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Naloxone hydrochloride nasal spray

A technology of nasal spray and naloxone hydrochloride, which is applied in aerosol delivery, anti-virus, and pharmaceutical formulations, and can solve the problems of absorption and bioavailability, inconvenient use, and poor compliance

Inactive Publication Date: 2005-02-09
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are injections and sublingual tablets for clinical application of the drug, but injections are usually used in hospitals or clinics, both of which have problems of inconvenient use and poor compliance; thus reducing drug efficacy and affecting absorption and bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of Nasal Spray of Naloxone Hydrochloride.

[0013] Weigh 0.03g of ethyl p-hydroxybenzoate, put it in a 100ml measuring bottle, add an appropriate amount of water for injection, heat in a warm water bath to dissolve, cool to room temperature, then add 1.0g of dry product of naloxone hydrochloride, 0.9g of sodium chloride, shake Shake to dissolve, add water for injection close to the mark, shake well, adjust to pH 3.8±0.8 with 0.1mol / L hydrochloric acid, add water for injection to the mark, shake well, filter with 0.25μm microporous membrane until the liquid is clear, Promptly get the naloxone hydrochloride nasal cavity spray liquid. Subsequently, they are respectively filled in single-dose and multi-dose nasal spray devices, and packed for later use.

Embodiment 2

[0014] Example 2 Preparation of Nasal Spray of Naloxone Hydrochloride.

[0015] Weigh 0.03g of ethyl p-hydroxybenzoate, put it in a 100ml measuring bottle, add 20g of propylene glycol, add an appropriate amount of water for injection, heat in a warm water bath to dissolve, cool to room temperature, then add 1.0g of dry product of naloxone hydrochloride, and chlorinate Sodium 0.9g, shake to dissolve, add water for injection up to the mark, shake well, adjust to pH 3.8±0.8 with 0.1mol / L hydrochloric acid, add water for injection to the mark, shake well, filter with 0.25μm microporous membrane Until the liquid is clear, the naloxone hydrochloride nasal spray liquid is obtained. Subsequently, they are respectively filled in single-dose and multi-dose nasal spray devices, and packed for later use.

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PUM

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Abstract

The present invention is nasal cavity spray of Naloxine hydrochloride and its preparation process. The preparation of the present invention may be applied in single dosage form or multiple dosage form. The spray of the present invention includes Naloxine hydrochloride, osmotic pressure regulator, preservative, osmotic promoter and water.

Description

field of invention [0001] The invention relates to naloxone hydrochloride nasal cavity spray and a preparation method thereof. The invention also relates to single-dose and multi-dose nasal cavity sprays of naloxone hydrochloride. The nasal cavity spray of the present invention includes naloxone hydrochloride, osmotic pressure regulator, preservative, penetration enhancer and water. Background technique [0002] Naloxone Hydrochloride is a morphine antagonist, which can be used for emergency treatment of morphine drug poisoning and acute alcohol poisoning. The clinical application of the drug includes injections and sublingual tablets, but injections are usually used in hospitals or clinics, both of which have problems of inconvenient use and poor compliance; thus reducing drug efficacy and affecting absorption and bioavailability. Contents of the invention [0003] The purpose of the present invention is to overcome the deficiencies in the two preparations of naloxone h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/485A61P39/02
Inventor 王维贤高立军梅兴国
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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