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Naloxone Hydrochloride nose powder preparation

A technology of naloxone hydrochloride and powder, which is applied in the fields of antidote, powder delivery, and pharmaceutical formulations, and can solve problems such as inconvenient use, impact on absorption and bioavailability, and poor compliance for patients

Inactive Publication Date: 2005-01-19
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, injections are usually used in hospitals or clinics, which is inconvenient for patients and poor in compliance; when sublingual tablets are used, the active ingredient naloxone hydrochloride usually encounters the first-pass effect of the liver, thereby reducing drug efficacy and absorption and bioavailability will be affected

Method used

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Examples

Experimental program
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Embodiment 1

[0011] Example 1 Preparation of naloxone hydrochloride nasal powder.

[0012] Weigh 10g of naloxone hydrochloride fine powder that has been crushed through a 120-mesh sieve (calculated as a dry product), and another 152g of lactose and 36g of mannitol that have passed through a 120-mesh sieve are weighed, and mixed uniformly by an equal-volume ascending method, and passed through a 40-mesh sieve. Sieve twice, add an appropriate amount of 0.5% sodium carboxymethylcellulose aqueous solution to make a soft material, granulate with an 80-mesh sieve, dry at 60°C, granulate with an 80-mesh sieve, add 2 g of sodium chloride through a 120-mesh sieve, Mix well to get naloxone hydrochloride nasal powder. At the same time, they are respectively filled in single-dose and multi-dose nasal powder devices, and packed for later use.

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Abstract

The invention relates to hydrochloric naloxone nose powder preparation and its preparation method, the invention also relates to the hydrochloric naloxone single dosage and multiple dosage administration nose powder preparation, which comprises hydrochloric naloxone and one or more selected from mannitol, glucose, and soluble starch, sodium chloride, microcrystalline cellulose and sodium carboxymethylcellulose as medicinal findings.

Description

Field of Invention [0001] The invention relates to naloxone hydrochloride nasal powder and a preparation method thereof. The present invention also relates to nasal powder in the form of single-dose and multi-dose administration of naloxone hydrochloride. The nasal powder preparation of the present invention includes naloxone hydrochloride and one or more pharmaceutical excipients selected from lactose, mannitol, glucose, soluble starch, sodium chloride, microcrystalline cellulose and sodium carboxymethyl cellulose. Background technique [0002] Naloxone Hydrochloride (Naloxone Hydrochloride) is a morphine antagonist, which can be used for emergency treatment of morphine drug poisoning and acute alcoholism, etc. The clinical application of this drug is injection and sublingual lozenge. However, injections are usually used in hospitals or clinics, which is inconvenient for patients and poor in compliance; when sublingual tablets are used, the active ingredient naloxone hydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/485A61P39/02
Inventor 王维贤高立军梅兴国
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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