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Method for eliminating static electricity in micro-pill room

A technology of micro-pills and static electricity, which is applied in the direction of static electricity, electrical components, and devices that make drugs into special physical or ingestible forms. It can solve the problems of insufficient water content, long processing time, and unfeasible drugs, etc. Prevention or morbidity, enhanced efficacy, morbidity-reducing effect

Active Publication Date: 2012-10-03
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, we have also done a lot of tests on the ground wire, which proves that it is not advisable, because there is almost no change when it is simply connected to the equipment. If it is placed in the medicine for 24 hours, it can indeed greatly change the static electricity. It does not meet the requirements and the processing time is extremely long
Finally, the antistatic machine is removed when the medicine passes through the antistatic bar, which also consumes a lot of time
Adding electrostatic liquid can remove static electricity, but most of the existing electrostatic liquid is inedible, so it is not feasible for medicine

Method used

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  • Method for eliminating static electricity in micro-pill room

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Adjust the rotating speed of the main engine of the coating granulator to 60r / min, and the blast pressure to 0.2Pa. Weigh 15Kg of the semi-finished Lemai pills and put them into the coating granulator. After the temperature of the pot body reaches the requirement, spray a certain amount of Soybean oil is relatively moist to the surface of the meatballs, and the medicine can be collected only after there is a smooth oil layer. Considering that the lower the temperature, the smaller the static electricity, the applicant then investigated the temperature of the pan body of the coating granulator. The investigation results are shown in Table 1 below.

[0017] Table 1

[0018]

[0019] Conclusion: It can be seen from Table 1 that when the temperature of the pot body is below 43°C, Lemai Pills will not stick to the composite film.

Embodiment 2

[0021] The composite film is not sticky when the temperature of the pot is below 43°C, but when the temperature of the pot is low, the surface of the meatballs will be too wet, and then there will be adhesion between the meatballs, and finally the actual yield will be reduced. The applicant Statistical investigations were carried out on meatballs at different temperatures, and the results are shown in Table 2 below.

[0022] Table 2

[0023]

[0024]

[0025] Conclusion: It can be seen from the above table 2 that when the temperature of the pot body is at 40±2°C, the yield is higher.

Embodiment 3

[0027] After spraying medicinal soybean oil, transfer the balls to boiling drying for drying. At this time, the drying temperature is particularly critical. On the one hand, considering the high friction between the balls in boiling drying, high temperature will make static electricity more serious. On the other hand, high temperature Otherwise, the active ingredients in Lemai Pills will volatilize (Lemai Pills contain woody fragrance, and woody fragrance contains volatile oil). The applicant also investigated the temperature of boiling drying. We investigated the experience temperature when no soybean oil was sprayed in the past. The results of the investigation are shown in Table 3 below:

[0028] table 3

[0029]

[0030] Conclusion: It is consistent with the temperature requirement when no soybean oil is sprayed in the past. The effective ingredient identification is obvious when the air inlet temperature is 65-70°C and the outlet air temperature is 60°C.

[0031] Note...

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Abstract

The invention discloses a method for eliminating static electricity in a micro-pill room. The method is characterized by comprising the following steps of: coating micro-pills, and spraying medicinal soybean oil which is 0.03-0.05 percent by weight the mass of the micro-pills into a coating granulator, wherein during spraying of the medicinal soybean oil, the rotating speed of a host machine of the coating granulator is controlled at 50-70 revolutions per minute, the blowing pressure is controlled at 0.2-0.4Pa, and the temperature of a boiler body of the coating granulator is controlled to be less than or equal to 43 DEG C; and after the surfaces of the micro-pills are coated with a layer of medicinal soybean oil, taking out and transferring into a boiling drying furnace for drying. The medicinal soybean oil is added, so that the problem of electric electricity in a pill room is solved, the quality of naloxone hydrochloride pills for injection is ensured, and linoleic acid in soybean oil can play a certain role in enhancing the medicinal effect of a medicament.

Description

Technical field: [0001] The invention relates to a method for removing static electricity between micro-pills, in particular to a method for removing static electricity between micro-pills. Background technique: [0002] Static electricity is the imagination that the positive and negative charges of atoms will be unbalanced due to external effects such as friction or in the form of various energies such as kinetic energy, potential energy, thermal energy, chemical energy, etc. In solid pharmaceuticals, especially during the preparation of pellets, the possibility of generating static electricity is particularly serious. In the preparation of pellets, because the pellets are small, there is a lot of friction during the preparation process (during coating machine preparation, boiling drying, coating machine coating, subpackaging machine subpackaging), resulting in serious electrostatic imagination, so The adhesion of the pellets to the PE bag and the composite film can even a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/06A61K9/16A61K47/44H05F1/02
Inventor 叶湘武余渊赵久发
Owner GUIZHOU JINGFENG INJECTION
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