENTION[0002]The present invention provides improved vitamin B12 compositions containing a mixture of vitamin B12 analogues in effective amounts for enhanced delivery via the mucosal membranes, such as the mouth, nose, etc., to ameliorate any condition associated with vitamin B12 deficiency in a human.BACKGROUND OF THE INVENTION[0003]Vitamin B12, otherwise known as cobalamin, is the largest and most structurally complex of the eight water-soluble B vitamins. Vitamin B12 is a class of cobalt and corrin ring molecules that possess vitamin activity. The sixth coordination site of the corrin ring is either a cyano group (—CN), a hydroxyl group (—OH), a methyl group (—CH3) or a 5′-deoxyadenosyl group, creating four forms of vitamin B12, including, cyanocobalamin, hydroxoc...

Claims

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Application Information

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IPC IPC(8): A61K31/714
CPCA61K31/714A61K9/006A61K9/485A61K9/0095A61K9/007
Inventor BROWN, CHAD
Owner BEBAAS
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